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Literature for peptidase S01.302: matriptase

Summary Gene structure Alignment Tree Sequences Sequence features Distribution Structure Literature Substrates Inhibitors Pharma

(Topics flags: A Assay, S Structure, T Target, K Knockout, P Specificity, E Expression, V Review, M Mutation, I Inhibitor, R Splicing, L Localization. To select only the references relevant to a single topic, click the link above. See explanation.)

    2026
  1. Banas,V., Seehra,K., Mahoney,M., Alisio,C., Kyriukha,Y., Weiland,E., Fath,M., Han,Z., Bricker,T., Tartell,M., Whelan,S., Boon,A.C.M. and Janetka,J.W.
    Inhibitors of membrane associated serine proteases block replication of coronavirus SARS-CoV-2 and influenza virus H1N1
    Eur J Med Chem (2026) 302, 118385-118385. PubMed  Europe PubMed DOI
    2. 2025
  2. Aapjeet,F., Tang,T., Zhang,Y., Gopalan,A., Kallappagoudar,S., Pan,J., Ma,F., Shah,S.S., Rivera,S., Liu,A.P., Juan,V. and Liu,R.
    Fragmentation of recombinant human interleukin-12 by matriptase in CHO cell culture
    J Biotechnol (2025) 404, 112-120. PubMed  Europe PubMed DOI
  3. Ji,L., Zhang,M., Liu,Y., Zhang,H., Luo,T., Zhao,L., Zhang,W., Chen,B. and Chen,R.
    Suppressor of Tumorigenicity 14 inhibits non-small cell lung cancer cell proliferation by suppressing Transketolase O-GlcNAcylation
    Exp Cell Res (2025) 452, 114776-114776. PubMed  Europe PubMed DOI
  4. Peng,T., Liu,J. and Zhao,H.
    Preliminary Observations of a Substrate-Based Radiotracer Biosensor for In Vivo Positron Emission Tomography Imaging of Tumor Transmembrane Protease ST14
    ACS Sens (2025) 10, 2768-2778. PubMed  Europe PubMed DOI
  5. Peng,T., Huang,G., Zhao,H. and Liu,J.
    Development of an Irreversible Peptidomimetic Radioligand for PET Imaging of ST14 Protease
    Bioconjug Chem (2025) PubMed  Europe PubMed DOI
    6. 2024
  6. Colombo,E., Desilets,A., Hassanzadeh,M., Lemieux,G., Marois,I., Cliche,D., Delbrouck,J.A., Murza,A., Jean,F., Marsault,E., Richter,M.V., Leduc,R. and Boudreault,P.L.
    Optimization of Ketobenzothiazole-Based Type II Transmembrane Serine Protease Inhibitors to Block H1N1 Influenza Virus Replication
    ChemMedChem (2024) 19, e202300458-e202300458. PubMed  Europe PubMed DOI
  7. Peng,T., Wen,J., Huang,G., Zhao,H. and Liu,J.
    First-generation high-affinity ST14 radiopharmaceutical: Design, synthesis, and preclinical PET imaging evaluation for pancreatic cancer detection
    Bioorg Chem (2024) 154, 108085-108085. PubMed  Europe PubMed DOI
    8. 2023
  8. Ehret,E., Stroh,S., Auberson,M., Ino,F., Jager,Y., Maillard,M., Szabo,R., Bugge,T.H., Frateschi,S. and Hummler,E.
    Kidney-Specific Membrane-Bound Serine Proteases CAP1/Prss8 and CAP3/St14 Affect ENaC Subunit Abundances but Not Its Activity
    Cells (2023) 12 PubMed  Europe PubMed DOI  PMC  EPMC
  9. Gaymon,D.O., Barndt,R., Stires,H., Riggins,R.B. and Johnson,M.D.
    ROS is a master regulator of in vitro matriptase activation
    PLoS ONE (2023) 18, e0267492-e0267492. PubMed  Europe PubMed DOI  PMC  EPMC
  10. Koistinen,H., Kovanen,R.M., Hollenberg,M.D., Dufour,A., Radisky,E.S., Stenman,U.H., Batra,J., Clements,J., Hooper,J.D., Diamandis,E., Schilling,O., Rannikko,A. and Mirtti,T.
