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Literature for peptidase S01.302: matriptase

Summary Gene structure Alignment Tree Sequences Sequence features Distribution Structure Literature Substrates Pharma

(Topics flags: A Assay, S Structure, T Target, K Knockout, P Specificity, E Expression, V Review, M Mutation, I Inhibitor, R Splicing, L Localization. To select only the references relevant to a single topic, click the link above. See explanation.)

    2025
  1. Aapjeet,F., Tang,T., Zhang,Y., Gopalan,A., Kallappagoudar,S., Pan,J., Ma,F., Shah,S.S., Rivera,S., Liu,A.P., Juan,V. and Liu,R.
    Fragmentation of recombinant human interleukin-12 by matriptase in CHO cell culture
    J Biotechnol404, 112-120. PubMed  Europe PubMed DOI
  2. Peng,T., Liu,J. and Zhao,H.
    Preliminary Observations of a Substrate-Based Radiotracer Biosensor for In Vivo Positron Emission Tomography Imaging of Tumor Transmembrane Protease ST14
    ACS Sens10, 2768-2778. PubMed  Europe PubMed DOI
  3. Peng,T., Huang,G., Zhao,H. and Liu,J.
    Development of an Irreversible Peptidomimetic Radioligand for PET Imaging of ST14 Protease
    Bioconjug Chem PubMed  Europe PubMed DOI
    4. 2024
  4. Colombo,E., Desilets,A., Hassanzadeh,M., Lemieux,G., Marois,I., Cliche,D., Delbrouck,J.A., Murza,A., Jean,F., Marsault,E., Richter,M.V., Leduc,R. and Boudreault,P.L.
    Optimization of Ketobenzothiazole-Based Type II Transmembrane Serine Protease Inhibitors to Block H1N1 Influenza Virus Replication
    ChemMedChem19, e202300458-e202300458. PubMed  Europe PubMed DOI
  5. Peng,T., Wen,J., Huang,G., Zhao,H. and Liu,J.
    First-generation high-affinity ST14 radiopharmaceutical: Design, synthesis, and preclinical PET imaging evaluation for pancreatic cancer detection
    Bioorg Chem154, 108085-108085. PubMed  Europe PubMed DOI
    6. 2023
  6. Ehret,E., Stroh,S., Auberson,M., Ino,F., Jager,Y., Maillard,M., Szabo,R., Bugge,T.H., Frateschi,S. and Hummler,E.
    Kidney-Specific Membrane-Bound Serine Proteases CAP1/Prss8 and CAP3/St14 Affect ENaC Subunit Abundances but Not Its Activity
    Cells12, PubMed  Europe PubMed DOI
  7. Gaymon,D.O., Barndt,R., Stires,H., Riggins,R.B. and Johnson,M.D.
    ROS is a master regulator of in vitro matriptase activation
    PLoS ONE18, e0267492-e0267492. PubMed  Europe PubMed DOI
  8. Koistinen,H., Kovanen,R.M., Hollenberg,M.D., Dufour,A., Radisky,E.S., Stenman,U.H., Batra,J., Clements,J., Hooper,J.D., Diamandis,E., Schilling,O., Rannikko,A. and Mirtti,T.
    The roles of proteases in prostate cancer
    IUBMB Life75, 493-513. PubMed  Europe PubMed DOI  V
  9. Pawar,N.R., Buzza,M.S., Duru,N., Strong,A.A. and Antalis,T.M.
    Matriptase drives dissemination of ovarian cancer spheroids by a PAR-2/PI3K/Akt/MMP9 signaling axis
    J Cell Biol222, PubMed  Europe PubMed DOI
    10. 2022
  10. Jang,J., Cho,E.H., Cho,Y., Ganzorig,B., Kim,K.Y., Kim,M.G. and Kim,C.
    Environment-Sensitive Ectodomain Shedding of Epithin/PRSS14 Increases Metastatic Potential of Breast Cancer Cells by Producing CCL2
