Literature for peptidase M12.217: ADAM17 peptidase

Summary Gene structure Alignment Tree Sequences Sequence features Distribution Structure Literature Substrates Pharma

(Topics flags: S Structure, A Assay, T Target, P Specificity, K Knockout, E Expression, V Review, M Mutation, I Inhibitor, L Localization. To select only the references relevant to a single topic, click the link above. See explanation.)

2026

Yu,Y., Babendreyer,A., Pabst,A., Michely,A., Tauscher,M., Martin,C., Kuhnel,M.P., Jonigk,D.D., Dusterhoft,S. and Ludwig,A. ADAM10 and ADAM17 differently mediate induced pulmonary ACE release by either direct proteolysis or indirect upregulation protein synthesis Biochim Biophys Acta Mol Cell Res (2026) 1873, 120112-120112. PubMed Europe PubMed DOI

2025

Bruno,F., Aceto,M.A., Paparazzo,E., Arcuri,D., Vozzo,F., Mirante,S., Greco,B.M., Serra Cassano,T., Abondio,P., Canterini,S., Malvaso,A., Grecucci,A., Citrigno,L., Geracitano,S., Spadafora,P., Puccio,G., Frangipane,F., Curcio,S.M., Ferrise,F., Lagana,V., Colao,R., Passarino,G., Bruni,A.C., Maletta,R., Cavalcanti,F. and Montesanto,A. Genetic variability in ADAM17/TACE is associated with sporadic Alzheimer's disease risk, neuropsychiatric symptoms and cognitive performance on the Rey Auditory Verbal Learning and Clock Drawing Tests PLoS ONE (2025) 20, e0309631-e0309631. PubMed Europe PubMed DOI PMC EPMC
Lu,F., Fournier,M. and Freeman,M. The cytoplasmic domain of the pseudoprotease iRhom2 mediates distinct signaling mechanisms to control activation of the cell surface protease ADAM17 J Biol Chem (2025) , 110643-110643. PubMed Europe PubMed DOI
Lumi Tanaka Dino,C., Maria Cavalli,B., Konzen Klein,C., Paes Gomes da Silva,F., Henrique Borges,N., Catharina Joaquim,A., Rodrigues Dos Santos,T., de Araujo,N., Baena Cartens,L., Simoes Florido Almeida,A.C., Nagashima,S., Busatta Vaz De Paula,C., Machado-Souza,C., de Noronha,L. and Bordignon Nogueira,M. Placental infection by SARS-CoV-2: exploring alternative entry pathways Tissue Barriers (2025) , 2585246-2585246. PubMed Europe PubMed DOI
Maciag,J.J., Slone,C.E., Alnajjar,H.F., Rich,M.F., Guion,B., Ifergan,I., Blobel,C.P. and Seegar,T.C.M. Structural insights into the activation and inhibition of the ADAM17-iRhom2 complex Proc Natl Acad Sci U S A (2025) 122, e2500732122-e2500732122. PubMed Europe PubMed DOI PMC EPMC
Moon,O.R., Newman,A.C., Alanazi,A.S., Wehenkel,S.C., Gawel-Beben,K., Ivetic,A., Price,D.A., Knauper,V. and Ager,A. TCR activation stimulates regulated intramembrane proteolysis of L-selectin by presenilin 1 and localized proteasomal degradation of the cytoplasmic tail J Biol Chem (2025) 301, 110473-110473. PubMed Europe PubMed DOI
Oliveira,K.B., de Souza,F.M.A., de Sa,L.B.M., Pacheco,A.L.D., Prado,M.R., de Sousa Rodrigues,C.F., Bassi,E.J., Santana-Melo,I., Silva-Junior,A., Sabino-Silva,R., Shetty,A.K. and de Castro,O.W. Potential Mechanisms Underlying COVID-19-Mediated Central and Peripheral Demyelination: Roles of the RAAS and ADAM-17 Mol Neurobiol (2025) 62, 1151-1164. PubMed Europe PubMed DOI V
Puthiyottil,S., Jose,D., Kuriakose,N. and Skaria,T. The developmental and inflammatory disease target protein ADAM17 is vulnerable to off-target interaction by the drug eltrombopag: Insights from molecular modeling Comput Biol Med (2025) 186, 109693-109693. PubMed Europe PubMed DOI

2024

Azzopardi,S.A., Lu,H.Y., Monette,S., Rabinowitsch,A.I., Salmon,J.E., Matsunami,H. and Blobel,C.P. Role of iRhom2 in Olfaction: Implications for Odorant Receptor Regulation and Activity-Dependent Adaptation Int J Mol Sci (2024) 25 PubMed Europe PubMed DOI PMC EPMC
Babendreyer,A., Kieselhorst,J., Rinkens,C., Lyashenko,A.M., Dusterhoft,S., Jahr,H., Craveiro,R.B., Wolf,M. and Ludwig,A. Downregulation of the metalloproteinases ADAM10 or ADAM17 promotes osteoclast differentiation Cell Commun Signal (2024) 22, 322-322. PubMed Europe PubMed DOI PMC EPMC
Bauer,L., Edwards,J., Heil,A., Dewitt,S., Biebermann,H., Aeschlimann,D. and Knauper,V. Mesenchymal Transglutaminase 2 Activates Epithelial ADAM17: Link to G-Protein-Coupled Receptor 56 (ADGRG1) Signalling Int J Mol Sci (2024) 25 PubMed Europe PubMed DOI PMC EPMC
Calligaris,M., Spano,D.P., Bonelli,S., Muller,S.A., Carcione,C., D'Apolito,D., Amico,G., Miele,M., Di Bella,M., Zito,G., Nuti,E., Rossello,A., Blobel,C.P., Lichtenthaler,S.F. and Scilabra,S.D. iRhom2 regulates ectodomain shedding and surface expression of the major histocompatibility complex (MHC) class I Cell Mol Life Sci (2024) 81, 163-163. PubMed Europe PubMed DOI PMC EPMC
Chen,H.W., Zaruba,M., Dawood,A., Dusterhoft,S., Lamp,B., Ruemenapf,T. and Riedel,C. Modulation of ADAM17 Levels by Pestiviruses Is Species-Specific Viruses (2024) 16 PubMed Europe PubMed DOI PMC EPMC
Ferreira-Santos,L., Ramirez-Perez,F.I., Foote,C.A., Augenreich,M.A., McMillan,N.J., Williams,M.B., Gonzalez-Vallejo,J.D., Power,G., Wheeler,A.A., Manrique-Acevedo,C., Martinez-Lemus,L.A. and Padilla,J. Neuraminidase-induced externalization of phosphatidylserine activates ADAM17 and impairs insulin signaling in endothelial cells Am J Physiol Heart Circ Physiol (2024) 326, H270-H270. PubMed Europe PubMed DOI
Liu,J., Su,G., Duan,C., Sun,Z., Xiao,S., Zhou,Y. and Fang,L. Porcine reproductive and respiratory syndrome virus infection activates ADAM17 to induce inflammatory responses Vet Microbiol (2024) 292, 110066-110066. PubMed Europe PubMed DOI
Lu,F., Zhao,H., Dai,Y., Wang,Y., Lee,C.H. and Freeman,M. Cryo-EM reveals that iRhom2 restrains ADAM17 protease activity to control the release of growth factor and inflammatory signals Mol Cell (2024) 84, 2152-2165. PubMed Europe PubMed DOI
Markham,M. and Troeberg,L. Using siRNA Silencing to Analyze ADAM17 in Macrophages Methods Mol Biol (2024) 2747, 119-129. PubMed Europe PubMed DOI
Saad,M.I. and Jenkins,B.J. The protease ADAM17 at the crossroads of disease: revisiting its significance in inflammation, cancer, and beyond FEBS J (2024) 291, 10-24. PubMed Europe PubMed DOI V
Wu,A., Shi,K., Wang,J., Zhang,R. and Wang,Y. Targeting SARS-CoV-2 entry processes: The promising potential and future of host-targeted small-molecule inhibitors Eur J Med Chem (2024) 263, 115923-115923. PubMed Europe PubMed DOI V
Zhu,B., Lane,M.D., Baller,J.A., Jagtap,P.D., Griffin,T.J. and Seelig,B. Comprehensive protease specificity profiling bioRxiv (2024) PubMed Europe PubMed DOI PMC EPMC

2023

Bhardwaj,T. and Giri,R. Potential of ADAM 17 Signal Peptide To Form Amyloid Aggregates in Vitro ACS Chem Neurosci (2023) 14, 3818-3825. PubMed Europe PubMed DOI
Dwivedi,S.D., Shukla,R., Yadav,K., Rathor,L.S., Singh,D. and Singh,M.R. Mechanistic insight on the role of iRhom2-TNF-alpha-BAFF signaling pathway in various autoimmune disorders Adv Biol Regul (2023) 92, 101011-101011. PubMed Europe PubMed DOI
Jiang,S., Yang,H., Sun,Z., Zhang,Y., Li,Y. and Li,J. The basis of complications in the context of SARS-CoV-2 infection: Pathological activation of ADAM17 Biochem Biophys Res Commun (2023) 679, 37-46. PubMed Europe PubMed DOI V
Maas,S.L., Donners,M.M.P.C. and van der Vorst,E.P.C. ADAM10 and ADAM17, Major Regulators of Chronic Kidney Disease Induced Atherosclerosis? Int J Mol Sci (2023) 24 PubMed Europe PubMed DOI PMC EPMC V
Rubina,A., Patel,M., Nightingale,K., Potts,M., Fielding,C.A., Kollnberger,S., Lau,B., Ladell,K., Miners,K.L., Nichols,J., Nobre,L., Roberts,D., Trinca,T.M., Twohig,J.P., Vlahava,V.M., Davison,A.J., Price,D.A., Tomasec,P., Wilkinson,G.W.G., Weekes,M.P., Stanton,R.J. and Wang,E.C.Y. ADAM17 targeting by human cytomegalovirus remodels the cell surface proteome to simultaneously regulate multiple immune pathways Proc Natl Acad Sci U S A (2023) 120, e2303155120-e2303155120. PubMed Europe PubMed DOI PMC EPMC
Schumacher,N., Thomsen,I., Brundert,F., Hejret,V., Dusterhoft,S., Tichy,B., Schmidt-Arras,D., Voss,M. and Rose-John,S. EGFR stimulation enables IL-6 trans-signalling via iRhom2-dependent ADAM17 activation in mammary epithelial cells Biochim Biophys Acta Mol Cell Res (2023) 1870, 119489-119489. PubMed Europe PubMed DOI
Sikora,H., Gruba,N., Wysocka,M., Piwkowska,A. and Lesner,A. Optimization of fluorescent substrates for ADAM17 and their utility in the detection of diabetes Anal Biochem (2023) 681, 115337-115337. PubMed Europe PubMed DOI