    The roles of proteases in prostate cancer
    IUBMB Life (2023) 75, 493-513. PubMed  Europe PubMed DOI  PMC  EPMC  V
  11. Pawar,N.R., Buzza,M.S., Duru,N., Strong,A.A. and Antalis,T.M.
    Matriptase drives dissemination of ovarian cancer spheroids by a PAR-2/PI3K/Akt/MMP9 signaling axis
    J Cell Biol (2023) 222 PubMed  Europe PubMed DOI  PMC  EPMC
    12. 2022
  12. Jang,J., Cho,E.H., Cho,Y., Ganzorig,B., Kim,K.Y., Kim,M.G. and Kim,C.
    Environment-Sensitive Ectodomain Shedding of Epithin/PRSS14 Increases Metastatic Potential of Breast Cancer Cells by Producing CCL2
    Mol Cells (2022) 45, 564-574. PubMed  Europe PubMed DOI  PMC  EPMC
    13. 2020
  13. Armistead,J., Hatzold,J., van Roye,A., Fahle,E. and Hammerschmidt,M.
    Entosis and apical cell extrusion constitute a tumor-suppressive mechanism downstream of matriptase
    J Cell Biol (2020) 219 PubMed  Europe PubMed DOI
  14. Blay,V., Li,M.C., Ho,S.P., Stoller,M.L., Hsieh,H.P. and Houston,D.R.
    Design of drug-like hepsin inhibitors against prostate cancer and kidney stones
    Acta Pharm Sin B (2020) 10, 1309-1320. PubMed  Europe PubMed DOI  PMC  EPMC
  15. Chang,S.C., Chiang,C.P., Lai,C.H., Du,P.A., Hung,Y.S., Chen,Y.H., Yang,H.Y., Fang,H.Y., Lee,S.P., Tang,H.J., Wang,J.K., Johnson,M.D. and Lin,C.Y.
    Matriptase and prostasin proteolytic activities are differentially regulated in normal and wounded skin
    Hum Cell (2020) PubMed  Europe PubMed DOI
  16. Holt-Danborg,L., Skovbjerg,S., Goderum,K.W., Nonboe,A.W., Stankevic,E., Frost,A.K., Vitved,L., Jensen,J.K. and Vogel,L.K.
    Insights into the regulation of the matriptase-prostasin proteolytic system
    Biochem J (2020) PubMed  Europe PubMed DOI
  17. Hu,P., Shang,L., Chen,J., Chen,X., Chen,C., Hong,W., Huang,M., Xu,P. and Chen,Z.
    A nanometer-sized protease inhibitor for precise cancer diagnosis and treatment
    J Mater Chem B (2020) 8, 504-514. PubMed  Europe PubMed DOI  I
  18. Jaimes,J., Millet,J. and Whittaker,G.
    Proteolytic Cleavage of the SARS-CoV-2 Spike Protein and the Role of the Novel S1/S2 Site
    SSRN (2020) , 3581359-3581359. PubMed  Europe PubMed DOI  PMC  EPMC
  19. Jia,B., Thompson,H.A., Barndt,R.B., Chiu,Y.L., Lee,M.J., Lee,S.C., Wang,J.K., Tang,H.J., Lin,C.Y. and Johnson,M.D.
    Mild acidity likely accelerates the physiological matriptase autoactivation process: a comparative study between spontaneous and acid-induced matriptase zymogen activation
    Hum Cell (2020) PubMed  Europe PubMed DOI
  20. Kamble,P.R., Rane,S., Breed,A.A., Joseph,S., Mahale,S.D. and Pathak,B.R.
    Proteolytic cleavage of Trop2 at Arg87 is mediated by matriptase and regulated by Val194
    FEBS Lett (2020) PubMed  Europe PubMed DOI
  21. Kwon,H., Ha,H., Jeon,H., Jang,J., Son,S.H., Lee,K., Park,S.K. and Byun,Y.
    Structure-activity relationship studies of dipeptide-based hepsin inhibitors with Arg bioisosteres
    Bioorg Chem (2020) , 104521-104521. PubMed  Europe PubMed DOI
  22. Murza,A., Dion,S.P., Boudreault,P.L., Desilets,A., Leduc,R. and Marsault,E.
    Inhibitors of type II transmembrane serine proteases in the treatment of diseases of the respiratory tract - A review of patent literature
    Expert Opin Ther Pat (2020) , 1-18. PubMed  Europe PubMed DOI
  23. Ozawa,S., Matsubayashi,M., Nanaura,H., Yanagita,M., Mori,K., Asanuma,K., Kajiwara,N., Hayashi,K., Ohashi,H., Kasahara,M., Yokoi,H., Kataoka,H., Mori,E. and Nakagawa,T.
