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Literature for peptidase M12.217: ADAM17 peptidase

Summary Gene structure Alignment Tree Sequences Sequence features Distribution Structure Literature Substrates Pharma

(Topics flags: S Structure, A Assay, T Target, P Specificity, K Knockout, E Expression, V Review, M Mutation, I Inhibitor, L Localization. To select only the references relevant to a single topic, click the link above. See explanation.)

    2025
  1. Bruno,F., Aceto,M.A., Paparazzo,E., Arcuri,D., Vozzo,F., Mirante,S., Greco,B.M., Serra Cassano,T., Abondio,P., Canterini,S., Malvaso,A., Grecucci,A., Citrigno,L., Geracitano,S., Spadafora,P., Puccio,G., Frangipane,F., Curcio,S.M., Ferrise,F., Lagana,V., Colao,R., Passarino,G., Bruni,A.C., Maletta,R., Cavalcanti,F. and Montesanto,A.
    Genetic variability in ADAM17/TACE is associated with sporadic Alzheimer's disease risk, neuropsychiatric symptoms and cognitive performance on the Rey Auditory Verbal Learning and Clock Drawing Tests
    PLoS ONE20, e0309631-e0309631. PubMed  Europe PubMed DOI
  2. Oliveira,K.B., de Souza,F.M.A., de Sa,L.B.M., Pacheco,A.L.D., Prado,M.R., de Sousa Rodrigues,C.F., Bassi,E.J., Santana-Melo,I., Silva-Junior,A., Sabino-Silva,R., Shetty,A.K. and de Castro,O.W.
    Potential Mechanisms Underlying COVID-19-Mediated Central and Peripheral Demyelination: Roles of the RAAS and ADAM-17
    Mol Neurobiol62, 1151-1164. PubMed  Europe PubMed DOI  V
  3. Puthiyottil,S., Jose,D., Kuriakose,N. and Skaria,T.
    The developmental and inflammatory disease target protein ADAM17 is vulnerable to off-target interaction by the drug eltrombopag: Insights from molecular modeling
    Comput Biol Med186, 109693-109693. PubMed  Europe PubMed DOI
    4. 2024
  4. Azzopardi,S.A., Lu,H.Y., Monette,S., Rabinowitsch,A.I., Salmon,J.E., Matsunami,H. and Blobel,C.P.
    Role of iRhom2 in Olfaction: Implications for Odorant Receptor Regulation and Activity-Dependent Adaptation
    Int J Mol Sci25, PubMed  Europe PubMed DOI
  5. Babendreyer,A., Kieselhorst,J., Rinkens,C., Lyashenko,A.M., Dusterhoft,S., Jahr,H., Craveiro,R.B., Wolf,M. and Ludwig,A.
    Downregulation of the metalloproteinases ADAM10 or ADAM17 promotes osteoclast differentiation
    Cell Commun Signal22, 322-322. PubMed  Europe PubMed DOI
  6. Bauer,L., Edwards,J., Heil,A., Dewitt,S., Biebermann,H., Aeschlimann,D. and Knauper,V.
    Mesenchymal Transglutaminase 2 Activates Epithelial ADAM17: Link to G-Protein-Coupled Receptor 56 (ADGRG1) Signalling
    Int J Mol Sci25, PubMed  Europe PubMed DOI
  7. Calligaris,M., Spano,D.P., Bonelli,S., Muller,S.A., Carcione,C., D'Apolito,D., Amico,G., Miele,M., Di Bella,M., Zito,G., Nuti,E., Rossello,A., Blobel,C.P., Lichtenthaler,S.F. and Scilabra,S.D.
    iRhom2 regulates ectodomain shedding and surface expression of the major histocompatibility complex (MHC) class I
    Cell Mol Life Sci81, 163-163. PubMed  Europe PubMed DOI
  8. Chen,H.W., Zaruba,M., Dawood,A., Dusterhoft,S., Lamp,B., Ruemenapf,T. and Riedel,C.
    Modulation of ADAM17 Levels by Pestiviruses Is Species-Specific
    Viruses16, PubMed  Europe PubMed DOI
  9. Ferreira-Santos,L., Ramirez-Perez,F.I., Foote,C.A., Augenreich,M.A., McMillan,N.J., Williams,M.B., Gonzalez-Vallejo,J.D., Power,G., Wheeler,A.A., Manrique-Acevedo,C., Martinez-Lemus,L.A. and Padilla,J.