2022

Aljohmani,A., Andres,N.N. and Yildiz,D. Pseudomonas aeruginosa Alters Critical Lung Epithelial Cell Functions through Activation of ADAM17 Cells (2022) 11, 2303-2303. PubMed Europe PubMed DOI PMC EPMC
AmeliMojarad,M., AmeliMojarad,M. and Pourmahdian,A. Circular RNA circ_0051620 sponges miR-338-3p and regulates ADAM17 to promote the gastric cancer progression Pathol Res Pract (2022) 233, 153887-153887. PubMed Europe PubMed DOI
de Seabra Rodrigues Dias,I.R., Cao,Z. and Kwok,H.F. Adamalysins in COVID-19 - Potential mechanisms behind exacerbating the disease Biomed Pharmacother (2022) 150, 112970-112970. PubMed Europe PubMed DOI PMC EPMC V
Garrido,M.P., Vallejos,C., Girardi,S., Gabler,F., Selman,A., Lopez,F., Vega,M. and Romero,C. NGF/TRKA Promotes ADAM17-Dependent Cleavage of P75 in Ovarian Cells: Elucidating a Pro-Tumoral Mechanism Int J Mol Sci (2022) 23 PubMed Europe PubMed DOI PMC EPMC
Gul,C., Kilic,S. and Sehitoglu,M.H. The importance of a disintegrin and metalloproteinase (ADAM)10 and ADAM17 in the pathogenesis of psoriasis Clin Exp Dermatol (2022) 47, 1673-1678. PubMed Europe PubMed DOI
Healy,E.F. How tetraspanin-mediated cell entry of SARS-CoV-2 can dysregulate the shedding of the ACE2 receptor by ADAM17 Biochem Biophys Res Commun (2022) 593, 52-56. PubMed Europe PubMed DOI PMC EPMC
Hitschler,L. and Lang,T. The transmembrane domain of the amyloid precursor protein is required for antiamyloidogenic processing by alpha-secretase ADAM10 J Biol Chem (2022) 298, 101911-101911. PubMed Europe PubMed DOI PMC EPMC
Jocher,G., Grass,V., Tschirner,S.K., Riepler,L., Breimann,S., Kaya,T., Oelsner,M., Hamad,M.S., Hofmann,L.I., Blobel,C.P., Schmidt-Weber,C.B., Gokce,O., Jakwerth,C.A., Trimpert,J., Kimpel,J., Pichlmair,A. and Lichtenthaler,S.F. ADAM10 and ADAM17 promote SARS-CoV-2 cell entry and spike protein-mediated lung cell fusion EMBO Rep (2022) 23, e54305-e54305. PubMed Europe PubMed DOI
Kadurin,I., Dahimene,S., Page,K.M., Ellaway,J.I.J., Chaggar,K., Troeberg,L., Nagase,H. and Dolphin,A.C. ADAM17 Mediates Proteolytic Maturation of Voltage-Gated Calcium Channel Auxiliary alpha2delta Subunits, and Enables Calcium Current Enhancement Function (Oxf) (2022) 3, zqac013-zqac013. PubMed Europe PubMed DOI PMC EPMC
Kirschke,S., Ogunsulire,I., Selvakumar,B., Schumacher,N., Sezin,T., Rose-John,S., Scheffold,A., Garbers,C. and Lokau,J. The metalloprotease ADAM10 generates soluble interleukin-2 receptor alpha (sCD25) in vivo J Biol Chem (2022) 298, 101910-101910. PubMed Europe PubMed DOI PMC EPMC
Louis,T.J., Qasem,A. and Naser,S.A. Attenuation of Excess TNF-alpha Release in Crohn's Disease by Silencing of iRHOMs 1/2 and the Restoration of TGF-beta Mediated Immunosuppression Through Modulation of TACE Trafficking Front Immunol (2022) 13, 887830-887830. PubMed Europe PubMed DOI PMC EPMC K
Muller,M., Saunders,C., Senftleben,A., Heidbuechel,J.P.W., Halwachs,B., Bolik,J., Hedemann,N., Roder,C., Bauerschlag,D., Rose-John,S. and Schmidt-Arras,D. Tetraspanin 8 Subfamily Members Regulate Substrate-Specificity of a Disintegrin and Metalloprotease 17 Cells (2022) 11, 2683-2683. PubMed Europe PubMed DOI PMC EPMC
Ojaghi,M., Varghese,J., Kastelic,J.P. and Thundathil,J.C. Characterization of the Testis-Specific Angiotensin Converting Enzyme (tACE)-Interactome during Bovine Sperm Capacitation Curr Issues Mol Biol (2022) 44, 449-469. PubMed Europe PubMed DOI PMC EPMC
Pellegatta,M., Canevazzi,P., Forese,M.G., Podini,P., Valenzano,S., Del Carro,U., Quattrini,A. and Taveggia,C. ADAM17 Regulates p75(NTR)-Mediated Fibrinolysis and Nerve Remyelination J Neurosci (2022) 42, 2433-2447. PubMed Europe PubMed DOI PMC EPMC
Reiss,K., Leitzke,S., Seidel,J., Sperrhacke,M. and Bhakdi,S. Scramblases as Regulators of Proteolytic ADAM Function Membranes (Basel) (2022) 12, 185-185. PubMed Europe PubMed DOI PMC EPMC
Saad,M.I., Weng,T., Lundy,J., Gearing,L.J., West,A.C., Harpur,C.M., Alanazi,M., Hodges,C., Croagh,D., Kumar,B., Sagi,I., Rose-John,S. and Jenkins,B.J. Blockade of the protease ADAM17 ameliorates experimental pancreatitis Proc Natl Acad Sci U S A (2022) 119, e2213744119-e2213744119. PubMed Europe PubMed DOI PMC EPMC
Saha,N., Xu,K., Zhu,Z., Robev,D., Kalidindi,T., Xu,Y., Himanen,J., de Stanchina,E., Pillarsetty,N.V.K., Dimitrov,D.S. and Nikolov,D.B. Inhibitory monoclonal antibody targeting ADAM17 expressed on cancer cells Transl Oncol (2022) 15, 101265-101265. PubMed Europe PubMed DOI PMC EPMC
Samuelov,L., Sarig,O., Malovitski,K., Bergson,S., Meijers,O., Shouval,D.S. and Sprecher,E. Neonatal inflammatory skin and bowel disease type 1 caused by a complex genetic defect and responsive to combined anti-TNF-alpha and IL-12/23 blockade Br J Dermatol (2022) 186, 1026-1029. PubMed Europe PubMed DOI
Sieber,B., Lu,F., Stribbling,S.M., Grieve,A.G., Ryan,A.J. and Freeman,M. iRhom2 regulates ERBB signalling to promote KRAS-driven tumour growth of lung cancer cells J Cell Sci (2022) 135 PubMed Europe PubMed DOI PMC EPMC
Werny,L., Grogro,A., Bickenbach,K., Bulck,C., Armbrust,F., Koudelka,T., Pathak,K., Scharfenberg,F., Sammel,M., Sheikhouny,F., Tholey,A., Linder,S. and Becker-Pauly,C. MT1-MMP and ADAM10/17 exhibit a remarkable overlap of shedding properties FEBS J (2022) 290, 93-111. PubMed Europe PubMed DOI
Zaruba,M., Chen,H.W., Pietsch,O.F., Szakmary-Braendle,K., Auer,A., Motz,M., Seitz,K., Dusterhoft,S., Workman,A.M., Rumenapf,T. and Riedel,C. ADAM17 Is an Essential Factor for the Infection of Bovine Cells with Pestiviruses Viruses (2022) 14 PubMed Europe PubMed DOI PMC EPMC
Zhao,Y., Davila,E.M., Li,X., Tang,B., Rabinowitsch,A.I., Perez-Aguilar,J.M. and Blobel,C.P. Identification of Molecular Determinants in iRhoms1 and 2 That Contribute to the Substrate Selectivity of Stimulated ADAM17 Int J Mol Sci (2022) 23, 12796-12796. PubMed Europe PubMed DOI PMC EPMC