    Proteolytic Cleavage of Podocin by Matriptase Exacerbates Podocyte Injury
    J Biol Chem (2020) PubMed  Europe PubMed DOI
  24. Skovbjerg,S., Holt-Danborg,L., Nonboe,A.W., Hong,Z., Frost,A.K., Schar,C.R., Thomas,C.C., Vitved,L., Jensen,J.K. and Vogel,L.K.
    Inhibition of an active zymogen protease: the zymogen form of matriptase is regulated by HAI-1 and HAI-2
    Biochem J (2020) 477, 1779-1794. PubMed  Europe PubMed DOI
  25. Tseng,C.C., Jia,B., Barndt,R.B., Dai,Y.H., Chen,Y.H., Du,P.A., Wang,J.K., Tang,H.J., Lin,C.Y. and Johnson,M.D.
    The intracellular seven amino acid motif EEGEVFL is required for matriptase vesicle sorting and translocation to the basolateral plasma membrane
    PLoS ONE (2020) 15, e0228874-e0228874. PubMed  Europe PubMed DOI
  26. Whittaker,G.R. and Millet,J.K.
    Biochemical characterization of Middle East respiratory syndrome coronavirus spike protein proteolytic processing
    Methods Mol Biol (2020) 2099, 21-37. PubMed  Europe PubMed DOI
  27. Whittaker,G.R. and Straus,M.R.
    Human matriptase/ST 14 proteolytically cleaves H7N9 hemagglutinin and facilitates the activation of influenza A/Shanghai/2/2013 virus in cell culture
    Influenza Other Respir Viruses (2020) 14, 189-195. PubMed  Europe PubMed DOI  P
  28. Wu,C.J., Lu,M., Feng,X., Nakato,G. and Udey,M.C.
    Matriptase cleaves EpCAM and TROP2 in keratinocytes, destabilizing both proteins and associated claudins
    Cells (2020) 9 PubMed  Europe PubMed DOI
  29. Yoon,J., Cho,Y., Kim,K.Y., Yoon,M.J., Lee,H.S., Jeon,S.D., Cho,Y., Kim,C. and Kim,M.G.
    A JUN N-terminal kinase inhibitor induces ectodomain shedding of the cancer-associated membrane protease Prss14/epithin via protein kinase CbetaII
    J Biol Chem (2020) 295, 7168-7177. PubMed  Europe PubMed DOI
    30. 2019
  30. Barna,R.F., Pomothy,J.M., Parej,Z. and Pasztine Gere,E.
    Investigation of sphingosin-1-phosphate-triggered matriptase activation using a rat primary hepatocyte model
    Acta Vet Hung (2019) 67, 578-587. PubMed  Europe PubMed DOI
  31. Chen,L.M. and Chai,K.X.
    Matriptase cleaves the amyloid-beta peptide 1-42 at Arg-5, Lys-16, and Lys-28
    BMC Res Notes (2019) 12, 5-5. PubMed  Europe PubMed DOI  PMC  EPMC  P
  32. Damalanka,V.C., Han,Z., Karmakar,P., O'Donoghue,A.J., La Greca,F., Kim,T., Pant,S.M., Helander,J., Klefstrom,J., Craik,C.S. and Janetka,J.W.
