Literature for peptidase S01.302: matriptase

Summary Gene structure Alignment Tree Sequences Sequence features Distribution Structure Literature Substrates Pharma

(Topics flags: A Assay, S Structure, T Target, K Knockout, P Specificity, E Expression, V Review, M Mutation, I Inhibitor, R Splicing, L Localization. To select only the references relevant to a single topic, click the link above. See explanation.)

2026

Banas,V., Seehra,K., Mahoney,M., Alisio,C., Kyriukha,Y., Weiland,E., Fath,M., Han,Z., Bricker,T., Tartell,M., Whelan,S., Boon,A.C.M. and Janetka,J.W. Inhibitors of membrane associated serine proteases block replication of coronavirus SARS-CoV-2 and influenza virus H1N1 Eur J Med Chem (2026) 302, 118385-118385. PubMed Europe PubMed DOI

2025

Aapjeet,F., Tang,T., Zhang,Y., Gopalan,A., Kallappagoudar,S., Pan,J., Ma,F., Shah,S.S., Rivera,S., Liu,A.P., Juan,V. and Liu,R. Fragmentation of recombinant human interleukin-12 by matriptase in CHO cell culture J Biotechnol (2025) 404, 112-120. PubMed Europe PubMed DOI
Ji,L., Zhang,M., Liu,Y., Zhang,H., Luo,T., Zhao,L., Zhang,W., Chen,B. and Chen,R. Suppressor of Tumorigenicity 14 inhibits non-small cell lung cancer cell proliferation by suppressing Transketolase O-GlcNAcylation Exp Cell Res (2025) 452, 114776-114776. PubMed Europe PubMed DOI
Peng,T., Liu,J. and Zhao,H. Preliminary Observations of a Substrate-Based Radiotracer Biosensor for In Vivo Positron Emission Tomography Imaging of Tumor Transmembrane Protease ST14 ACS Sens (2025) 10, 2768-2778. PubMed Europe PubMed DOI
Peng,T., Huang,G., Zhao,H. and Liu,J. Development of an Irreversible Peptidomimetic Radioligand for PET Imaging of ST14 Protease Bioconjug Chem (2025) PubMed Europe PubMed DOI

2024

Colombo,E., Desilets,A., Hassanzadeh,M., Lemieux,G., Marois,I., Cliche,D., Delbrouck,J.A., Murza,A., Jean,F., Marsault,E., Richter,M.V., Leduc,R. and Boudreault,P.L. Optimization of Ketobenzothiazole-Based Type II Transmembrane Serine Protease Inhibitors to Block H1N1 Influenza Virus Replication ChemMedChem (2024) 19, e202300458-e202300458. PubMed Europe PubMed DOI
Peng,T., Wen,J., Huang,G., Zhao,H. and Liu,J. First-generation high-affinity ST14 radiopharmaceutical: Design, synthesis, and preclinical PET imaging evaluation for pancreatic cancer detection Bioorg Chem (2024) 154, 108085-108085. PubMed Europe PubMed DOI

2023

Ehret,E., Stroh,S., Auberson,M., Ino,F., Jager,Y., Maillard,M., Szabo,R., Bugge,T.H., Frateschi,S. and Hummler,E. Kidney-Specific Membrane-Bound Serine Proteases CAP1/Prss8 and CAP3/St14 Affect ENaC Subunit Abundances but Not Its Activity Cells (2023) 12 PubMed Europe PubMed DOI PMC EPMC
Gaymon,D.O., Barndt,R., Stires,H., Riggins,R.B. and Johnson,M.D. ROS is a master regulator of in vitro matriptase activation PLoS ONE (2023) 18, e0267492-e0267492. PubMed Europe PubMed DOI PMC EPMC
Koistinen,H., Kovanen,R.M., Hollenberg,M.D., Dufour,A., Radisky,E.S., Stenman,U.H., Batra,J., Clements,J., Hooper,J.D., Diamandis,E., Schilling,O., Rannikko,A. and Mirtti,T. The roles of proteases in prostate cancer IUBMB Life (2023) 75, 493-513. PubMed Europe PubMed DOI PMC EPMC V
Pawar,N.R., Buzza,M.S., Duru,N., Strong,A.A. and Antalis,T.M. Matriptase drives dissemination of ovarian cancer spheroids by a PAR-2/PI3K/Akt/MMP9 signaling axis J Cell Biol (2023) 222 PubMed Europe PubMed DOI PMC EPMC

2022

Jang,J., Cho,E.H., Cho,Y., Ganzorig,B., Kim,K.Y., Kim,M.G. and Kim,C. Environment-Sensitive Ectodomain Shedding of Epithin/PRSS14 Increases Metastatic Potential of Breast Cancer Cells by Producing CCL2 Mol Cells (2022) 45, 564-574. PubMed Europe PubMed DOI PMC EPMC

2020

Armistead,J., Hatzold,J., van Roye,A., Fahle,E. and Hammerschmidt,M. Entosis and apical cell extrusion constitute a tumor-suppressive mechanism downstream of matriptase J Cell Biol (2020) 219 PubMed Europe PubMed DOI
Blay,V., Li,M.C., Ho,S.P., Stoller,M.L., Hsieh,H.P. and Houston,D.R. Design of drug-like hepsin inhibitors against prostate cancer and kidney stones Acta Pharm Sin B (2020) 10, 1309-1320. PubMed Europe PubMed DOI PMC EPMC
Chang,S.C., Chiang,C.P., Lai,C.H., Du,P.A., Hung,Y.S., Chen,Y.H., Yang,H.Y., Fang,H.Y., Lee,S.P., Tang,H.J., Wang,J.K., Johnson,M.D. and Lin,C.Y. Matriptase and prostasin proteolytic activities are differentially regulated in normal and wounded skin Hum Cell (2020) PubMed Europe PubMed DOI
Holt-Danborg,L., Skovbjerg,S., Goderum,K.W., Nonboe,A.W., Stankevic,E., Frost,A.K., Vitved,L., Jensen,J.K. and Vogel,L.K. Insights into the regulation of the matriptase-prostasin proteolytic system Biochem J (2020) PubMed Europe PubMed DOI
Hu,P., Shang,L., Chen,J., Chen,X., Chen,C., Hong,W., Huang,M., Xu,P. and Chen,Z. A nanometer-sized protease inhibitor for precise cancer diagnosis and treatment J Mater Chem B (2020) 8, 504-514. PubMed Europe PubMed DOI I
Jaimes,J., Millet,J. and Whittaker,G. Proteolytic Cleavage of the SARS-CoV-2 Spike Protein and the Role of the Novel S1/S2 Site SSRN (2020) , 3581359-3581359. PubMed Europe PubMed DOI PMC EPMC
Jia,B., Thompson,H.A., Barndt,R.B., Chiu,Y.L., Lee,M.J., Lee,S.C., Wang,J.K., Tang,H.J., Lin,C.Y. and Johnson,M.D. Mild acidity likely accelerates the physiological matriptase autoactivation process: a comparative study between spontaneous and acid-induced matriptase zymogen activation Hum Cell (2020) PubMed Europe PubMed DOI
Kamble,P.R., Rane,S., Breed,A.A., Joseph,S., Mahale,S.D. and Pathak,B.R. Proteolytic cleavage of Trop2 at Arg87 is mediated by matriptase and regulated by Val194 FEBS Lett (2020) PubMed Europe PubMed DOI
Kwon,H., Ha,H., Jeon,H., Jang,J., Son,S.H., Lee,K., Park,S.K. and Byun,Y. Structure-activity relationship studies of dipeptide-based hepsin inhibitors with Arg bioisosteres Bioorg Chem (2020) , 104521-104521. PubMed Europe PubMed DOI
Murza,A., Dion,S.P., Boudreault,P.L., Desilets,A., Leduc,R. and Marsault,E. Inhibitors of type II transmembrane serine proteases in the treatment of diseases of the respiratory tract - A review of patent literature Expert Opin Ther Pat (2020) , 1-18. PubMed Europe PubMed DOI
Ozawa,S., Matsubayashi,M., Nanaura,H., Yanagita,M., Mori,K., Asanuma,K., Kajiwara,N., Hayashi,K., Ohashi,H., Kasahara,M., Yokoi,H., Kataoka,H., Mori,E. and Nakagawa,T. Proteolytic Cleavage of Podocin by Matriptase Exacerbates Podocyte Injury J Biol Chem (2020) PubMed Europe PubMed DOI
Skovbjerg,S., Holt-Danborg,L., Nonboe,A.W., Hong,Z., Frost,A.K., Schar,C.R., Thomas,C.C., Vitved,L., Jensen,J.K. and Vogel,L.K. Inhibition of an active zymogen protease: the zymogen form of matriptase is regulated by HAI-1 and HAI-2 Biochem J (2020) 477, 1779-1794. PubMed Europe PubMed DOI
Tseng,C.C., Jia,B., Barndt,R.B., Dai,Y.H., Chen,Y.H., Du,P.A., Wang,J.K., Tang,H.J., Lin,C.Y. and Johnson,M.D. The intracellular seven amino acid motif EEGEVFL is required for matriptase vesicle sorting and translocation to the basolateral plasma membrane PLoS ONE (2020) 15, e0228874-e0228874. PubMed Europe PubMed DOI
Whittaker,G.R. and Millet,J.K. Biochemical characterization of Middle East respiratory syndrome coronavirus spike protein proteolytic processing Methods Mol Biol (2020) 2099, 21-37. PubMed Europe PubMed DOI
Whittaker,G.R. and Straus,M.R. Human matriptase/ST 14 proteolytically cleaves H7N9 hemagglutinin and facilitates the activation of influenza A/Shanghai/2/2013 virus in cell culture Influenza Other Respir Viruses (2020) 14, 189-195. PubMed Europe PubMed DOI P
Wu,C.J., Lu,M., Feng,X., Nakato,G. and Udey,M.C. Matriptase cleaves EpCAM and TROP2 in keratinocytes, destabilizing both proteins and associated claudins Cells (2020) 9 PubMed Europe PubMed DOI
Yoon,J., Cho,Y., Kim,K.Y., Yoon,M.J., Lee,H.S., Jeon,S.D., Cho,Y., Kim,C. and Kim,M.G. A JUN N-terminal kinase inhibitor induces ectodomain shedding of the cancer-associated membrane protease Prss14/epithin via protein kinase CbetaII J Biol Chem (2020) 295, 7168-7177. PubMed Europe PubMed DOI

