Searches of the MEROPS database

Display Known Cleavages for a Protein

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Accession:

Sequence P53999

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Peptide and protein substrates that are thought to be physiologically relevant are indicated by P. Peptide and protein substrates that are not physiologically relevant are indicated by N. How cleavage sites have been identified are indicated by the following evidence codes: NT = N-terminal sequencing, MS = mass spectroscopy, MU = mutation, CS = consensus sequence, LC = liquid chromatography. To see all annotated cleavages for a peptidase, click on the peptidase name.

Cleavage Site	Peptidase	Residue range	Cleavage type	Description	Evidence	Reference
1	unknown peptidase	1-127	P		NT	<%Agarwal et al., 2012[]%>
9	cathepsin L	6-24	N		MS	Biniossek et al., 2011
9	cathepsin S	6-24	N		MS	Biniossek et al., 2011
9	cathepsin B	6-24	N		MS	Biniossek et al., 2011
9	meprin beta subunit	2-127	N		MS	Becker-Pauly et al., 2011
10	meprin alpha subunit	2-127	N		MS	Becker-Pauly et al., 2011
10	meprin beta subunit	2-127	N		MS	Becker-Pauly et al., 2011
47	granzyme A	1-127	N			Van Damme et al., 2010
50	unknown peptidase	1-127	P		NT	<%Agarwal et al., 2012[]%>
54	meprin alpha subunit	2-127	N		MS	Becker-Pauly et al., 2011
59	meprin alpha subunit	2-127	N		MS	Becker-Pauly et al., 2011
59	meprin beta subunit	2-127	N		MS	Becker-Pauly et al., 2011
59	trypsin 1	2-127	N		MS	Schilling & Overall, 2008
60	unknown peptidase	1-127	P		MS	Van Damme et al., 2005
68	trypsin 1	2-127	N		MS	Schilling & Overall, 2008
86	trypsin 1	2-127	N		MS	Schilling & Overall, 2008
100	trypsin 1	2-127	N		MS	Schilling & Overall, 2008
101	trypsin 1	2-127	N		MS	Schilling & Overall, 2008
103	elastase-2	101-114	N		MS	Schilling & Overall, 2008
104	meprin beta subunit	101-114	N		MS	Becker-Pauly et al., 2011
113	cathepsin G	101-125	N		MS	Schilling & Overall, 2008
114	trypsin 1	2-127	N		MS	Schilling & Overall, 2008
115	matrix metallopeptidase-2	113-127	N		MS	Schilling & Overall, 2008
125	trypsin 1	2-127	N		MS	Schilling & Overall, 2008