    Discovery of selective matriptase and hepsin serine protease inhibitors: useful chemical tools for cancer cell biology
    J Med Chem (2019) 62, 480-490. PubMed  Europe PubMed DOI  I
  33. Damalanka,V.C. and Janetka,J.W.
    Recent progress on inhibitors of the type II transmembrane serine proteases, hepsin, matriptase and matriptase-2
    Future Med Chem (2019) 11, 743-769. PubMed  Europe PubMed DOI  I
  34. Damalanka,V.C., Wildman,S.A. and Janetka,J.W.
    Piperidine carbamate peptidomimetic inhibitors of the serine proteases HGFA, matriptase and hepsin
    MedChemComm (2019) 10, 1646-1655. PubMed  Europe PubMed DOI  PMC  EPMC  I
  35. Fang,J.D., Tung,H.H. and Lee,S.L.
    Mitochondrial localization of St14-encoding transmembrane serine protease is involved in neural stem/progenitor cell bioenergetics through binding to F0F1-ATP synthase complex
    FASEB J (2019) 33, 4327-4340. PubMed  Europe PubMed DOI  K
  36. Kim,K.Y., Yoon,M., Cho,Y., Lee,K.H., Park,S., Lee,S.R., Choi,S.Y., Lee,D., Yang,C., Cho,E.H., Jeon,S.D., Kim,S.H., Kim,C. and Kim,M.G.
    Targeting metastatic breast cancer with peptide epitopes derived from autocatalytic loop of Prss14/ST14 membrane serine protease and with monoclonal antibodies
    J Exp Clin Cancer Res (2019) 38, 363-363. PubMed  Europe PubMed DOI  PMC  EPMC
  37. Mirza,A.Z. and Shamshad,H.
    QSAR and docking studies on piperidyl-cyclohexylurea derivatives for prediction of selective and potent inhibitor of matriptase
    Curr Comput Aided Drug Des (2019) 15, 167-181. PubMed  Europe PubMed DOI  I
  38. Szabo,R., Callies,L.K. and Bugge,T.H.
    Matriptase drives early-onset intestinal failure in a mouse model of congenital tufting enteropathy
    Development (2019) 146, dev183392-dev183392. PubMed  Europe PubMed DOI  M
  39. Tamberg,T., Hong,Z., De Schepper,D., Skovbjerg,S., Dupont,D.M., Vitved,L., Schar,C.R., Skjoedt,K., Vogel,L.K. and Jensen,J.K.
    Blocking the proteolytic activity of zymogen matriptase with antibody-based inhibitors
    J Biol Chem (2019) 294, 314-326. PubMed  Europe PubMed DOI  S
  40. Zuo,K., Qi,Y., Yuan,C., Jiang,L., Xu,P., Hu,J., Huang,M. and Li,J.
    Specifically targeting cancer proliferation and metastasis processes: the development of matriptase inhibitors
    Cancer Metastasis Rev (2019) 38, 507-524. PubMed  Europe PubMed DOI  V  I
    41. 2018
  41. Ahmad,F., Ahmed,I., Nasir,A., Umair,M., Shahzad,S., Muhammad,D., Santos-Cortez,R.L.P., Leal,S.M. and Ahmad,W.
    A disease-causing novel missense mutation in the ST14 gene underlies autosomal recessive ichthyosis with hypotrichosis syndrome in a consanguineous family
    Eur J Dermatol (2018) 28, 209-216. PubMed  Europe PubMed DOI  M
  42. Laux,H., Romand,S., Nuciforo,S., Farady,C.J., Tapparel,J., Buechmann-Moeller,S., Sommer,B., Oakeley,E.J. and Bodendorf,U.
    Degradation of recombinant proteins by Chinese hamster ovary host cell proteases is prevented by matriptase-1 knockout
    Biotechnol Bioeng (2018) 115, 2530-2540. PubMed  Europe PubMed DOI  K
  43. Mitchell,A.C., Alford,S.C., Hunter,S.A., Kannan,D., Parra Sperberg,R.A., Chang,C.H. and Cochran,J.R.
    Development of a protease biosensor based on a dimerization-dependent red fluorescent protein
    ACS Chem Biol (2018) 13, 66-72. PubMed  Europe PubMed DOI  A  L
  44. Mitchell,A.C., Kannan,D., Hunter,S.A., Parra Sperberg,R.A., Chang,C.H. and Cochran,J.R.
    Engineering a potent inhibitor of matriptase from the natural hepatocyte growth factor activator inhibitor type-1 (HAI-1) protein
    J Biol Chem (2018) 293, 4969-4980. PubMed  Europe PubMed DOI
  45. Yamasaki,K., Mukai,S., Nagai,T., Nakahara,K., Fujii,M., Terada,N., Ohno,A., Sato,Y., Toda,Y., Kataoka,H. and Kamoto,T.