    Mol Cells45, 564-574. PubMed  Europe PubMed DOI
    11. 2020
  11. Armistead,J., Hatzold,J., van Roye,A., Fahle,E. and Hammerschmidt,M.
    Entosis and apical cell extrusion constitute a tumor-suppressive mechanism downstream of matriptase
    J Cell Biol219, PubMed  Europe PubMed DOI
  12. Blay,V., Li,M.C., Ho,S.P., Stoller,M.L., Hsieh,H.P. and Houston,D.R.
    Design of drug-like hepsin inhibitors against prostate cancer and kidney stones
    Acta Pharm Sin B10, 1309-1320. PubMed  Europe PubMed DOI
  13. Chang,S.C., Chiang,C.P., Lai,C.H., Du,P.A., Hung,Y.S., Chen,Y.H., Yang,H.Y., Fang,H.Y., Lee,S.P., Tang,H.J., Wang,J.K., Johnson,M.D. and Lin,C.Y.
    Matriptase and prostasin proteolytic activities are differentially regulated in normal and wounded skin
    Hum Cell PubMed  Europe PubMed DOI
  14. Holt-Danborg,L., Skovbjerg,S., Goderum,K.W., Nonboe,A.W., Stankevic,E., Frost,A.K., Vitved,L., Jensen,J.K. and Vogel,L.K.
    Insights into the regulation of the matriptase-prostasin proteolytic system
    Biochem J PubMed  Europe PubMed DOI
  15. Hu,P., Shang,L., Chen,J., Chen,X., Chen,C., Hong,W., Huang,M., Xu,P. and Chen,Z.
    A nanometer-sized protease inhibitor for precise cancer diagnosis and treatment
    J Mater Chem B8, 504-514. PubMed  Europe PubMed DOI  I
  16. Jaimes,J., Millet,J. and Whittaker,G.
    Proteolytic Cleavage of the SARS-CoV-2 Spike Protein and the Role of the Novel S1/S2 Site
    SSRN3581359-3581359. PubMed  Europe PubMed DOI
  17. Jia,B., Thompson,H.A., Barndt,R.B., Chiu,Y.L., Lee,M.J., Lee,S.C., Wang,J.K., Tang,H.J., Lin,C.Y. and Johnson,M.D.
    Mild acidity likely accelerates the physiological matriptase autoactivation process: a comparative study between spontaneous and acid-induced matriptase zymogen activation
    Hum Cell PubMed  Europe PubMed DOI
  18. Kamble,P.R., Rane,S., Breed,A.A., Joseph,S., Mahale,S.D. and Pathak,B.R.
    Proteolytic cleavage of Trop2 at Arg87 is mediated by matriptase and regulated by Val194
    FEBS Lett PubMed  Europe PubMed DOI
  19. Kwon,H., Ha,H., Jeon,H., Jang,J., Son,S.H., Lee,K., Park,S.K. and Byun,Y.
    Structure-activity relationship studies of dipeptide-based hepsin inhibitors with Arg bioisosteres
    Bioorg Chem104521-104521. PubMed  Europe PubMed DOI
  20. Murza,A., Dion,S.P., Boudreault,P.L., Desilets,A., Leduc,R. and Marsault,E.
    Inhibitors of type II transmembrane serine proteases in the treatment of diseases of the respiratory tract - A review of patent literature
    Expert Opin Ther Pat1-18. PubMed  Europe PubMed DOI
  21. Ozawa,S., Matsubayashi,M., Nanaura,H., Yanagita,M., Mori,K., Asanuma,K., Kajiwara,N., Hayashi,K., Ohashi,H., Kasahara,M., Yokoi,H., Kataoka,H., Mori,E. and Nakagawa,T.
    Proteolytic Cleavage of Podocin by Matriptase Exacerbates Podocyte Injury
    J Biol Chem PubMed  Europe PubMed DOI
  22. Skovbjerg,S., Holt-Danborg,L., Nonboe,A.W., Hong,Z., Frost,A.K., Schar,C.R., Thomas,C.C., Vitved,L., Jensen,J.K. and Vogel,L.K.
