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Substrates for peptidase S01.302: matriptase

Summary Gene structure Alignment Tree Sequences Sequence features Distribution Structure Literature Substrates Pharma

Peptide and protein substrates that are thought to be physiologically relevant are indicated by P. Peptide and protein substrates that are thought to be pathologically relevant are indicated by D. Peptide and protein substrates that are not physiologically relevant are indicated by N. Synthetic substrates are indicated by S. Click on the symbol to show only physiological, non-physiological or synthetic substrates, or here to display all substrates. How cleavage sites have been identified are indicated by the following evidence codes: NT = N-terminal sequencing, MS = mass spectroscopy, MU = mutation, CS = consensus sequence, LC = liquid chromatography. To see all annotated cleavages for a protein substrate, click on the UniProt Accession.

Substrate Uniprot Residue range Cleavage Site Cleavage type Evidence P4 P3 P2 P1 P1' P2' P3' P4' Reference CutDB MERNUM
Q9BQ02 366-377 GSVR+ARIVTDRE N MS Gly Ser Val Arg Ala Arg Ile Val Barré et al., 2014
Q9BQ02 329-353 peptide-Arg339+Ser-peptide N MS Pro Asn Ala Arg Ser Gln Pro Ser Barré et al., 2014
14-3-3 protein epsilon Q7M4R4 190-205 RACR+LAKAAFDDAIAE N MS Arg Ala Cys Arg Leu Ala Lys Ala Barré et al., 2014
26S protease regulatory subunit 10B P62333 297-306 R+KIHIDLPNE N MS - - - Arg Lys Ile His Ile Barré et al., 2014
40S ribosomal protein S10 P46783 126-141 TYRR+SAVPPGADKKAE N MS Thr Tyr Arg Arg Ser Ala Val Pro Barré et al., 2014
40S ribosomal protein S16 P62249 2-40 peptide-Arg27+Gly-peptide N MS His Cys Lys Arg Gly Asn Gly Leu Barré et al., 2014
40S ribosomal protein S24 P62847 4-39 peptide-Arg20+Lys-peptide N MS Leu Leu Gln Arg Lys Gln Met Val Barré et al., 2014
40S ribosomal protein S3a P61247 33-68 peptide-Arg51+Thr-peptide N MS Leu Val Thr Arg Thr Gln Gly Thr Barré et al., 2014
60S ribosomal protein L4 P36578 36-56 IVNFVHTNLR+KNNRQPYAVSE N MS Thr Asn Leu Arg Lys Asn Asn Arg Barré et al., 2014
60S ribosomal protein L7a P62424 2-23 peptide-Lys10+Lys-peptide N MS Ala Lys Gly Lys Lys Val Ala Pro Barré et al., 2014
78 kDa glucose-regulated protein P11021 294-308 KAKR+ALSSQHQARIE N MS Lys Ala Lys Arg Ala Leu Ser Ser Barré et al., 2014
Abz-Arg-Ala-Ala-Arg-Val-Val-Gly-Gly-Tyr(NO2) Abz-Arg-Ala-Ala-Arg+Val-Val-Gly-Gly-Tyr(NO2) S Arg Ala Ala Arg Val Val Gly Gly Beliveau et al., 2009
Abz-Arg-Arg-Ala-Arg-Val-Val-Gly-Gly-Tyr(NO2) Abz-Arg-Arg-Ala-Arg+Val-Val-Gly-Gly-Tyr(NO2) S Arg Arg Ala Arg Val Val Gly Gly Beliveau et al., 2009