2019

Barna,R.F., Pomothy,J.M., Parej,Z. and Pasztine Gere,E. Investigation of sphingosin-1-phosphate-triggered matriptase activation using a rat primary hepatocyte model Acta Vet Hung (2019) 67, 578-587. PubMed Europe PubMed DOI
Chen,L.M. and Chai,K.X. Matriptase cleaves the amyloid-beta peptide 1-42 at Arg-5, Lys-16, and Lys-28 BMC Res Notes (2019) 12, 5-5. PubMed Europe PubMed DOI PMC EPMC P
Damalanka,V.C., Han,Z., Karmakar,P., O'Donoghue,A.J., La Greca,F., Kim,T., Pant,S.M., Helander,J., Klefstrom,J., Craik,C.S. and Janetka,J.W. Discovery of selective matriptase and hepsin serine protease inhibitors: useful chemical tools for cancer cell biology J Med Chem (2019) 62, 480-490. PubMed Europe PubMed DOI I
Damalanka,V.C. and Janetka,J.W. Recent progress on inhibitors of the type II transmembrane serine proteases, hepsin, matriptase and matriptase-2 Future Med Chem (2019) 11, 743-769. PubMed Europe PubMed DOI I
Damalanka,V.C., Wildman,S.A. and Janetka,J.W. Piperidine carbamate peptidomimetic inhibitors of the serine proteases HGFA, matriptase and hepsin MedChemComm (2019) 10, 1646-1655. PubMed Europe PubMed DOI PMC EPMC I
Fang,J.D., Tung,H.H. and Lee,S.L. Mitochondrial localization of St14-encoding transmembrane serine protease is involved in neural stem/progenitor cell bioenergetics through binding to F0F1-ATP synthase complex FASEB J (2019) 33, 4327-4340. PubMed Europe PubMed DOI K
Kim,K.Y., Yoon,M., Cho,Y., Lee,K.H., Park,S., Lee,S.R., Choi,S.Y., Lee,D., Yang,C., Cho,E.H., Jeon,S.D., Kim,S.H., Kim,C. and Kim,M.G. Targeting metastatic breast cancer with peptide epitopes derived from autocatalytic loop of Prss14/ST14 membrane serine protease and with monoclonal antibodies J Exp Clin Cancer Res (2019) 38, 363-363. PubMed Europe PubMed DOI PMC EPMC
Mirza,A.Z. and Shamshad,H. QSAR and docking studies on piperidyl-cyclohexylurea derivatives for prediction of selective and potent inhibitor of matriptase Curr Comput Aided Drug Des (2019) 15, 167-181. PubMed Europe PubMed DOI I
Szabo,R., Callies,L.K. and Bugge,T.H. Matriptase drives early-onset intestinal failure in a mouse model of congenital tufting enteropathy Development (2019) 146, dev183392-dev183392. PubMed Europe PubMed DOI M
Tamberg,T., Hong,Z., De Schepper,D., Skovbjerg,S., Dupont,D.M., Vitved,L., Schar,C.R., Skjoedt,K., Vogel,L.K. and Jensen,J.K. Blocking the proteolytic activity of zymogen matriptase with antibody-based inhibitors J Biol Chem (2019) 294, 314-326. PubMed Europe PubMed DOI S
Zuo,K., Qi,Y., Yuan,C., Jiang,L., Xu,P., Hu,J., Huang,M. and Li,J. Specifically targeting cancer proliferation and metastasis processes: the development of matriptase inhibitors Cancer Metastasis Rev (2019) 38, 507-524. PubMed Europe PubMed DOI V I

2018

Ahmad,F., Ahmed,I., Nasir,A., Umair,M., Shahzad,S., Muhammad,D., Santos-Cortez,R.L.P., Leal,S.M. and Ahmad,W. A disease-causing novel missense mutation in the ST14 gene underlies autosomal recessive ichthyosis with hypotrichosis syndrome in a consanguineous family Eur J Dermatol (2018) 28, 209-216. PubMed Europe PubMed DOI M
Laux,H., Romand,S., Nuciforo,S., Farady,C.J., Tapparel,J., Buechmann-Moeller,S., Sommer,B., Oakeley,E.J. and Bodendorf,U. Degradation of recombinant proteins by Chinese hamster ovary host cell proteases is prevented by matriptase-1 knockout Biotechnol Bioeng (2018) 115, 2530-2540. PubMed Europe PubMed DOI K
Mitchell,A.C., Alford,S.C., Hunter,S.A., Kannan,D., Parra Sperberg,R.A., Chang,C.H. and Cochran,J.R. Development of a protease biosensor based on a dimerization-dependent red fluorescent protein ACS Chem Biol (2018) 13, 66-72. PubMed Europe PubMed DOI A L
Mitchell,A.C., Kannan,D., Hunter,S.A., Parra Sperberg,R.A., Chang,C.H. and Cochran,J.R. Engineering a potent inhibitor of matriptase from the natural hepatocyte growth factor activator inhibitor type-1 (HAI-1) protein J Biol Chem (2018) 293, 4969-4980. PubMed Europe PubMed DOI
Yamasaki,K., Mukai,S., Nagai,T., Nakahara,K., Fujii,M., Terada,N., Ohno,A., Sato,Y., Toda,Y., Kataoka,H. and Kamoto,T. Matriptase-induced phosphorylation of MET is significantly associated with poor prognosis in invasive bladder cancer; an immunohistochemical analysis Int J Mol Sci (2018) 19 PubMed Europe PubMed DOI
Zaman,S., Chobrutskiy,B.I., Patel,J.S., Callahan,B.M., Tong,W.L. and Blanck,G. Mutant cytoskeletal and ECM peptides sensitive to the ST14 protease are associated with a worse outcome for glioblastoma multiforme Biochem Biophys Res Commun (2018) 503, 2218-2225. PubMed Europe PubMed DOI

2017

Friis,S., Tadeo,D., Le-Gall,S.M., Jurgensen,H.J., Sales,K.U., Camerer,E. and Bugge,T.H. Matriptase zymogen supports epithelial development, homeostasis and regeneration BMC Biol (2017) 15, 46-46. PubMed Europe PubMed DOI PMC EPMC
Haussler,D., Schulz-Fincke,A.C., Beckmann,A.M., Keils,A., Gilberg,E., Mangold,M., Bajorath,J., Stirnberg,M., Steinmetzer,T. and Gutschow,M. A fluorescent-labeled phosphono bisbenzguanidine as an activity-based probe for matriptase Chemistry (2017) 23, 5205-5209. PubMed Europe PubMed DOI L I
Lanchec,E., Desilets,A., Beliveau,F., Flamier,A., Mahmoud,S., Bernier,G., Gris,D., Leduc,R. and Lavoie,C. The type II transmembrane serine protease matriptase cleaves the amyloid precursor protein and reduces its processing to beta-amyloid peptide J Biol Chem (2017) 292, 20669-20682. PubMed Europe PubMed DOI
Nonboe,A.W., Krigslund,O., Soendergaard,C., Skovbjerg,S., Friis,S., Andersen,M.N., Ellis,V., Kawaguchi,M., Kataoka,H., Bugge,T.H. and Vogel,L.K. HAI-2 stabilizes, inhibits, and regulates SEA-cleavage-dependent secretory transport of matriptase Traffic (2017) 18, 378-391. PubMed Europe PubMed DOI
Sun,D.R., Zheng,Q.C. and Zhang,H.X. Probing the interaction mechanism of small molecule inhibitors with matriptase based on molecular dynamics simulation and free energy calculations J Biomol Struct Dyn (2017) 35, 755-764. PubMed Europe PubMed DOI I
Tanabe,L.M. and List,K. The role of type II transmembrane serine protease-mediated signaling in cancer FEBS J (2017) 284, 1421-1436. PubMed Europe PubMed DOI I
Tseng,C.C., Jia,B., Barndt,R., Gu,Y., Chen,C.Y., Tseng,I.C., Su,S.F., Wang,J.K., Johnson,M.D. and Lin,C.Y. Matriptase shedding is closely coupled with matriptase zymogen activation and requires de novo proteolytic cleavage likely involving its own activity PLoS ONE (2017) 12, e0183507-e0183507. PubMed Europe PubMed DOI
Wilkinson,D.J., Habgood,A., Lamb,H.K., Thompson,P., Hawkins,A.R., Desilets,A., Leduc,R., Steinmetzer,T., Hammami,M., Lee,M.S., Craik,C.S., Watson,S., Lin,H., Milner,J.M. and Rowan,A.D. Matriptase induction of metalloproteinase-dependent aggrecanolysis in vitro and in vivo: promotion of osteoarthritic cartilage damage by multiple mechanisms Arthritis Rheumatol (2017) 69, 1601-1611. PubMed Europe PubMed DOI
Wu,C.J., Feng,X., Lu,M., Morimura,S. and Udey,M.C. Matriptase-mediated cleavage of EpCAM destabilizes claudins and dysregulates intestinal epithelial homeostasis J Clin Invest (2017) 127, 623-634. PubMed Europe PubMed DOI P
Wu,S.R., Teng,C.H., Tu,Y.T., Ko,C.J., Cheng,T.S., Lan,S.W., Lin,H.Y., Lin,H.H., Tu,H.F., Hsiao,P.W., Huang,H.P., Chen,C.H. and Lee,M.S. The Kunitz domain I of hepatocyte growth factor activator inhibitor-2 inhibits matriptase activity and invasive ability of human prostate cancer cells Sci Rep (2017) 7, 15101-15101. PubMed Europe PubMed DOI
Yogo,T., Umezawa,K., Kamiya,M., Hino,R. and Urano,Y. Development of an activatable fluorescent probe for prostate cancer imaging Bioconjug Chem (2017) 28, 2069-2076. PubMed Europe PubMed DOI L
Youssefian,L., Touati,A., Saeidian,A.H., Zargari,O., Zeinali,S., Vahidnezhad,H. and Uitto,J. A novel mutation in ST14 at a functionally significant amino acid residue expands the spectrum of ichthyosis-hypotrichosis syndrome Orphanet J Rare Dis (2017) 12, 176-176. PubMed Europe PubMed DOI PMC EPMC M