    Neuraminidase-induced externalization of phosphatidylserine activates ADAM17 and impairs insulin signaling in endothelial cells
    Am J Physiol Heart Circ Physiol326, H270-H270. PubMed  Europe PubMed DOI
  10. Liu,J., Su,G., Duan,C., Sun,Z., Xiao,S., Zhou,Y. and Fang,L.
    Porcine reproductive and respiratory syndrome virus infection activates ADAM17 to induce inflammatory responses
    Vet Microbiol292, 110066-110066. PubMed  Europe PubMed DOI
  11. Lu,F., Zhao,H., Dai,Y., Wang,Y., Lee,C.H. and Freeman,M.
    Cryo-EM reveals that iRhom2 restrains ADAM17 protease activity to control the release of growth factor and inflammatory signals
    Mol Cell84, 2152-2165. PubMed  Europe PubMed DOI
  12. Markham,M. and Troeberg,L.
    Using siRNA Silencing to Analyze ADAM17 in Macrophages
    Methods Mol Biol2747, 119-129. PubMed  Europe PubMed DOI
  13. Saad,M.I. and Jenkins,B.J.
    The protease ADAM17 at the crossroads of disease: revisiting its significance in inflammation, cancer, and beyond
    FEBS J291, 10-24. PubMed  Europe PubMed DOI  V
  14. Zhu,B., Lane,M.D., Baller,J.A., Jagtap,P.D., Griffin,T.J. and Seelig,B.
    Comprehensive protease specificity profiling
    bioRxiv PubMed  Europe PubMed DOI
    15. 2023
  15. Bhardwaj,T. and Giri,R.
    Potential of ADAM 17 Signal Peptide To Form Amyloid Aggregates in Vitro
    ACS Chem Neurosci14, 3818-3825. PubMed  Europe PubMed DOI
  16. Dwivedi,S.D., Shukla,R., Yadav,K., Rathor,L.S., Singh,D. and Singh,M.R.
    Mechanistic insight on the role of iRhom2-TNF-alpha-BAFF signaling pathway in various autoimmune disorders
    Adv Biol Regul92, 101011-101011. PubMed  Europe PubMed DOI
  17. Jiang,S., Yang,H., Sun,Z., Zhang,Y., Li,Y. and Li,J.
    The basis of complications in the context of SARS-CoV-2 infection: Pathological activation of ADAM17
    Biochem Biophys Res Commun679, 37-46. PubMed  Europe PubMed DOI  V
  18. Maas,S.L., Donners,M.M.P.C. and van der Vorst,E.P.C.
    ADAM10 and ADAM17, Major Regulators of Chronic Kidney Disease Induced Atherosclerosis?
    Int J Mol Sci24, PubMed  Europe PubMed DOI  V
  19. Rubina,A., Patel,M., Nightingale,K., Potts,M., Fielding,C.A., Kollnberger,S., Lau,B., Ladell,K., Miners,K.L., Nichols,J., Nobre,L., Roberts,D., Trinca,T.M., Twohig,J.P., Vlahava,V.M., Davison,A.J., Price,D.A., Tomasec,P., Wilkinson,G.W.G., Weekes,M.P., Stanton,R.J. and Wang,E.C.Y.
    ADAM17 targeting by human cytomegalovirus remodels the cell surface proteome to simultaneously regulate multiple immune pathways
    Proc Natl Acad Sci U S A120, e2303155120-e2303155120. PubMed  Europe PubMed DOI
  20. Schumacher,N., Thomsen,I., Brundert,F., Hejret,V., Dusterhoft,S., Tichy,B., Schmidt-Arras,D., Voss,M. and Rose-John,S.