Abz-Arg-Gln-Ala-Arg-Ala-Val-Gly-Gly-Tyr(NO2) Abz-Arg-Gln-Ala-Arg+Ala-Val-Gly-Gly-Tyr(NO2) S Arg Gln Ala Arg Ala Val Gly Gly Beliveau et al., 2009
Abz-Arg-Gln-Ala-Arg-Gln-Val-Gly-Gly-Tyr(NO2) Abz-Arg-Gln-Ala-Arg+Gln-Val-Gly-Gly-Tyr(NO2) S Arg Gln Ala Arg Gln Val Gly Gly Beliveau et al., 2009
Abz-Arg-Gln-Ala-Arg-Tyr-Val-Gly-Gly-Tyr(NO2) Abz-Arg-Gln-Ala-Arg+Tyr-Val-Gly-Gly-Tyr(NO2) S Arg Gln Ala Arg Tyr Val Gly Gly Beliveau et al., 2009
Abz-Arg-Gln-Ala-Arg-Val-Val-Gly-Gly-Tyr(NO2) Abz-Arg-Gln-Ala-Arg+Val-Val-Gly-Gly-Tyr(NO2) S Arg Gln Ala Arg Val Val Gly Gly Beliveau et al., 2009
Abz-Arg-Gln-Arg-Arg-Val-Val-Gly-Gly-Tyr(NO2) Abz-Arg-Gln-Arg-Arg+Val-Val-Gly-Gly-Tyr(NO2) S Arg Gln Arg Arg Val Val Gly Gly Beliveau et al., 2009
Abz-Arg-Gln-Asp-Arg-ANB-NH2 Abz-Arg-Gln-Asp-Arg+ANB-NH2 S Arg Gln Asp Arg ANB NH2 - - Wysocka %eta, 2010
Abz-Arg-Gln-Asp-Lys-ANB-NH2 Abz-Arg-Gln-Asp-Lys+ANB-NH2 S Arg Gln Asp Lys ANB NH2 - - Wysocka %eta, 2010
Abz-Arg-Gln-Leu-Arg-Val-Val-Gly-Gly-Tyr(NO2) Abz-Arg-Gln-Leu-Arg+Val-Val-Gly-Gly-Tyr(NO2) S Arg Gln Leu Arg Val Val Gly Gly Beliveau et al., 2009
Abz-Arg-Gln-Tyr-Arg-Val-Val-Gly-Gly-Tyr(NO2) Abz-Arg-Gln-Tyr-Arg+Val-Val-Gly-Gly-Tyr(NO2) S Arg Gln Tyr Arg Val Val Gly Gly Beliveau et al., 2009
Abz-Arg-Leu-Ala-Arg-Val-Val-Gly-Gly-Tyr(NO2) Abz-Arg-Leu-Ala-Arg+Val-Val-Gly-Gly-Tyr(NO2) S Arg Leu Ala Arg Val Val Gly Gly Beliveau et al., 2009
Abz-Arg-Tyr-Ala-Arg-Val-Val-Gly-Gly-Tyr(NO2) Abz-Arg-Tyr-Ala-Arg+Val-Val-Gly-Gly-Tyr(NO2) S Arg Tyr Ala Arg Val Val Gly Gly Beliveau et al., 2009
Activated RNA polymerase II transcriptional coactivator p15 P53999 96-108 MKPGR+KGISLNPE N MS Lys Pro Gly Arg Lys Gly Ile Ser Barré et al., 2014
Adenylosuccinate lyase P30566 446-464 PSSFTGR+ASQQVQRFLEEE N MS Phe Thr Gly Arg Ala Ser Gln Gln Barré et al., 2014
Aldehyde dehydrogenase, mitochondrial P05091 48-63 AVSR+KTFPTVNPSTGE N MS Ala Val Ser Arg Lys Thr Phe Pro Barré et al., 2014
Alpha-actinin-4 O43707 214-229 KLR+KDDPVTNLNNAFE N MS - Lys Leu Arg Lys Asp Asp Pro Barré et al., 2014
amyloid-like protein 1 P51693 1-650 peptide-Arg124+Ser-peptide P NT Gly Gly Ser Arg Ser Gly Ser Cys Lanchec et al., 2020
Annexin A6NN80 369-383 AKALR+KAMKGLGTDE N MS Lys Ala Leu Arg Lys Ala Met Lys Barré et al., 2014
Annexin A7 P20073 193-205 ILR+KAMKGFGTDE N MS - Ile Leu Arg Lys Ala Met Lys Barré et al., 2014
Aspartate aminotransferase, mitochondrial P00505 350-365 RIIGMR+TQLVSNLKKE N MS Ile Gly Met Arg Thr Gln Leu Val Barré et al., 2014
Boc-Bz-Glu-Ala-Arg-NHMec Boc-Bz-Glu-Ala-Arg+NHMec S Bz Glu Ala Arg AMC - - - Lee et al., 2000