2021

Al-Salihi,M., Bornikoel,A., Zhuang,Y., Stachura,P., Scheller,J., Lang,K.S. and Lang,P.A. The role of ADAM17 during liver damage Biol Chem (2021) PubMed Europe PubMed DOI
Chen,X., Zhang,Y. and Guan,X. Simultaneous detection of multiple proteases using a non-array nanopore platform Nanoscale (2021) 13, 13658-13664. PubMed Europe PubMed DOI
Fritsch,J., Frankenheim,J., Marischen,L., Vadasz,T., Troeger,A., Rose-John,S., Schmidt-Arras,D. and Schneider-Brachert,W. Roles for ADAM17 in TNF-R1 Mediated Cell Death and Survival in Human U937 and Jurkat Cells Cells (2021) 10 PubMed Europe PubMed DOI PMC EPMC
Healy,E.F. and Lilic,M. A model for COVID-19-induced dysregulation of ACE2 shedding by ADAM17 Biochem Biophys Res Commun (2021) 573, 158-163. PubMed Europe PubMed DOI PMC EPMC
Khoury,E.E., Knaney,Y., Fokra,A., Kinaneh,S., Azzam,Z., Heyman,S.N. and Abassi,Z. Pulmonary, cardiac and renal distribution of ACE2, furin, TMPRSS2 and ADAM17 in rats with heart failure: Potential implication for COVID-19 disease J Cell Mol Med (2021) PubMed Europe PubMed DOI
Ma,X., Takahashi,Y., Wu,W., Liang,W., Chen,J., Chakraborty,D., Li,Y., Du,Y., Benyajati,S. and Ma,J.X. ADAM17 mediates ectodomain shedding of the soluble VLDL receptor fragment in the retinal epithelium J Biol Chem (2021) 297, 101185-101185. PubMed Europe PubMed DOI PMC EPMC K
Maitra,S., Sornjai,W., Smith,D.R. and Vincent,B. Phenanthroline impairs betaAPP processing and expression, increases p53 protein levels and induces cell cycle arrest in human neuroblastoma cells Brain Res Bull (2021) 170, 29-38. PubMed Europe PubMed DOI I
Meyer-Schwesinger,C., Seipold,L. and Saftig,P. Ectodomain shedding by ADAM proteases as a central regulator in kidney physiology and disease Biochim Biophys Acta Mol Cell Res (2021) , 119165-119165. PubMed Europe PubMed DOI
Radziejewska,I., Borzym-Kluczyk,M. and Leszczynska,K. Luteolin alters MUC1 extracellular domain, sT antigen, ADAM-17, IL-8, IL-10 and NF-kappaB expression in Helicobacter pylori-infected gastric cancer CRL-1739 cells: A preliminary study Biomed Rep (2021) 14, 19-19. PubMed Europe PubMed DOI PMC EPMC I
Rahman,M.M., Hasan,M. and Ahmed,A. Potential detrimental role of soluble ACE2 in severe COVID-19 comorbid patients Rev Med Virol (2021) 31, 1-12. PubMed Europe PubMed DOI V
Rahn,S. and Becker-Pauly,C. Meprin and ADAM proteases as triggers of systemic inflammation in sepsis FEBS Lett (2021) 596, 534-556. PubMed Europe PubMed DOI
Schumacher,N. and Rose-John,S. ADAM17 orchestrates Interleukin-6, TNFalpha and EGF-R signaling in inflammation and cancer Biochim Biophys Acta Mol Cell Res (2021) 1869, 119141-119141. PubMed Europe PubMed DOI V
Schumertl,T., Lokau,J., Rose-John,S. and Garbers,C. Function and proteolytic generation of the soluble interleukin-6 receptor in health and disease Biochim Biophys Acta Mol Cell Res (2021) 1869, 119143-119143. PubMed Europe PubMed DOI V
Seidel,J., Leitzke,S., Ahrens,B., Sperrhacke,M., Bhakdi,S. and Reiss,K. Role of ADAM10 and ADAM17 in Regulating CD137 Function Int J Mol Sci (2021) 22, 2730-2730. PubMed Europe PubMed DOI PMC EPMC
Sharma,R.K., Li,J., Krishnan,S., Richards,E.M., Raizada,M.K. and Mohandas,R. Angiotensin-converting enzyme 2 and COVID-19 in cardiorenal diseases Clin Sci (Lond) (2021) 135, 1-17. PubMed Europe PubMed DOI PMC EPMC V
Sisto,M., Ribatti,D. and Lisi,S. ADAM 17 and Epithelial-to-Mesenchymal Transition: The Evolving Story and Its Link to Fibrosis and Cancer J Clin Med (2021) 10, 3373-3373. PubMed Europe PubMed DOI PMC EPMC V
Song,Y., Jo,S., Chung,J.Y., Oh,Y., Yoon,S., Lee,Y.L., Kim,S.S., Yang,J.H., Jang,K., Yang,C.S., Kim,T.H. and Kim,Y.H. RNA interference-mediated suppression of TNF-alpha converting enzyme as an alternative anti-TNF-alpha therapy for rheumatoid arthritis J Control Release (2021) 330, 1300-1312. PubMed Europe PubMed DOI
Tateishi,H., Tateishi,M., Radwan,M.O., Masunaga,T., Kawatashiro,K., Oba,Y., Oyama,M., Inoue-Kitahashi,N., Fujita,M., Okamoto,Y. and Otsuka,M. A New Inhibitor of ADAM17 Composed of a Zinc-Binding Dithiol Moiety and a Specificity Pocket-Binding Appendage Chem Pharm Bull (Tokyo) (2021) 69, 1123-1130. [PMID:c] DOI I
Tushaus,J., Muller,S.A., Shrouder,J., Arends,M., Simons,M., Plesnila,N., Blobel,C.P. and Lichtenthaler,S.F. The pseudoprotease iRhom1 controls ectodomain shedding of membrane proteins in the nervous system FASEB J (2021) 35, e21962-e21962. PubMed Europe PubMed DOI
Viveiros,A., Rasmuson,J., Vu,J., Mulvagh,S.L., Yip,C.Y.Y., Norris,C.M. and Oudit,G.Y. Sex Differences in COVID-19: Candidate Pathways, Genetics of ACE2, and Sex Hormones Am J Physiol Heart Circ Physiol (2021) 320, H296-H304. PubMed Europe PubMed DOI
Wang,L.F., Sun,Y.Y., Pan,Q., Yin,Y.Q., Tian,X.M., Liu,Y., Bu,T., Zhang,Q., Wang,Y.A., Zhao,J. and Luo,Y. Diminazen Aceturate Protects Pulmonary Ischemia-Reperfusion Injury via Inhibition of ADAM17-Mediated Angiotensin-Converting Enzyme 2 Shedding Front Pharmacol (2021) 12, 713632-713632. PubMed Europe PubMed DOI PMC EPMC
Yang,G., Cui,M., Jiang,W., Sheng,J., Yang,Y. and Zhang,X. Molecular switch in human diseases-disintegrin and metalloproteinases, ADAM17 Aging (Albany NY) (2021) 13, 16859-16872. PubMed Europe PubMed DOI PMC EPMC V
Zhang,X., Tang,L. and Zhang,Z. ADAM10 and ADAM17 are degraded by lysosomal pathway via asparagine endopeptidase Biochem Biophys Res Commun (2021) 537, 15-21. PubMed Europe PubMed DOI
Zhu,J. and Steinberg,S.F. ß(1)-adrenergic receptor N-terminal cleavage by ADAM17; the mechanism for redox-dependent downregulation of cardiomyocyte ß(1)-adrenergic receptors J Mol Cell Cardiol (2021) 154, 70-79. PubMed Europe PubMed