    Matriptase-induced phosphorylation of MET is significantly associated with poor prognosis in invasive bladder cancer; an immunohistochemical analysis
    Int J Mol Sci (2018) 19 PubMed  Europe PubMed DOI
  46. Zaman,S., Chobrutskiy,B.I., Patel,J.S., Callahan,B.M., Tong,W.L. and Blanck,G.
    Mutant cytoskeletal and ECM peptides sensitive to the ST14 protease are associated with a worse outcome for glioblastoma multiforme
    Biochem Biophys Res Commun (2018) 503, 2218-2225. PubMed  Europe PubMed DOI
    47. 2017
  47. Friis,S., Tadeo,D., Le-Gall,S.M., Jurgensen,H.J., Sales,K.U., Camerer,E. and Bugge,T.H.
    Matriptase zymogen supports epithelial development, homeostasis and regeneration
    BMC Biol (2017) 15, 46-46. PubMed  Europe PubMed DOI  PMC  EPMC
  48. Haussler,D., Schulz-Fincke,A.C., Beckmann,A.M., Keils,A., Gilberg,E., Mangold,M., Bajorath,J., Stirnberg,M., Steinmetzer,T. and Gutschow,M.
    A fluorescent-labeled phosphono bisbenzguanidine as an activity-based probe for matriptase
    Chemistry (2017) 23, 5205-5209. PubMed  Europe PubMed DOI  L  I
  49. Lanchec,E., Desilets,A., Beliveau,F., Flamier,A., Mahmoud,S., Bernier,G., Gris,D., Leduc,R. and Lavoie,C.
    The type II transmembrane serine protease matriptase cleaves the amyloid precursor protein and reduces its processing to beta-amyloid peptide
    J Biol Chem (2017) 292, 20669-20682. PubMed  Europe PubMed DOI
  50. Nonboe,A.W., Krigslund,O., Soendergaard,C., Skovbjerg,S., Friis,S., Andersen,M.N., Ellis,V., Kawaguchi,M., Kataoka,H., Bugge,T.H. and Vogel,L.K.
    HAI-2 stabilizes, inhibits, and regulates SEA-cleavage-dependent secretory transport of matriptase
    Traffic (2017) 18, 378-391. PubMed  Europe PubMed DOI
  51. Sun,D.R., Zheng,Q.C. and Zhang,H.X.
    Probing the interaction mechanism of small molecule inhibitors with matriptase based on molecular dynamics simulation and free energy calculations
    J Biomol Struct Dyn (2017) 35, 755-764. PubMed  Europe PubMed DOI  I
  52. Tanabe,L.M. and List,K.
    The role of type II transmembrane serine protease-mediated signaling in cancer
    FEBS J (2017) 284, 1421-1436. PubMed  Europe PubMed DOI  I
  53. Tseng,C.C., Jia,B., Barndt,R., Gu,Y., Chen,C.Y., Tseng,I.C., Su,S.F., Wang,J.K., Johnson,M.D. and Lin,C.Y.
    Matriptase shedding is closely coupled with matriptase zymogen activation and requires de novo proteolytic cleavage likely involving its own activity
    PLoS ONE (2017) 12, e0183507-e0183507. PubMed  Europe PubMed DOI
  54. Wilkinson,D.J., Habgood,A., Lamb,H.K., Thompson,P., Hawkins,A.R., Desilets,A., Leduc,R., Steinmetzer,T., Hammami,M., Lee,M.S., Craik,C.S., Watson,S., Lin,H., Milner,J.M. and Rowan,A.D.
    Matriptase induction of metalloproteinase-dependent aggrecanolysis in vitro and in vivo: promotion of osteoarthritic cartilage damage by multiple mechanisms
    Arthritis Rheumatol (2017) 69, 1601-1611. PubMed  Europe PubMed DOI
  55. Wu,C.J., Feng,X., Lu,M., Morimura,S. and Udey,M.C.
    Matriptase-mediated cleavage of EpCAM destabilizes claudins and dysregulates intestinal epithelial homeostasis
    J Clin Invest (2017) 127, 623-634. PubMed  Europe PubMed DOI  P
  56. Wu,S.R., Teng,C.H., Tu,Y.T., Ko,C.J., Cheng,T.S., Lan,S.W., Lin,H.Y., Lin,H.H., Tu,H.F., Hsiao,P.W., Huang,H.P., Chen,C.H. and Lee,M.S.