Boc-Bz-Glu-Gly-Arg-NHMec Boc-Bz-Glu-Gly-Arg+NHMec S Bz Glu Gly Arg AMC - - - Lee et al., 2000
Boc-Gln-Ala-Arg-NHMec Boc-Gln-Ala-Arg+NHMec S Boc Gln Ala Arg AMC - - - Lee et al., 2000
Boc-Gln-Gly-Arg-NHMec Boc-Gln-Gly-Arg+NHMec S Boc Gln Gly Arg AMC - - - Lee et al., 2000
Boc-Leu-Gly-Arg-NHMec Boc-Leu-Gly-Arg+NHMec S Boc Leu Gly Arg AMC - - - Lee et al., 2000
Boc-Phe-Ser-Arg-NHMec Boc-Phe-Ser-Arg+NHMec S Boc Phe Ser Arg AMC - - - Wysocka %eta, 2010
C-1-tetrahydrofolate synthase, cytoplasmic P11586 245-260 KKPNGR+KVVGDVAYDE N MS Pro Asn Gly Arg Lys Val Val Gly Barré et al., 2014
CDCP1 Q9H5V8 30-836 peptide-Arg368+Lys-peptide P Lys Gln Ser Arg Lys Phe Val Pro Bhatt et al., 2005 18860
Clathrin heavy chain 1 Q00610 213-232 STLFCFAVR+GQAGGKLHIIE N MS Phe Ala Val Arg Gly Gln Ala Gly Barré et al., 2014
Clathrin heavy chain 1 Q00610 963-981 SNPYR+RPLIDQVVQTALSE N MS Asn Pro Tyr Arg Arg Pro Leu Ile Barré et al., 2014
Cullin-associated NEDD8-dissociated protein 1 Q9H0G2 117-146 peptide-Arg137+Leu-peptide N MS Ile Thr Gly Arg Leu Thr Ser Ala Barré et al., 2014
Cytoplasmic dynein 1 heavy chain 1 Q14204 3576-3598 peptide-Asn3584+Arg-peptide N MS Lys Arg Phe Asn Arg Tyr Pro Leu Barré et al., 2014
D-3-phosphoglycerate dehydrogenase O43175 87-108 peptide-Arg90+Lys-peptide N MS Ala Ala Thr Arg Lys Gly Ile Leu Barré et al., 2014
D-3-phosphoglycerate dehydrogenase O43175 50-68 GLIVR+SATKVTADVINAAE N MS Leu Ile Val Arg Ser Ala Thr Lys Barré et al., 2014
Double-strand-break repair protein rad21 homolog O60216 316-331 TKAKRKR+KLIVDSVKE N MS Lys Arg Lys Arg Lys Leu Ile Val Barré et al., 2014
Dynactin subunit 2 Q13561 329-341 LVQR+LVTIKQLHE N MS Leu Val Gln Arg Leu Val Thr Ile Barré et al., 2014
Dynein light chain 1, cytoplasmic P63167 4-16 R+KAVIKNADMSEE N MS - - - Arg Lys Ala Val Ile Barré et al., 2014
Elongation factor 1-delta P29692 225-250 peptide-Arg241+Lys-peptide N MS Tyr Gly Ile Arg Lys Leu Gln Ile Barré et al., 2014
Endoplasmin P14625 236-253 PRGNTLGR+GTTITLVLKE N MS Thr Leu Gly Arg Gly Thr Thr Ile Barré et al., 2014
Endothelial differentiation-related factor 1 O60869 111-125 SGR+AIPNNQVLGKIE N MS - Ser Gly Arg Ala Ile Pro Asn Barré et al., 2014
fibronectin P07589 33-2478 peptide-Arg1616+Gly-peptide P NT Val Thr Gly Arg Gly Asp Ser Pro Satomi et al., 2001
filaggrin P20930 1-4061 peptide-Arg293+Gly-peptide P Arg Lys Arg Arg Gly Ser Arg Val Uhland, 2006
filaggrin P20930 20-1356 peptide-Gly728+Gln-peptide P Thr Gly His Gly Gln Ala Ser Ser Darragh et al., 2008
Fructose-bisphosphate aldolase C P09972 19-35 IALR+IVAPGKGILAADE N MS Ile Ala Leu Arg Ile Val Ala Pro Barré et al., 2014