    Inhibition of an active zymogen protease: the zymogen form of matriptase is regulated by HAI-1 and HAI-2
    Biochem J477, 1779-1794. PubMed  Europe PubMed DOI
  23. Tseng,C.C., Jia,B., Barndt,R.B., Dai,Y.H., Chen,Y.H., Du,P.A., Wang,J.K., Tang,H.J., Lin,C.Y. and Johnson,M.D.
    The intracellular seven amino acid motif EEGEVFL is required for matriptase vesicle sorting and translocation to the basolateral plasma membrane
    PLoS ONE15, e0228874-e0228874. PubMed  Europe PubMed DOI
  24. Whittaker,G.R. and Straus,M.R.
    Human matriptase/ST 14 proteolytically cleaves H7N9 hemagglutinin and facilitates the activation of influenza A/Shanghai/2/2013 virus in cell culture
    Influenza Other Respir Viruses14, 189-195. PubMed  Europe PubMed DOI  P
  25. Whittaker,G.R. and Millet,J.K.
    Biochemical characterization of Middle East respiratory syndrome coronavirus spike protein proteolytic processing
    Methods Mol Biol2099, 21-37. PubMed  Europe PubMed DOI
  26. Wu,C.J., Lu,M., Feng,X., Nakato,G. and Udey,M.C.
    Matriptase cleaves EpCAM and TROP2 in keratinocytes, destabilizing both proteins and associated claudins
    Cells9, PubMed  Europe PubMed DOI
  27. Yoon,J., Cho,Y., Kim,K.Y., Yoon,M.J., Lee,H.S., Jeon,S.D., Cho,Y., Kim,C. and Kim,M.G.
    A JUN N-terminal kinase inhibitor induces ectodomain shedding of the cancer-associated membrane protease Prss14/epithin via protein kinase CbetaII
    J Biol Chem295, 7168-7177. PubMed  Europe PubMed DOI
    28. 2019
  28. Barna,R.F., Pomothy,J.M., Parej,Z. and Pasztine Gere,E.
    Investigation of sphingosin-1-phosphate-triggered matriptase activation using a rat primary hepatocyte model
    Acta Vet Hung67, 578-587. PubMed  Europe PubMed DOI
  29. Chen,L.M. and Chai,K.X.
    Matriptase cleaves the amyloid-beta peptide 1-42 at Arg-5, Lys-16, and Lys-28
    BMC Res Notes12, 5-5. PubMed  Europe PubMed DOI  P
  30. Damalanka,V.C., Han,Z., Karmakar,P., O'Donoghue,A.J., La Greca,F., Kim,T., Pant,S.M., Helander,J., Klefstrom,J., Craik,C.S. and Janetka,J.W.
    Discovery of selective matriptase and hepsin serine protease inhibitors: useful chemical tools for cancer cell biology
    J Med Chem62, 480-490. PubMed  Europe PubMed DOI  I
  31. Damalanka,V.C., Wildman,S.A. and Janetka,J.W.
    Piperidine carbamate peptidomimetic inhibitors of the serine proteases HGFA, matriptase and hepsin
    MedChemComm10, 1646-1655. PubMed  Europe PubMed DOI  I
  32. Damalanka,V.C. and Janetka,J.W.
    Recent progress on inhibitors of the type II transmembrane serine proteases, hepsin, matriptase and matriptase-2
    Future Med Chem11, 743-769. PubMed  Europe PubMed DOI  I
  33. Fang,J.D., Tung,H.H. and Lee,S.L.
    Mitochondrial localization of St14-encoding transmembrane serine protease is involved in neural stem/progenitor cell bioenergetics through binding to F0F1-ATP synthase complex
    FASEB J33, 4327-4340. PubMed  Europe PubMed DOI  K
  34. Kim,K.Y., Yoon,M., Cho,Y., Lee,K.H., Park,S., Lee,S.R., Choi,S.Y., Lee,D., Yang,C., Cho,E.H., Jeon,S.D., Kim,S.H., Kim,C. and Kim,M.G.
    Targeting metastatic breast cancer with peptide epitopes derived from autocatalytic loop of Prss14/ST14 membrane serine protease and with monoclonal antibodies
    J Exp Clin Cancer Res38, 363-363. PubMed  Europe PubMed DOI
  35. Mirza,A.Z. and Shamshad,H.
    QSAR and docking studies on piperidyl-cyclohexylurea derivatives for prediction of selective and potent inhibitor of matriptase
    Curr Comput Aided Drug Des15, 167-181. PubMed  Europe PubMed DOI  I
  36. Szabo,R., Callies,L.K. and Bugge,T.H.
    Matriptase drives early-onset intestinal failure in a mouse model of congenital tufting enteropathy
    Development146, dev183392-dev183392. PubMed  Europe PubMed DOI  M
  37. Tamberg,T., Hong,Z., De Schepper,D., Skovbjerg,S., Dupont,D.M., Vitved,L., Schar,C.R., Skjoedt,K., Vogel,L.K. and Jensen,J.K.