2016

Bardou,O., Menou,A., Francois,C., Duitman,J.W., von der Thusen,J.H., Borie,R., Sales,K.U., Mutze,K., Castier,Y., Sage,E., Liu,L., Bugge,T.H., Fairlie,D.P., Konigshoff,M., Crestani,B. and Borensztajn,K.S. Membrane-anchored serine protease matriptase is a trigger of pulmonary fibrogenesis Am J Respir Crit Care Med (2016) 193, 847-860. PubMed Europe PubMed DOI I
Beckmann,A.M., Gilberg,E., Gattner,S., Huang,T.L., Vanden Eynde,J.J., Mayence,A., Bajorath,J., Stirnberg,M. and Gutschow,M. Evaluation of bisbenzamidines as inhibitors for matriptase-2 Bioorg Med Chem Lett (2016) 26, 3741-3745. PubMed Europe PubMed DOI I
Chen,C.Y., Chen,C.J., Lai,C.H., Wu,B.Y., Lee,S.P., Johnson,M.D., Lin,C.Y. and Wang,J.K. Increased matriptase zymogen activation by UV irradiation protects keratinocyte from cell death J Dermatol Sci (2016) 83, 34-44. PubMed Europe PubMed DOI
Chen,Y.W., Yin,S., Lai,Y.J., Johnson,M.D. and Lin,C.Y. Plasminogen-dependent matriptase activation accelerates plasmin generation by differentiating primary human keratinocytes J Invest Dermatol (2016) 136, 1210-1218. PubMed Europe PubMed DOI
Han,Z., Harris,P.K., Karmakar,P., Kim,T., Owusu,B.Y., Wildman,S.A., Klampfer,L. and Janetka,J.W. alpha-Ketobenzothiazole serine protease inhibitors of aberrant HGF/c-MET and MSP/RON kinase pathway signaling in cancer ChemMedChem (2016) 11, 585-599. PubMed Europe PubMed DOI I
Le Gall,S.M., Szabo,R., Lee,M., Kirchhofer,D., Craik,C.S., Bugge,T.H. and Camerer,E. Matriptase activation connects tissue factor-dependent coagulation initiation to epithelial proteolysis and signaling Blood (2016) 127, 3260-3269. PubMed Europe PubMed DOI
Maiwald,A., Hammami,M., Wagner,S., Heine,A., Klebe,G. and Steinmetzer,T. Changing the selectivity profile - from substrate analog inhibitors of thrombin and factor Xa to potent matriptase inhibitors J Enzyme Inhib Med Chem (2016) 31, 89-97. PubMed Europe PubMed DOI I
Murray,A.S., Varela,F.A. and List,K. Type II transmembrane serine proteases as potential targets for cancer therapy Biol Chem (2016) 397, 815-826. PubMed Europe PubMed DOI
Najy,A.J., Dyson,G., Jena,B.P., Lin,C.Y. and Kim,H.R. Matriptase activation and shedding through PDGF-D-mediated extracellular acidosis Am J Physiol Cell Physiol (2016) 310, C293-C304. PubMed Europe PubMed DOI
Su,H.C., Liang,Y.A., Lai,Y.J., Chiu,Y.L., Barndt,R.B., Shiao,F., Chang,H.D., Lu,D.D., Huang,N., Tseng,C.C., Wang,J.K., Lee,M.S., Johnson,M.D., Huang,S.M. and Lin,C.Y. Natural endogenous human matriptase and prostasin undergo zymogen activation via independent mechanisms in an uncoupled manner PLoS ONE (2016) 11, e0167894-e0167894. PubMed Europe PubMed DOI
Venukadasula,P.K., Owusu,B.Y., Bansal,N., Ross,L.J., Hobrath,J.V., Bao,D., Truss,J.W., Stackhouse,M., Messick,T.E., Klampfer,L. and Galemmo RA Jr Design and synthesis of nonpeptide inhibitors of hepatocyte growth factor activation ACS Med Chem Lett (2016) 7, 177-181. PubMed Europe PubMed DOI PMC EPMC I

2015

Goswami,R., Wohlfahrt,G., Mukherjee,S., Ghadiyaram,C., Nagaraj,J., Satyam,L.K., Subbarao,K., Gopinath,S., Krishnamurthy,N.R., Subramanya,H.S. and Ramachandra,M. Discovery of O-(3-carbamimidoylphenyl)-l-serine amides as matriptase inhibitors using a fragment-linking approach Bioorg Med Chem Lett (2015) 25, 616-620. PubMed Europe PubMed DOI I
Huang,W. and Kim,H.R. Dynamic regulation of platelet-derived growth factor D (PDGF-D) activity and extracellular spatial distribution by matriptase-mediated proteolysis J Biol Chem (2015) 290, 9162-9170. PubMed Europe PubMed DOI
Ko,C.J., Huang,C.C., Lin,H.Y., Juan,C.P., Lan,S.W., Shyu,H.Y., Wu,S.R., Hsiao,P.W., Huang,H.P., Shun,C.T. and Lee,M.S. Androgen-induced TMPRSS2 activates matriptase and promotes extracellular matrix degradation, prostate cancer cell invasion, tumor growth, and metastasis Cancer Res (2015) 75, 2949-2960. PubMed Europe PubMed DOI
Paszti-Gere,E., McManus,S., Meggyeshazi,N., Balla,P., Galfi,P. and Steinmetzer,T. Inhibition of matriptase activity results in decreased intestinal epithelial monolayer integrity in vitro PLoS ONE (2015) 10, e0141077-e0141077. PubMed Europe PubMed DOI PMC EPMC I
Takeichi,T., Nanda,A., Aristodemou,S., McMillan,J.R., Lee,J., Akiyama,M., Al-Ajmi,H., Simpson,M.A. and McGrath,J.A. Whole-exome sequencing diagnosis of two autosomal recessive disorders in one family Br J Dermatol (2015) 172, 1407-1411. PubMed Europe PubMed DOI M
Tan,X., Soualmia,F., Furio,L., Renard,J.F., Kempen,I., Qin,L., Pagano,M., Pirotte,B., El Amri,C., Hovnanian,A. and Reboud-Ravaux,M. Toward the first class of suicide inhibitors of kallikreins involved in skin diseases J Med Chem (2015) 58, 598-612. PubMed Europe PubMed DOI I
Zarif,J.C., Lamb,L.E., Schulz,V.V., Nollet,E.A. and Miranti,C.K. Androgen receptor non-nuclear regulation of prostate cancer cell invasion mediated by Src and matriptase Oncotarget (2015) 6, 6862-6876. PubMed Europe PubMed DOI
Zoratti,G.L., Tanabe,L.M., Varela,F.A., Murray,A.S., Bergum,C., Colombo,E., Lang,J.E., Molinolo,A.A., Leduc,R., Marsault,E., Boerner,J. and List,K. Targeting matriptase in breast cancer abrogates tumour progression via impairment of stromal-epithelial growth factor signalling Nat Commun (2015) 6, 6776-6776. PubMed Europe PubMed DOI I

2014

Barre,O., Dufour,A., Eckhard,U., Kappelhoff,R., Beliveau,F., Leduc,R. and Overall,C.M. Cleavage specificity analysis of six type II transmembrane serine proteases (TTSPs) using PICS with proteome-derived peptide libraries PLoS ONE (2014) 9, e105984-e105984. PubMed Europe PubMed DOI PMC EPMC P
Chen,Y.W., Wang,J.K., Chou,F.P., Wu,B.Y., Hsiao,H.C., Chiu,H., Xu,Z., Baksh,A.N., Shi,G., Kaul,M., Barndt,R., Shanmugam,V.K., Johnson,M.D. and Lin,C.Y. Matriptase regulates proliferation and early, but not terminal, differentiation of human keratinocytes J Invest Dermatol (2014) 134, 405-414. PubMed Europe PubMed DOI
Chu,L.L., Xu,Y., Yang,J.R., Hu,Y.A., Chang,H.H., Lai,H.Y., Tseng,C.C., Wang,H.Y., Johnson,M.D., Wang,J.K. and Lin,C.Y. Human cancer cells retain modest levels of enzymatically active matriptase only in extracellular milieu following induction of zymogen activation PLoS ONE (2014) 9, e92244-e92244. PubMed Europe PubMed DOI PMC EPMC
Dargahi,D., Swayze,R.D., Yee,L., Bergqvist,P.J., Hedberg,B.J., Heravi-Moussavi,A., Dullaghan,E.M., Dercho,R., An,J., Babcook,J.S. and Jones,S.J. A pan-cancer analysis of alternative splicing events reveals novel tumor-associated splice variants of matriptase Cancer Inform (2014) 13, 167-177. PubMed Europe PubMed DOI PMC EPMC M R
Duchene,D., Colombo,E., Desilets,A., Boudreault,P.L., Leduc,R., Marsault,E. and Najmanovich,R. Analysis of subpocket selectivity and identification of potent selective inhibitors for matriptase and matriptase-2 J Med Chem (2014) 57, 10198-10204. PubMed Europe PubMed DOI I
Fittler,H., Avrutina,O., Empting,M. and Kolmar,H. Potent inhibitors of human matriptase-1 based on the scaffold of sunflower trypsin inhibitor J Pept Sci (2014) 20, 415-420. PubMed Europe PubMed DOI I
Friis,S., Sales,K.U., Schafer,J.M., Vogel,L.K., Kataoka,H. and Bugge,T.H. The protease inhibitor HAI-2, but not HAI-1, regulates matriptase activation and shedding through prostasin J Biol Chem (2014) 289, 22319-22332. PubMed Europe PubMed DOI
Goswami,R., Mukherjee,S., Ghadiyaram,C., Wohlfahrt,G., Sistla,R.K., Nagaraj,J., Satyam,L.K., Subbarao,K., Palakurthy,R.K., Gopinath,S., Krishnamurthy,N.R., Ikonen,T., Moilanen,A., Subramanya,H.S., Kallio,P. and Ramachandra,M. Structure-guided discovery of 1,3,5 tri-substituted benzenes as potent and selective matriptase inhibitors exhibiting in vivo antitumor efficacy Bioorg Med Chem (2014) 22, 3187-3203. PubMed Europe PubMed DOI S I
Gray,K., Elghadban,S., Thongyoo,P., Owen,K.A., Szabo,R., Bugge,T.H., Tate,E.W., Leatherbarrow,R.J. and Ellis,V. Potent and specific inhibition of the biological activity of the type-II transmembrane serine protease matriptase by the cyclic microprotein MCoTI-II Thromb Haemost (2014) 112, 402-411. PubMed Europe PubMed DOI
Han,Z., Harris,P.K., Jones,D.E., Chugani,R., Kim,T., Agarwal,M., Shen,W., Wildman,S.A. and Janetka,J.W. Inhibitors of HGFA, matriptase, and hepsin serine proteases: a nonkinase strategy to block cell signaling in cancer ACS Med Chem Lett (2014) 5, 1219-1224. PubMed Europe PubMed DOI PMC EPMC I
Lee,H.S., Park,B.M., Cho,Y., Kim,S., Kim,C., Kim,M.G. and Park,D. Shedding of epithin/PRSS14 is induced by TGF-beta and mediated by tumor necrosis factor-alpha converting enzyme Biochem Biophys Res Commun (2014) 452, 1084-1090. PubMed Europe PubMed DOI
Tsai,C.H., Teng,C.H., Tu,Y.T., Cheng,T.S., Wu,S.R., Ko,C.J., Shyu,H.Y., Lan,S.W., Huang,H.P., Tzeng,S.F., Johnson,M.D., Lin,C.Y., Hsiao,P.W. and Lee,M.S. HAI-2 suppresses the invasive growth and metastasis of prostate cancer through regulation of matriptase Oncogene (2014) 33, 4643-4652. PubMed Europe PubMed DOI
Wang,J.K., Teng,I.J., Lo,T.J., Moore,S., Yeo,Y.H., Teng,Y.C., Kaul,M., Chen,C.C., Zuo,A.H., Chou,F.P., Yang,X., Tseng,I.C., Johnson,M.D. and Lin,C.Y. Matriptase autoactivation is tightly regulated by the cellular chemical environments PLoS ONE (2014) 9, e93899-e93899. PubMed Europe PubMed DOI PMC EPMC
Wood,M.P., Cole,A.L., Eade,C.R., Chen,L.M., Chai,K.X. and Cole,A.M. The HIV-1 gp41 ectodomain is cleaved by matriptase to produce a chemotactic peptide that acts through FPR2 Immunology (2014) 142, 474-483. PubMed Europe PubMed DOI

