Searches of the MEROPS database

Display Known Cleavages for a Protein

Please enter a UniProt accession (eg P05067):

Accession:

Sequence O43707

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Peptide and protein substrates that are thought to be physiologically relevant are indicated by P. Peptide and protein substrates that are not physiologically relevant are indicated by N. How cleavage sites have been identified are indicated by the following evidence codes: NT = N-terminal sequencing, MS = mass spectroscopy, MU = mutation, CS = consensus sequence, LC = liquid chromatography. To see all annotated cleavages for a peptidase, click on the peptidase name.

Cleavage Site	Peptidase	Residue range	Cleavage type	Description	Evidence	Reference
37	caspase-6	1-911	P		MS	Klaiman et al., 2008
39	caspase-6	1-911	P		MS	Klaiman et al., 2008
40	trypsin 1	1-911	N		MS	Schilling & Overall, 2008
50	trypsin 1	1-911	N		MS	Schilling & Overall, 2008
66	trypsin 1	1-911	N		MS	Schilling & Overall, 2008
77	caspase-6	1-911	P		MS	Klaiman et al., 2008
79	trypsin 1	1-911	N		MS	Schilling & Overall, 2008
114	trypsin 1	1-911	N		MS	Schilling & Overall, 2008
122	trypsin 1	1-911	N		MS	Schilling & Overall, 2008
128	cathepsin L	126-140	N		MS	Biniossek et al., 2011
128	cathepsin S	127-140	N		MS	Biniossek et al., 2011
213	caspase-6	1-911	P		MS	Klaiman et al., 2008
216	trypsin 1	1-911	N		MS	Schilling & Overall, 2008
221	elastase-2	217-233	N		MS	Schilling & Overall, 2008
225	cathepsin S	218-233	N		MS	Biniossek et al., 2011
233	trypsin 1	1-911	N		MS	Schilling & Overall, 2008
244	meprin beta subunit	241-255	N		MS	Becker-Pauly et al., 2011
354	cathepsin S	351-363	N		MS	Biniossek et al., 2011
354	glutamyl endopeptidase I	350-363	N		MS	Schilling & Overall, 2008
363	trypsin 1	1-911	N		MS	Schilling & Overall, 2008
395	trypsin 1	1-911	N		MS	Schilling & Overall, 2008
406	trypsin 1	1-911	N		MS	Schilling & Overall, 2008
439	trypsin 1	1-911	N		MS	Schilling & Overall, 2008
450	trypsin 1	1-911	N		MS	Schilling & Overall, 2008
460	cathepsin L	456-473	N		MS	Biniossek et al., 2011
462	caspase-6	1-911	P		MS	Klaiman et al., 2008
464	cathepsin L	456-473	N		MS	Biniossek et al., 2011
484	caspase-6	1-911	P		MS	Klaiman et al., 2008
502	meprin beta subunit	499-512	N		MS	Becker-Pauly et al., 2011
503	caspase-6	1-911	P		MS	Klaiman et al., 2008
526	elastase-2	521-535	N		MS	Schilling & Overall, 2008
535	trypsin 1	1-911	N		MS	Schilling & Overall, 2008
565	matrix metallopeptidase-2	564-574	N		MS	Schilling & Overall, 2008
574	trypsin 1	1-911	N		MS	Schilling & Overall, 2008
652	trypsin 1	1-911	N		MS	Schilling & Overall, 2008
659	matrix metallopeptidase-2	652-668	N		MS	Schilling & Overall, 2008
668	trypsin 1	1-911	N		MS	Schilling & Overall, 2008
671	glutamyl endopeptidase I	1-911	N		MS	Schilling & Overall, 2008
680	astacin	677-691	N		MS	Becker-Pauly et al., 2011
745	trypsin 1	1-911	N		MS	Schilling & Overall, 2008
757	trypsin 1	1-911	N		MS	Schilling & Overall, 2008
778	cathepsin L	772-791	N		MS	Biniossek et al., 2011
793	matrix metallopeptidase-2	791-805	N		MS	Schilling & Overall, 2008
804	caspase-6	1-911	P		MS	Klaiman et al., 2008
805	trypsin 1	1-911	N		MS	Schilling & Overall, 2008
837	trypsin 1	1-911	N		MS	Schilling & Overall, 2008
843	caspase-6	1-911	P		MS	Klaiman et al., 2008
851	matrix metallopeptidase-2	846-866	N		MS	Schilling & Overall, 2008
853	trypsin 1	1-911	N		MS	Schilling & Overall, 2008
856	astacin	853-868	N		MS	Becker-Pauly et al., 2011
866	glutamyl endopeptidase I	1-911	N		MS	Schilling & Overall, 2008
869	trypsin 1	1-911	N		MS	Schilling & Overall, 2008
882	trypsin 1	1-911	N		MS	Schilling & Overall, 2008
899	trypsin 1	1-911	N		MS	Schilling & Overall, 2008
910	caspase-6	1-911	P		MS	Klaiman et al., 2008