Searches of the MEROPS database

Display Known Cleavages for a Protein

Please enter a UniProt accession (eg P05067):

Accession:

Sequence P08833

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Peptide and protein substrates that are thought to be physiologically relevant are indicated by P. Peptide and protein substrates that are not physiologically relevant are indicated by N. How cleavage sites have been identified are indicated by the following evidence codes: NT = N-terminal sequencing, MS = mass spectroscopy, MU = mutation, CS = consensus sequence, LC = liquid chromatography. To see all annotated cleavages for a peptidase, click on the peptidase name.

Cleavage Site	Peptidase	Residue range	Cleavage type	Description	Evidence	Reference
25	kallikrein-related peptidase 5	1-259	P		NT	Michael et al., 2006
25	unknown peptidase	1-259	P	release of a signal peptide	NT	Busby et al., 1988
162	kallikrein-related peptidase 5	26-259	P		NT	Michael et al., 2006
165	matrix metallopeptidase-11	26-259	P	normal turnover		Mañes et al., 1997
165	matrix metallopeptidase-26	26-259	P			Park et al., 2002
165	matriptase	26-259	P			Uhland, 2006