    Blocking the proteolytic activity of zymogen matriptase with antibody-based inhibitors
    J Biol Chem294, 314-326. PubMed  Europe PubMed DOI  S
  38. Zuo,K., Qi,Y., Yuan,C., Jiang,L., Xu,P., Hu,J., Huang,M. and Li,J.
    Specifically targeting cancer proliferation and metastasis processes: the development of matriptase inhibitors
    Cancer Metastasis Rev38, 507-524. PubMed  Europe PubMed DOI  V  I
    39. 2018
  39. Ahmad,F., Ahmed,I., Nasir,A., Umair,M., Shahzad,S., Muhammad,D., Santos-Cortez,R.L.P., Leal,S.M. and Ahmad,W.
    A disease-causing novel missense mutation in the ST14 gene underlies autosomal recessive ichthyosis with hypotrichosis syndrome in a consanguineous family
    Eur J Dermatol28, 209-216. PubMed  Europe PubMed DOI  M
  40. Laux,H., Romand,S., Nuciforo,S., Farady,C.J., Tapparel,J., Buechmann-Moeller,S., Sommer,B., Oakeley,E.J. and Bodendorf,U.
    Degradation of recombinant proteins by Chinese hamster ovary host cell proteases is prevented by matriptase-1 knockout
    Biotechnol Bioeng115, 2530-2540. PubMed  Europe PubMed DOI  K
  41. Mitchell,A.C., Alford,S.C., Hunter,S.A., Kannan,D., Parra Sperberg,R.A., Chang,C.H. and Cochran,J.R.
    Development of a protease biosensor based on a dimerization-dependent red fluorescent protein
    ACS Chem Biol13, 66-72. PubMed  Europe PubMed DOI  A  L
  42. Mitchell,A.C., Kannan,D., Hunter,S.A., Parra Sperberg,R.A., Chang,C.H. and Cochran,J.R.
    Engineering a potent inhibitor of matriptase from the natural hepatocyte growth factor activator inhibitor type-1 (HAI-1) protein
    J Biol Chem293, 4969-4980. PubMed  Europe PubMed DOI
  43. Yamasaki,K., Mukai,S., Nagai,T., Nakahara,K., Fujii,M., Terada,N., Ohno,A., Sato,Y., Toda,Y., Kataoka,H. and Kamoto,T.
    Matriptase-induced phosphorylation of MET is significantly associated with poor prognosis in invasive bladder cancer; an immunohistochemical analysis
    Int J Mol Sci19, PubMed  Europe PubMed DOI
  44. Zaman,S., Chobrutskiy,B.I., Patel,J.S., Callahan,B.M., Tong,W.L. and Blanck,G.
    Mutant cytoskeletal and ECM peptides sensitive to the ST14 protease are associated with a worse outcome for glioblastoma multiforme
    Biochem Biophys Res Commun503, 2218-2225. PubMed  Europe PubMed DOI
    45. 2017
  45. Friis,S., Tadeo,D., Le-Gall,S.M., Jurgensen,H.J., Sales,K.U., Camerer,E. and Bugge,T.H.
    Matriptase zymogen supports epithelial development, homeostasis and regeneration
    BMC Biol15, 46-46. PubMed  Europe PubMed DOI
  46. Haussler,D., Schulz-Fincke,A.C., Beckmann,A.M., Keils,A., Gilberg,E., Mangold,M., Bajorath,J., Stirnberg,M., Steinmetzer,T. and Gutschow,M.