2020

Al-Salihi,M.A. and Lang,P.A. iRhom2: An Emerging Adaptor Regulating Immunity and Disease Int J Mol Sci (2020) 21 PubMed Europe PubMed DOI PMC EPMC V
Andrews,L.P., Somasundaram,A., Moskovitz,J.M., Szymczak-Workman,A.L., Liu,C., Cillo,A.R., Lin,H., Normolle,D.P., Moynihan,K.D., Taniuchi,I., Irvine,D.J., Kirkwood,J.M., Lipson,E.J., Ferris,R.L., Bruno,T.C., Workman,C.J. and Vignali,D.A.A. Resistance to PD1 blockade in the absence of metalloprotease-mediated LAG3 shedding Sci Immunol (2020) 5 PubMed Europe PubMed DOI
Babendreyer,A., Rojas-Gonzalez,D.M., Giese,A.A., Fellendorf,S., Dusterhoft,S., Mela,P. and Ludwig,A. Differential Induction of the ADAM17 Regulators iRhom1 and 2 in Endothelial Cells Front Cardiovasc Med (2020) 7, 610344-610344. PubMed Europe PubMed DOI PMC EPMC
Couselo-Seijas,M., Almenglo,C., Agra-Bermejo,M., Luis Fernandez,A., Alvarez,E., Gonzalez-Juanatey,R. and Eiras,S. Higher ACE2 expression levels in epicardial cells than subcutaneous stromal cells from patients with cardiovascular disease: Diabetes and obesity as possible enhancer Eur J Clin Invest (2020) , e13463-e13463. PubMed Europe PubMed DOI PMC EPMC
Fang,R., Haxaire,C., Otero,M., Lessard,S., Weskamp,G., McIlwain,D.R., Mak,T.W., Lichtenthaler,S.F. and Blobel,C.P. Role of iRhoms 1 and 2 in Endochondral Ossification Int J Mol Sci (2020) 21 PubMed Europe PubMed DOI PMC EPMC
Flynn,C.M., Garbers,Y., Dusterhoft,S., Wichert,R., Lokau,J., Lehmann,C.H.K., Dudziak,D., Schroder,B., Becker-Pauly,C., Rose-John,S., Aparicio-Siegmund,S. and Garbers,C. Cathepsin S provokes interleukin-6 (IL-6) trans-signaling through cleavage of the IL-6 receptor in vitro Sci Rep (2020) 10, 21612-21612. PubMed Europe PubMed DOI PMC EPMC
Geesala,R., Issuree,P.D. and Maretzky,T. The Role of iRhom2 in Metabolic and Cardiovascular-Related Disorders Front Cardiovasc Med (2020) 7, 612808-612808. PubMed Europe PubMed DOI PMC EPMC V
Guardiola,C.J.A., Clemente-Napimoga,J.T., Martinez,E.F., Abdalla,H.B., Peruzzo,D.C., Joly,J.C. and Napimoga,M.H. DC-STAMP and TACE Levels are Higher in Patients with Periodontitis Braz Dent J (2020) 31, 122-126. PubMed Europe PubMed DOI
Lichtenthaler,S.F. and Meinl,E. To cut or not to cut: New rules for proteolytic shedding of membrane proteins J Biol Chem (2020) 295, 12353-12354. PubMed Europe PubMed DOI PMC EPMC
Lownik,J.C., Farrar,J.S., Pearce,J.V., Celi,F.S. and Martin,R.K. Adipocyte ADAM17 plays a limited role in metabolic inflammation Adipocyte (2020) 9, 509-522. PubMed Europe PubMed DOI K
Lu,H.Y., Chu,H.X., Tan,Y.X., Qin,X.C., Liu,M.Y., Li,J.D., Ren,T.S., Zhang,Y.S. and Zhao,Q.C. Novel ADAM-17 inhibitor ZLDI-8 inhibits the metastasis of hepatocellular carcinoma by reversing epithelial-mesenchymal transition in vitro and in vivo Life Sci (2020) 244, 117343-117343. PubMed Europe PubMed DOI I
Lu,W., Fei,A., Jiang,Y., Chen,L. and Wang,Y. Tetraspanin CD9 interacts with alpha-secretase to enhance its oncogenic function in pancreatic cancer Am J Transl Res (2020) 12, 5525-5537. PubMed Europe PubMed PMC EPMC K
Mishra,H.K., Ma,J., Mendez,D., Hullsiek,R., Pore,N. and Walcheck,B. Blocking ADAM17 Function with a Monoclonal Antibody Improves Sepsis Survival in a Murine Model of Polymicrobial Sepsis Int J Mol Sci (2020) 21 PubMed Europe PubMed DOI PMC EPMC
Parekh,R.U. and Sriramula,S. Activation of Kinin B1R Upregulates ADAM17 and Results in ACE2 Shedding in Neurons Int J Mol Sci (2020) 22 PubMed Europe PubMed DOI PMC EPMC
Perez-Vizcaino,F. Lung ACE2 and ADAM17 in pulmonary arterial hypertension: Implications for COVID-19? J Heart Lung Transplant (2020) PubMed Europe PubMed DOI PMC EPMC
Ragia,G. and Manolopoulos,V.G. Inhibition of SARS-CoV-2 entry through the ACE2/TMPRSS2 pathway: a promising approach for uncovering early COVID-19 drug therapies Eur J Clin Pharmacol (2020) PubMed Europe PubMed DOI PMC EPMC V I
Ragia,G. and Manolopoulos,V.G. Assessing COVID-19 susceptibility through analysis of the genetic and epigenetic diversity of ACE2 mediated SARS-CoV-2 entry Pharmacogenomics (2020) PubMed Europe PubMed DOI PMC EPMC
Roman-Melendez,G.D., Venkataraman,T., Monaco,D.R. and Larman,H.B. Protease Activity Profiling via Programmable Phage Display of Comprehensive Proteome-Scale Peptide Libraries Cell Syst (2020) 11, 375-381. PubMed Europe PubMed DOI
Saad,M.I., McLeod,L., Hodges,C., Vlahos,R., Rose-John,S., Ruwanpura,S. and Jenkins,B.J. ADAM17 Deficiency Protects Against Pulmonary Emphysema Am J Respir Cell Mol Biol (2020) PubMed Europe PubMed DOI
Scharfenberg,F., Helbig,A., Sammel,M., Benzel,J., Schlomann,U., Peters,F., Wichert,R., Bettendorff,M., Schmidt-Arras,D., Rose-John,S., Moali,C., Lichtenthaler,S.F., Pietrzik,C.U., Bartsch,J.W., Tholey,A. and Becker-Pauly,C. Degradome of soluble ADAM10 and ADAM17 metalloproteases Cell Mol Life Sci (2020) 77, 331-350. PubMed Europe PubMed DOI P
Skurski,J., Dixit,G., Blobel,C.P., Issuree,P.D. and Maretzky,T. The Threshold Effect: Lipopolysaccharide-Induced Inflammatory Responses in Primary Macrophages Are Differentially Regulated in an iRhom2-Dependent Manner Front Cell Infect Microbiol (2020) 10, 620392-620392. PubMed Europe PubMed DOI PMC EPMC
Snyder,K.M., McAloney,C.A., Montel,J.S., Modiano,J.F. and Walcheck,B. Ectodomain shedding by ADAM17 (a disintegrin and metalloproteinase 17) in canine neutrophils Vet Immunol Immunopathol (2020) 231, 110162-110162. PubMed Europe PubMed DOI
Soto-Gamez,A., Chen,D., Nabuurs,A.G.E., Quax,W.J., Demaria,M. and Boersma,A.Y.L. A bispecific inhibitor of the EGFR/ADAM17 axis decreases cell proliferation and migration of EGFR-dependent cancer cells Cancers (Basel) (2020) 12 PubMed Europe PubMed DOI
Taneera,J., El-Huneidi,W., Hamad,M., Mohammed,A.K., Elaraby,E. and Hachim,M.Y. Expression Profile of SARS-CoV-2 Host Receptors in Human Pancreatic Islets Revealed Upregulation of ACE2 in Diabetic Donors Biology (Basel) (2020) 9 PubMed Europe PubMed DOI PMC EPMC
Tang,B., Li,X., Maretzky,T., Perez-Aguilar,J.M., McIlwain,D., Xie,Y., Zheng,Y., Mak,T.W., Weinstein,H. and Blobel,C.P. Substrate-selective protein ectodomain shedding by ADAM17 and iRhom2 depends on their juxtamembrane and transmembrane domains FASEB J (2020) 34, 4956-4969. PubMed Europe PubMed DOI
Weskamp,G., Tushaus,J., Li,D., Feederle,R., Maretzky,T., Swendemann,S., Falck-Pedersen,E., McIlwain,D.R., Mak,T.W., Salmon,J.E., Lichtenthaler,S.F. and Blobel,C.P. ADAM17 stabilizes its interacting partner inactive rhomboid 2 (iRhom2) but not inactive rhomboid 1 (iRhom1) J Biol Chem (2020) 295, 4350-4358. PubMed Europe PubMed DOI
Zhou,C., Qin,Y., Chen,R., Gao,F., Zhang,J. and Lu,F. Fenugreek attenuates obesity-induced inflammation and improves insulin resistance through downregulation of iRhom2/TACE Life Sci (2020) 258, 118222-118222. PubMed Europe PubMed DOI
Zipeto,D., Palmeira,J.D.F., Arganaraz,G.A. and Arganaraz,E.R. ACE2/ADAM17/TMPRSS2 Interplay May Be the Main Risk Factor for COVID-19 Front Immunol (2020) 11, 576745-576745. PubMed Europe PubMed DOI PMC EPMC V

2019

Lu,H.Y., Zu,Y.X., Jiang,X.W., Sun,X.T., Liu,T.Y., Li,R.L., Wu,Q., Zhang,Y.S. and Zhao,Q.C. Novel ADAM-17 inhibitor ZLDI-8 inhibits the proliferation and metastasis of chemo-resistant non-small-cell lung cancer by reversing Notch and epithelial mesenchymal transition in vitro and in vivo Pharmacol Res (2019) 148, 104406-104406. PubMed Europe PubMed DOI I
Maekawa,M., Tadaki,H., Tomimoto,D., Okuma,C., Sano,R., Ishii,Y., Katsuda,Y., Yoshiuchi,H., Kakefuda,R., Ohta,T. and Sasase,T. A novel TNF-alpha converting enzyme (TACE) selective inhibitor JTP-96193 prevents insulin resistance in KK-A(y) Type 2 diabetic mice and diabetic peripheral neuropathy in Type 1 diabetic mice Biol Pharm Bull (2019) 42, 1906-1912. PubMed Europe PubMed DOI I
Mohammed,R.N., Wehenkel,S.C., Galkina,E.V., Yates,E.K., Preece,G., Newman,A., Watson,H.A., Ohme,J., Bridgeman,J.S., Durairaj,R.R.P., Moon,O.R., Ladell,K., Miners,K.L., Dolton,G., Troeberg,L., Kashiwagi,M., Murphy,G., Nagase,H., Price,D.A., Matthews,R.J., Knauper,V. and Ager,A. ADAM17-dependent proteolysis of L-selectin promotes early clonal expansion of cytotoxic T cells Sci Rep (2019) 9, 5487-5487. PubMed Europe PubMed DOI PMC EPMC
Saha,N., Robev,D., Himanen,J.P. and Nikolov,D.B. ADAM proteases: emerging role and targeting of the non-catalytic domains Cancer Lett (2019) 467, 50-57. PubMed Europe PubMed DOI
Veit,M., Ahrens,B., Seidel,J., Sommer,A., Bhakdi,S. and Reiss,K. Mutagenesis of the ADAM17-phosphatidylserine-binding motif leads to embryonic lethality in mice Life Sci Alliance (2019) 2, e201900430-e201900430. PubMed Europe PubMed
Wichert,R., Scharfenberg,F., Colmorgen,C., Koudelka,T., Schwarz,J., Wetzel,S., Potempa,B., Potempa,J., Bartsch,J.W., Sagi,I., Tholey,A., Saftig,P., Rose-John,S. and Becker-Pauly,C. Meprin beta induces activities of a disintegrin and metalloproteinases 9, 10, and 17 by specific prodomain cleavage FASEB J (2019) 33, 11925-11940. PubMed Europe PubMed DOI

2018

Cabron,A.S., El Azzouzi,K., Boss,M., Arnold,P., Schwarz,J., Rosas,M., Dobert,J.P., Pavlenko,E., Schumacher,N., Renne,T., Taylor,P.R., Linder,S., Rose-John,S. and Zunke,F. Structural and functional analyses of the shedding protease ADAM17 in HoxB8-immortalized macrophages and dendritic-like cells J Immunol (2018) 201, 3106-3118. PubMed Europe PubMed DOI
Krossa,S., Scheidig,A.J., Grotzinger,J. and Lorenzen,I. Redundancy of protein disulfide isomerases in the catalysis of the inactivating disulfide switch in A Disintegrin and Metalloprotease 17 Sci Rep (2018) 8, 1103-1103. PubMed Europe PubMed DOI PMC EPMC
Kunzel,U., Grieve,A.G., Meng,Y., Sieber,B., Cowley,S.A. and Freeman,M. FRMD8 promotes inflammatory and growth factor signalling by stabilising the iRhom/ADAM17 sheddase complex elife (2018) 7, e35012-e35012. PubMed Europe PubMed DOI
Li,Y.Q., Liu,Y.S., Ying,X.W., Zhou,H.B., Wang,Z., Wu,S.C., Yan,J.P., Jing,Y.T. and Yang,Y. Lentivirus-mediated disintegrin and metalloproteinase 17 RNA interference reversed the acquired resistance to gefitinib in lung adenocarcinoma cells in vitro Biotechnol Prog (2018) 34, 196-205. PubMed Europe PubMed DOI K
Nicolaou,A., Northoff,B.H., Zhao,Z., Kohlmaier,A., Sass,K., Rose-John,S., Steffens,S., Weber,C., Teupser,D. and Holdt,L.M. The ADAM17 metalloproteinase maintains arterial elasticity Thromb Haemost (2018) 118, 210-213. PubMed Europe PubMed DOI
Schaal,J.B., Maretzky,T., Tran,D.Q., Tran,P.A., Tongaonkar,P., Blobel,C.P., Ouellette,A.J. and Selsted,M.E. Macrocyclic theta-defensins suppress tumor necrosis factor-alpha (TNF-alpha) shedding by inhibition of TNF-alpha-converting enzyme J Biol Chem (2018) 293, 2725-2734. PubMed Europe PubMed DOI
Zhang,Y., Li,D., Jiang,Q., Cao,S., Sun,H., Chai,Y., Li,X., Ren,T., Yang,R., Feng,F., Li,B.A. and Zhao,Q. Novel ADAM-17 inhibitor ZLDI-8 enhances the in vitro and in vivo chemotherapeutic effects of Sorafenib on hepatocellular carcinoma cells Cell Death Dis (2018) 9, 743-743. PubMed Europe PubMed DOI PMC EPMC I

