Searches of the MEROPS database

Display Known Cleavages for a Protein

Please enter a UniProt accession (eg P05067):

Accession:

Sequence P60710

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Peptide and protein substrates that are thought to be physiologically relevant are indicated by P. Peptide and protein substrates that are not physiologically relevant are indicated by N. How cleavage sites have been identified are indicated by the following evidence codes: NT = N-terminal sequencing, MS = mass spectroscopy, MU = mutation, CS = consensus sequence, LC = liquid chromatography. To see all annotated cleavages for a peptidase, click on the peptidase name.

Cleavage Site	Peptidase	Residue range	Cleavage type	Description	Evidence	Reference
1	unknown peptidase	1-375	P		NT	<%Agarwal et al., 2012[]%>
4	cathepsin E	1-375	P		MS	Impens et al., 2010
6	cathepsin E	1-375	P		MS	Impens et al., 2010
6	matrix metallopeptidase-2	2-375	N		MS	auf dem Keller et al., 2010
7	cathepsin D	1-375	P		MS	Impens et al., 2010
7	cathepsin E	1-375	P		MS	Impens et al., 2010
7	matrix metallopeptidase-2	2-375	N		MS	Prudova et al., 2010
8	cathepsin D	1-375	P		MS	Impens et al., 2010
8	cathepsin E	1-375	P		MS	Impens et al., 2010
11	caspase-1	2-375	P	normal turnover	MS	Lamkanfi et al., 2008
11	caspase-3	1-375	N		MS	Demon et al., 2009
11	caspase-7	1-375	N		MS	Demon et al., 2009
11	granzyme B (Homo sapiens-type)	2-375	N			Van Damme et al., 2009
11	granzyme B, rodent-type	2-375	P			Van Damme et al., 2009
15	matrix metallopeptidase-2	1-375	N		MS	auf dem Keller et al., 2010
16	matrix metallopeptidase-2	2-375	N		MS	auf dem Keller et al., 2010
28	matrix metallopeptidase-2	2-375	N		MS	auf dem Keller et al., 2010
28	trypsin 1	2-375	N			Van Damme et al., 2009
40	matrix metallopeptidase-2	1-375	N		MS	Kleifeld et al., 2010
42	matrix metallopeptidase-2	1-375	N		MS	auf dem Keller et al., 2010
44	cathepsin E	1-375	P		MS	Impens et al., 2010
53	cathepsin E	1-375	P		MS	Impens et al., 2010
104	matrix metallopeptidase-2	1-375	N		MS	auf dem Keller et al., 2010
139	cathepsin E	1-375	P		MS	Impens et al., 2010
177	carboxypeptidase A4	170-178	P		MS	Tanco et al., 2010
189	cathepsin E	1-375	P		MS	Impens et al., 2010
197	matrix metallopeptidase-2	1-375	N		MS	auf dem Keller et al., 2010
227	cathepsin D	1-375	P		MS	Impens et al., 2010
231	matrix metallopeptidase-2	1-375	N		MS	auf dem Keller et al., 2010
232	matrix metallopeptidase-2	1-375	N		MS	auf dem Keller et al., 2010
235	matrix metallopeptidase-2	2-375	N		MS	auf dem Keller et al., 2010
244	caspase-1	2-375	P	normal turnover	MS	Lamkanfi et al., 2008
244	granzyme B (Homo sapiens-type)	2-375	N		MS	Van Damme et al., 2009
245	matrix metallopeptidase-2	1-375	N		MS	auf dem Keller et al., 2010
260	matrix metallopeptidase-2	1-375	N		MS	Kleifeld et al., 2010
266	matrix metallopeptidase-2	2-375	N		MS	auf dem Keller et al., 2010
268	cathepsin D	1-375	P		MS	Impens et al., 2010
273	matrix metallopeptidase-2	2-375	N		MS	auf dem Keller et al., 2010
279	cathepsin D	1-375	P		MS	Impens et al., 2010
279	cathepsin E	1-375	P		MS	Impens et al., 2010
292	matrix metallopeptidase-2	1-375	N		MS	Kleifeld et al., 2010
293	cathepsin D	1-375	P		MS	Impens et al., 2010
293	cathepsin E	1-375	P		MS	Impens et al., 2010
296	cathepsin E	1-375	P		MS	Impens et al., 2010
297	cathepsin E	1-375	P		MS	Impens et al., 2010
297	matrix metallopeptidase-2	1-375	N		MS	auf dem Keller et al., 2010
299	cathepsin D	1-375	P		MS	Impens et al., 2010
299	cathepsin E	1-375	P		MS	Impens et al., 2010
348	matrix metallopeptidase-2	1-375	N		MS	Kleifeld et al., 2010
354	matrix metallopeptidase-2	1-375	N		MS	auf dem Keller et al., 2010
355	matrix metallopeptidase-2	1-375	N		MS	auf dem Keller et al., 2010
356	cathepsin D	1-375	P		MS	Impens et al., 2010
356	cathepsin E	1-375	P		MS	Impens et al., 2010