Searches of the MEROPS database

Display Known Cleavages for a Protein

Please enter a UniProt accession (eg P05067):

Accession:

Sequence P00505

,

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Peptide and protein substrates that are thought to be physiologically relevant are indicated by P. Peptide and protein substrates that are not physiologically relevant are indicated by N. How cleavage sites have been identified are indicated by the following evidence codes: NT = N-terminal sequencing, MS = mass spectroscopy, MU = mutation, CS = consensus sequence, LC = liquid chromatography. To see all annotated cleavages for a peptidase, click on the peptidase name.

Cleavage Site	Peptidase	Residue range	Cleavage type	Description	Evidence	Reference
29	unknown peptidase	1-430	P		NT	<%Agarwal et al., 2012[]%>
38	meprin alpha subunit	35-53	N		MS	Becker-Pauly et al., 2011
38	meprin beta subunit	35-53	N		MS	Becker-Pauly et al., 2011
38	LAST peptidase (Limulus-type)	35-53	N		MS	Becker-Pauly et al., 2011
38	LAST_MAM peptidase (Limulus-type)	35-53	N		MS	Becker-Pauly et al., 2011
43	matrix metallopeptidase-2	28-53	N		MS	Schilling & Overall, 2008
52	trypsin 1	30-430	N		MS	Schilling & Overall, 2008
53	trypsin 1	1-430	N			Martini et al., 1985
59	trypsin 1	1-430	N			Martini et al., 1985
68	trypsin 1	1-430	N			Martini et al., 1985
81	trypsin 1	1-430	N			Martini et al., 1985
90	trypsin 1	1-430	N			Martini et al., 1985
94	trypsin 1	30-430	N		MS	Schilling & Overall, 2008
96	meprin beta subunit	93-107	N		MS	Becker-Pauly et al., 2011
99	elastase-2	94-107	N		MS	Schilling & Overall, 2008
107	trypsin 1	1-430	N			Martini et al., 1985
111	cathepsin B	108-122	N		MS	Biniossek et al., 2011
122	trypsin 1	1-430	N			Martini et al., 1985
125	trypsin 1	1-430	N			Martini et al., 1985
139	trypsin 1	1-430	N			Martini et al., 1985
147	trypsin 1	1-430	N			Martini et al., 1985
150	trypsin 1	1-430	N			Martini et al., 1985
153	trypsin 1	1-430	N			Martini et al., 1985
160	matrix metallopeptidase-2	153-170	N		MS	Schilling & Overall, 2008
170	trypsin 1	1-430	N			Martini et al., 1985
180	trypsin 1	1-430	N			Martini et al., 1985
185	trypsin 1	1-430	N			Martini et al., 1985
190	cathepsin S	186-200	N		MS	Biniossek et al., 2011
190	cathepsin B	186-200	N		MS	Biniossek et al., 2011
211	cathepsin B	201-225	N		MS	Biniossek et al., 2011
225	matrix metallopeptidase-2	200-234	N		MS	Schilling & Overall, 2008
227	trypsin 1	1-430	N			Martini et al., 1985
234	trypsin 1	1-430	N			Martini et al., 1985
236	trypsin 1	1-430	N			Martini et al., 1985
247	cathepsin L	237-262	N		MS	Biniossek et al., 2011
262	trypsin 1	1-430	N			Martini et al., 1985
279	trypsin 1	1-430	N			Martini et al., 1985
287	trypsin 1	1-430	N			Martini et al., 1985
296	trypsin 1	1-430	N			Martini et al., 1985
302	trypsin 1	1-430	N			Martini et al., 1985
309	trypsin 1	1-430	N			Martini et al., 1985
325	trypsin 1	1-430	N			Martini et al., 1985
329	matrix metallopeptidase-2	325-338	N		MS	Schilling & Overall, 2008
337	trypsin 1	1-430	N			Martini et al., 1985
338	trypsin 1	30-430	N		MS	Schilling & Overall, 2008
350	trypsin 1	1-430	N			Martini et al., 1985
355	trypsin 1	1-430	N			Martini et al., 1985
364	trypsin 1	1-430	N			Martini et al., 1985
384	cathepsin L	365-393	N		MS	Biniossek et al., 2011
393	trypsin 1	1-430	N			Martini et al., 1985
396	trypsin 1	1-430	N			Martini et al., 1985
404	trypsin 1	1-430	N			Martini et al., 1985
407	trypsin 1	1-430	N			Martini et al., 1985