| Activity |
|---|
| Catalytic type | Metallo |
| Peplist | Included in the Peplist with identifier PL00195 |
| NC-IUBMB | Subclass 3.4 (Peptidases) >> Sub-subclass 3.4.24 (Metalloendopeptidases) >> Peptidase 3.4.24.86
|
| Enzymology | BRENDA database |
| Proteolytic events | CutDB database (30 cleavages) |
| Activity status | human: active (Black, 2004)
mouse: active (Zhao et al., 2001)
|
| Physiology | The cleavage of the precursor of tumor necrosis factor alpha releases the soluble, 17-kDa factor, which is a mediator of inflammation. The enzyme also causes shedding of many external membrane proteins including receptors by cleavage at sites near the membrane. |
| Knockout | Gene knockout in mice showed that the enzyme plays a central role in regulated alpha-cleavage of Alzheimer"s amyloid protein precursor (APP). The data suggest that it may be the alpha-secretase responsible for the majority of regulated alpha-cleavage in cultured cells, and that inhibiting this enzyme affects both APP secretion and A beta formation in cultured cells (Buxbaum et al., 1998). |
| Pharmaceutical relevance | Potential drug target for control of formation of tumor necrosis factor alpha (TNF alpha). |
| Pathways |
KEGG | Alzheimer's disease |
|
KEGG | Epithelial cell signaling in Helicobacter pylori infection |
|
KEGG | Notch signaling pathway |
|
Other databases
| WIKIPEDIA | http://en.wikipedia.org/wiki/ADAM17 |
| Cleavage site specificity |
Explanations of how to interpret the
following cleavage site sequence logo and specificity matrix can be found here. |
|---|
| Cleavage pattern | -/a/a/a vl/-/s/- (based on 184 cleavages) |