    EGFR stimulation enables IL-6 trans-signalling via iRhom2-dependent ADAM17 activation in mammary epithelial cells
    Biochim Biophys Acta Mol Cell Res1870, 119489-119489. PubMed  Europe PubMed DOI
  21. Sikora,H., Gruba,N., Wysocka,M., Piwkowska,A. and Lesner,A.
    Optimization of fluorescent substrates for ADAM17 and their utility in the detection of diabetes
    Anal Biochem681, 115337-115337. PubMed  Europe PubMed DOI
    22. 2022
  22. Aljohmani,A., Andres,N.N. and Yildiz,D.
    Pseudomonas aeruginosa Alters Critical Lung Epithelial Cell Functions through Activation of ADAM17
    Cells11, 2303-2303. PubMed  Europe PubMed DOI
  23. AmeliMojarad,M., AmeliMojarad,M. and Pourmahdian,A.
    Circular RNA circ_0051620 sponges miR-338-3p and regulates ADAM17 to promote the gastric cancer progression
    Pathol Res Pract233, 153887-153887. PubMed  Europe PubMed DOI
  24. de Seabra Rodrigues Dias,I.R., Cao,Z. and Kwok,H.F.
    Adamalysins in COVID-19 - Potential mechanisms behind exacerbating the disease
    Biomed Pharmacother150, 112970-112970. PubMed  Europe PubMed DOI  V
  25. Garrido,M.P., Vallejos,C., Girardi,S., Gabler,F., Selman,A., Lopez,F., Vega,M. and Romero,C.
    NGF/TRKA Promotes ADAM17-Dependent Cleavage of P75 in Ovarian Cells: Elucidating a Pro-Tumoral Mechanism
    Int J Mol Sci23, PubMed  Europe PubMed DOI
  26. Gul,C., Kilic,S. and Sehitoglu,M.H.
    The importance of a disintegrin and metalloproteinase (ADAM)10 and ADAM17 in the pathogenesis of psoriasis
    Clin Exp Dermatol47, 1673-1678. PubMed  Europe PubMed DOI
  27. Healy,E.F.
    How tetraspanin-mediated cell entry of SARS-CoV-2 can dysregulate the shedding of the ACE2 receptor by ADAM17
    Biochem Biophys Res Commun593, 52-56. PubMed  Europe PubMed DOI
  28. Hitschler,L. and Lang,T.
    The transmembrane domain of the amyloid precursor protein is required for antiamyloidogenic processing by alpha-secretase ADAM10
    J Biol Chem298, 101911-101911. PubMed  Europe PubMed DOI
  29. Jocher,G., Grass,V., Tschirner,S.K., Riepler,L., Breimann,S., Kaya,T., Oelsner,M., Hamad,M.S., Hofmann,L.I., Blobel,C.P., Schmidt-Weber,C.B., Gokce,O., Jakwerth,C.A., Trimpert,J., Kimpel,J., Pichlmair,A. and Lichtenthaler,S.F.
    ADAM10 and ADAM17 promote SARS-CoV-2 cell entry and spike protein-mediated lung cell fusion
    EMBO Rep23, e54305-e54305. PubMed  Europe PubMed DOI
  30. Kadurin,I., Dahimene,S., Page,K.M., Ellaway,J.I.J., Chaggar,K., Troeberg,L., Nagase,H. and Dolphin,A.C.
    ADAM17 Mediates Proteolytic Maturation of Voltage-Gated Calcium Channel Auxiliary alpha2delta Subunits, and Enables Calcium Current Enhancement
    Function (Oxf)3, zqac013-zqac013. PubMed  Europe PubMed DOI
  31. Kirschke,S., Ogunsulire,I., Selvakumar,B., Schumacher,N., Sezin,T., Rose-John,S., Scheffold,A., Garbers,C. and Lokau,J.
    The metalloprotease ADAM10 generates soluble interleukin-2 receptor alpha (sCD25) in vivo
    J Biol Chem298, 101910-101910. PubMed  Europe PubMed DOI
  32. Louis,T.J., Qasem,A. and Naser,S.A.
    Attenuation of Excess TNF-alpha Release in Crohn's Disease by Silencing of iRHOMs 1/2 and the Restoration of TGF-beta Mediated Immunosuppression Through Modulation of TACE Trafficking
    Front Immunol13, 887830-887830. PubMed  Europe PubMed DOI  K
  33. Muller,M., Saunders,C., Senftleben,A., Heidbuechel,J.P.W., Halwachs,B., Bolik,J., Hedemann,N., Roder,C., Bauerschlag,D., Rose-John,S. and Schmidt-Arras,D.
