Searches of the MEROPS database

Display Known Cleavages for a Protein

Please enter a UniProt accession (eg P05067):

Accession:

Sequence P62333

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Peptide and protein substrates that are thought to be physiologically relevant are indicated by P. Peptide and protein substrates that are not physiologically relevant are indicated by N. How cleavage sites have been identified are indicated by the following evidence codes: NT = N-terminal sequencing, MS = mass spectroscopy, MU = mutation, CS = consensus sequence, LC = liquid chromatography. To see all annotated cleavages for a peptidase, click on the peptidase name.

Cleavage Site	Peptidase	Residue range	Cleavage type	Description	Evidence	Reference
1	unknown peptidase	1-389	P		NT	<%Agarwal et al., 2012[]%>
48	trypsin 1	2-389	N		MS	Schilling & Overall, 2008
51	cathepsin B	49-61	N		MS	Biniossek et al., 2011
53	elastase-2	48-62	N		MS	Schilling & Overall, 2008
62	trypsin 1	2-389	N		MS	Schilling & Overall, 2008
188	cathepsin L	186-197	N		MS	Biniossek et al., 2011
188	cathepsin S	186-197	N		MS	Biniossek et al., 2011
197	trypsin 1	2-389	N		MS	Schilling & Overall, 2008
206	trypsin 1	2-389	N		MS	Schilling & Overall, 2008
255	trypsin 1	2-389	N		MS	Schilling & Overall, 2008
261	cathepsin L	256-272	N		MS	Biniossek et al., 2011
262	cathepsin S	256-272	N		MS	Biniossek et al., 2011
265	cathepsin S	256-272	N		MS	Biniossek et al., 2011
272	trypsin 1	2-389	N		MS	Schilling & Overall, 2008
322	trypsin 1	2-389	N		MS	Schilling & Overall, 2008
333	trypsin 1	2-389	N		MS	Schilling & Overall, 2008
381	granzyme B (Homo sapiens-type)	2-389	N		MS	Van Damme et al., 2010