2013

Beaulieu,A., Gravel,E., Cloutier,A., Marois,I., Colombo,E., Desilets,A., Verreault,C., Leduc,R., Marsault,E. and Richter,M.V. Matriptase proteolytically activates influenza virus and promotes multicycle replication in the human airway epithelium J Virol (2013) 87, 4237-4251. PubMed Europe PubMed DOI
Buzza,M.S., Martin,E.W., Driesbaugh,K.H., Desilets,A., Leduc,R. and Antalis,T.M. Prostasin is required for matriptase activation in intestinal epithelial cells to regulate closure of the paracellular pathway J Biol Chem (2013) 288, 10328-10337. PubMed Europe PubMed DOI
Chou,F.P., Chen,Y.W., Zhao,X.F., Xu-Monette,Z.Y., Young,K.H., Gartenhaus,R.B., Wang,J.K., Kataoka,H., Zuo,A.H., Barndt,R.J., Johnson,M. and Lin,C.Y. Imbalanced matriptase pericellular proteolysis contributes to the pathogenesis of malignant B-cell lymphomas Am J Pathol (2013) 183, 1306-1317. PubMed Europe PubMed DOI
Fittler,H., Avrutina,O., Glotzbach,B., Empting,M. and Kolmar,H. Combinatorial tuning of peptidic drug candidates: high-affinity matriptase inhibitors through incremental structure-guided optimization Org Biomol Chem (2013) 11, 1848-1857. PubMed Europe PubMed DOI I
Friis,S., Uzzun Sales,K., Godiksen,S., Peters,D.E., Lin,C.Y., Vogel,L.K. and Bugge,T.H. A matriptase-prostasin reciprocal zymogen activation complex with unique features: prostasin as a non-enzymatic co-factor for matriptase activation J Biol Chem (2013) 288, 19028-19039. PubMed Europe PubMed DOI
Glotzbach,B., Reinwarth,M., Weber,N., Fabritz,S., Tomaszowski,M., Fittler,H., Christmann,A., Avrutina,O. and Kolmar,H. Combinatorial optimization of cystine-knot peptides towards high-affinity inhibitors of human matriptase-1 PLoS ONE (2013) 8, e76956-e76956. PubMed Europe PubMed DOI PMC EPMC
Godiksen,S., Soendergaard,C., Friis,S., Jensen,J.K., Bornholdt,J., Sales,K.U., Huang,M., Bugge,T.H. and Vogel,L.K. Detection of active matriptase using a biotinylated chloromethyl ketone peptide PLoS ONE (2013) 8, e77146-e77146. PubMed Europe PubMed DOI PMC EPMC L I
Goswami,R., Mukherjee,S., Wohlfahrt,G., Ghadiyaram,C., Nagaraj,J., Chandra,B.R., Sistla,R.K., Satyam,L.K., Samiulla,D.S., Moilanen,A., Subramanya,H.S. and Ramachandra,M. Discovery of pyridyl bis(oxy)dibenzimidamide derivatives as selective matriptase inhibitors ACS Med Chem Lett (2013) 4, 1152-1157. PubMed Europe PubMed DOI S I
Inouye,K., Tomoishi,M., Yasumoto,M., Miyake,Y., Kojima,K., Tsuzuki,S. and Fushiki,T. Roles of CUB and LDL receptor class A domain repeats of a transmembrane serine protease matriptase in its zymogen activation J Biochem (2013) 153, 51-61. PubMed Europe PubMed DOI
Lebeau,A.M., Lee,M., Murphy,S.T., Hann,B.C., Warren,R.S., Delos Santos,R., Kurhanewicz,J., Hanash,S.M., Vanbrocklin,H.F. and Craik,C.S. Imaging a functional tumorigenic biomarker in the transformed epithelium Proc Natl Acad Sci U S A (2013) 110, 93-98. PubMed Europe PubMed DOI L
Miller,G.S. and List,K. The matriptase-prostasin proteolytic cascade in epithelial development and pathology Cell Tissue Res (2013) 351, 245-253. PubMed Europe PubMed DOI
Quimbar,P., Malik,U., Sommerhoff,C.P., Kaas,Q., Chan,L.Y., Huang,Y.H., Grundhuber,M., Dunse,K., Craik,D.J., Anderson,M.A. and Daly,N.L. High-affinity cyclic peptide matriptase inhibitors J Biol Chem (2013) 288, 13885-13896. PubMed Europe PubMed DOI
Tan,X., Furio,L., Reboud-Ravaux,M., Villoutreix,B.O., Hovnanian,A. and El Amri,C. 1,2,4-Triazole derivatives as transient inactivators of kallikreins involved in skin diseases Bioorg Med Chem Lett (2013) 23, 4547-4551. PubMed Europe PubMed DOI I
Zhao,B., Yuan,C., Li,R., QU,D., Huang,M. and Ngo,J.C. Crystal structures of matriptase in complex with its inhibitor hepatocyte growth factor activator inhibitor-1 J Biol Chem (2013) 288, 11155-11164. PubMed Europe PubMed DOI S

2012

Bergum,C., Zoratti,G., Boerner,J. and List,K. Strong expression association between matriptase and its substrate prostasin in breast cancer J Cell Physiol (2012) 227, 1604-1609. PubMed Europe PubMed DOI
Chen,Y.W., Eckert,R.D., Johnson,M.D. and Lin,C.Y. The transmembrane serine protease matriptase: implications for cellular biology and human diseases J Med Sci (2012) 32, 97-108. V
Colombo,E., Desilets,A., Duchene,D., Chagnon,F., Najmanovich,R., Leduc,R. and Marsault,E. Design and synthesis of potent, selective inhibitors of matriptase ACS Med Chem Lett (2012) 3, 530-534. PubMed Europe PubMed DOI I
Domoto,T., Takino,T., Guo,L. and Sato,H. Cleavage of hepatocyte growth factor activator inhibitor-1 by membrane-type MMP-1 activates matriptase Cancer Sci (2012) 103, 448-454. PubMed Europe PubMed DOI
Hamilton,B.S., Gludish,D.W. and Whittaker,G.R. Cleavage activation of the human-adapted influenza virus subtypes by matriptase reveals both subtype and strain specificities J Virol (2012) 86, 10579-10586. PubMed Europe PubMed DOI
Hammami,M., Ruhmann,E., Maurer,E., Heine,A., Gutschow,M., Klebe,G. and Steinmetzer,T. New 3-amidinophenylalanine-derived inhibitors of matriptase MedChemComm (2012) 3, 807-813. DOI I
Kosa,P., Szabo,R., Molinolo,A.A. and Bugge,T.H. Suppression of Tumorigenicity-14, encoding matriptase, is a critical suppressor of colitis and colitis-associated colon carcinogenesis Oncogene (2012) 31, 3679-3695. PubMed Europe PubMed DOI
Kota,P., Garcia-Caballero,A., Dang,H., Gentzsch,M., Stutts,M.J. and Dokholyan,N.V. Energetic and structural basis for activation of the epithelial sodium channel by matriptase Biochemistry (2012) 51, 3460-3469. PubMed Europe PubMed DOI
Lin,C.Y., Chen,Y.W., Xu,Z. and Johnson,M.D. Matriptase [ISSN:978-0-12-407742-3] (2012) 3, 2969-2975. DOI
Netzel-Arnett,S., Buzza,M.S., Shea-Donohue,T., Desilets,A., Leduc,R., Fasano,A., Bugge,T.H. and Antalis,T.M. Matriptase protects against experimental colitis and promotes intestinal barrier recovery Inflamm Bowel Dis (2012) 18, 1303-1314. PubMed Europe PubMed DOI
Szabo,R., Uzzun Sales,K., Kosa,P., Shylo,N.A., Godiksen,S., Hansen,K.K., Friis,S., Gutkind,J.S., Vogel,L.K., Hummler,E., Camerer,E. and Bugge,T.H. Reduced prostasin (CAP1/PRSS8) activity eliminates HAI-1 and HAI-2 deficiency-associated developmental defects by preventing matriptase activation PLoS Genet (2012) 8, e1002937-e1002937. PubMed Europe PubMed DOI PMC EPMC
Xu,H., Xu,Z., Tseng,I.C., Chou,F.P., Chen,Y.W., Wang,J.K., Johnson,M.D., Kataoka,H. and Lin,C.Y. Mechanisms for the control of matriptase activity in the absence of sufficient HAI-1 Am J Physiol Cell Physiol (2012) 302, C453-C462. PubMed Europe PubMed DOI

