Searches of the MEROPS database

Display Known Cleavages for a Protein

Please enter a UniProt accession (eg P05067):

Accession:

Sequence Q01705

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Peptide and protein substrates that are thought to be physiologically relevant are indicated by P. Peptide and protein substrates that are not physiologically relevant are indicated by N. How cleavage sites have been identified are indicated by the following evidence codes: NT = N-terminal sequencing, MS = mass spectroscopy, MU = mutation, CS = consensus sequence, LC = liquid chromatography. To see all annotated cleavages for a peptidase, click on the peptidase name.

Cleavage Site	Peptidase	Residue range	Cleavage type	Description	Evidence	Reference
18	unknown peptidase	1-2531	P		NT	<%Agarwal et al., 2012[]%>
1654	furin	19-2531	P			<%Logeat et al., 1998[]%>
1710	ADAM17 peptidase	19-2531	P			Brou et al., 2000
1731	presenilin 1	19-2531	P	release from a membrane surface		Okochi et al., 2002
1743	presenilin 1	19-2531	P	release from a membrane surface		Ikeuchi & Sisodia, 2003
1823	granzyme B, rodent-type	19-2531	N		CS	Loeb et al., 2006
1860	granzyme B, rodent-type	19-2531	N		CS	Loeb et al., 2006
1902	granzyme B, rodent-type	19-2531	N		CS	Loeb et al., 2006
1961	granzyme B, rodent-type	19-2531	N		CS	Loeb et al., 2006
2071	granzyme B, rodent-type	19-2531	N		CS	Loeb et al., 2006