Peptide and protein substrates that are thought to be physiologically relevant are indicated by P.
Peptide and protein substrates that are not physiologically relevant are indicated by N.
How cleavage sites have been identified are indicated by the following evidence codes:
NT = N-terminal sequencing,
MS = mass spectroscopy,
MU = mutation,
CS = consensus sequence,
LC = liquid chromatography.
To see all annotated cleavages for a peptidase, click on the peptidase name.
| Cleavage Site |
Peptidase |
Residue range |
Cleavage type |
Description |
Evidence |
Reference |
|---|
| 18 |
unknown peptidase |
1-654 |
P |
release of a signal peptide |
NT |
Ji et al., 1997 |
| 40 |
matrix metallopeptidase-2 |
34-51 |
N |
|
MS |
Schilling & Overall, 2008 |
| 49 |
trypsin 1 |
19-654 |
N |
|
MS |
Schilling & Overall, 2008 |
| 51 |
glutamyl endopeptidase I |
19-654 |
N |
|
MS |
Schilling & Overall, 2008 |
| 60 |
trypsin 1 |
19-654 |
N |
|
MS |
Schilling & Overall, 2008 |
| 74 |
trypsin 1 |
19-654 |
N |
|
MS |
Schilling & Overall, 2008 |
| 81 |
trypsin 1 |
19-654 |
N |
|
MS |
Schilling & Overall, 2008 |
| 85 |
cathepsin S |
82-96 |
N |
|
MS |
Biniossek et al., 2011 |
| 97 |
matrix metallopeptidase-2 |
94-111 |
N |
|
MS |
Schilling & Overall, 2008 |
| 101 |
trypsin 1 |
19-654 |
N |
|
MS |
Schilling & Overall, 2008 |
| 111 |
glutamyl endopeptidase I |
19-654 |
N |
|
MS |
Schilling & Overall, 2008 |
| 113 |
trypsin 1 |
19-654 |
N |
|
MS |
Schilling & Overall, 2008 |
| 127 |
cathepsin G |
123-138 |
N |
|
MS |
Schilling & Overall, 2008 |
| 138 |
trypsin 1 |
19-654 |
N |
|
MS |
Schilling & Overall, 2008 |
| 152 |
trypsin 1 |
19-654 |
N |
|
MS |
Schilling & Overall, 2008 |
| 164 |
trypsin 1 |
19-654 |
N |
|
MS |
Schilling & Overall, 2008 |
| 181 |
trypsin 1 |
19-654 |
N |
|
MS |
Schilling & Overall, 2008 |
| 185 |
trypsin 1 |
19-654 |
N |
|
MS |
Schilling & Overall, 2008 |
| 197 |
trypsin 1 |
19-654 |
N |
|
MS |
Schilling & Overall, 2008 |
| 213 |
trypsin 1 |
19-654 |
N |
|
MS |
Schilling & Overall, 2008 |
| 348 |
meprin beta subunit |
19-654 |
N |
|
MS |
Becker-Pauly et al., 2011 |
| 352 |
trypsin 1 |
19-654 |
N |
|
MS |
Schilling & Overall, 2008 |
| 353 |
trypsin 1 |
19-654 |
N |
|
MS |
Schilling & Overall, 2008 |
| 367 |
trypsin 1 |
19-654 |
N |
|
MS |
Schilling & Overall, 2008 |
| 440 |
matrix metallopeptidase-2 |
427-467 |
N |
|
MS |
Schilling & Overall, 2008 |
| 447 |
trypsin 1 |
19-654 |
N |
|
MS |
Schilling & Overall, 2008 |
| 451 |
cathepsin G |
447-464 |
N |
|
MS |
Schilling & Overall, 2008 |
| 452 |
cathepsin L |
448-464 |
N |
|
MS |
Biniossek et al., 2011 |
| 452 |
cathepsin S |
448-464 |
N |
|
MS |
Biniossek et al., 2011 |
| 464 |
trypsin 1 |
19-654 |
N |
|
MS |
Schilling & Overall, 2008 |
| 467 |
glutamyl endopeptidase I |
19-654 |
N |
|
MS |
Schilling & Overall, 2008 |
| 474 |
trypsin 1 |
19-654 |
N |
|
MS |
Schilling & Overall, 2008 |
| 477 |
matrix metallopeptidase-2 |
474-492 |
N |
|
MS |
Schilling & Overall, 2008 |
| 492 |
trypsin 1 |
19-654 |
N |
|
MS |
Schilling & Overall, 2008 |
| 601 |
trypsin 1 |
19-654 |
N |
|
MS |
Schilling & Overall, 2008 |
| 604 |
HIV-1 retropepsin |
601-619 |
N |
|
MS |
Schilling & Overall, 2008 |
| 604 |
matrix metallopeptidase-2 |
601-617 |
N |
|
MS |
Schilling & Overall, 2008 |
| 606 |
cathepsin L |
602-617 |
N |
|
MS |
Biniossek et al., 2011 |
| 606 |
cathepsin S |
602-617 |
N |
|
MS |
Biniossek et al., 2011 |
| 606 |
cathepsin K |
601-617 |
N |
|
MS |
Schilling & Overall, 2008 |
| 606 |
glutamyl endopeptidase I |
601-617 |
N |
|
MS |
Schilling & Overall, 2008 |
| 617 |
trypsin 1 |
19-654 |
N |
|
MS |
Schilling & Overall, 2008 |
| 619 |
trypsin 1 |
19-654 |
N |
|
MS |
Schilling & Overall, 2008 |
| 621 |
trypsin 1 |
19-654 |
N |
|
MS |
Schilling & Overall, 2008 |
| 623 |
meprin beta subunit |
620-633 |
N |
|
MS |
Becker-Pauly et al., 2011 |
| 633 |
trypsin 1 |
19-654 |
N |
|
MS |
Schilling & Overall, 2008 |