2011

Antalis,T.M., Bugge,T.H. and Wu,Q. Membrane-anchored serine proteases in health and disease Prog Mol Biol Transl Sci (2011) 99, 1-50. PubMed Europe PubMed DOI V
Chou,F.P., Xu,H., Lee,M.S., Chen,Y.W., Durand Richards,O.X., Swanson,R., Olson,S.T., Johnson,M.D. and Lin,C.Y. Matriptase is inhibited by extravascular antithrombin in epithelial cells but not in most carcinoma cells Am J Physiol Cell Physiol (2011) 301, C1093-C1103. PubMed Europe PubMed DOI
Kim,C., Seon Lee,H., Lee,D., Lee,S.D., Cho,E.G., Yang,S.J., Kim,S.B., Park,D. and Kim,M.G. Epithin/PRSS14 proteolytically regulates angiopoietin receptor Tie2 during transendothelial migration Blood (2011) 117, 1415-1424. PubMed Europe PubMed DOI
Kojima,K. and Inouye,K. Activation of matriptase zymogen J Biochem (2011) 150, 123-125. PubMed Europe PubMed DOI
Lee,D., Lee,H.S., Yang,S.J., Jeong,H., Kim,D.Y., Lee,S.D., Oh,J.W., Park,D. and Kim,M.G. PRSS14/epithin is induced in macrophages by the IFN-gamma/JAK/STAT pathway and mediates transendothelial migration Biochem Biophys Res Commun (2011) 405, 644-650. PubMed Europe PubMed DOI
Szabo,R., Rasmussen,A.L., Moyer,A.B., Kosa,P., Schafer,J.M., Molinolo,A.A., Gutkind,J.S. and Bugge,T.H. c-Met-induced epithelial carcinogenesis is initiated by the serine protease matriptase Oncogene (2011) 30, 2003-2016. PubMed Europe PubMed DOI
Tripathi,M., Potdar,A.A., Yamashita,H., Weidow,B., Cummings,P.T., Kirchhofer,D. and Quaranta,V. Laminin-332 cleavage by matriptase alters motility parameters of prostate cancer cells Prostate (2011) 71, 184-196. PubMed Europe PubMed DOI
Xu,Z., Chen,Y.W., Battu,A., Wilder,P., Weber,D., Yu,W., Mackerell,A.D., Chen,L.M., Chai,K.X., Johnson,M.D. and Lin,C.Y. Targeting zymogen activation to control the matriptase-prostasin proteolytic cascade J Med Chem (2011) 54, 7567-7578. PubMed Europe PubMed DOI I
Yuan,C., Chen,L., Meehan,E.J., Daly,N.L., Craik,D.J., Huang,M. and Ngo,J.C. Structure of catalytic domain of matriptase in complex with sunflower trypsin inhibitor-1 BMC Struct Biol (2011) 11, 30-30. PubMed Europe PubMed DOI S

2010

Buzza,M.S., Netzel-Arnett,S., Shea-Donohue,T., Zhao,A., Lin,C.Y., List,K., Szabo,R., Fasano,A., Bugge,T.H. and Antalis,T.M. Membrane-anchored serine protease matriptase regulates epithelial barrier formation and permeability in the intestine Proc Natl Acad Sci U S A (2010) 107, 4200-4205. PubMed Europe PubMed DOI
Camerer,E., Barker,A., Duong,D.N., Ganesan,R., Kataoka,H., Cornelissen,I., Darragh,M.R., Hussain,A., Zheng,Y.W., Srinivasan,Y., Brown,C., Xu,S.M., Regard,J.B., Lin,C.Y., Craik,C.S., Kirchhofer,D. and Coughlin,S.R. Local protease signaling contributes to neural tube closure in the mouse embryo Dev Cell (2010) 18, 25-38. PubMed Europe PubMed DOI PMC EPMC
Chen,Y.W., Wang,J.K., Chou,F.P., Chen,C.Y., Rorke,E.A., Chen,L.M., Chai,K.X., Eckert,R.L., Johnson,M.D. and Lin,C.Y. Regulation of the matriptase-prostasin cell surface proteolytic cascade by hepatocyte growth factor activator inhibitor-1 during epidermal differentiation J Biol Chem (2010) 285, 31755-31762. PubMed Europe PubMed DOI
Clark,E.B., Jovov,B., Rooj,A.K., Fuller,C.M. and Benos,D.J. Proteolytic cleavage of human acid-sensing ion channel 1 by the serine protease matriptase J Biol Chem (2010) 285, 27130-27143. PubMed Europe PubMed DOI
Ganesan,R., Eigenbrot,C. and Kirchhofer,D. Structural and mechanistic insight into how antibodies inhibit serine proteases Biochem J (2010) 430, 179-189. PubMed Europe PubMed DOI
Inouye,K., Yasumoto,M., Tsuzuki,S., Mochida,S. and Fushiki,T. The optimal activity of a pseudozymogen form of recombinant matriptase under the mildly acidic pH and low ionic strength conditions J Biochem (2010) 147, 485-492. PubMed Europe PubMed DOI A
Inouye,K., Tsuzuki,S., Yasumoto,M., Kojima,K., Mochida,S. and Fushiki,T. Identification of the matriptase second CUB domain as the secondary site for interaction with hepatocyte growth factor activator inhibitor type-1 J Biol Chem (2010) 285, 33394-33403. PubMed Europe PubMed DOI
Kim,S.B., Lee,D., Jeong,J.W., Kim,C., Park,D. and Kim,M.G. Soluble epithin/PRSS14 secreted from cancer cells contains active angiogenic potential Mol Cells (2010) 29, 617-623. PubMed Europe PubMed DOI
Kotthaus,J., Steinmetzer,T., Kotthaus,J., Schade,D., van de Locht,A. and Clement,B. Metabolism and distribution of two highly potent and selective peptidomimetic inhibitors of matriptase Xenobiotica (2010) 40, 93-101. PubMed Europe PubMed DOI I
Lee,S.L., Huang,P.Y., Roller,P., Cho,E.G., Park,D. and Dickson,R.B. Matriptase/epithin participates in mammary epithelial cell growth and morphogenesis through HGF activation Mech Dev (2010) 127, 82-95. PubMed Europe PubMed DOI
Milner,J.M., Patel,A., Davidson,R.K., Swingler,T.E., Desilets,A., Young,D.A., Kelso,E.B., Donell,S.T., Cawston,T.E., Clark,I.M., Ferrell,W.R., Plevin,R., Lockhart,J.C., Leduc,R. and Rowan,A.D. Matriptase is a novel initiator of cartilage matrix degradation in osteoarthritis Arthritis Rheum (2010) 62, 1955-1966. PubMed Europe PubMed DOI
Miyake,Y., Tsuzuki,S., Mochida,S., Fushiki,T. and Inouye,K. The role of asparagine-linked glycosylation site on the catalytic domain of matriptase in its zymogen activation Biochim Biophys Acta (2010) 1804, 156-165. PubMed Europe PubMed DOI
Miyake,Y., Tsuzuki,S., Fushiki,T. and Inouye,K. Matriptase does not require hepatocyte growth factor activator inhibitor type-1 for activation in an epithelial cell expression model Biosci Biotechnol Biochem (2010) 74, 848-850. PubMed Europe PubMed DOI
Mochida,S., Tsuzuki,S., Inouye,K. and Fushiki,T. A recombinant catalytic domain of matriptase induces detachment and apoptosis of small-intestinal epithelial IEC-6 cells cultured on laminin-coated surface J Biochem (2010) 148, 721-732. PubMed Europe PubMed DOI E
Napp,J., Dullin,C., Muller,F., Uhland,K., Petri,J.B., van de Locht,A., Steinmetzer,T. and Alves,F. Time-domain in vivo near infrared fluorescence imaging for evaluation of matriptase as a potential target for the development of novel, inhibitor-based tumor therapies Int J Cancer (2010) 127, 1958-1974. PubMed Europe PubMed DOI L
Owen,K.A., Qiu,D., Alves,J., Schumacher,A.M., Kilpatrick,L.M., Li,J., Harris,J.L. and Ellis,V. Pericellular activation of hepatocyte growth factor by the transmembrane serine proteases matriptase and hepsin, but not by the membrane-associated protease uPA Biochem J (2010) 426, 219-228. PubMed Europe PubMed DOI
Sales,K.U., Masedunskas,A., Bey,A.L., Rasmussen,A.L., Weigert,R., List,K., Szabo,R., Overbeek,P.A. and Bugge,T.H. Matriptase initiates activation of epidermal pro-kallikrein and disease onset in a mouse model of Netherton syndrome Nat Genet (2010) 42, 676-683. PubMed Europe PubMed DOI
Tseng,I.C., Xu,H., Chou,F.P., Li,G., Vazzano,A.P., Kao,J.P., Johnson,M.D. and Lin,C.Y. Matriptase activation, an early cellular response to acidosis J Biol Chem (2010) 285, 3261-3270. PubMed Europe PubMed DOI
Tsuzuki,S., Murai,N., Miyake,Y., Inouye,K. and Fushiki,T. The structural requirements of matriptase in its ectodomain release in polarized epithelial cells Biosci Biotechnol Biochem (2010) 74, 1295-1297. PubMed Europe PubMed DOI
Ustach,C.V., Huang,W., Conley-Lacomb,M.K., Lin,C.Y., Che,M., Abrams,J. and Kim,H.R. A novel signaling axis of matriptase/PDGF-D/beta-PDGFR in human prostate cancer Cancer Res (2010) 70, 9631-9640. PubMed Europe PubMed DOI

