Searches of the MEROPS database

Display Known Cleavages for a Protein

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Accession:

Sequence P05783

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Peptide and protein substrates that are thought to be physiologically relevant are indicated by P. Peptide and protein substrates that are not physiologically relevant are indicated by N. How cleavage sites have been identified are indicated by the following evidence codes: NT = N-terminal sequencing, MS = mass spectroscopy, MU = mutation, CS = consensus sequence, LC = liquid chromatography. To see all annotated cleavages for a peptidase, click on the peptidase name.

Cleavage Site	Peptidase	Residue range	Cleavage type	Description	Evidence	Reference
1	unknown peptidase	1-430	P		NT	<%Agarwal et al., 2012[]%>
65	elastase-2	55-81	N		MS	Schilling & Overall, 2008
81	trypsin 1	2-430	N		MS	Schilling & Overall, 2008
113	meprin alpha subunit	2-430	N		MS	Becker-Pauly et al., 2011
113	meprin beta subunit	2-430	N		MS	Becker-Pauly et al., 2011
184	matrix metallopeptidase-2	181-200	N		MS	Schilling & Overall, 2008
200	glutamyl endopeptidase I	2-430	N		MS	Schilling & Overall, 2008
223	matrix metallopeptidase-2	220-236	N		MS	Schilling & Overall, 2008
236	glutamyl endopeptidase I	2-430	N		MS	Schilling & Overall, 2008
238	caspase-3	2-430	P			Ku et al., 1997
238	caspase-7	2-430	P			Caulin et al., 1997
238	caspase-6	2-430	P			Caulin et al., 1997
337	matrix metallopeptidase-2	334-353	N		MS	Schilling & Overall, 2008
353	trypsin 1	2-430	N		MS	Schilling & Overall, 2008
393	meprin beta subunit	2-430	N		MS	Becker-Pauly et al., 2011
394	granzyme B (Homo sapiens-type)	2-430	N		MS	Van Damme et al., 2010
397	caspase-3	1-430	P			MacFarlane et al., 2000
397	caspase-7	1-430	P			MacFarlane et al., 2000