    A fluorescent-labeled phosphono bisbenzguanidine as an activity-based probe for matriptase
    Chemistry23, 5205-5209. PubMed  Europe PubMed DOI  L  I
  47. Lanchec,E., Desilets,A., Beliveau,F., Flamier,A., Mahmoud,S., Bernier,G., Gris,D., Leduc,R. and Lavoie,C.
    The type II transmembrane serine protease matriptase cleaves the amyloid precursor protein and reduces its processing to beta-amyloid peptide
    J Biol Chem292, 20669-20682. PubMed  Europe PubMed DOI
  48. Nonboe,A.W., Krigslund,O., Soendergaard,C., Skovbjerg,S., Friis,S., Andersen,M.N., Ellis,V., Kawaguchi,M., Kataoka,H., Bugge,T.H. and Vogel,L.K.
    HAI-2 stabilizes, inhibits, and regulates SEA-cleavage-dependent secretory transport of matriptase
    Traffic18, 378-391. PubMed  Europe PubMed DOI
  49. Sun,D.R., Zheng,Q.C. and Zhang,H.X.
    Probing the interaction mechanism of small molecule inhibitors with matriptase based on molecular dynamics simulation and free energy calculations
    J Biomol Struct Dyn35, 755-764. PubMed  Europe PubMed DOI  I
  50. Tanabe,L.M. and List,K.
    The role of type II transmembrane serine protease-mediated signaling in cancer
    FEBS J284, 1421-1436. PubMed  Europe PubMed DOI  I
  51. Tseng,C.C., Jia,B., Barndt,R., Gu,Y., Chen,C.Y., Tseng,I.C., Su,S.F., Wang,J.K., Johnson,M.D. and Lin,C.Y.
    Matriptase shedding is closely coupled with matriptase zymogen activation and requires de novo proteolytic cleavage likely involving its own activity
    PLoS ONE12, e0183507-e0183507. PubMed  Europe PubMed DOI
  52. Wilkinson,D.J., Habgood,A., Lamb,H.K., Thompson,P., Hawkins,A.R., Desilets,A., Leduc,R., Steinmetzer,T., Hammami,M., Lee,M.S., Craik,C.S., Watson,S., Lin,H., Milner,J.M. and Rowan,A.D.
    Matriptase induction of metalloproteinase-dependent aggrecanolysis in vitro and in vivo: promotion of osteoarthritic cartilage damage by multiple mechanisms
    Arthritis Rheumatol69, 1601-1611. PubMed  Europe PubMed DOI
  53. Wu,C.J., Feng,X., Lu,M., Morimura,S. and Udey,M.C.
    Matriptase-mediated cleavage of EpCAM destabilizes claudins and dysregulates intestinal epithelial homeostasis
    J Clin Invest127, 623-634. PubMed  Europe PubMed DOI  P
  54. Wu,S.R., Teng,C.H., Tu,Y.T., Ko,C.J., Cheng,T.S., Lan,S.W., Lin,H.Y., Lin,H.H., Tu,H.F., Hsiao,P.W., Huang,H.P., Chen,C.H. and Lee,M.S.
    The Kunitz domain I of hepatocyte growth factor activator inhibitor-2 inhibits matriptase activity and invasive ability of human prostate cancer cells
    Sci Rep7, 15101-15101. PubMed  Europe PubMed DOI
  55. Yogo,T., Umezawa,K., Kamiya,M., Hino,R. and Urano,Y.
    Development of an activatable fluorescent probe for prostate cancer imaging
    Bioconjug Chem28, 2069-2076. PubMed  Europe PubMed DOI  L
  56. Youssefian,L., Touati,A., Saeidian,A.H., Zargari,O., Zeinali,S., Vahidnezhad,H. and Uitto,J.
    A novel mutation in ST14 at a functionally significant amino acid residue expands the spectrum of ichthyosis-hypotrichosis syndrome
    Orphanet J Rare Dis12, 176-176. PubMed  Europe PubMed DOI  M
    57. 2016
  57. Bardou,O., Menou,A., Francois,C., Duitman,J.W., von der Thusen,J.H., Borie,R., Sales,K.U., Mutze,K., Castier,Y., Sage,E., Liu,L., Bugge,T.H., Fairlie,D.P., Konigshoff,M., Crestani,B. and Borensztajn,K.S.