2009

Alef,T., Torres,S., Hausser,I., Metze,D., Tursen,U., Lestringant,G.G. and Hennies,H.C. Ichthyosis, follicular atrophoderma, and hypotrichosis caused by mutations in ST14 is associated with impaired profilaggrin processing J Invest Dermatol (2009) 129, 862-869. PubMed Europe PubMed DOI M
Beliveau,F., Desilets,A. and Leduc,R. Probing the substrate specificities of matriptase, matriptase-2, hepsin and DESC1 with internally quenched fluorescent peptides FEBS J (2009) 276, 2213-2226. PubMed Europe PubMed DOI A P
Kojima,K., Tsuzuki,S., Fushiki,T. and Inouye,K. The activity of a type II transmembrane serine protease, matriptase, is dependent solely on the catalytic domain Biosci Biotechnol Biochem (2009) 73, 454-456. PubMed Europe PubMed DOI E
Kojima,K., Tsuzuki,S., Fushiki,T. and Inouye,K. Role of the stem domain of matriptase in the interaction with its physiological inhibitor, hepatocyte growth factor activator inhibitor type I J Biochem (2009) 145, 783-790. PubMed Europe PubMed DOI
List,K. Matriptase: a culprit in cancer? Future Oncol (2009) 5, 97-104. PubMed Europe PubMed DOI T
List,K., Kosa,P., Szabo,R., Bey,A.L., Wang,C.B., Molinolo,A. and Bugge,T.H. Epithelial integrity is maintained by a matriptase-dependent proteolytic pathway Am J Pathol (2009) 175, 1453-1463. PubMed Europe PubMed DOI PMC EPMC
Miyake,Y., Tsuzuki,S., Yasumoto,M., Fushiki,T. and Inouye,K. Requirement of the activity of hepatocyte growth factor activator inhibitor type 1 for the extracellular appearance of a transmembrane serine protease matriptase in monkey kidney COS-1 cells Cytotechnology (2009) 60, 95-103. PubMed Europe PubMed DOI
Miyake,Y., Yasumoto,M., Tsuzuki,S., Fushiki,T. and Inouye,K. Activation of a membrane-bound serine protease matriptase on the cell surface J Biochem (2009) 146, 273-282. PubMed Europe PubMed DOI
Mochida,S., Tsuzuki,S., Yasumoto,M., Inouye,K. and Fushiki,T. Secreted expression of pseudozymogen forms of recombinant matriptase in Pichia pastoris Enzyme Microb Technol (2009) 45, 288-294. DOI
Scharschmidt,T.C., List,K., Grice,E.A., Szabo,R., Renaud,G., Lee,C.C., Wolfsberg,T.G., Bugge,T.H. and Segre,J.A. Matriptase-deficient mice exhibit ichthyotic skin with a selective shift in skin microbiota J Invest Dermatol (2009) 129, 2435-2442. PubMed Europe PubMed DOI K
Schweinitz,A., Donnecke,D., Ludwig,A., Steinmetzer,P., Schulze,A., Kotthaus,J., Wein,S., Clement,B. and Steinmetzer,T. Incorporation of neutral C-terminal residues in 3-amidinophenylalanine-derived matriptase inhibitors Bioorg Med Chem Lett (2009) 19, 1960-1965. PubMed Europe PubMed DOI I
Steinmetzer,T., Donnecke,D., Korsonewski,M., Neuwirth,C., Steinmetzer,P., Schulze,A., Saupe,S.M. and Schweinitz,A. Modification of the N-terminal sulfonyl residue in 3-amidinophenylalanine-based matriptase inhibitors Bioorg Med Chem Lett (2009) 19, 67-73. PubMed Europe PubMed DOI I
Szabo,R., Hobson,J.P., Christoph,K., Kosa,P., List,K. and Bugge,T.H. Regulation of cell surface protease matriptase by HAI2 is essential for placental development, neural tube closure and embryonic survival in mice Development (2009) 136, 2653-2663. PubMed Europe PubMed DOI
Szabo,R., Kosa,P., List,K. and Bugge,T.H. Loss of matriptase suppression underlies spint1 mutation-associated ichthyosis and postnatal lethality Am J Pathol (2009) 174, 2015-2022. PubMed Europe PubMed DOI PMC EPMC
Uhland,K., Siphos,B., Arkona,C., Schuster,M., Petri,B., Steinmetzer,P., Mueller,F., Schweinitz,A., Steinmetzer,T. and van de Locht,A. Use of IHC and newly designed matriptase inhibitors to elucidate the role of matriptase in pancreatic ductal adenocarcinoma Int J Oncol (2009) 35, 347-357. PubMed Europe PubMed DOI

2008

Avrahami,L., Maas,S., Pasmanik-Chor,M., Rainshtein,L., Magal,N., Smitt,J., van Marle,J., Shohat,M. and Basel-Vanagaite,L. Autosomal recessive ichthyosis with hypotrichosis syndrome: further delineation of the phenotype Clin Genet (2008) 74, 47-53. PubMed Europe PubMed DOI M
Chen,M., Chen,L.M., Lin,C.Y. and Chai,K.X. The epidermal growth factor receptor (EGFR) is proteolytically modified by the matriptase-prostasin serine protease cascade in cultured epithelial cells Biochim Biophys Acta (2008) 1783, 896-903. PubMed Europe PubMed DOI PMC EPMC
Darragh,M.R., Bhatt,A.S. and Craik,C.S. MT-SP1 proteolysis and regulation of cell-microenvironment interactions Front Biosci (2008) 13, 528-539. PubMed Europe PubMed DOI V
Desilets,A., Beliveau,F., Vandal,G., McDuff,F.O., Lavigne,P. and Leduc,R. Mutation G827R in matriptase causing autosomal recessive ichthyosis with hypotrichosis yields an inactive protease J Biol Chem (2008) 283, 10535-10542. PubMed Europe PubMed DOI PMC EPMC M
Farady,C.J., Egea,P.F., Schneider,E.L., Darragh,M.R. and Craik,C.S. Structure of an Fab-protease complex reveals a highly specific non-canonical mechanism of inhibition J Mol Biol (2008) 380, 351-360. PubMed Europe PubMed DOI PMC EPMC S
Kojima,K., Tsuzuki,S., Fushiki,T. and Inouye,K. Roles of functional and structural domains of hepatocyte growth factor activator inhibitor type 1 in the inhibition of matriptase J Biol Chem (2008) 283, 2478-2487. PubMed Europe PubMed DOI
Lin,C.Y., Tseng,I.C., Chou,F.P., Su,S.F., Chen,Y.W., Johnson,M.D. and Dickson,R.B. Zymogen activation, inhibition, and ectodomain shedding of matriptase Front Biosci (2008) 13, 621-635. PubMed Europe PubMed DOI V
Szabo,R., Hobson,J.P., List,K., Molinolo,A., Lin,C.Y. and Bugge,T.H. Potent inhibition and global co-localization implicate the transmembrane Kunitz-type serine protease inhibitor hepatocyte growth factor activator inhibitor-2 in the regulation of epithelial matriptase activity J Biol Chem (2008) 283, 29495-29504. PubMed Europe PubMed DOI PMC EPMC
Tseng,I.C., Chou,F.P., Su,S.F., Oberst,M., Madayiputhiya,N., Lee,M.S., Wang,J.K., Sloane,D.E., Johnson,M. and Lin,C.Y. Purification from human milk of matriptase complexes with secreted serpins: mechanism for inhibition of matriptase other than HAI-1 Am J Physiol Cell Physiol (2008) 295, C423-C431. PubMed Europe PubMed DOI PMC EPMC

2007

Basel-Vanagaite,L., Attia,R., Ishida-Yamamoto,A., Rainshtein,L., Ben Amitai,D., Lurie,R., Pasmanik-Chor,M., Indelman,M., Zvulunov,A., Saban,S., Magal,N., Sprecher,E. and Shohat,M. Autosomal recessive ichthyosis with hypotrichosis caused by a mutation in ST14, encoding type II transmembrane serine protease matriptase Am J Hum Genet (2007) 80, 467-477. PubMed Europe PubMed DOI PMC EPMC M
Bhatt,A.S., Welm,A., Farady,C.J., Vasquez,M., Wilson,K. and Craik,C.S. Coordinate expression and functional profiling identify an extracellular proteolytic signaling pathway Proc Natl Acad Sci U S A (2007) 104, 5771-5776. PubMed Europe PubMed DOI PMC EPMC
Bugge,T.H., List,K. and Szabo,R. Matriptase-dependent cell surface proteolysis in epithelial development and pathogenesis Front Biosci (2007) 12, 5060-5070. PubMed Europe PubMed DOI
Carney,T.J., von der Hardt,S., Sonntag,C., Amsterdam,A., Topczewski,J., Hopkins,N. and Hammerschmidt,M. Inactivation of serine protease matriptase1a by its inhibitor Hai1 is required for epithelial integrity of the zebrafish epidermis Development (2007) 134, 3461-3471. PubMed Europe PubMed DOI
Cheng,M.F., Jin,J.S., Wu,H.W., Chiang,P.C., Sheu,L.F. and Lee,H.S. Matriptase expression in the normal and neoplastic mast cells Eur J Dermatol (2007) 17, 375-380. PubMed Europe PubMed DOI
Farady,C.J., Sun,J., Darragh,M.R., Miller,S.M. and Craik,C.S. The mechanism of inhibition of antibody-based inhibitors of membrane-type serine protease 1 (MT-SP1) J Mol Biol (2007) 369, 1041-1051. PubMed Europe PubMed DOI PMC EPMC
[YEAR:4-1-2007]Jiang,S., Li,P., Lee,S.L., Lin,C.Y., Long,Y.Q., Johnson,M.D., Dickson,R.B. and Roller,P.P. Design and synthesis of redox stable analogues of sunflower trypsin inhibitors (SFTI-1) on solid support, potent inhibitors of matriptase Org Lett (4-1-2007) 9, 9-12. PubMed Europe PubMed DOI
Lee,M.S., Tseng,I.C., Wang,Y., Kiyomiya,K., Johnson,M.D., Dickson,R.B. and Lin,C.Y. Autoactivation of matriptase in vitro: requirement for biomembrane and LDL receptor domain Am J Physiol Cell Physiol (2007) 293, C95-C105. PubMed Europe PubMed DOI
Li,P., Jiang,S., Lee,S.L., Lin,C.Y., Johnson,M.D., Dickson,R.B., Michejda,C.J. and Roller,P.P. Design and synthesis of novel and potent inhibitors of the type II transmembrane serine protease, matriptase, based upon the sunflower trypsin inhibitor-1 J Med Chem (2007) 50, 5976-5983. PubMed Europe PubMed DOI I
List,K., Hobson,J.P., Molinolo,A. and Bugge,T.H. Co-localization of the channel activating protease prostasin/(CAP1/PRSS8) with its candidate activator, matriptase J Cell Physiol (2007) 213, 237-245. PubMed Europe PubMed DOI
List,K., Currie,B., Scharschmidt,T.C., Szabo,R., Shireman,J., Molinolo,A., Cravatt,B.F., Segre,J. and Bugge,T.H. Autosomal Ichthyosis with hypotrichosis syndrome displays low matriptase proteolytic activity and is phenocopied in ST14 hypomorphic mice J Biol Chem (2007) 282, 36714-36723. PubMed Europe PubMed DOI M
Planes,C. and Caughey,G.H. Regulation of the epithelial Na+ channel by peptidases Curr Top Dev Biol (2007) 78, 23-46. PubMed Europe PubMed DOI PMC EPMC
Qiu,D., Owen,K., Gray,K., Bass,R. and Ellis,V. Roles and regulation of membrane-associated serine proteases Biochem Soc Trans (2007) 35, 583-587. PubMed Europe PubMed DOI
Seitz,I., Hess,S., Schulz,H., Eckl,R., Busch,G., Montens,H.P., Brandl,R., Seidl,S., Schomig,A. and Ott,I. Membrane-type serine protease-1/matriptase induces interleukin-6 and -8 in endothelial cells by activation of protease-activated receptor-2: potential implications in atherosclerosis Arterioscler Thromb Vasc Biol (2007) 27, 769-775. PubMed Europe PubMed DOI
Szabo,R., Molinolo,A., List,K. and Bugge,T.H. Matriptase inhibition by hepatocyte growth factor activator inhibitor-1 is essential for placental development Oncogene (2007) 26, 1546-1556. PubMed Europe PubMed DOI

