Searches of the MEROPS database

Display Known Cleavages for a Protein

Please enter a UniProt accession (eg P05067):

Accession:

Sequence P26039

,

Click here to display alignment and conservation of cleavage sites of this sequence with close homologues. This will take a few moments.

Peptide and protein substrates that are thought to be physiologically relevant are indicated by P. Peptide and protein substrates that are not physiologically relevant are indicated by N. How cleavage sites have been identified are indicated by the following evidence codes: NT = N-terminal sequencing, MS = mass spectroscopy, MU = mutation, CS = consensus sequence, LC = liquid chromatography. To see all annotated cleavages for a peptidase, click on the peptidase name.

Cleavage Site	Peptidase	Residue range	Cleavage type	Description	Evidence	Reference
133	cathepsin D	1-2541	P		MS	Impens et al., 2010
269	cathepsin D	1-2541	P		MS	Impens et al., 2010
270	cathepsin E	1-2541	P		MS	Impens et al., 2010
422	cathepsin E	1-2541	P		MS	Impens et al., 2010
424	caspase-1	1-2541	P		MS	Lamkanfi et al., 2008
806	cathepsin D	1-2541	P		MS	Impens et al., 2010
806	cathepsin E	1-2541	P		MS	Impens et al., 2010
829	cathepsin E	1-2541	P		MS	Impens et al., 2010
1572	cathepsin D	1-2541	P		MS	Impens et al., 2010
1606	cathepsin E	1-2541	P		MS	Impens et al., 2010
1607	cathepsin D	1-2541	P		MS	Impens et al., 2010
1850	cathepsin E	1-2541	P		MS	Impens et al., 2010
1965	cathepsin E	1-2541	P		MS	Impens et al., 2010
1997	cathepsin D	1-2541	P		MS	Impens et al., 2010
1997	cathepsin E	1-2541	P		MS	Impens et al., 2010
2033	cathepsin D	1-2541	P		MS	Impens et al., 2010
2033	cathepsin E	1-2541	P		MS	Impens et al., 2010
2128	cathepsin D	1-2541	P		MS	Impens et al., 2010
2145	matrix metallopeptidase-2	1-2541	N		MS	auf dem Keller et al., 2010
2184	cathepsin E	1-2541	P		MS	Impens et al., 2010
2200	cathepsin E	1-2541	P		MS	Impens et al., 2010
2500	matrix metallopeptidase-2	1-2541	N		MS	auf dem Keller et al., 2010