$VAR1 = undef;

Summary for peptidase S01.302: matriptase

Names
MEROPS Name	matriptase
Other names	breast cancer 80 kDa protease, CAP3, channel-activating protease 3, epithin, matriptase-1, membrane-type serine protease 1, MT-SP1, serine endopeptidase SNC19, serine protease TADG-15, PRSS14 [obs.] g.p. (Homo sapiens), ST14 g.p. (Homo sapiens), suppression of tumorigenicity-14

Domain architecture

MEROPS Classification
Classification	Clan PA >> Subclan PA(S) >> Family S1 >> Subfamily A >> S01.302
Holotype	matriptase (Homo sapiens), Uniprot accession Q9Y5Y6 (peptidase unit: 615-855), MERNUM MER0003735
History	Identifier created: MEROPS 3.02 (25 June 1998)

Activity
Catalytic type	Serine
Peplist	Included in the Peplist with identifier PL00337
NC-IUBMB	Subclass 3.4 (Peptidases) >> Sub-subclass 3.4.21 (Serine endopeptidases) >> Peptidase 3.4.21.109
Enzymology	BRENDA database
Proteolytic events	CutDB database (2 cleavages)
Activity status	human: active (Lin et al., 2004) mouse: active (Cho et al., 2001)
Physiology	Matriptase is a type II transmembrane serine peptidase.
Knockout	Mice deficient in matriptase die shortly after birth, showing major epidermal abnormalities, and also a dramatically increased thymocyte apoptosis (List et al., 2002).
Pharmaceutical relevance	A drug target for some forms of cancer (Galkin et al., 2004). In vitro inhibition of matriptase prevents invasive growth of certain cell lines (Forbs et al., 2005).
Other databases	TREEFAM	http://www.treefam.org/family/TF330647
Cleavage site specificity	Explanations of how to interpret the following cleavage site sequence logo and specificity matrix can be found here.
Cleavage pattern	r/-/-/Rk/v/-/g (based on 119 cleavages)

Specificity matrix

Amino acid	P4	P3	P2	P1	P1'	P2'	P3'	P4'
Gly	7	8	19	1	10	13	21	24
Pro	6	5	9	0	0	4	8	15
Ala	10	13	21	0	12	12	6	8
Val	3	8	7	0	12	26	12	10
Leu	8	8	13	1	5	18	8	9
Ile	9	4	3	0	4	6	10	13
Met	0	2	1	0	0	0	3	0
Phe	3	4	5	0	0	1	4	0
Tyr	3	2	3	0	1	2	0	0
Trp	1	0	0	0	0	0	0	0
Ser	3	11	6	0	9	2	11	6
Thr	5	8	2	0	5	8	5	3
Cys	0	2	1	0	1	0	0	3
Asn	2	6	5	1	1	6	5	2
Gln	0	19	4	0	5	7	6	4
Asp	0	0	2	0	0	3	2	5
Glu	0	2	0	0	0	0	0	1
Lys	11	7	8	5	35	0	7	5
Arg	24	6	6	110	9	1	1	2
His	4	1	1	1	1	1	1	0