2006

Ahmed,S., Jin,X., Yagi,M., Yasuda,C., Sato,Y., Higashi,S., Lin,C.Y., Dickson,R.B. and Miyazaki,K. Identification of membrane-bound serine proteinase matriptase as processing enzyme of insulin-like growth factor binding protein-related protein-1 (IGFBP-rP1/angiomodulin/mac25) FEBS J (2006) 273, 615-627. PubMed Europe PubMed DOI
[YEAR:8-3-2006]Andreasen,D., Vuagniaux,G., Fowler-Jaeger,N., Hummler,E. and Rossier,B.C. Activation of epithelial sodium channels by mouse channel activating proteases (mCAP) expressed in Xenopus oocytes requires catalytic activity of mCAP3 and mCAP2 but not mCAP1 J Am Soc Nephrol (8-3-2006) 17, 968-976. PubMed Europe PubMed DOI
[YEAR:20-3-2006]Desilets,A., Longpre,J.M., Beaulieu,M.E. and Leduc,R. Inhibition of human matriptase by eglin c variants FEBS Lett (20-3-2006) 580, 2227-2232. PubMed Europe PubMed DOI
[YEAR:9-1-2006]Ge,W., Hu,H., Ding,K., Sun,L. and Zheng,S. Protein interaction analysis of ST14 domains and their point and deletion mutants J Biol Chem (9-1-2006) 281, 7406-7412. PubMed Europe PubMed DOI M
[YEAR:25-9-2006]Jin,X., Yagi,M., Akiyama,N., Hirosaki,T., Higashi,S., Lin,C.Y., Dickson,R.B., Kitamura,H. and Miyazaki,K. Matriptase activates stromelysin (MMP-3) and promotes tumor growth and angiogenesis Cancer Sci (25-9-2006) 97, 1327-1334. PubMed Europe PubMed DOI
[YEAR:22-6-2006]Kilpatrick,L.M., Harris,R.L., Owen,K.A., Bass,R., Ghorayeb,C., Bar-Or,A. and Ellis,V. Initiation of plasminogen activation on the surface of monocytes expressing the type II transmembrane serine protease matriptase Blood (22-6-2006) 108, 2616-2623. PubMed Europe PubMed DOI
List,K., Szabo,R., Molinolo,A., Nielsen,B.S. and Bugge,T.H. Delineation of matriptase protein expression by enzymatic gene trapping suggests diverging roles in barrier function, hair formation, and squamous cell carcinogenesis Am J Pathol (2006) 168, 1513-1525. PubMed Europe PubMed DOI PMC EPMC
[YEAR:20-6-2006]List,K., Bugge,T.H. and Szabo,R. Matriptase: potent proteolysis on the cell surface Mol Med (20-6-2006) 12, 1-7. PubMed Europe PubMed DOI
[YEAR:15-9-2006]Netzel-Arnett,S., Currie,B.M., Szabo,R., Lin,C.Y., Chen,L.M., Chai,K.X., Antalis,T.M., Bugge,T.H. and List,K. Evidence for a matriptase-prostasin proteolytic cascade regulating terminal epidermal differentiation J Biol Chem (15-9-2006) 281, 32941-32945. PubMed Europe PubMed DOI
Sanders,A.J., Parr,C., Davies,G., Martin,T.A., Lane,J., Mason,M.D. and Jiang,W.G. Genetic reduction of matriptase-1 expression is associated with a reduction in the aggressive phenotype of prostate cancer cells in vitro and in vivo J Exp Ther Oncol (2006) 6, 39-48. PubMed Europe PubMed
[YEAR:13-7-2006]Steinmetzer,T., Schweinitz,A., Sturzebecher,A., Donnecke,D., Uhland,K., Schuster,O., Steinmetzer,P., Muller,F., Friedrich,R., Than,M.E., Bode,W. and Sturzebecher,J. Secondary amides of sulfonylated 3-amidinophenylalanine. New potent and selective inhibitors of matriptase J Med Chem (13-7-2006) 49, 4116-4126. PubMed Europe PubMed DOI I
Uhland,K. Matriptase and its putative role in cancer Cell Mol Life Sci (2006) 63, 2968-2978. PubMed Europe PubMed DOI V

2005

[YEAR:4-2-2005]Cho,E.G., Schwartz,R.H. and Kim,M.G. Shedding of membrane epithin is blocked without LDLRA4 and its protease activation site Biochem Biophys Res Commun (4-2-2005) 327, 328-334. PubMed Europe PubMed DOI R
Forbs,D., Thiel,S., Stella,M.C., Sturzebecher,A., Schweinitz,A., Steinmetzer,T., Sturzebecher,J. and Uhland,K. In vitro inhibition of matriptase prevents invasive growth of cell lines of prostate and colon carcinoma Int J Oncol (2005) 27, 1061-1070. PubMed Europe PubMed I
[YEAR:1-5-2005]Khang,I., Sonn,S., Park,J.H., Rhee,K., Park,D. and Kim,K. Expression of epithin in mouse preimplantation development: its functional role in compaction Dev Biol (1-5-2005) 281, 134-144. PubMed Europe PubMed DOI
[YEAR:16-9-2005]Kim,C., Cho,Y., Kang,C.H., Kim,M.G., Lee,H., Cho,E.G. and Park,D. Filamin is essential for shedding of the transmembrane serine protease, epithin EMBO Rep (16-9-2005) 6, 1045-1051. PubMed Europe PubMed DOI PMC EPMC I
Lee,J.W., Yong Song,S., Choi,J.J., Lee,S.J., Kim,B.G., Park,C.S., Lee,J.H., Lin,C.Y., Dickson,R.B. and Bae,D.S. Increased expression of matriptase is associated with histopathologic grades of cervical neoplasia Hum Pathol (2005) 36, 626-633. PubMed Europe PubMed DOI
List,K., Szabo,R., Molinolo,A., Sriuranpong,V., Redeye,V., Murdock,T., Burke,B., Nielsen,B.S., Gutkind,J.S. and Bugge,T.H. Deregulated matriptase causes ras-independent multistage carcinogenesis and promotes ras-mediated malignant transformation Genes Dev (2005) 19, 1934-1950. PubMed Europe PubMed DOI PMC EPMC
[YEAR:30-3-2005]Oberst,M.D., Chen,L.Y., Kiyomiya,K., Williams,C.A., Lee,M.S., Johnson,M.D., Dickson,R.B. and Lin,C.Y. HAI-1 regulates activation and expression of matriptase, a membrane-bound serine protease Am J Physiol Cell Physiol (30-3-2005) 289, C462-C470. PubMed Europe PubMed DOI
[YEAR:21-12-2005]Tanimoto,H., Shigemasa,K., Tian,X., Gu,L., Beard,J.B., Sawasaki,T. and O'Brien,T.J. Transmembrane serine protease TADG-15 (ST14/Matriptase/MT-SP1): expression and prognostic value in ovarian cancer Br J Cancer (21-12-2005) 92, 278-283. PubMed Europe PubMed DOI PMC EPMC
[YEAR:26-1-2005]Tsuzuki,S., Murai,N., Miyake,Y., Inouye,K., Hirayasu,H., Iwanaga,T. and Fushiki,T. Evidence for the occurrence of membrane-type serine protease 1/matriptase on the basolateral sides of enterocytes Biochem J (26-1-2005) 388, 679-687. PubMed Europe PubMed DOI PMC EPMC

2004

[YEAR:1-11-2004]Galkin,A.V., Mullen,L., Fox,W.D., Brown,J., Duncan,D., Moreno,O., Madison,E.L. and Agus,D.B. CVS-3983, a selective matriptase inhibitor, suppresses the growth of androgen independent prostate tumor xenografts Prostate (1-11-2004) 61, 228-235. PubMed Europe PubMed DOI I
Hoang,C.D., D'Cunha,J., Kratzke,M.G., Casmey,C.E., Frizelle,S.P., Maddaus,M.A. and Kratzke,R.A. Gene expression profiling identifies matriptase overexpression in malignant mesothelioma Chest (2004) 125, 1843-1852. PubMed Europe PubMed DOI
Ihara,S., Miyoshi,E., Nakahara,S., Sakiyama,H., Ihara,H., Akinaga,A., Honke,K., Dickson,R.B., Lin,C.Y. and Taniguchi,N. Addition of beta1-6 GlcNAc branching to the oligosaccharide attached to Asn 772 in the serine protease domain of matriptase plays a pivotal role in its stability and resistance against trypsin Glycobiology (2004) 14, 139-146. PubMed Europe PubMed DOI
Lin,C.Y., Oberst,M., Johnson,M. and Dickson,R.B. Matriptase [ISSN:0-12-079610-4] (2004) 2, 1559-1561. V