    Tetraspanin 8 Subfamily Members Regulate Substrate-Specificity of a Disintegrin and Metalloprotease 17
    Cells11, 2683-2683. PubMed  Europe PubMed DOI
  34. Ojaghi,M., Varghese,J., Kastelic,J.P. and Thundathil,J.C.
    Characterization of the Testis-Specific Angiotensin Converting Enzyme (tACE)-Interactome during Bovine Sperm Capacitation
    Curr Issues Mol Biol44, 449-469. PubMed  Europe PubMed DOI
  35. Pellegatta,M., Canevazzi,P., Forese,M.G., Podini,P., Valenzano,S., Del Carro,U., Quattrini,A. and Taveggia,C.
    ADAM17 Regulates p75(NTR)-Mediated Fibrinolysis and Nerve Remyelination
    J Neurosci42, 2433-2447. PubMed  Europe PubMed DOI
  36. Reiss,K., Leitzke,S., Seidel,J., Sperrhacke,M. and Bhakdi,S.
    Scramblases as Regulators of Proteolytic ADAM Function
    Membranes (Basel)12, 185-185. PubMed  Europe PubMed DOI
  37. Saad,M.I., Weng,T., Lundy,J., Gearing,L.J., West,A.C., Harpur,C.M., Alanazi,M., Hodges,C., Croagh,D., Kumar,B., Sagi,I., Rose-John,S. and Jenkins,B.J.
    Blockade of the protease ADAM17 ameliorates experimental pancreatitis
    Proc Natl Acad Sci U S A119, e2213744119-e2213744119. PubMed  Europe PubMed DOI
  38. Saha,N., Xu,K., Zhu,Z., Robev,D., Kalidindi,T., Xu,Y., Himanen,J., de Stanchina,E., Pillarsetty,N.V.K., Dimitrov,D.S. and Nikolov,D.B.
    Inhibitory monoclonal antibody targeting ADAM17 expressed on cancer cells
    Transl Oncol15, 101265-101265. PubMed  Europe PubMed DOI
  39. Samuelov,L., Sarig,O., Malovitski,K., Bergson,S., Meijers,O., Shouval,D.S. and Sprecher,E.
    Neonatal inflammatory skin and bowel disease type 1 caused by a complex genetic defect and responsive to combined anti-TNF-alpha and IL-12/23 blockade
    Br J Dermatol186, 1026-1029. PubMed  Europe PubMed DOI
  40. Sieber,B., Lu,F., Stribbling,S.M., Grieve,A.G., Ryan,A.J. and Freeman,M.
    iRhom2 regulates ERBB signalling to promote KRAS-driven tumour growth of lung cancer cells
    J Cell Sci135, PubMed  Europe PubMed DOI
  41. Werny,L., Grogro,A., Bickenbach,K., Bulck,C., Armbrust,F., Koudelka,T., Pathak,K., Scharfenberg,F., Sammel,M., Sheikhouny,F., Tholey,A., Linder,S. and Becker-Pauly,C.
    MT1-MMP and ADAM10/17 exhibit a remarkable overlap of shedding properties
    FEBS J290, 93-111. PubMed  Europe PubMed DOI
  42. Zaruba,M., Chen,H.W., Pietsch,O.F., Szakmary-Braendle,K., Auer,A., Motz,M., Seitz,K., Dusterhoft,S., Workman,A.M., Rumenapf,T. and Riedel,C.
    ADAM17 Is an Essential Factor for the Infection of Bovine Cells with Pestiviruses
    Viruses14, PubMed  Europe PubMed DOI
  43. Zhao,Y., Davila,E.M., Li,X., Tang,B., Rabinowitsch,A.I., Perez-Aguilar,J.M. and Blobel,C.P.
    Identification of Molecular Determinants in iRhoms1 and 2 That Contribute to the Substrate Selectivity of Stimulated ADAM17
    Int J Mol Sci23, 12796-12796. PubMed  Europe PubMed DOI
    44. 2021
  44. Al-Salihi,M., Bornikoel,A., Zhuang,Y., Stachura,P., Scheller,J., Lang,K.S. and Lang,P.A.
    The role of ADAM17 during liver damage
    Biol Chem PubMed  Europe PubMed DOI
  45. Chen,X., Zhang,Y. and Guan,X.
    Simultaneous detection of multiple proteases using a non-array nanopore platform
    Nanoscale13, 13658-13664. PubMed  Europe PubMed DOI
  46. Fritsch,J., Frankenheim,J., Marischen,L., Vadasz,T., Troeger,A., Rose-John,S., Schmidt-Arras,D. and Schneider-Brachert,W.
