Searches of the MEROPS database

Display Known Cleavages for a Protein

Please enter a UniProt accession (eg P05067):

Accession:

Sequence P62424

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Peptide and protein substrates that are thought to be physiologically relevant are indicated by P. Peptide and protein substrates that are not physiologically relevant are indicated by N. How cleavage sites have been identified are indicated by the following evidence codes: NT = N-terminal sequencing, MS = mass spectroscopy, MU = mutation, CS = consensus sequence, LC = liquid chromatography. To see all annotated cleavages for a peptidase, click on the peptidase name.

Cleavage Site	Peptidase	Residue range	Cleavage type	Description	Evidence	Reference
1	unknown peptidase	1-266	P		NT	<%Agarwal et al., 2012[]%>
11	trypsin 1	2-266	N		MS	Schilling & Overall, 2008
20	trypsin 1	2-266	N		MS	Schilling & Overall, 2008
21	granzyme A	1-266	N			Van Damme et al., 2010
37	granzyme A	1-266	N			Van Damme et al., 2010
37	trypsin 1	2-266	N		MS	Schilling & Overall, 2008
48	trypsin 1	2-266	N		MS	Schilling & Overall, 2008
74	peptidyl-Lys metallopeptidase	1-266	N		MS
75	trypsin 1	2-266	N		MS	Schilling & Overall, 2008
79	matrix metallopeptidase-2	75-89	N		MS	Schilling & Overall, 2008
89	trypsin 1	2-266	N		MS	Schilling & Overall, 2008
96	peptidyl-Lys metallopeptidase	1-266	N		MS
137	trypsin 1	2-266	N		MS	Schilling & Overall, 2008
141	cathepsin L	138-150	N		MS	Biniossek et al., 2011
150	trypsin 1	2-266	N		MS	Schilling & Overall, 2008
196	peptidyl-Lys metallopeptidase	1-266	N		MS
197	trypsin 1	2-266	N		MS	Schilling & Overall, 2008
201	cathepsin B	198-212	N		MS	Biniossek et al., 2011
205	cathepsin L	198-217	N		MS	Biniossek et al., 2011
205	cathepsin S	198-217	N		MS	Biniossek et al., 2011
212	trypsin 1	2-266	N		MS	Schilling & Overall, 2008
216	peptidyl-Lys metallopeptidase	1-266	N		MS