    The Kunitz domain I of hepatocyte growth factor activator inhibitor-2 inhibits matriptase activity and invasive ability of human prostate cancer cells
    Sci Rep (2017) 7, 15101-15101. PubMed  Europe PubMed DOI
  57. Yogo,T., Umezawa,K., Kamiya,M., Hino,R. and Urano,Y.
    Development of an activatable fluorescent probe for prostate cancer imaging
    Bioconjug Chem (2017) 28, 2069-2076. PubMed  Europe PubMed DOI  L
  58. Youssefian,L., Touati,A., Saeidian,A.H., Zargari,O., Zeinali,S., Vahidnezhad,H. and Uitto,J.
    A novel mutation in ST14 at a functionally significant amino acid residue expands the spectrum of ichthyosis-hypotrichosis syndrome
    Orphanet J Rare Dis (2017) 12, 176-176. PubMed  Europe PubMed DOI  PMC  EPMC  M
    59. 2016
  59. Bardou,O., Menou,A., Francois,C., Duitman,J.W., von der Thusen,J.H., Borie,R., Sales,K.U., Mutze,K., Castier,Y., Sage,E., Liu,L., Bugge,T.H., Fairlie,D.P., Konigshoff,M., Crestani,B. and Borensztajn,K.S.
    Membrane-anchored serine protease matriptase is a trigger of pulmonary fibrogenesis
    Am J Respir Crit Care Med (2016) 193, 847-860. PubMed  Europe PubMed DOI  I
  60. Beckmann,A.M., Gilberg,E., Gattner,S., Huang,T.L., Vanden Eynde,J.J., Mayence,A., Bajorath,J., Stirnberg,M. and Gutschow,M.
    Evaluation of bisbenzamidines as inhibitors for matriptase-2
    Bioorg Med Chem Lett (2016) 26, 3741-3745. PubMed  Europe PubMed DOI  I
  61. Chen,C.Y., Chen,C.J., Lai,C.H., Wu,B.Y., Lee,S.P., Johnson,M.D., Lin,C.Y. and Wang,J.K.
    Increased matriptase zymogen activation by UV irradiation protects keratinocyte from cell death
    J Dermatol Sci (2016) 83, 34-44. PubMed  Europe PubMed DOI
  62. Chen,Y.W., Yin,S., Lai,Y.J., Johnson,M.D. and Lin,C.Y.
    Plasminogen-dependent matriptase activation accelerates plasmin generation by differentiating primary human keratinocytes
    J Invest Dermatol (2016) 136, 1210-1218. PubMed  Europe PubMed DOI
  63. Han,Z., Harris,P.K., Karmakar,P., Kim,T., Owusu,B.Y., Wildman,S.A., Klampfer,L. and Janetka,J.W.
    alpha-Ketobenzothiazole serine protease inhibitors of aberrant HGF/c-MET and MSP/RON kinase pathway signaling in cancer
    ChemMedChem (2016) 11, 585-599. PubMed  Europe PubMed DOI  I
  64. Le Gall,S.M., Szabo,R., Lee,M., Kirchhofer,D., Craik,C.S., Bugge,T.H. and Camerer,E.
    Matriptase activation connects tissue factor-dependent coagulation initiation to epithelial proteolysis and signaling
    Blood (2016) 127, 3260-3269. PubMed  Europe PubMed DOI
  65. Maiwald,A., Hammami,M., Wagner,S., Heine,A., Klebe,G. and Steinmetzer,T.
    Changing the selectivity profile - from substrate analog inhibitors of thrombin and factor Xa to potent matriptase inhibitors