    Roles for ADAM17 in TNF-R1 Mediated Cell Death and Survival in Human U937 and Jurkat Cells
    Cells10, PubMed  Europe PubMed DOI
  47. Healy,E.F. and Lilic,M.
    A model for COVID-19-induced dysregulation of ACE2 shedding by ADAM17
    Biochem Biophys Res Commun573, 158-163. PubMed  Europe PubMed DOI
  48. Khoury,E.E., Knaney,Y., Fokra,A., Kinaneh,S., Azzam,Z., Heyman,S.N. and Abassi,Z.
    Pulmonary, cardiac and renal distribution of ACE2, furin, TMPRSS2 and ADAM17 in rats with heart failure: Potential implication for COVID-19 disease
    J Cell Mol Med PubMed  Europe PubMed DOI
  49. Ma,X., Takahashi,Y., Wu,W., Liang,W., Chen,J., Chakraborty,D., Li,Y., Du,Y., Benyajati,S. and Ma,J.X.
    ADAM17 mediates ectodomain shedding of the soluble VLDL receptor fragment in the retinal epithelium
    J Biol Chem297, 101185-101185. PubMed  Europe PubMed DOI  K
  50. Maitra,S., Sornjai,W., Smith,D.R. and Vincent,B.
    Phenanthroline impairs betaAPP processing and expression, increases p53 protein levels and induces cell cycle arrest in human neuroblastoma cells
    Brain Res Bull170, 29-38. PubMed  Europe PubMed DOI  I
  51. Meyer-Schwesinger,C., Seipold,L. and Saftig,P.
    Ectodomain shedding by ADAM proteases as a central regulator in kidney physiology and disease
    Biochim Biophys Acta Mol Cell Res119165-119165. PubMed  Europe PubMed DOI
  52. Radziejewska,I., Borzym-Kluczyk,M. and Leszczynska,K.
    Luteolin alters MUC1 extracellular domain, sT antigen, ADAM-17, IL-8, IL-10 and NF-kappaB expression in Helicobacter pylori-infected gastric cancer CRL-1739 cells: A preliminary study
    Biomed Rep14, 19-19. PubMed  Europe PubMed DOI  I
  53. Rahman,M.M., Hasan,M. and Ahmed,A.
    Potential detrimental role of soluble ACE2 in severe COVID-19 comorbid patients
    Rev Med Virol31, 1-12. PubMed  Europe PubMed DOI  V
  54. Rahn,S. and Becker-Pauly,C.
    Meprin and ADAM proteases as triggers of systemic inflammation in sepsis
    FEBS Lett596, 534-556. PubMed  Europe PubMed DOI
  55. Schumacher,N. and Rose-John,S.
    ADAM17 orchestrates Interleukin-6, TNFalpha and EGF-R signaling in inflammation and cancer
    Biochim Biophys Acta Mol Cell Res1869, 119141-119141. PubMed  Europe PubMed DOI  V
  56. Schumertl,T., Lokau,J., Rose-John,S. and Garbers,C.
    Function and proteolytic generation of the soluble interleukin-6 receptor in health and disease
    Biochim Biophys Acta Mol Cell Res1869, 119143-119143. PubMed  Europe PubMed DOI  V