    Membrane-anchored serine protease matriptase is a trigger of pulmonary fibrogenesis
    Am J Respir Crit Care Med193, 847-860. PubMed  Europe PubMed DOI  I
  58. Beckmann,A.M., Gilberg,E., Gattner,S., Huang,T.L., Vanden Eynde,J.J., Mayence,A., Bajorath,J., Stirnberg,M. and Gutschow,M.
    Evaluation of bisbenzamidines as inhibitors for matriptase-2
    Bioorg Med Chem Lett26, 3741-3745. PubMed  Europe PubMed DOI  I
  59. Chen,C.Y., Chen,C.J., Lai,C.H., Wu,B.Y., Lee,S.P., Johnson,M.D., Lin,C.Y. and Wang,J.K.
    Increased matriptase zymogen activation by UV irradiation protects keratinocyte from cell death
    J Dermatol Sci83, 34-44. PubMed  Europe PubMed DOI
  60. Chen,Y.W., Yin,S., Lai,Y.J., Johnson,M.D. and Lin,C.Y.
    Plasminogen-dependent matriptase activation accelerates plasmin generation by differentiating primary human keratinocytes
    J Invest Dermatol136, 1210-1218. PubMed  Europe PubMed DOI
  61. Han,Z., Harris,P.K., Karmakar,P., Kim,T., Owusu,B.Y., Wildman,S.A., Klampfer,L. and Janetka,J.W.
    alpha-Ketobenzothiazole serine protease inhibitors of aberrant HGF/c-MET and MSP/RON kinase pathway signaling in cancer
    ChemMedChem11, 585-599. PubMed  Europe PubMed DOI  I
  62. Le Gall,S.M., Szabo,R., Lee,M., Kirchhofer,D., Craik,C.S., Bugge,T.H. and Camerer,E.
    Matriptase activation connects tissue factor-dependent coagulation initiation to epithelial proteolysis and signaling
    Blood127, 3260-3269. PubMed  Europe PubMed DOI
  63. Maiwald,A., Hammami,M., Wagner,S., Heine,A., Klebe,G. and Steinmetzer,T.
    Changing the selectivity profile - from substrate analog inhibitors of thrombin and factor Xa to potent matriptase inhibitors
    J Enzyme Inhib Med Chem31, 89-97. PubMed  Europe PubMed DOI  I
  64. Murray,A.S., Varela,F.A. and List,K.
    Type II transmembrane serine proteases as potential targets for cancer therapy
    Biol Chem397, 815-826. PubMed  Europe PubMed DOI
  65. Najy,A.J., Dyson,G., Jena,B.P., Lin,C.Y. and Kim,H.R.
    Matriptase activation and shedding through PDGF-D-mediated extracellular acidosis
    Am J Physiol Cell Physiol310, C293-C304. PubMed  Europe PubMed DOI
  66. Su,H.C., Liang,Y.A., Lai,Y.J., Chiu,Y.L., Barndt,R.B., Shiao,F., Chang,H.D., Lu,D.D., Huang,N., Tseng,C.C., Wang,J.K., Lee,M.S., Johnson,M.D., Huang,S.M. and Lin,C.Y.
    Natural endogenous human matriptase and prostasin undergo zymogen activation via independent mechanisms in an uncoupled manner
    PLoS ONE11, e0167894-e0167894. PubMed  Europe PubMed DOI
  67. Venukadasula,P.K., Owusu,B.Y., Bansal,N., Ross,L.J., Hobrath,J.V., Bao,D., Truss,J.W., Stackhouse,M., Messick,T.E., Klampfer,L. and Galemmo RA Jr
    Design and synthesis of nonpeptide inhibitors of hepatocyte growth factor activation
    ACS Med Chem Lett7, 177-181. PubMed  Europe PubMed DOI  I
    68. 2015
  68. Goswami,R., Wohlfahrt,G., Mukherjee,S., Ghadiyaram,C., Nagaraj,J., Satyam,L.K., Subbarao,K., Gopinath,S., Krishnamurthy,N.R., Subramanya,H.S. and Ramachandra,M.
