Searches of the MEROPS database

Display Known Cleavages for a Protein

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Accession:

Sequence P02687

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Peptide and protein substrates that are thought to be physiologically relevant are indicated by P. Peptide and protein substrates that are not physiologically relevant are indicated by N. How cleavage sites have been identified are indicated by the following evidence codes: NT = N-terminal sequencing, MS = mass spectroscopy, MU = mutation, CS = consensus sequence, LC = liquid chromatography. To see all annotated cleavages for a peptidase, click on the peptidase name.

Cleavage Site	Peptidase	Residue range	Cleavage type	Description	Evidence	Reference
14	ADAM17 peptidase	1-169	P			Chesneau et al., 2003
16	calpain-1	1-169	P			Tsubata & Takahashi, 1989
16	calpain-2	1-169	P			Tsubata & Takahashi, 1989
16	ADAM28 peptidase (mouse-type)	1-169	P			Blobel, 2004
16	ADAM10 peptidase	1-169	P			Chesneau et al., 2003
16	ADAM19 peptidase	1-169	P			Chesneau et al., 2003
16	ADAM17 peptidase	1-169	P			Chesneau et al., 2003
16	ADAM28 peptidase (Homo sapiens-type)	1-169	N			Howard et al., 2001
36	cathepsin D	1-169	P	normal turnover		Whitaker & Seyer, 1979
42	cathepsin D	1-169	P	normal turnover		Whitaker & Seyer, 1979
42	angiotensin-converting enzyme peptidase unit 2	1-169	N			Amour et al., 1999
62	ADAM28 peptidase (mouse-type)	1-169	P			Blobel, 2004
62	ADAM10 peptidase	1-169	P			Chesneau et al., 2003
63	ADAM17 peptidase	1-169	P			Chesneau et al., 2003
68	calpain-1	1-169	P			Tsubata & Takahashi, 1989
68	calpain-2	1-169	P			Tsubata & Takahashi, 1989
71	ADAM28 peptidase (mouse-type)	1-169	P			Blobel, 2004
71	ADAM8 peptidase	1-169	P			Schlomann et al., 2002
71	ADAM10 peptidase	1-169	P			Chesneau et al., 2003
71	ADAM19 peptidase	1-169	P			Chesneau et al., 2003
71	ADAM28 peptidase (Homo sapiens-type)	1-169	N			Howard et al., 2001
73	ADAM19 peptidase	1-169	P			Chesneau et al., 2003
88	cathepsin D	1-169	P	normal turnover		Whitaker & Seyer, 1979
88	angiotensin-converting enzyme peptidase unit 2	1-169	N			Amour et al., 1999
88	ADAM17 peptidase	1-169	P			Chesneau et al., 2003
91	cathepsin D	1-169	P	normal turnover		Whitaker & Seyer, 1979
93	calpain-1	1-169	P			Tsubata & Takahashi, 1989
93	calpain-2	1-169	P			Tsubata & Takahashi, 1989
96	calpain-1	1-169	P			Tsubata & Takahashi, 1989
96	calpain-2	1-169	P			Tsubata & Takahashi, 1989
106	ADAM28 peptidase (mouse-type)	1-169	P			Blobel, 2004
106	ADAM28 peptidase (Homo sapiens-type)	1-169	N			Howard et al., 2001
110	ADAM19 peptidase	1-169	P			Chesneau et al., 2003
135	ADAM19 peptidase	1-169	P			Chesneau et al., 2003