2017

Cavadas,M., Oikonomidi,I., Gaspar,C.J., Burbridge,E., Badenes,M., Felix,I., Bolado,A., Hu,T., Bileck,A., Gerner,C., Domingos,P.M., von Kriegsheim,A. and Adrain,C. Phosphorylation of iRhom2 controls stimulated proteolytic shedding by the metalloprotease ADAM17/TACE Cell Rep (2017) 21, 745-757. PubMed Europe PubMed DOI
Feuerbach,D., Schindler,P., Barske,C., Joller,S., Beng-Louka,E., Worringer,K.A., Kommineni,S., Kaykas,A., Ho,D.J., Ye,C., Welzenbach,K., Elain,G., Klein,L., Brzak,I., Mir,A.K., Farady,C.J., Aichholz,R., Popp,S., George,N. and Neumann,U. ADAM17 is the main sheddase for the generation of human triggering receptor expressed in myeloid cells (hTREM2) ectodomain and cleaves TREM2 after Histidine 157 Neurosci Lett (2017) 660, 109-114. PubMed Europe PubMed DOI
Grotzinger,J., Lorenzen,I. and Dusterhoft,S. Molecular insights into the multilayered regulation of ADAM17: the role of the extracellular region Biochim Biophys Acta (2017) 1864, 2088-2095. PubMed Europe PubMed DOI
Li,X., Maretzky,T., Perez-Aguilar,J.M., Monette,S., Weskamp,G., Le Gall,S., Beutler,B., Weinstein,H. and Blobel,C.P. Structural modeling defines transmembrane residues in ADAM17 that are crucial for Rhbdf2-ADAM17-dependent proteolysis J Cell Sci (2017) 130, 868-878. PubMed Europe PubMed DOI
Matthews,A.L., Noy,P.J., Reyat,J.S. and Tomlinson,M.G. Regulation of A disintegrin and metalloproteinase (ADAM) family sheddases ADAM10 and ADAM17: the emerging role of tetraspanins and rhomboids Platelets (2017) 28, 333-341. PubMed Europe PubMed DOI
Schafer,M., Granato,D.C., Krossa,S., Bartels,A.K., Yokoo,S., Dusterhoft,S., Koudelka,T., Scheidig,A.J., Tholey,A., Paes Leme,A.F., Grotzinger,J. and Lorenzen,I. GRP78 protects a disintegrin and metalloprotease 17 against protein-disulfide isomerase A6 catalyzed inactivation FEBS Lett (2017) 591, 3567-3587. PubMed Europe PubMed DOI
Wu,J., Tao,N., Tian,Y., Xing,G., Lv,H., Han,J., Lin,C. and Xie,W. Proteolytic maturation of Drosophila neuroligin 3 by tumor necrosis factor alpha-converting enzyme in the nervous system Biochim Biophys Acta (2017) 1862, 440-450. PubMed Europe PubMed DOI
Yamamoto,K., Santamaria,S., Botkjaer,K.A., Dudhia,J., Troeberg,L., Itoh,Y., Murphy,G. and Nagase,H. Inhibition of shedding of low-density lipoprotein receptor-related protein 1 reverses cartilage matrix degradation in osteoarthritis Arthritis Rheumatol (2017) 69, 1246-1256. PubMed Europe PubMed DOI
Zunke,F. and Rose-John,S. The shedding protease ADAM17: physiology and pathophysiology Biochim Biophys Acta (2017) 1864, 2059-2070. PubMed Europe PubMed DOI V

2016

Alizadeh,A.A., Hamzeh-Mivehroud,M., Sokouti,B. and Dastmalchi,S. An alignment-independent 3D-QSAR study on series of hydroxamic acid-based tumor necrosis factor-alpha converting enzyme inhibitors J Chemometr (2016) 30, 537-547. DOI I
Fan,D., Takawale,A., Shen,M., Samokhvalov,V., Basu,R., Patel,V., Wang,X., Fernandez-Patron,C., Seubert,J.M., Oudit,G.Y. and Kassiri,Z. A disintegrin and metalloprotease-17 regulates pressure overload-induced myocardial hypertrophy and dysfunction through proteolytic processing of integrin beta1 Hypertension (2016) 68, 937-948. PubMed Europe PubMed DOI K
Franke,M., Schroder,J., Monhasery,N., Ackfeld,T., Hummel,T.M., Rabe,B., Garbers,C., Becker-Pauly,C., Floss,D.M. and Scheller,J. Human and murine Interleukin 23 receptors are novel substrates for a disintegrin and metalloproteases ADAM10 and ADAM17 J Biol Chem (2016) 291, 10551-10561. PubMed Europe PubMed DOI
Kanzaki,H., Shinohara,F., Suzuki,M., Wada,S., Miyamoto,Y., Yamaguchi,Y., Katsumata,Y., Makihira,S., Kawai,T., Taubman,M.A. and Nakamura,Y. A-disintegrin and metalloproteinase (ADAM) 17 enzymatically degrades interferon-gamma Sci Rep (2016) 6, 32259-32259. PubMed Europe PubMed DOI PMC EPMC
Lokau,J., Nitz,R., Agthe,M., Monhasery,N., Aparicio-Siegmund,S., Schumacher,N., Wolf,J., Moller-Hackbarth,K., Waetzig,G.H., Grotzinger,J., Muller-Newen,G., Rose-John,S., Scheller,J. and Garbers,C. Proteolytic cleavage governs interleukin-11 trans-signaling Cell Rep (2016) 14, 1761-1773. PubMed Europe PubMed DOI P
Moss,M.L., Minond,D., Yoneyama,T., Hansen,H.P., Vujanovic,N. and Rasmussen,F.H. An improved fluorescent substrate for assaying soluble and membrane-associated ADAM family member activities Anal Biochem (2016) 507, 13-17. PubMed Europe PubMed DOI A
Orme,J.J., Du,Y., Vanarsa,K., Mayeux,J., Li,L., Mutwally,A., Arriens,C., Min,S., Hutcheson,J., Davis,L.S., Chong,B.F., Satterthwaite,A.B., Wu,T. and Mohan,C. Heightened cleavage of Axl receptor tyrosine kinase by ADAM metalloproteases may contribute to disease pathogenesis in SLE Clin Immunol (2016) 169, 58-68. PubMed Europe PubMed DOI T
Riethmueller,S., Ehlers,J.C., Lokau,J., Dusterhoft,S., Knittler,K., Dombrowsky,G., Grotzinger,J., Rabe,B., Rose-John,S. and Garbers,C. Cleavage site localization differentially controls interleukin-6 receptor proteolysis by ADAM10 and ADAM17 Sci Rep (2016) 6, 25550-25550. PubMed Europe PubMed DOI P
Sommer,A., Bhakdi,S. and Reiss,K. How membrane asymmetry regulates ADAM17 sheddase function Cell Cycle (2016) 15, 2995-2996. PubMed Europe PubMed DOI
[YEAR:10-5-2016]Sommer,A., Kordowski,F., Büch,J., Maretzky,T., Evers,A., Andrä,J., Düsterhöft,S., Michalek,M., Lorenzen,I., Somasundaram,P., Tholey,A., Sönnichsen,F.D., Kunzelmann,K., Heinbockel,L., Nehls,C., Gutsmann,T., Grötzinger,J., Bhakdi,S. and Reiss,K. Phosphatidylserine exposure is required for ADAM17 sheddase function Nat Commun (10-5-2016) 7, 11523-11523. PubMed Europe PubMed
Wang,Z., Wang,L., Fan,R., Zhou,J. and Zhong,J. Molecular design and structural optimization of potent peptide hydroxamate inhibitors to selectively target human ADAM metallopeptidase domain 17 Comput Biol Chem (2016) 61, 15-22. PubMed Europe PubMed DOI I
Wong,E., Cohen,T., Romi,E., Levin,M., Peleg,Y., Arad,U., Yaron,A., Milla,M.E. and Sagi,I. Harnessing the natural inhibitory domain to control TNFalpha converting enzyme (TACE) activity in vivo Sci Rep (2016) 6, 35598-35598. PubMed Europe PubMed DOI PMC EPMC
Xu,J., Mukerjee,S., Silva-Alves,C.R., Carvalho-Galvao,A., Cruz,J.C., Balarini,C.M., Braga,V.A., Lazartigues,E. and Franca-Silva,M.S. A disintegrin and metalloprotease 17 in the cardiovascular and central nervous systems Front Physiol (2016) 7, 469-469. PubMed Europe PubMed DOI PMC EPMC V