Fructose-bisphosphate aldolase C P09972 19-35 IAL+RIVAPGKGILAADE N MS - Ile Ala Leu Arg Ile Val Ala Barré et al., 2014
Glutathione S-transferase P P09211 61-86 peptide-Arg75+Thr-peptide N MS His Leu Gly Arg Thr Leu Gly Leu Barré et al., 2014
GTP-binding nuclear protein Ran Q9CSP3 159-175 KPFLWLAR+KLIGDPNLE N MS Trp Leu Ala Arg Lys Leu Ile Gly Barré et al., 2014
hemagglutinin {ECO:0000313|EMBL:ABM46228.1} A3R530 1-518 peptide-Arg320+Gly-peptide N NT Arg Ser Ser Arg Gly Leu Phe Gly Baron et al., 2013
hemagglutinin {ECO:0000313|EMBL:ABM46232.1} A3R534 1-536 peptide-Arg338+Gly-peptide N NT Arg Ser Arg Arg Gly Leu Phe Gly Baron et al., 2013
Hematological and neurological expressed 1 protein Q9UK76 122-154 peptide-Arg141+Arg-peptide N MS Val Pro Ser Arg Arg Asn Pro Pro Barré et al., 2014
hepatocyte growth factor P14210 32-728 peptide-Arg494+Val-peptide P Lys Gln Leu Arg Val Val Asn Gly Uhland, 2006 18886
Heterogeneous nuclear ribonucleoprotein U-like protein 1 Q9UG75 523-536 GFQR+KAIVICPTDE N MS Gly Phe Gln Arg Lys Ala Ile Val Barré et al., 2014
Histone H1.2 P16403 17-42 peptide-Arg33+Lys-peptide N MS Gly Thr Pro Arg Lys Ala Ser Gly Barré et al., 2014
Histone H2A type 1-B/E P04908 74-93 NKKTRIIPR+HLQLAIRNDEE N MS Ile Ile Pro Arg His Leu Gln Leu Barré et al., 2014
Histone H2A type 1-B/E P04908 94-122 peptide-Arg100+Val-peptide N MS Leu Leu Gly Arg Val Thr Ile Ala Barré et al., 2014
Hypoxia up-regulated protein 1 Q9Y4L1 64-76 SRR+KTPVIVTLKE N MS - Ser Arg Arg Lys Thr Pro Val Barré et al., 2014
Insulin-like growth factor 2 mRNA-binding protein 3 O00425 131-145 QAR+QALDKLNGFQLE N MS - Gln Ala Arg Gln Ala Leu Asp Barré et al., 2014
insulin-like growth factor-binding protein 1 P08833 26-259 peptide-His165+Val-peptide P Lys Ala Leu His Val Thr Asn Ile Uhland, 2006
insulin-like growth factor-binding protein 7 precursor Q16270 27-282 peptide-Lys97+Ala-peptide P Arg Lys Gly Lys Ala Gly Ala Ala Ahmed et al., 2006
Intracellular hyaluronan-binding protein 4 Q5JVS0 343-358 SHVFR+KPANDITSQLE N MS His Val Phe Arg Lys Pro Ala Asn Barré et al., 2014
Keratin, type I cytoskeletal 18 P05783 182-200 IHGLR+KVIDDTNITRLQLE N MS His Gly Leu Arg Lys Val Ile Asp Barré et al., 2014
laminin, alpha 1-like DAA15893 peptide-Arg2400+Lys-peptide P NT Arg Val Val Arg Lys Gly Val Ser Satomi et al., 2001
Low molecular weight phosphotyrosine protein phosphatase Q53RU0 25-38 AVFR+KLVTDQNISE N MS Ala Val Phe Arg Lys Leu Val Thr Barré et al., 2014
Macrophage migration inhibitory factor P14174 56-86 peptide-Arg74+Ser-peptide N MS Ala Gln Asn Arg Ser Tyr Ser Lys Barré et al., 2014
matriptase Q9Y5Y6 1-855 peptide-Arg614+Val-peptide P Arg Gln Ala Arg Val Val Gly Gly Uhland, 2006