  57. Seidel,J., Leitzke,S., Ahrens,B., Sperrhacke,M., Bhakdi,S. and Reiss,K.
    Role of ADAM10 and ADAM17 in Regulating CD137 Function
    Int J Mol Sci22, 2730-2730. PubMed  Europe PubMed DOI
  58. Sharma,R.K., Li,J., Krishnan,S., Richards,E.M., Raizada,M.K. and Mohandas,R.
    Angiotensin-converting enzyme 2 and COVID-19 in cardiorenal diseases
    Clin Sci (Lond)135, 1-17. PubMed  Europe PubMed DOI  V
  59. Sisto,M., Ribatti,D. and Lisi,S.
    ADAM 17 and Epithelial-to-Mesenchymal Transition: The Evolving Story and Its Link to Fibrosis and Cancer
    J Clin Med10, 3373-3373. PubMed  Europe PubMed DOI  V
  60. Song,Y., Jo,S., Chung,J.Y., Oh,Y., Yoon,S., Lee,Y.L., Kim,S.S., Yang,J.H., Jang,K., Yang,C.S., Kim,T.H. and Kim,Y.H.
    RNA interference-mediated suppression of TNF-alpha converting enzyme as an alternative anti-TNF-alpha therapy for rheumatoid arthritis
    J Control Release330, 1300-1312. PubMed  Europe PubMed DOI
  61. Tateishi,H., Tateishi,M., Radwan,M.O., Masunaga,T., Kawatashiro,K., Oba,Y., Oyama,M., Inoue-Kitahashi,N., Fujita,M., Okamoto,Y. and Otsuka,M.
    A New Inhibitor of ADAM17 Composed of a Zinc-Binding Dithiol Moiety and a Specificity Pocket-Binding Appendage
    Chem Pharm Bull (Tokyo)69, 1123-1130.[PMID:c] DOI  I
  62. Tushaus,J., Muller,S.A., Shrouder,J., Arends,M., Simons,M., Plesnila,N., Blobel,C.P. and Lichtenthaler,S.F.
    The pseudoprotease iRhom1 controls ectodomain shedding of membrane proteins in the nervous system
    FASEB J35, e21962-e21962. PubMed  Europe PubMed DOI
  63. Viveiros,A., Rasmuson,J., Vu,J., Mulvagh,S.L., Yip,C.Y.Y., Norris,C.M. and Oudit,G.Y.
    Sex Differences in COVID-19: Candidate Pathways, Genetics of ACE2, and Sex Hormones
    Am J Physiol Heart Circ Physiol320, H296-H304. PubMed  Europe PubMed DOI
  64. Wang,L.F., Sun,Y.Y., Pan,Q., Yin,Y.Q., Tian,X.M., Liu,Y., Bu,T., Zhang,Q., Wang,Y.A., Zhao,J. and Luo,Y.
    Diminazen Aceturate Protects Pulmonary Ischemia-Reperfusion Injury via Inhibition of ADAM17-Mediated Angiotensin-Converting Enzyme 2 Shedding
    Front Pharmacol12, 713632-713632. PubMed  Europe PubMed DOI
  65. Yang,G., Cui,M., Jiang,W., Sheng,J., Yang,Y. and Zhang,X.
    Molecular switch in human diseases-disintegrin and metalloproteinases, ADAM17
    Aging (Albany NY)13, 16859-16872. PubMed  Europe PubMed DOI  V
  66. Zhang,X., Tang,L. and Zhang,Z.
    ADAM10 and ADAM17 are degraded by lysosomal pathway via asparagine endopeptidase
    Biochem Biophys Res Commun537, 15-21. PubMed  Europe PubMed DOI
  67. Zhu,J. and Steinberg,S.F.
    ß(1)-adrenergic receptor N-terminal cleavage by ADAM17; the mechanism for redox-dependent downregulation of cardiomyocyte ß(1)-adrenergic receptors
    J Mol Cell Cardiol154, 70-79. PubMed  Europe PubMed
    68. 2020
  68. Al-Salihi,M.A. and Lang,P.A.
    iRhom2: An Emerging Adaptor Regulating Immunity and Disease
    Int J Mol Sci21, PubMed  Europe PubMed DOI  V
  69. Andrews,L.P., Somasundaram,A., Moskovitz,J.M., Szymczak-Workman,A.L., Liu,C., Cillo,A.R., Lin,H., Normolle,D.P., Moynihan,K.D., Taniuchi,I., Irvine,D.J., Kirkwood,J.M., Lipson,E.J., Ferris,R.L., Bruno,T.C., Workman,C.J. and Vignali,D.A.A.