2015

Andrews,R.K. and Gardiner,E.E. Editorial: ADAMs control inflammation from afar J Leukoc Biol (2015) 97, 437-438. PubMed Europe PubMed DOI
Chapnick,D.A., Bunker,E. and Liu,X. A biosensor for the activity of the "sheddase" TACE (ADAM17) reveals novel and cell type-specific mechanisms of TACE activation Sci Signal (2015) 8, rs1-rs1. PubMed Europe PubMed DOI A
Knapinska,A.M., Dreymuller,D., Ludwig,A., Smith,L., Golubkov,V., Sohail,A., Fridman,R., Giulianotti,M., LaVoi,T.M., Houghten,R.A., Fields,G.B. and Minond,D. SAR Studies of exosite-binding substrate-selective inhibitors of a disintegrin and metalloprotease 17 (ADAM17) and application as selective in vitro probes J Med Chem (2015) 58, 5808-5824. PubMed Europe PubMed DOI I
Leung,C.H., Liu,L.J., Lu,L., He,B., Kwong,D.W., Wong,C.Y. and Ma,D.L. A metal-based tumour necrosis factor-alpha converting enzyme inhibitor Chem Commun (Camb) (2015) 51, 3973-3976. PubMed Europe PubMed DOI I
Li,X., Maretzky,T., Weskamp,G., Monette,S., Qing,X., Issuree,P.D., Crawford,H.C., McIlwain,D.R., Mak,T.W., Salmon,J.E. and Blobel,C.P. iRhoms 1 and 2 are essential upstream regulators of ADAM17-dependent EGFR signaling Proc Natl Acad Sci U S A (2015) 112, 6080-6085. PubMed Europe PubMed DOI
Lu,X.J., Chen,Q., Yang,G.J. and Chen,J. The TNFalpha converting enzyme (TACE) from ayu (Plecoglossus altivelis) exhibits TNFalpha shedding activity Mol Immunol (2015) 63, 497-504. PubMed Europe PubMed DOI
Pasqualon,T., Pruessmeyer,J., Weidenfeld,S., Babendreyer,A., Groth,E., Schumacher,J., Schwarz,N., Denecke,B., Jahr,H., Zimmermann,P., Dreymueller,D. and Ludwig,A. A transmembrane C-terminal fragment of syndecan-1 is generated by the metalloproteinase ADAM17 and promotes lung epithelial tumor cell migration and lung metastasis formation Cell Mol Life Sci (2015) 72, 3783-3801. PubMed Europe PubMed DOI
Wong,E., Maretzky,T., Peleg,Y., Blobel,C.P. and Sagi,I. The functional maturation of A Disintegrin and Metalloproteinase (ADAM) 9, 10, and 17 requires processing at a newly identified proprotein convertase (PC) cleavage site J Biol Chem (2015) 290, 12135-12146. PubMed Europe PubMed DOI
Wu,D., Gu,Q., Zhao,N., Xia,F. and Li,Z. Structure-based rational design of peptide hydroxamic acid inhibitors to target tumor necrosis factor-alpha converting enzyme as potential therapeutics for hepatitis J Drug Target (2015) 23, 936-942. PubMed Europe PubMed DOI I
Wu,L., Claas,A.M., Sarkar,A., Lauffenburger,D.A. and Han,J. High-throughput protease activity cytometry reveals dose-dependent heterogeneity in PMA-mediated ADAM17 activation Integr Biol (Camb) (2015) 7, 513-524. PubMed Europe PubMed DOI L

2014

Chavaroche,A., Cudic,M., Giulianotti,M., Houghten,R.A., Fields,G.B. and Minond,D. Glycosylation of a disintegrin and metalloprotease 17 affects its activity and inhibition Anal Biochem (2014) 449, 68-75. PubMed Europe PubMed DOI
Dusterhoft,S., Hobel,K., Oldefest,M., Lokau,J., Waetzig,G.H., Chalaris,A., Garbers,C., Scheller,J., Rose-John,S., Lorenzen,I. and Grotzinger,J. A disintegrin and metalloprotease 17 dynamic interaction sequence, the sweet tooth for the human interleukin 6 receptor J Biol Chem (2014) 289, 16336-16348. PubMed Europe PubMed DOI
Guo,L., Niu,J., Yu,H., Gu,W., Li,R., Luo,X., Huang,M., Tian,Z., Feng,L. and Wang,Y. Modulation of CD163 expression by metalloprotease ADAM17 regulates porcine reproductive and respiratory syndrome virus entry J Virol (2014) 88, 10448-10458. PubMed Europe PubMed DOI
Lisi,S., D'Amore,M. and Sisto,M. ADAM17 at the interface between inflammation and autoimmunity Immunol Lett (2014) 162, 159-169. PubMed Europe PubMed DOI V
Liu,S., Liu,S., Wang,Y. and Liao,Z. The P2/P2' sites affect the substrate cleavage of TNF-alpha converting enzyme (TACE) Mol Immunol (2014) 62, 122-128. PubMed Europe PubMed DOI P
Marczynska,J., Ozga,A., Wlodarczyk,A., Majchrzak-Gorecka,M., Kulig,P., Banas,M., Michalczyk-Wetula,D., Majewski,P., Hutloff,A., Schwarz,J., Chalaris,A., Scheller,J., Rose-John,S. and Cichy,J. The Role of Metalloproteinase ADAM17 in Regulating ICOS Ligand-Mediated Humoral Immune Responses J Immunol (2014) 193, 2753-2763. PubMed Europe PubMed DOI
Otulakowski,G., Engelberts,D., Gusarova,G.A., Bhattacharya,J., Post,M. and Kavanagh,B.P. Hypercapnia attenuates ventilator-induced lung injury via a disintegrin and metalloprotease-17 J Physiol (2014) 592, 4507-4521. PubMed Europe PubMed DOI
Pruessmeyer,J., Hess,F.M., Alert,H., Groth,E., Pasqualon,T., Schwarz,N., Nyamoya,S., Kollert,J., van der Vorst,E., Donners,M., Martin,C., Uhlig,S., Saftig,P., Dreymueller,D. and Ludwig,A. Leukocytes require ADAM10 but not ADAM17 for their migration and inflammatory recruitment into the alveolar space Blood (2014) 123, 4077-4088. PubMed Europe PubMed DOI
Raikwar,N.S., Liu,K.Z. and Thomas,C.P. N-Terminal cleavage and release of the ectodomain of Flt1 is mediated via ADAM10 and ADAM 17 and regulated by VEGFR2 and the Flt1 intracellular domain PLoS ONE (2014) 9, e112794-e112794. PubMed Europe PubMed DOI PMC EPMC
Ren,S., Hesk,D., McNamara,P., Koharski,D. and Borges,S. Synthesis of [(3) H], [(13) C3 , (15) N], and [(14) C]SCH 900567: an inhibitor of TNF-alpha (tumor necrosis factor alpha) converting enzyme (TACE) J Labelled Comp Radiopharm (2014) 57, 632-636. PubMed Europe PubMed DOI I
Vahidi,A., Glenn,G. and van der Geer,P. Identification and mutagenesis of the TACE and gamma-secretase cleavage sites in the colony-stimulating factor 1 receptor Biochem Biophys Res Commun (2014) 450, 782-787. PubMed Europe PubMed DOI P
Zhang,C., Zheng,L., Nurnberg,J., Vacari,B.M., Zhou,J. and Wang,Y. Cleavage of pro-tumor necrosis factor alpha by ADAM metallopeptidase domain 17: A fluorescence-based protease assay cleaves its natural protein substrate Anal Biochem (2014) 445, 14-19. PubMed Europe PubMed DOI A

2013

Christova,Y., Adrain,C., Bambrough,P., Ibrahim,A. and Freeman,M. Mammalian iRhoms have distinct physiological functions including an essential role in TACE regulation EMBO Rep (2013) 14, 884-890. PubMed Europe PubMed DOI
Horiuchi,K. A brief history of tumor necrosis factor alpha-converting enzyme: an overview of ectodomain shedding Keio J Med (2013) 62, 29-36. PubMed Europe PubMed V
Li,Q., Zhang,Z., Li,Z., Zhou,M., Liu,B., Pan,L., Ma,Z. and Zheng,Y. ADAM17 is critical for multipolar exit and radial migration of neuronal intermediate progenitor cells in mice cerebral cortex PLoS ONE (2013) 8, e65703-e65703. PubMed Europe PubMed DOI PMC EPMC K
McGowan,P.M., Mullooly,M., Caiazza,F., Sukor,S., Madden,S.F., Maguire,A.A., Pierce,A., McDermott,E.W., Crown,J., O'Donovan,N. and Duffy,M.J. ADAM-17: a novel therapeutic target for triple negative breast cancer Ann Oncol (2013) 24, 362-369. PubMed Europe PubMed DOI I
Miller,M.A., Meyer,A.S., Beste,M.T., Lasisi,Z., Reddy,S., Jeng,K.W., Chen,C.H., Han,J., Isaacson,K., Griffith,L.G. and Lauffenburger,D.A. ADAM-10 and -17 regulate endometriotic cell migration via concerted ligand and receptor shedding feedback on kinase signaling Proc Natl Acad Sci U S A (2013) 110, E2074-E2083. PubMed Europe PubMed DOI
Moller-Hackbarth,K., Dewitz,C., Schweigert,O., Trad,A., Garbers,C., Rose-John,S. and Scheller,J. A disintegrin and metalloprotease (ADAM) 10 and ADAM17 are major sheddases of T cell immunoglobulin and mucin domain 3 (Tim-3) J Biol Chem (2013) 288, 34529-34544. PubMed Europe PubMed DOI
Nuti,E., Casalini,F., Santamaria,S., Fabbi,M., Carbotti,G., Ferrini,S., Marinelli,L., La Pietra,V., Novellino,E., Camodeca,C., Orlandini,E., Nencetti,S. and Rossello,A. Selective arylsulfonamide inhibitors of ADAM-17: hit optimization and activity in ovarian cancer cell models J Med Chem (2013) 56, 8089-8103. PubMed Europe PubMed DOI I
Sharma,M., Mohapatra,J., Acharya,A., Deshpande,S.S., Chatterjee,A. and Jain,M.R. Blockade of tumor necrosis factor-alpha converting enzyme (TACE) enhances IL-1beta and IFN-gamma via caspase-1 activation: a probable cause for loss of efficacy of TACE inhibitors in humans? Eur J Pharmacol (2013) 701, 106-113. PubMed Europe PubMed DOI I
Singh,P. Molecular descriptors in modelling the tumour necrosis factor-alpha converting enzyme inhibition activity of novel tartrate-based analogues Indian J Pharm Sci (2013) 75, 36-44. PubMed Europe PubMed DOI PMC EPMC I
Singh,P. Molecular descriptors in modeling of TNF-alpha converting enzyme (TACE) inhibition activity of 2-(2-aminothiazol-4-yl)pyrrolidine-based tartrate diamides Indian J Chem Sect B Org Med Chem (2013) 52, 1325-1341. I
Stawikowska,R., Cudic,M., Giulianotti,M., Houghten,R.A., Fields,G.B. and Minond,D. Activity of ADAM17 (a disintegrin and metalloprotease 17) is regulated by its noncatalytic domains and secondary structure of its substrates J Biol Chem (2013) 288, 22871-22879. PubMed Europe PubMed DOI
Wang,Y., Wu,J., Newton,R., Bahaie,N.S., Long,C. and Walcheck,B. ADAM17 cleaves CD16b (FcgammaRIIIb) in human neutrophils Biochim Biophys Acta (2013) 1833, 680-685. PubMed Europe PubMed DOI
Yoda,M., Kimura,T., Tohmonda,T., Morioka,H., Matsumoto,M., Okada,Y., Toyama,Y. and Horiuchi,K. Systemic Overexpression of TNFalpha-converting Enzyme Does Not Lead to Enhanced Shedding Activity In Vivo PLoS ONE (2013) 8, e54412-e54412. PubMed Europe PubMed DOI PMC EPMC