    Discovery of O-(3-carbamimidoylphenyl)-l-serine amides as matriptase inhibitors using a fragment-linking approach
    Bioorg Med Chem Lett25, 616-620. PubMed  Europe PubMed DOI  I
  69. Huang,W. and Kim,H.R.
    Dynamic regulation of platelet-derived growth factor D (PDGF-D) activity and extracellular spatial distribution by matriptase-mediated proteolysis
    J Biol Chem290, 9162-9170. PubMed  Europe PubMed DOI
  70. Ko,C.J., Huang,C.C., Lin,H.Y., Juan,C.P., Lan,S.W., Shyu,H.Y., Wu,S.R., Hsiao,P.W., Huang,H.P., Shun,C.T. and Lee,M.S.
    Androgen-induced TMPRSS2 activates matriptase and promotes extracellular matrix degradation, prostate cancer cell invasion, tumor growth, and metastasis
    Cancer Res75, 2949-2960. PubMed  Europe PubMed DOI
  71. Paszti-Gere,E., McManus,S., Meggyeshazi,N., Balla,P., Galfi,P. and Steinmetzer,T.
    Inhibition of matriptase activity results in decreased intestinal epithelial monolayer integrity in vitro
    PLoS ONE10, e0141077-e0141077. PubMed  Europe PubMed DOI  I
  72. Takeichi,T., Nanda,A., Aristodemou,S., McMillan,J.R., Lee,J., Akiyama,M., Al-Ajmi,H., Simpson,M.A. and McGrath,J.A.
    Whole-exome sequencing diagnosis of two autosomal recessive disorders in one family
    Br J Dermatol172, 1407-1411. PubMed  Europe PubMed DOI  M
  73. Tan,X., Soualmia,F., Furio,L., Renard,J.F., Kempen,I., Qin,L., Pagano,M., Pirotte,B., El Amri,C., Hovnanian,A. and Reboud-Ravaux,M.
    Toward the first class of suicide inhibitors of kallikreins involved in skin diseases
    J Med Chem58, 598-612. PubMed  Europe PubMed DOI  I
  74. Zarif,J.C., Lamb,L.E., Schulz,V.V., Nollet,E.A. and Miranti,C.K.
    Androgen receptor non-nuclear regulation of prostate cancer cell invasion mediated by Src and matriptase
    Oncotarget6, 6862-6876. PubMed  Europe PubMed DOI
  75. Zoratti,G.L., Tanabe,L.M., Varela,F.A., Murray,A.S., Bergum,C., Colombo,E., Lang,J.E., Molinolo,A.A., Leduc,R., Marsault,E., Boerner,J. and List,K.
    Targeting matriptase in breast cancer abrogates tumour progression via impairment of stromal-epithelial growth factor signalling
    Nat Commun6, 6776-6776. PubMed  Europe PubMed DOI  I
    76. 2014
  76. Barre,O., Dufour,A., Eckhard,U., Kappelhoff,R., Beliveau,F., Leduc,R. and Overall,C.M.
    Cleavage specificity analysis of six type II transmembrane serine proteases (TTSPs) using PICS with proteome-derived peptide libraries
    PLoS ONE9, e105984-e105984. PubMed  Europe PubMed DOI  P
  77. Chen,Y.W., Wang,J.K., Chou,F.P., Wu,B.Y., Hsiao,H.C., Chiu,H., Xu,Z., Baksh,A.N., Shi,G., Kaul,M., Barndt,R., Shanmugam,V.K., Johnson,M.D. and Lin,C.Y.
    Matriptase regulates proliferation and early, but not terminal, differentiation of human keratinocytes
    J Invest Dermatol134, 405-414. PubMed  Europe PubMed DOI
  78. Chu,L.L., Xu,Y., Yang,J.R., Hu,Y.A., Chang,H.H., Lai,H.Y., Tseng,C.C., Wang,H.Y., Johnson,M.D., Wang,J.K. and Lin,C.Y.
    Human cancer cells retain modest levels of enzymatically active matriptase only in extracellular milieu following induction of zymogen activation
    PLoS ONE9, e92244-e92244. PubMed  Europe PubMed DOI
  79. Dargahi,D., Swayze,R.D., Yee,L., Bergqvist,P.J., Hedberg,B.J., Heravi-Moussavi,A., Dullaghan,E.M., Dercho,R., An,J., Babcook,J.S. and Jones,S.J.
    A pan-cancer analysis of alternative splicing events reveals novel tumor-associated splice variants of matriptase
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