    Resistance to PD1 blockade in the absence of metalloprotease-mediated LAG3 shedding
    Sci Immunol5, PubMed  Europe PubMed DOI
  70. Babendreyer,A., Rojas-Gonzalez,D.M., Giese,A.A., Fellendorf,S., Dusterhoft,S., Mela,P. and Ludwig,A.
    Differential Induction of the ADAM17 Regulators iRhom1 and 2 in Endothelial Cells
    Front Cardiovasc Med7, 610344-610344. PubMed  Europe PubMed DOI
  71. Couselo-Seijas,M., Almenglo,C., Agra-Bermejo,M., Luis Fernandez,A., Alvarez,E., Gonzalez-Juanatey,R. and Eiras,S.
    Higher ACE2 expression levels in epicardial cells than subcutaneous stromal cells from patients with cardiovascular disease: Diabetes and obesity as possible enhancer
    Eur J Clin Investe13463-e13463. PubMed  Europe PubMed DOI
  72. Fang,R., Haxaire,C., Otero,M., Lessard,S., Weskamp,G., McIlwain,D.R., Mak,T.W., Lichtenthaler,S.F. and Blobel,C.P.
    Role of iRhoms 1 and 2 in Endochondral Ossification
    Int J Mol Sci21, PubMed  Europe PubMed DOI
  73. Flynn,C.M., Garbers,Y., Dusterhoft,S., Wichert,R., Lokau,J., Lehmann,C.H.K., Dudziak,D., Schroder,B., Becker-Pauly,C., Rose-John,S., Aparicio-Siegmund,S. and Garbers,C.
    Cathepsin S provokes interleukin-6 (IL-6) trans-signaling through cleavage of the IL-6 receptor in vitro
    Sci Rep10, 21612-21612. PubMed  Europe PubMed DOI
  74. Geesala,R., Issuree,P.D. and Maretzky,T.
    The Role of iRhom2 in Metabolic and Cardiovascular-Related Disorders
    Front Cardiovasc Med7, 612808-612808. PubMed  Europe PubMed DOI  V
  75. Guardiola,C.J.A., Clemente-Napimoga,J.T., Martinez,E.F., Abdalla,H.B., Peruzzo,D.C., Joly,J.C. and Napimoga,M.H.
    DC-STAMP and TACE Levels are Higher in Patients with Periodontitis
    Braz Dent J31, 122-126. PubMed  Europe PubMed DOI
  76. Lichtenthaler,S.F. and Meinl,E.
    To cut or not to cut: New rules for proteolytic shedding of membrane proteins
    J Biol Chem295, 12353-12354. PubMed  Europe PubMed DOI
  77. Lownik,J.C., Farrar,J.S., Pearce,J.V., Celi,F.S. and Martin,R.K.
    Adipocyte ADAM17 plays a limited role in metabolic inflammation
    Adipocyte9, 509-522. PubMed  Europe PubMed DOI  K
  78. Lu,H.Y., Chu,H.X., Tan,Y.X., Qin,X.C., Liu,M.Y., Li,J.D., Ren,T.S., Zhang,Y.S. and Zhao,Q.C.
    Novel ADAM-17 inhibitor ZLDI-8 inhibits the metastasis of hepatocellular carcinoma by reversing epithelial-mesenchymal transition in vitro and in vivo
    Life Sci244, 117343-117343. PubMed  Europe PubMed DOI  I
  79. Lu,W., Fei,A., Jiang,Y., Chen,L. and Wang,Y.
    Tetraspanin CD9 interacts with alpha-secretase to enhance its oncogenic function in pancreatic cancer
    Am J Transl Res12, 5525-5537. PubMed  Europe PubMed  K
  80. Mishra,H.K., Ma,J., Mendez,D., Hullsiek,R., Pore,N. and Walcheck,B.
    Blocking ADAM17 Function with a Monoclonal Antibody Improves Sepsis Survival in a Murine Model of Polymicrobial Sepsis
    Int J Mol Sci21, PubMed  Europe PubMed DOI
  81. Parekh,R.U. and Sriramula,S.
    Activation of Kinin B1R Upregulates ADAM17 and Results in ACE2 Shedding in Neurons
    Int J Mol Sci22, PubMed  Europe PubMed DOI
  82. Perez-Vizcaino,F.
    Lung ACE2 and ADAM17 in pulmonary arterial hypertension: Implications for COVID-19?
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