Searches of the MEROPS database

Display Known Cleavages for a Protein

Please enter a UniProt accession (eg P05067):

Accession:

Sequence O08585

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Peptide and protein substrates that are thought to be physiologically relevant are indicated by P. Peptide and protein substrates that are not physiologically relevant are indicated by N. How cleavage sites have been identified are indicated by the following evidence codes: NT = N-terminal sequencing, MS = mass spectroscopy, MU = mutation, CS = consensus sequence, LC = liquid chromatography. To see all annotated cleavages for a peptidase, click on the peptidase name.

Cleavage Site	Peptidase	Residue range	Cleavage type	Description	Evidence	Reference
75	caspase-3	1-235	N		MS	Demon et al., 2009
75	caspase-7	1-235	N		MS	Demon et al., 2009
82	cathepsin D	1-235	P		MS	Impens et al., 2010
82	cathepsin E	1-235	P		MS	Impens et al., 2010
93	cathepsin E	1-235	P		MS	Impens et al., 2010
152	cathepsin E	1-235	P		MS	Impens et al., 2010
153	cathepsin D	1-235	P		MS	Impens et al., 2010
204	cathepsin D	1-235	P		MS	Impens et al., 2010
205	cathepsin D	1-235	P		MS	Impens et al., 2010
206	cathepsin D	1-235	P		MS	Impens et al., 2010
234	carboxypeptidase A4	223-235	P		MS	Tanco et al., 2010