2012

Browne,K., Wang,W., Liu,R.Q., Piva,M. and O'Connor,T.P. Transmembrane semaphorin5b is proteolytically processed into a repulsive neural guidance cue J Neurochem (2012) 123, 135-146. PubMed Europe PubMed DOI
Gooz,P., Dang,Y., Higashiyama,S., Twal,W.O., Haycraft,C.J. and Gooz,M. A disintegrin and metalloenzyme (ADAM) 17 activation is regulated by alpha5beta1 integrin in kidney mesangial cells PLoS ONE (2012) 7, e33350-e33350. PubMed Europe PubMed DOI PMC EPMC
Lichtenthaler,S.F. Cell biology. Sheddase gets guidance Science (2012) 335, 179-180. PubMed Europe PubMed DOI
McIlwain,D.R., Lang,P.A., Maretzky,T., Hamada,K., Ohishi,K., Maney,S.K., Berger,T., Murthy,A., Duncan,G., Xu,H.C., Lang,K.S., Haussinger,D., Wakeham,A., Itie-Youten,A., Khokha,R., Ohashi,P.S., Blobel,C.P. and Mak,T.W. iRhom2 regulation of TACE controls TNF-mediated protection against Listeria and responses to LPS Science (2012) 335, 229-232. PubMed Europe PubMed DOI
Minond,D., Cudic,M., Bionda,N., Giulianotti,M., Maida,L., Houghten,R.A. and Fields,G.B. Discovery of novel inhibitors of a disintegrin and metalloprotease 17 (ADAM17) using glycosylated and non-glycosylated substrates J Biol Chem (2012) 287, 36473-36487. PubMed Europe PubMed DOI I
Murphy,G. ADAM17, tumor necrosis factor alpha-convertase [ISSN:978-0-12-407744-7] (2012) 3, 1126-1130. DOI
Murthy,A., Shao,Y.W., Narala,S.R., Molyneux,S.D., Zuniga-Pflucker,J.C. and Khokha,R. Notch activation by the metalloproteinase ADAM17 regulates myeloproliferation and atopic barrier immunity by suppressing epithelial cytokine synthesis Immunity (2012) 36, 105-119. PubMed Europe PubMed DOI
Qiu,Z., Yan,M., Li,Q., Liu,D., Van Den Steen,P.E., Wang,M., Opdenakker,G. and Hu,J. Definition of peptide inhibitors from a synthetic peptide library by targeting gelatinase B/matrix metalloproteinase-9 (MMP-9) and TNF-alpha converting enzyme (TACE/ADAM-17) J Enzyme Inhib Med Chem (2012) 27, 533-540. PubMed Europe PubMed DOI I

2011

Bahia,M.S., Chand,S., Gunda,S.K., Gade,S.R., Mahmood,S. and Silakari,O. CoMFA and CoMSIA analyses of highly selective pipecolic acid based TNF-alpha converting enzyme (TACE) inhibitors using docked conformations for molecular alignment Lett Drug Des Discov (2011) 8, 430-439. DOI I
Cisse,M., Braun,U., Leitges,M., Fisher,A., Pages,G., Checler,F. and Vincent,B. ERK1-independent alpha-secretase cut of beta-amyloid precursor protein via M1 muscarinic receptors and PKCalpha/epsilon Mol Cell Neurosci (2011) 47, 223-232. PubMed Europe PubMed DOI T
Garbers,C., Janner,N., Chalaris,A., Moss,M.L., Floss,D.M., Meyer,D., Koch-Nolte,F., Rose-John,S. and Scheller,J. Species specificity of ADAM10 and ADAM17 proteins in interleukin-6 (IL-6) trans-signaling and novel role of ADAM10 in inducible IL-6 receptor shedding J Biol Chem (2011) 286, 14804-14811. PubMed Europe PubMed DOI
Kaneko,H., Anzai,T., Horiuchi,K., Morimoto,K., Anzai,A., Nagai,T., Sugano,Y., Maekawa,Y., Itoh,H., Yoshikawa,T., Okada,Y., Ogawa,S. and Fukuda,K. Tumor necrosis factor-alpha converting enzyme inactivation ameliorates high-fat diet-induced insulin resistance and altered energy homeostasis Circ J (2011) 75, 2482-2490. PubMed Europe PubMed DOI K
Lorenzen,I., Trad,A. and Grotzinger,J. Multimerisation of a disintegrin and metalloprotease protein-17 (ADAM17) is mediated by its EGF-like domain Biochem Biophys Res Commun (2011) 415, 330-336. PubMed Europe PubMed DOI
Malapeira,J., Esselens,C., Bech-Serra,J.J., Canals,F. and Arribas,J. ADAM17 (TACE) regulates TGFbeta signaling through the cleavage of vasorin Oncogene (2011) 30, 1912-1922. PubMed Europe PubMed DOI
Maretzky,T., Zhou,W., Huang,X.Y. and Blobel,C.P. A transforming Src mutant increases the bioavailability of EGFR ligands via stimulation of the cell-surface metalloproteinase ADAM17 Oncogene (2011) 30, 611-618. PubMed Europe PubMed DOI
Saftig,P. and Reiss,K. The "A Disintegrin And Metalloproteases" ADAM10 and ADAM17: novel drug targets with therapeutic potential? Eur J Cell Biol (2011) 90, 527-535. PubMed Europe PubMed DOI
Takaguri,A., Kimura,K., Hinoki,A., Bourne,A.M., Autieri,M.V. and Eguchi,S. A disintegrin and metalloprotease 17 mediates neointimal hyperplasia in vasculature Hypertension (2011) 57, 841-845. PubMed Europe PubMed DOI

2010

Bahia,M.S. and Silakari,O. Tumor necrosis factor alpha converting enzyme: an encouraging target for various inflammatory disorders Chem Biol Drug Des (2010) 75, 415-443. PubMed Europe PubMed DOI T
Bass,R. and Edwards,D.R. ADAMs and protein disulfide isomerase: the key to regulated cell-surface protein ectodomain shedding? Biochem J (2010) 428, e3-e5. PubMed Europe PubMed DOI
Chalaris,A., Adam,N., Sina,C., Rosenstiel,P., Lehmann-Koch,J., Schirmacher,P., Hartmann,D., Cichy,J., Gavrilova,O., Schreiber,S., Jostock,T., Matthews,V., Hasler,R., Becker,C., Neurath,M.F., Reiss,K., Saftig,P., Scheller,J. and Rose-John,S. Critical role of the disintegrin metalloprotease ADAM17 for intestinal inflammation and regeneration in mice J Exp Med (2010) 207, 1617-1624. PubMed Europe PubMed DOI K
Etzerodt,A., Maniecki,M.B., Moller,K., Moller,H.J. and Moestrup,S.K. Tumor necrosis factor alpha-converting enzyme (TACE/ADAM17) mediates ectodomain shedding of the scavenger receptor CD163 J Leukoc Biol (2010) 88, 1201-1205. PubMed Europe PubMed DOI
Gooz,M. ADAM-17: the enzyme that does it all Crit Rev Biochem Mol Biol (2010) 45, 146-169. PubMed Europe PubMed DOI V
Hassemer,E.L., Le Gall,S.M., Liegel,R., McNally,M., Chang,B., Zeiss,C.J., Dubielzig,R.D., Horiuchi,K., Kimura,T., Okada,Y., Blobel,C.P. and Sidjanin,D.J. The waved with open eyelids (woe) locus is a hypomorphic mouse mutation in Adam17 Genetics (2010) 185, 245-255. PubMed Europe PubMed DOI PMC EPMC M
Lizama,C., Rojas-Benitez,D., Antonelli,M., Ludwig,A., Bustamante-Marin,X., Brouwer-Visser,J. and Moreno,R.D. TACE/ADAM17 is involved in germ cell apoptosis during rat spermatogenesis Reproduction (2010) 140, 305-317. PubMed Europe PubMed DOI
Mendelson,K., Swendeman,S., Saftig,P. and Blobel,C.P. Stimulation of platelet-derived growth factor receptor beta (PDGFRbeta) activates ADAM17 and promotes metalloproteinase-dependent cross-talk between the PDGFRbeta and epidermal growth factor receptor (EGFR) signaling pathways J Biol Chem (2010) 285, 25024-25032. PubMed Europe PubMed DOI PMC EPMC
Murthy,A., Defamie,V., Smookler,D.S., Di Grappa,M.A., Horiuchi,K., Federici,M., Sibilia,M., Blobel,C.P. and Khokha,R. Ectodomain shedding of EGFR ligands and TNFR1 dictates hepatocyte apoptosis during fulminant hepatitis in mice J Clin Invest (2010) 120, 2731-2744. PubMed Europe PubMed DOI PMC EPMC
Murumkar,P.R., Zambre,V.P. and Yadav,M.R. Development of predictive pharmacophore model for in silico screening, and 3D QSAR CoMFA and CoMSIA studies for lead optimization, for designing of potent tumor necrosis factor alpha converting enzyme inhibitors J Comput Aided Mol Des (2010) 24, 143-156. PubMed Europe PubMed DOI I
Murumkar,P.R., Dasgupta,S., Chandani,S.R., Giridhar,R. and Yadav,M.R. Novel TACE inhibitors in drug discovery: a review of patented compounds Expert Opin Ther Pat (2010) 20, 31-57. PubMed Europe PubMed DOI I
Nuti,E., Casalini,F., Avramova,S.I., Santamaria,S., Fabbi,M., Ferrini,S., Marinelli,L., La Pietra,V., Limongelli,V., Novellino,E., Cercignani,G., Orlandini,E., Nencetti,S. and Rossello,A. Potent arylsulfonamide inhibitors of tumor necrosis factor-alpha converting enzyme able to reduce activated leukocyte cell adhesion molecule shedding in cancer cell models J Med Chem (2010) 53, 2622-2635. PubMed Europe PubMed DOI I
Pruessmeyer,J., Martin,C., Hess,F.M., Schwarz,N., Schmidt,S., Kogel,T., Hoettecke,N., Schmidt,B., Sechi,A., Uhlig,S. and Ludwig,A. A disintegrin and metalloproteinase 17 (ADAM17) mediates inflammation-induced shedding of syndecan-1 and -4 by lung epithelial cells J Biol Chem (2010) 285, 555-564. PubMed Europe PubMed DOI
Rosner,K.E., Guo,Z., Orth,P., Shipps,G.W., Jr., Belanger,D.B., Chan,T.Y., Curran,P.J., Dai,C., Deng,Y., Girijavallabhan,V.M., Hong,L., Lavey,B.J., Lee,J.F., Li,D., Liu,Z., Popovici-Muller,J., Ting,P.C., Vaccaro,H., Wang,L., Wang,T., Yu,W., Zhou,G., Niu,X., Sun,J., Kozlowski,J.A., Lundell,D.J., Madison,V., McKittrick,B., Piwinski,J.J., Shih,N.Y., Arshad Siddiqui,M. and Strickland,C.O. The discovery of novel tartrate-based TNF-alpha converting enzyme (TACE) inhibitors Bioorg Med Chem Lett (2010) 20, 1189-1193. PubMed Europe PubMed DOI S I
Willems,S.H., Tape,C.J., Stanley,P.L., Taylor,N.A., Mills,I.G., Neal,D.E., McCafferty,J. and Murphy,G. Thiol isomerases negatively regulate the cellular shedding activity of ADAM17 Biochem J (2010) 428, 439-450. PubMed Europe PubMed DOI
Yang,J.S., Chun,K., Park,J.E., Cho,M., Seo,J., Song,D., Yoon,H., Park,C.H., Joe,B.Y., Choi,J.H., Kim,M.H. and Han,G. Structure based optimization of chromen-based TNF-alpha converting enzyme (TACE) inhibitors on S1' pocket and their quantitative structure-activity relationship (QSAR) study Bioorg Med Chem (2010) 18, 8618-8629. PubMed Europe PubMed DOI I