    J Enzyme Inhib Med Chem (2016) 31, 89-97. PubMed  Europe PubMed DOI  I
  66. Murray,A.S., Varela,F.A. and List,K.
    Type II transmembrane serine proteases as potential targets for cancer therapy
    Biol Chem (2016) 397, 815-826. PubMed  Europe PubMed DOI
  67. Najy,A.J., Dyson,G., Jena,B.P., Lin,C.Y. and Kim,H.R.
    Matriptase activation and shedding through PDGF-D-mediated extracellular acidosis
    Am J Physiol Cell Physiol (2016) 310, C293-C304. PubMed  Europe PubMed DOI
  68. Su,H.C., Liang,Y.A., Lai,Y.J., Chiu,Y.L., Barndt,R.B., Shiao,F., Chang,H.D., Lu,D.D., Huang,N., Tseng,C.C., Wang,J.K., Lee,M.S., Johnson,M.D., Huang,S.M. and Lin,C.Y.
    Natural endogenous human matriptase and prostasin undergo zymogen activation via independent mechanisms in an uncoupled manner
    PLoS ONE (2016) 11, e0167894-e0167894. PubMed  Europe PubMed DOI
  69. Venukadasula,P.K., Owusu,B.Y., Bansal,N., Ross,L.J., Hobrath,J.V., Bao,D., Truss,J.W., Stackhouse,M., Messick,T.E., Klampfer,L. and Galemmo RA Jr
    Design and synthesis of nonpeptide inhibitors of hepatocyte growth factor activation
    ACS Med Chem Lett (2016) 7, 177-181. PubMed  Europe PubMed DOI  PMC  EPMC  I
    70. 2015
  70. Goswami,R., Wohlfahrt,G., Mukherjee,S., Ghadiyaram,C., Nagaraj,J., Satyam,L.K., Subbarao,K., Gopinath,S., Krishnamurthy,N.R., Subramanya,H.S. and Ramachandra,M.
    Discovery of O-(3-carbamimidoylphenyl)-l-serine amides as matriptase inhibitors using a fragment-linking approach
    Bioorg Med Chem Lett (2015) 25, 616-620. PubMed  Europe PubMed DOI  I
  71. Huang,W. and Kim,H.R.
    Dynamic regulation of platelet-derived growth factor D (PDGF-D) activity and extracellular spatial distribution by matriptase-mediated proteolysis
    J Biol Chem (2015) 290, 9162-9170. PubMed  Europe PubMed DOI
  72. Ko,C.J., Huang,C.C., Lin,H.Y., Juan,C.P., Lan,S.W., Shyu,H.Y., Wu,S.R., Hsiao,P.W., Huang,H.P., Shun,C.T. and Lee,M.S.
    Androgen-induced TMPRSS2 activates matriptase and promotes extracellular matrix degradation, prostate cancer cell invasion, tumor growth, and metastasis
    Cancer Res (2015) 75, 2949-2960. PubMed  Europe PubMed DOI
  73. Paszti-Gere,E., McManus,S., Meggyeshazi,N., Balla,P., Galfi,P. and Steinmetzer,T.
    Inhibition of matriptase activity results in decreased intestinal epithelial monolayer integrity in vitro
    PLoS ONE (2015) 10, e0141077-e0141077. PubMed  Europe PubMed DOI  PMC  EPMC  I
  74. Takeichi,T., Nanda,A., Aristodemou,S., McMillan,J.R., Lee,J., Akiyama,M., Al-Ajmi,H., Simpson,M.A. and McGrath,J.A.
    Whole-exome sequencing diagnosis of two autosomal recessive disorders in one family
    Br J Dermatol (2015) 172, 1407-1411. PubMed  Europe PubMed DOI  M
  75. Tan,X., Soualmia,F., Furio,L., Renard,J.F., Kempen,I., Qin,L., Pagano,M., Pirotte,B., El Amri,C., Hovnanian,A. and Reboud-Ravaux,M.
    Toward the first class of suicide inhibitors of kallikreins involved in skin diseases
    J Med Chem (2015) 58, 598-612. PubMed  Europe PubMed DOI  I
  76. Zarif,J.C., Lamb,L.E., Schulz,V.V., Nollet,E.A. and Miranti,C.K.
    Androgen receptor non-nuclear regulation of prostate cancer cell invasion mediated by Src and matriptase
    Oncotarget (2015) 6, 6862-6876. PubMed  Europe PubMed DOI
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