Peptide and protein substrates that are thought to be physiologically relevant are indicated by P.
Peptide and protein substrates that are not physiologically relevant are indicated by N.
How cleavage sites have been identified are indicated by the following evidence codes:
NT = N-terminal sequencing,
MS = mass spectroscopy,
MU = mutation,
CS = consensus sequence,
LC = liquid chromatography.
To see all annotated cleavages for a peptidase, click on the peptidase name.
| Cleavage Site |
Peptidase |
Residue range |
Cleavage type |
Description |
Evidence |
Reference |
|---|
| 36 |
trypsin 1 |
1-4646 |
N |
|
MS |
Schilling & Overall, 2008 |
| 59 |
trypsin 1 |
1-4646 |
N |
|
MS |
Schilling & Overall, 2008 |
| 228 |
trypsin 1 |
1-4646 |
N |
|
MS |
Schilling & Overall, 2008 |
| 251 |
trypsin 1 |
1-4646 |
N |
|
MS |
Schilling & Overall, 2008 |
| 386 |
trypsin 1 |
1-4646 |
N |
|
MS |
Schilling & Overall, 2008 |
| 394 |
trypsin 1 |
1-4646 |
N |
|
MS |
Schilling & Overall, 2008 |
| 716 |
trypsin 1 |
1-4646 |
N |
|
MS |
Schilling & Overall, 2008 |
| 724 |
trypsin 1 |
1-4646 |
N |
|
MS |
Schilling & Overall, 2008 |
| 736 |
trypsin 1 |
1-4646 |
N |
|
MS |
Schilling & Overall, 2008 |
| 748 |
trypsin 1 |
1-4646 |
N |
|
MS |
Schilling & Overall, 2008 |
| 759 |
trypsin 1 |
1-4646 |
N |
|
MS |
Schilling & Overall, 2008 |
| 767 |
trypsin 1 |
1-4646 |
N |
|
MS |
Schilling & Overall, 2008 |
| 846 |
trypsin 1 |
1-4646 |
N |
|
MS |
Schilling & Overall, 2008 |
| 856 |
trypsin 1 |
1-4646 |
N |
|
MS |
Schilling & Overall, 2008 |
| 920 |
trypsin 1 |
1-4646 |
N |
|
MS |
Schilling & Overall, 2008 |
| 933 |
trypsin 1 |
1-4646 |
N |
|
MS |
Schilling & Overall, 2008 |
| 1301 |
trypsin 1 |
1-4646 |
N |
|
MS |
Schilling & Overall, 2008 |
| 1318 |
trypsin 1 |
1-4646 |
N |
|
MS |
Schilling & Overall, 2008 |
| 1338 |
trypsin 1 |
1-4646 |
N |
|
MS |
Schilling & Overall, 2008 |
| 1347 |
trypsin 1 |
1-4646 |
N |
|
MS |
Schilling & Overall, 2008 |
| 1546 |
HIV-1 retropepsin |
1543-1558 |
N |
|
MS |
Schilling & Overall, 2008 |
| 1558 |
trypsin 1 |
1-4646 |
N |
|
MS |
Schilling & Overall, 2008 |
| 1584 |
trypsin 1 |
1-4646 |
N |
|
MS |
Schilling & Overall, 2008 |
| 1599 |
trypsin 1 |
1-4646 |
N |
|
MS |
Schilling & Overall, 2008 |
| 1628 |
trypsin 1 |
1-4646 |
N |
|
MS |
Schilling & Overall, 2008 |
| 1645 |
trypsin 1 |
1-4646 |
N |
|
MS |
Schilling & Overall, 2008 |
| 1697 |
trypsin 1 |
1-4646 |
N |
|
MS |
Schilling & Overall, 2008 |
| 1707 |
trypsin 1 |
1-4646 |
N |
|
MS |
Schilling & Overall, 2008 |
| 1810 |
matrix metallopeptidase-2 |
1807-1819 |
N |
|
MS |
Schilling & Overall, 2008 |
| 1819 |
trypsin 1 |
1-4646 |
N |
|
MS |
Schilling & Overall, 2008 |
| 1865 |
trypsin 1 |
1-4646 |
N |
|
MS |
Schilling & Overall, 2008 |
| 1878 |
trypsin 1 |
1-4646 |
N |
|
MS |
Schilling & Overall, 2008 |
| 1899 |
trypsin 1 |
1-4646 |
N |
|
MS |
Schilling & Overall, 2008 |
| 1912 |
trypsin 1 |
1-4646 |
N |
|
MS |
Schilling & Overall, 2008 |
| 1994 |
astacin |
1991-2004 |
N |
|
MS |
Becker-Pauly et al., 2011 |
| 2246 |
HIV-1 retropepsin |
2243-2257 |
N |
|
MS |
Schilling & Overall, 2008 |
| 2257 |
trypsin 1 |
1-4646 |
N |
|
MS |
Schilling & Overall, 2008 |
| 2340 |
trypsin 1 |
1-4646 |
N |
|
MS |
Schilling & Overall, 2008 |
| 2349 |