2009

Bloch,L., Sineshchekova,O., Reichenbach,D., Reiss,K., Saftig,P., Kuro-o,M. and Kaether,C. Klotho is a substrate for alpha-, beta- and gamma-secretase FEBS Lett (2009) 583, 3221-3224. PubMed Europe PubMed DOI PMC EPMC
Boutet,P., Aguera-Gonzalez,S., Atkinson,S., Pennington,C.J., Edwards,D.R., Murphy,G., Reyburn,H.T. and Vales-Gomez,M. Cutting edge: the metalloproteinase ADAM17/TNF-alpha-converting enzyme regulates proteolytic shedding of the MHC class I-related chain B protein J Immunol (2009) 182, 49-53. PubMed Europe PubMed
Bozkulak,E.C. and Weinmaster,G. Selective use of ADAM10 and ADAM17 in activation of Notch1 signaling Mol Cell Biol (2009) 29, 5679-5695. PubMed Europe PubMed DOI PMC EPMC
Caescu,C.I., Jeschke,G.R. and Turk,B.E. Active-site determinants of substrate recognition by the metalloproteinases TACE and ADAM10 Biochem J (2009) 424, 79-88. PubMed Europe PubMed DOI PMC EPMC P
Glunde,K. and Stasinopoulos,I. ADAM17: The new face of breast cancer-promoting metalloprotease activity Cancer Biol Ther (2009) 8, 1055-1057. PubMed Europe PubMed
Gooz,P., Gooz,M., Baldys,A. and Hoffman,S. ADAM-17 regulates endothelial cell morphology, proliferation, and in vitro angiogenesis Biochem Biophys Res Commun (2009) 380, 33-38. PubMed Europe PubMed DOI
Hata,S., Fujishige,S., Araki,Y., Kato,N., Araseki,M., Nishimura,M., Hartmann,D., Saftig,P., Fahrenholz,F., Taniguchi,M., Urakami,K., Akatsu,H., Martins,R.N., Yamamoto,K., Maeda,M., Yamamoto,T., Nakaya,T., Gandy,S. and Suzuki,T. Alcadein cleavages by amyloid beta-precursor protein (APP) alpha- and gamma-secretases generate small peptides, p3-Alcs, indicating Alzheimer disease-related gamma-secretase dysfunction J Biol Chem (2009) 284, 36024-36033. PubMed Europe PubMed DOI PMC EPMC
Park,K., Gopalsamy,A., Aplasca,A., Ellingboe,J.W., Xu,W., Zhang,Y. and Levin,J.I. Synthesis and activity of tryptophan sulfonamide derivatives as novel non-hydroxamate TNF-alpha converting enzyme (TACE) inhibitors Bioorg Med Chem (2009) 17, 3857-3865. PubMed Europe PubMed DOI I
Shimizu,M., Hasegawa,N., Nishimura,T., Endo,Y., Shiraishi,Y., Yamasawa,W., Koh,H., Tasaka,S., Shimada,H., Nakano,Y., Fujishima,S., Yamaguchi,K. and Ishizaka,A. Effects of TNF-alpha-converting enzyme inhibition on acute lung injury induced by endotoxin in the rat Shock (2009) 32, 535-540. PubMed Europe PubMed DOI I
Zheng,X., Jiang,F., Katakowski,M., Zhang,Z.G., Lu,Q.E. and Chopp,M. ADAM17 promotes breast cancer cell malignant phenotype through EGFR-PI3K-AKT activation Cancer Biol Ther (2009) 8, 1045-1054. PubMed Europe PubMed PMC EPMC I

2008

Cho,R.W., Park,J.M., Wolff,S.B., Xu,D., Hopf,C., Kim,J.A., Reddy,R.C., Petralia,R.S., Perin,M.S., Linden,D.J. and Worley,P.F. mGluR1/5-dependent long-term depression requires the regulated ectodomain cleavage of neuronal pentraxin NPR by TACE Neuron (2008) 57, 858-871. PubMed Europe PubMed DOI PMC EPMC
Deuss,M., Reiss,K. and Hartmann,D. Part-time alpha-secretases: the functional biology of ADAM 9, 10 and 17 Curr Alzheimer Res (2008) 5, 187-201. PubMed Europe PubMed DOI K V
Gelling,R.W., Yan,W., Al-Noori,S., Pardini,A., Morton,G.J., Ogimoto,K., Schwartz,M.W. and Dempsey,P.J. Deficiency of TNFalpha converting enzyme (TACE/ADAM17) causes a lean, hypermetabolic phenotype in mice Endocrinology (2008) 149, 6053-6064. PubMed Europe PubMed DOI PMC EPMC K
Lu,Z., Ott,G.R., Anand,R., Liu,R.Q., Covington,M.B., Vaddi,K., Qian,M., Newton,R.C., Christ,D.D., Trzaskos,J. and Duan,J.J. Potent, selective, orally bioavailable inhibitors of tumor necrosis factor-alpha converting enzyme (TACE): discovery of indole, benzofuran, imidazopyridine and pyrazolopyridine P1' substituents Bioorg Med Chem Lett (2008) 18, 1958-1962. PubMed Europe PubMed DOI I
Mazzola,R.D., Jr., Zhu,Z., Sinning,L., McKittrick,B., Lavey,B., Spitler,J., Kozlowski,J., Neng-Yang,S., Zhou,G., Guo,Z., Orth,P., Madison,V., Sun,J., Lundell,D. and Niu,X. Discovery of novel hydroxamates as highly potent tumor necrosis factor-alpha converting enzyme inhibitors. Part II: optimization of the S3' pocket Bioorg Med Chem Lett (2008) 18, 5809-5814. PubMed Europe PubMed DOI S I
Merchant,N.B., Voskresensky,I., Rogers,C.M., Lafleur,B., Dempsey,P.J., Graves-Deal,R., Revetta,F., Foutch,A.C., Rothenberg,M.L., Washington,M.K. and Coffey,R.J. TACE/ADAM-17: a component of the epidermal growth factor receptor axis and a promising therapeutic target in colorectal cancer Clin Cancer Res (2008) 14, 1182-1191. PubMed Europe PubMed DOI T
Morange,P.E., Tregouet,D.A., Godefroy,T., Saut,N., Bickel,C., Rupprecht,H.J., Lackner,K., Barbaux,S., Poirier,O., Peiretti,F., Nalbone,G., Juhan-Vague,I., Blankenberg,S. and Tiret,L. Polymorphisms of the tumor necrosis factor-alpha (TNF) and the TNF-alpha converting enzyme (TACE/ADAM17) genes in relation to cardiovascular mortality: the AtheroGene study J Mol Med (Berl) (2008) 86, 1153-1161. PubMed Europe PubMed DOI M
Moss,M.L., Sklair-Tavron,L. and Nudelman,R. Drug insight: tumor necrosis factor-converting enzyme as a pharmaceutical target for rheumatoid arthritis Nat Clin Pract Rheumatol (2008) 4, 300-309. PubMed Europe PubMed DOI V T I
Murumkar,P.R., Giridhar,R. and Yadav,M.R. 3D-Quantitative structure-activity relationship studies on benzothiadiazepine hydroxamates as inhibitors of tumor necrosis factor-alpha converting enzyme Chem Biol Drug Des (2008) 71, 363-373. PubMed Europe PubMed DOI I
Ott,G.R., Asakawa,N., Lu,Z., Liu,R.Q., Covington,M.B., Vaddi,K., Qian,M., Newton,R.C., Christ,D.D., Traskos,J.M., Decicco,C.P. and Duan,J.J. alpha,beta-Cyclic-beta-benzamido hydroxamic acids: novel templates for the design, synthesis, and evaluation of selective inhibitors of TNF-alpha converting enzyme (TACE) Bioorg Med Chem Lett (2008) 18, 694-699. PubMed Europe PubMed DOI I
Ott,G.R., Asakawa,N., Liu,R.Q., