Structure for peptidase M12.217: ADAM17 peptidase

Summary Gene structure Alignment Tree Sequences Sequence features Distribution Structure Literature Substrates Pharma

PDB	Organism	Resolution	Comment
1BKC_A	Homo sapiens	2.00 Å	catalytic domain
One monomer of the tetramer is shown. The catalytic zinc is shown as a light grey CPK sphere. The zinc ligands are shown in ball-and-stick representation: His405, His409 and His415 in purple. The catalytic residues are shown in ball-and-stick representation: Glu406 in blue and Tyr436 in green.

		Show surface

TERTIARY STRUCTURE DATA
Comment	Resolution	PDB	PDBe	SCOP	CATH	PDBSum	Proteopedia	Reference
Homo sapiens
catalytic domain	2.00 Å	1BKC	1BKC	1BKC	1BKC	1BKC	1BKC	Maskos et al., 1998
mature peptidase	2.28 Å	1ZXC	1ZXC	1ZXC	1ZXC	1ZXC	1ZXC	Levin et al., 2005
mature peptidase	2.30 Å	2A8H	2A8H	2A8H	2A8H	2A8H	2A8H	Levin et al., 2006
mature peptidase	1.70 Å	2DDF	2DDF	2DDF	2DDF	2DDF	2DDF	Ingram et al., 2006
mature peptidase	2.10 Å	2FV5	2FV5	2FV5	2FV5	2FV5	2FV5	Niu et al., 2006
mature peptidase	2.02 Å	2FV9	2FV9	2FV9	2FV9	2FV9	2FV9	Ingram et al., 2006
mature peptidase	1.90 Å	2I47	2I47	2I47	2I47	2I47	2I47	Condon et al., 2007
mature peptidase	0.00 Å	2M2F	2M2F	2M2F	2M2F	2M2F	2M2F	Dusterhoft et al., 2013
mature peptidase	2.00 Å	2OI0	2OI0	2OI0	2OI0	2OI0	2OI0	Govinda et al., 2007
mature peptidase	2.00 Å	3B92	3B92	3B92	3B92	3B92	3B92	Bandarage et al., 2008
complex with TIMP-3	2.30 Å	3CKI	3CKI	3CKI	3CKI	3CKI	3CKI	Wisniewska et al., 2008
mature peptidase	1.90 Å	3E8R	3E8R	3E8R	3E8R	3E8R	3E8R	Mazzola et al., 2008
mature peptidase	1.90 Å	3EDZ	3EDZ	3EDZ	3EDZ	3EDZ	3EDZ	Mazzola et al., 2008
mature peptidase	1.80 Å	3EWJ	3EWJ	3EWJ	3EWJ	3EWJ	3EWJ	Guo et al., 2009
mature peptidase	2.10 Å	3G42	3G42	3G42	3G42	3G42	3G42	Park et al., 2009
mature peptidase	1.80 Å	3KMC	3KMC	3KMC	3KMC	3KMC	3KMC	Rosner et al., 2010
mature peptidase	1.85 Å	3KME	3KME	3KME	3KME	3KME	3KME	Rosner et al., 2010
mature peptidase	1.92 Å	3L0T	3L0T	3L0T	3L0T	3L0T	3L0T	Yu et al., 2010
mature peptidase	1.75 Å	3L0V	3L0V	3L0V	3L0V	3L0V	3L0V	Yu et al., 2010
mature peptidase	1.85 Å	3LE9	3LE9	3LE9	3LE9	3LE9	3LE9	Yu et al., 2010
mature peptidase	2.00 Å	3LEA	3LEA	3LEA	3LEA	3LEA	3LEA	Yu et al., 2010
mature peptidase	1.90 Å	3LGP	3LGP	3LGP	3LGP	3LGP	3LGP	Li et al., 2010
mature peptidase	1.88 Å	3O64	3O64	3O64	3O64	3O64	3O64	Dai et al., 2011