Searches of the MEROPS database

Display Known Cleavages for a Protein

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Accession:

Sequence P00749

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Peptide and protein substrates that are thought to be physiologically relevant are indicated by P. Peptide and protein substrates that are not physiologically relevant are indicated by N. How cleavage sites have been identified are indicated by the following evidence codes: NT = N-terminal sequencing, MS = mass spectroscopy, MU = mutation, CS = consensus sequence, LC = liquid chromatography. To see all annotated cleavages for a peptidase, click on the peptidase name.

Cleavage Site	Peptidase	Residue range	Cleavage type	Description	Evidence	Reference
20	unknown peptidase	1-431	P	release of a signal peptide	NT	Gunzler et al., 1982
25	cathepsin L	21-431	P	normal turnover	NT	Goretzki et al., 1992
43	urokinase-type plasminogen activator	21-431	P			Ellis, 2004
44	thermolysin	21-431	N			Narasaki et al., 2005
44	aureolysin	21-431	N			Beaufort et al., 2008
56	aureolysin	21-431	N			Beaufort et al., 2008
58	cathepsin L	21-431	P	normal turnover	NT	Goretzki et al., 1992
63	cathepsin L	21-431	P	normal turnover	NT	Goretzki et al., 1992
79	cathepsin L	21-431	P	normal turnover	NT	Goretzki et al., 1992
155	plasmin	21-431	P			Ellis, 2004
163	matrix metallopeptidase-3	21-431	P	normal turnover		Nagase, 2004
163	matrix metallopeptidase-7	21-431	P	normal turnover		Marcotte et al., 1992
176	thrombin	21-431	P			<%Ichinose et al., 1986[]%>
177	unknown peptidase	1-431	P		NT	<%Agarwal et al., 2012[]%>
178	cathepsin L	21-431	P	normal turnover		Goretzki et al., 1992
178	cathepsin B	21-431	P	normal turnover	NT	Kobayashi et al., 1991
178	thermolysin	21-431	N			Narasaki et al., 2005
178	pseudolysin	21-431	N			Beaufort et al.,2010
178	aureolysin	21-431	N			Beaufort et al., 2008
178	kallikrein-related peptidase 5	21-431	P		-	Debela et al., 2008
178	cathepsin G	21-431	P			Ellis, 2004
178	tryptase alpha	21-431	P
178	trypsin 1	21-431	P	conversion to two-chain form		Ellis, 2004
178	kallikrein-related peptidase 2	21-431	P
178	kallikrein-related peptidase 3	21-431	P
178	plasma kallikrein	21-431	P			Ellis, 2004
178	hepsin	21-431	P			Moran et al., 2006
178	plasmin	21-431	P			Ellis, 2004
178	prosemin	21-431	P		NT	Yasuda et al., 2005
178	matriptase	21-431	P			Uhland, 2006
178	polyserase-IA unit 1	21-432	P		CS	Okumura et al., 2006
179	elastase-2	21-431	P			Ellis, 2004
181	cathepsin L	21-431	P	normal turnover	NT	Goretzki et al., 1992
185	cathepsin L	21-431	P	normal turnover	NT	Goretzki et al., 1992
243	kallikrein-related peptidase 13	21-431	P		CS	Borgoņo et al., 2007
410	cathepsin L	21-431	P	normal turnover	NT	Goretzki et al., 1992
413	cathepsin L	21-431	P	normal turnover	NT	Goretzki et al., 1992