2003

Bhatt,A.S., Takeuchi,T., Ylstra,B., Ginzinger,D., Albertson,D., Shuman,M.A. and Craik,C.S. Quantitation of membrane type serine protease 1 (MT-SP1) in transformed and normal cells Biol Chem (2003) 384, 257-266. PubMed Europe PubMed DOI
[YEAR:1-3-2003]Kang,J.Y., Dolled-Filhart,M., Ocal,I.T., Singh,B., Lin,C.Y., Dickson,R.B., Rimm,D.L. and Camp,R.L. Tissue microarray analysis of hepatocyte growth factor/Met pathway components reveals a role for Met, matriptase, and hepatocyte growth factor activator inhibitor 1 in the progression of node-negative breast cancer Cancer Res (1-3-2003) 63, 1101-1105. PubMed Europe PubMed
[YEAR:24-11-2003]List,K., Szabo,R., Wertz,P.W., Segre,J., Haudenschild,C.C., Kim,S.Y. and Bugge,T.H. Loss of proteolytically processed filaggrin caused by epidermal deletion of matriptase/MT-SP1 J Cell Biol (24-11-2003) 163, 901-910. PubMed Europe PubMed DOI PMC EPMC
[YEAR:18-7-2003]Oberst,M.D., Williams,C.A., Dickson,R.B., Johnson,M.D. and Lin,C.Y. The activation of matriptase requires its noncatalytic domains, serine protease domain, and its cognate inhibitor J Biol Chem (18-7-2003) 278, 26773-26779. PubMed Europe PubMed DOI
[YEAR:1-11-2003]Santin,A.D., Cane',S., Bellone,S., Bignotti,E., Palmieri,M., De Las Casas,L.E., Anfossi,S., Roman,J.J., O'Brien,T. and Pecorelli,S. The novel serine protease tumor-associated differentially expressed gene-15 (matriptase/MT-SP1) is highly overexpressed in cervical carcinoma Cancer (1-11-2003) 98, 1898-1904. PubMed Europe PubMed DOI
[YEAR:4-2-2003]Sun,J., Pons,J. and Craik,C.S. Potent and selective inhibition of membrane-type serine protease 1 by human single-chain antibodies Biochemistry (4-2-2003) 42, 892-900. PubMed Europe PubMed DOI
Szabo,R., Wu,Q., Dickson,R.B., Netzel-Arnett,S., Antalis,T.M. and Bugge,T.H. Type II transmembrane serine proteases Thromb Haemost (2003) 90, 185-193. PubMed Europe PubMed DOI V
Yamasaki,Y., Satomi,S., Murai,N., Tsuzuki,S. and Fushiki,T. Inhibition of membrane-type serine protease 1/matriptase by natural and synthetic protease inhibitors J Nutr Sci Vitaminol (Tokyo) (2003) 49, 27-32. PubMed Europe PubMed I

2002

[YEAR:22-3-2002]Benaud,C., Oberst,M., Hobson,J.P., Spiegel,S., Dickson,R.B. and Lin,C.Y. Sphingosine 1-phosphate, present in serum-derived lipoproteins, activates matriptase J Biol Chem (22-3-2002) 277, 10539-10546. PubMed Europe PubMed DOI
Benaud,C.M., Oberst,M., Dickson,R.B. and Lin,C.Y. Deregulated activation of matriptase in breast cancer cells Clin Exp Metastasis (2002) 19, 639-649. PubMed Europe PubMed DOI
[YEAR:18-1-2002]Friedrich,R., Fuentes-Prior,P., Ong,E., Coombs,G., Hunter,M., Oehler,R., Pierson,D., Gonzalez,R., Huber,R., Bode,W. and Madison,E.L. Catalytic domain structures of MT-SP1/matriptase, a matrix-degrading transmembrane serine proteinase J Biol Chem (18-1-2002) 277, 2160-2168. PubMed Europe PubMed DOI S I
[YEAR:23-5-2002]List,K., Haudenschild,C.C., Szabo,R., Chen,W., Wahl,S.M., Swaim,W., Engelholm,L.H., Behrendt,N. and Bugge,T.H. Matriptase/MT-SP1 is required for postnatal survival, epidermal barrier function, hair follicle development, and thymic homeostasis Oncogene (23-5-2002) 21, 3765-3779. PubMed Europe PubMed DOI K
Oberst,M.D., Johnson,M.D., Dickson,R.B., Lin,C.Y., Singh,B., Stewart,M., Williams,A., al-Nafussi,A., Smyth,J.F., Gabra,H. and Sellar,G.C. Expression of the serine protease matriptase and its inhibitor HAI-1 in epithelial ovarian cancer: correlation with clinical outcome and tumor clinicopathological parameters Clin Cancer Res (2002) 8, 1101-1107. PubMed Europe PubMed
Vuagniaux,G., Vallet,V., Jaeger,N.F., Hummler,E. and Rossier,B.C. Synergistic activation of ENaC by three membrane-bound channel-activating serine proteases (mCAP1, mCAP2, and mCAP3) and serum- and glucocorticoid-regulated kinase (Sgk1) in Xenopus oocytes J Gen Physiol (2002) 120, 191-201. PubMed Europe PubMed DOI PMC EPMC

2001

Benaud,C., Dickson,R.B. and Lin,C.Y. Regulation of the activity of matriptase on epithelial cell surfaces by a blood-derived factor Eur J Biochem (2001) 268, 1439-1447. PubMed Europe PubMed DOI
Cao,J., Zheng,S., Zheng,L., Cai,X., Zhang,Y., Geng,L. and Fang,Y. A novel serine protease SNC19 associated with human colorectal cancer Chin Med J (Engl) (2001) 114, 726-730. PubMed Europe PubMed
[YEAR:30-11-2001]Cho,E.G., Kim,M.G., Kim,C., Kim,S.R., Seong,I.S., Chung,C., Schwartz,R.H. and Park,D. N-terminal processing is essential for release of epithin, a mouse type II membrane serine protease J Biol Chem (30-11-2001) 276, 44581-44589. PubMed Europe PubMed DOI
[YEAR:26-4-2001]Enyedy,I.J., Lee,S.L., Kuo,A.H., Dickson,R.B., Lin,C.Y. and Wang,S. Structure-based approach for the discovery of bis-benzamidines as novel inhibitors of matriptase J Med Chem (26-4-2001) 44, 1349-1355. PubMed Europe PubMed DOI I
Kishi,K., Yamazaki,K., Yasuda,I., Yahagi,N., Ichinose,M., Tsuchiya,Y., Athauda,S.B.P., Inoue,H. and Takahashi,K. Characterization of a membrane-bound arginine-specific serine protease from rat intestinal mucosa J Biochem (2001) 130, 425-430. PubMed Europe PubMed
[YEAR:17-9-2001]Long,Y.Q., Lee,S.L., Lin,C.Y., Enyedy,I.J., Wang,S., Li,P., Dickson,R.B. and Roller,P.P. Synthesis and evaluation of the sunflower derived trypsin inhibitor as a potent inhibitor of the type II transmembrane serine protease, matriptase Bioorg Med Chem Lett (17-9-2001) 11, 2515-2519. PubMed Europe PubMed DOI
Oberst,M., Anders,J., Xie,B., Singh,B., Ossandon,M., Johnson,M., Dickson,R.B. and Lin,C.Y. Matriptase and HAI-1 are expressed by normal and malignant epithelial cells in vitro and in vivo Am J Pathol (2001) 158, 1301-1311. PubMed Europe PubMed DOI PMC EPMC
[YEAR:5-10-2001]Satomi,S., Yamasaki,Y., Tsuzuki,S., Hitomi,Y., Iwanaga,T. and Fushiki,T. A role for membrane-type serine protease (MT-SP1) in intestinal epithelial turnover Biochem Biophys Res Commun (5-10-2001) 287, 995-1002. PubMed Europe PubMed DOI
Tanimoto,H., Underwood,L.J., Wang,Y., Shigemasa,K., Parmley,T.H. and O'Brien,T.J. Ovarian tumor cells express a transmembrane serine protease: A potential candidate for early diagnosis and therapeutic intervention Tumour Biol (2001) 22, 104-114. PubMed Europe PubMed DOI

2000

[YEAR:24-11-2000]Lee,S.L., Dickson,R.B. and Lin,C.Y. Activation of hepatocyte growth factor and urokinase/plasminogen activator by matriptase, an epithelial membrane serine protease J Biol Chem (24-11-2000) 275, 36720-36725. PubMed Europe PubMed DOI
[YEAR:25-8-2000]Takeuchi,T., Harris,J.L., Huang,W., Yan,K.W., Coughlin,S.R. and Craik,C.S. Cellular localization of membrane-type serine protease 1 and identification of protease-activated receptor-2 and single-chain urokinase-type plasminogen activator as substrates J Biol Chem (25-8-2000) 275, 26333-26342. PubMed Europe PubMed DOI P

1999

Kim,M.G., Chen,C., Lyu,M.S., Cho,E.G., Park,D., Kozak,C. and Schwartz,R.H. Cloning and chromosomal mapping of a gene isolated from thymic stromal cells encoding a new mouse type II membrane serine protease, epithin, containing four LDL receptor modules and two CUB domains Immunogenetics (1999) 49, 420-428. PubMed Europe PubMed DOI
[YEAR:25-6-1999]Lin,C.Y., Anders,J., Johnson,M., Sang,Q.A. and Dickson,R.B. Molecular cloning of cDNA for matriptase, a matrix-degrading serine protease with trypsin-like activity J Biol Chem (25-6-1999) 274, 18231-18236. PubMed Europe PubMed DOI
[YEAR:25-6-1999]Lin,C.Y., Anders,J., Johnson,M. and Dickson,R.B. Purification and characterization of a complex containing matriptase and a Kunitz-type serine protease inhibitor from human milk J Biol Chem (25-6-1999) 274, 18237-18242. PubMed Europe PubMed DOI

1997

Lin,C.Y., Wang,J.K., Torri,J., Dou,L., Sang,Q.A. and Dickson,R.B. Characterization of a novel, membrane-bound, 80-kDa matrix-degrading protease from human breast cancer cells. Monoclonal antibody production, isolation, and localization J Biol Chem (1997) 272, 9147-9152. PubMed Europe PubMed DOI

1993

Shi,Y.E., Torri,J., Yieh,L., Wellstein,A., Lippman,M.E. and Dickson,R.B. Identification and characterization of a novel matrix-degrading protease from hormone-dependent human breast cancer cells Cancer Res (1993) 53, 1409-1415. PubMed Europe PubMed