trypsin 1 |
1-4646 |
N |
|
MS |
Schilling & Overall, 2008 |
| 2383 |
trypsin 1 |
1-4646 |
N |
|
MS |
Schilling & Overall, 2008 |
| 2396 |
trypsin 1 |
1-4646 |
N |
|
MS |
Schilling & Overall, 2008 |
| 2561 |
trypsin 1 |
1-4646 |
N |
|
MS |
Schilling & Overall, 2008 |
| 2576 |
trypsin 1 |
1-4646 |
N |
|
MS |
Schilling & Overall, 2008 |
| 2610 |
trypsin 1 |
1-4646 |
N |
|
MS |
Schilling & Overall, 2008 |
| 2633 |
trypsin 1 |
1-4646 |
N |
|
MS |
Schilling & Overall, 2008 |
| 2710 |
cathepsin L |
2706-2720 |
N |
|
MS |
Biniossek et al., 2011 |
| 2710 |
cathepsin S |
2706-2720 |
N |
|
MS |
Biniossek et al., 2011 |
| 2814 |
cathepsin L |
2805-2823 |
N |
|
MS |
Biniossek et al., 2011 |
| 2879 |
trypsin 1 |
1-4646 |
N |
|
MS |
Schilling & Overall, 2008 |
| 2890 |
trypsin 1 |
1-4646 |
N |
|
MS |
Schilling & Overall, 2008 |
| 3044 |
cathepsin S |
3040-3052 |
N |
|
MS |
Biniossek et al., 2011 |
| 3194 |
HIV-1 retropepsin |
3191-3206 |
N |
|
MS |
Schilling & Overall, 2008 |
| 3206 |
trypsin 1 |
1-4646 |
N |
|
MS |
Schilling & Overall, 2008 |
| 3209 |
trypsin 1 |
1-4646 |
N |
|
MS |
Schilling & Overall, 2008 |
| 3219 |
trypsin 1 |
1-4646 |
N |
|
MS |
Schilling & Overall, 2008 |
| 3220 |
trypsin 1 |
1-4646 |
N |
|
MS |
Schilling & Overall, 2008 |
| 3254 |
trypsin 1 |
1-4646 |
N |
|
MS |
Schilling & Overall, 2008 |
| 3256 |
astacin |
3253-3266 |
N |
|
MS |
Becker-Pauly et al., 2011 |
| 3257 |
cathepsin S |
3255-3266 |
N |
|
MS |
Biniossek et al., 2011 |
| 3266 |
trypsin 1 |
1-4646 |
N |
|
MS |
Schilling & Overall, 2008 |
| 3451 |
HIV-1 retropepsin |
3448-3462 |
N |
|
MS |
Schilling & Overall, 2008 |
| 3462 |
trypsin 1 |
1-4646 |
N |
|
MS |
Schilling & Overall, 2008 |
| 3549 |
trypsin 1 |
1-4646 |
N |
|
MS |
Schilling & Overall, 2008 |
| 3559 |
trypsin 1 |
1-4646 |
N |
|
MS |
Schilling & Overall, 2008 |
| 3611 |
trypsin 1 |
1-4646 |
N |
|
MS |
Schilling & Overall, 2008 |
| 3621 |
trypsin 1 |
1-4646 |
N |
|
MS |
Schilling & Overall, 2008 |
| 3705 |
trypsin 1 |
1-4646 |
N |
|
MS |
Schilling & Overall, 2008 |
| 3718 |
trypsin 1 |
1-4646 |
N |
|
MS |
Schilling & Overall, 2008 |
| 3759 |
trypsin 1 |
1-4646 |
N |
|
MS |
Schilling & Overall, 2008 |
| 3764 |
meprin beta subunit |
3761-3775 |
N |
|
MS |
Becker-Pauly et al., 2011 |
| 3775 |
trypsin 1 |
1-4646 |
N |
|
MS |
Schilling & Overall, 2008 |
| 3861 |
trypsin 1 |
1-4646 |
N |
|
MS |
Schilling & Overall, 2008 |
| 3870 |
trypsin 1 |
1-4646 |
N |
|
MS |
Schilling & Overall, 2008 |
| 3910 |
trypsin 1 |
1-4646 |
N |
|
MS |
Schilling & Overall, 2008 |
| 3923 |
trypsin 1 |
1-4646 |
N |
|
MS |
Schilling & Overall, 2008 |
| 4123 |
trypsin 1 |
1-4646 |
N |
|
MS |
Schilling & Overall, 2008 |
| 4133 |
trypsin 1 |
1-4646 |
N |
|
MS |
Schilling & Overall, 2008 |
| 4143 |
trypsin 1 |
1-4646 |
N |
|
MS |
Schilling & Overall, 2008 |
| 4154 |
trypsin 1 |
1-4646 |
N |
|
MS |
Schilling & Overall, 2008 |
| 4230 |
trypsin 1 |
1-4646 |
N |
|
MS |
Schilling & Overall, 2008 |
| 4244 |
trypsin 1 |
1-4646 |
N |
|
MS |
Schilling & Overall, 2008 |
| 4574 |
trypsin 1 |
1-4646 |
N |
|
MS |
Schilling & Overall, 2008 |
| 4579 |
matrix metallopeptidase-2 |
4574-4591 |
N |
|
MS |
Schilling & Overall, 2008 |
| 4591 |
trypsin 1 |
1-4646 |
N |
|
MS |
Schilling & Overall, 2008 |
