Searches of the MEROPS database

Display Known Cleavages for a Protein

Please enter a UniProt accession (eg P05067):

Accession:

Sequence P01135

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Peptide and protein substrates that are thought to be physiologically relevant are indicated by P. Peptide and protein substrates that are not physiologically relevant are indicated by N. How cleavage sites have been identified are indicated by the following evidence codes: NT = N-terminal sequencing, MS = mass spectroscopy, MU = mutation, CS = consensus sequence, LC = liquid chromatography. To see all annotated cleavages for a peptidase, click on the peptidase name.

Cleavage Site	Peptidase	Residue range	Cleavage type	Description	Evidence	Reference
23	unknown peptidase	1-160	P		NT	<%Agarwal et al., 2012[]%>
39	ADAM10 peptidase	24-160	P			Hinkle et al., 2003
39	ADAM17 peptidase	24-160	P			Hinkle et al., 2003
50	insulysin	40-89	P		MS	Guo et al., 2009
53	insulysin	40-89	P		MS	Guo et al., 2009
54	insulysin	40-89	P		MS	Guo et al., 2009
56	insulysin	40-89	P		MS	Guo et al., 2009
59	insulysin	40-89	P		MS	Guo et al., 2009
60	insulysin	40-89	P		MS	Guo et al., 2009
73	insulysin	40-89	P		MS	Guo et al., 2009
74	insulysin	40-89	P		MS	Guo et al., 2009
79	insulysin	40-89	P		MS	Guo et al., 2009
89	ADAM17 peptidase	24-160	P			Sunnarborg et al., 2002