Mitochondrial import inner membrane translocase subunit TIM44 O43615 45-70 peptide-Arg56+Lys-peptide N MS Ser Gly Asn Arg Lys Gly Phe Leu Barré et al., 2014
Non-POU domain-containing octamer-binding protein Q15233 195-210 FSGKPAAR+KALDRCSE N MS Pro Ala Ala Arg Lys Ala Leu Asp Barré et al., 2014
Nuclear ubiquitous casein and cyclin-dependent kinase substrate 1 Q9H1E3 2-18 SRPVRNR+KVVDYSQFQE N MS Val Arg Asn Arg Lys Val Val Asp Barré et al., 2014
Nucleolar RNA helicase 2 Q9NR30 255-271 RKRGR+APQVLVLAPTRE N MS Lys Arg Gly Arg Ala Pro Gln Val Barré et al., 2014
Nucleophosmin Q8WTW5 40-56 HQLSLR+TVSLGAGAKDE N MS Leu Ser Leu Arg Thr Val Ser Leu Barré et al., 2014
Peroxiredoxin-6 P30041 61-77 FAKR+NVKLIALSIDSVE N MS Phe Ala Lys Arg Asn Val Lys Leu Barré et al., 2014
Phenylalanine--tRNA ligase beta subunit Q9NSD9 551-573 peptide-Arg554+Gly-peptide N MS Ile Phe Ala Arg Gly Gln Ser Val Barré et al., 2014
Plasminogen activator inhibitor 1 RNA-binding protein Q9Y367 78-93 R+KNPLPPSVGVVDKKE N MS - - - Arg Lys Asn Pro Leu Barré et al., 2014
podocin Q9NP85 1-383 peptide-Arg50+Ala-peptide P NT Gly Ser Gly Arg Ala Gly Thr Pro Ozawa et al., 2020
Poly(ADP-ribose) glycohydrolase ARH3 Q9NX46 79-93 TAMAR+ALVQSLLAKE N MS Ala Met Ala Arg Ala Leu Val Gln Barré et al., 2014
Polypyrimidine tract-binding protein 1 P26599 51-72 peptide-Arg64+Lys-peptide N MS Ile His Ile Arg Lys Leu Pro Ile Barré et al., 2014
Probable ATP-dependent RNA helicase DDX46 Q7L014 303-327 peptide-Arg315+Lys-peptide N MS Thr Lys Gln Arg Lys Leu Leu Glu Barré et al., 2014
Probable ATP-dependent RNA helicase DDX5 P17844 82-98 ITVR+GHNCPKPVLNFYE N MS Ile Thr Val Arg Gly His Asn Cys Barré et al., 2014
Proliferation-associated protein 2G4 Q9UQ80 152-168 AALR+LVKPGNQNTQVTE N MS Ala Ala Leu Arg Leu Val Lys Pro Barré et al., 2014
Prostasin Q9ESD1 33-322 peptide-Arg44+Ile-peptide P Ile Gln Pro Arg Ile Thr Gly Gly Netzel-Arnett et al., 2006
Protein disulfide-isomerase A4 P13667 223-240 LSKR+SPPIPLAKVDATAE N MS Leu Ser Lys Arg Ser Pro Pro Ile Barré et al., 2014
Protein disulfide-isomerase A6 Q99778 138-164 peptide-Arg153+Ser-peptide N MS Lys Gln Gly Arg Ser Asp Ser Ser Barré et al., 2014
Protein DJ-1 Q99497 2-16 ASKR+ALVILAKGAEE N MS Ala Ser Lys Arg Ala Leu Val Ile Barré et al., 2014
Protein PRRC2A Q96QC6 942-963 peptide-Arg947+Arg-peptide N MS Ala Pro Pro Arg Arg Ala Gly Pro Barré et al., 2014
proteinase-activated receptor 2 P55085 26-397 peptide-Arg36+Ser-peptide P Ser Lys Gly Arg Ser Leu Ile Gly Uhland, 2006
Putative annexin A2-like protein A6NMY6 201-219 AGVKR+KGTDVPKWISIMTE N MS Gly Val Lys Arg Lys Gly Thr Asp Barré et al., 2014
Putative heat shock protein HSP 90-alpha A2 Q14568 179-192 RMGR+GTKVILHLKE N MS Arg Met Gly Arg Gly Thr Lys Val Barré et al., 2014
Pyruvate kinase PKM Q96E76 305-332 peptide-Arg319+Ala-peptide N MS Arg Cys Asn Arg Ala Gly Lys Pro Barré et al., 2014
Radixin P35241 561-579 KYKTLRQIR+QGNTKQRIDE N MS Arg Gln Ile Arg Gln Gly Asn Thr Barré et al., 2014
Ribonucleoprotein PTB-binding 1 Q8IY67 428-451 peptide-Arg431+Arg-peptide N MS Leu Pro Pro Arg Arg Gly Lys Pro Barré et al., 2014
Ribulose-phosphate 3-epimerase-like protein 1 Q2QD12 56-68 SLR+KQLGQDPFFD N MS - Ser Leu Arg Lys Gln Leu Gly Barré et al., 2014
Serine dehydratase-like Q96GA7 59-96 peptide-Arg84+Lys-peptide N MS Tyr Ala Ala Arg Lys Leu Gly Ile Barré et al., 2014
Spermidine synthase P19623 82-110 peptide-Arg95+Lys-peptide N MS Pro Asn Pro Arg Lys Val Leu Ile Barré et al., 2014
stromelysin-1 P08254 18-477 peptide-Arg91+Cys-peptide P CS Arg Lys Pro Arg Cys Gly Val Pro Jin et al., 2006
Suc-Ala-Phe-Lys-NHMec Suc-Ala-Phe-Lys+NHMec S Suc Ala Phe Lys AMC - - - Lee et al., 2000
T-complex protein 1 subunit delta P50991 489-505 KTAGINVR+KGGISNILE N MS Ile Asn Val Arg Lys Gly Gly Ile Barré et al., 2014
T-complex protein 1 subunit delta P50991 525-539 TVR+SILKIDDVVNTR N MS - Thr Val Arg Ser Ile Leu Lys Barré et al., 2014
TATA-binding protein-associated factor 2N Q92804 358-385 peptide-Arg372+Arg-peptide N MS Asn Phe Ala Arg Arg Asn Ser Cys Barré et al., 2014
Thioredoxin-dependent peroxide reductase, mitochondrial Q96HK4 212-223 TLR+LVKAFQYVE N MS - Thr Leu Arg Leu Val Lys Ala Barré et al., 2014
Tropomyosin alpha-4 chain Q9UCS3 9-23 AVKR+KIQALQQQADE N MS Ala Val Lys Arg Lys Ile Gln Ala Barré et al., 2014
tumor-associated calcium signal transducer 2 P09758 1-323 peptide-Arg87+Thr-peptide P NT Lys Asn Ala Arg Thr Leu Val Arg Kamble et al., 2020
Uncharacterized protein CXorf57 Q9H7W5 804-821 RLPGPR+AVAGDIIKAATE N MS Pro Gly Pro Arg Ala Val Ala Gly Barré et al., 2014
urokinase-type plasminogen activator P00749 21-431 peptide-Lys178+Ile-peptide P Pro Arg Phe Lys Ile Ile Gly Gly Uhland, 2006
Vesicle-associated membrane protein 3 Q15836 2-24 peptide-Arg13+Arg-peptide N MS Gly Ser Asn Arg Arg Leu Gln Gln Barré et al., 2014
Vimentin Q8N850 157-172 LRR+QVDQLTNDKARVE N MS - Leu Arg Arg Gln Val Asp Gln Barré et al., 2014
Vinculin P18206 820-833 SGYR+ILGAVAKVRE N MS Ser Gly Tyr Arg Ile Leu Gly Ala Barré et al., 2014
X-ray repair cross-complementing protein 6 P12956 394-419 peptide-Arg403+Arg-peptide N MS Tyr Thr Pro Arg Arg Asn Ile Pro Barré et al., 2014

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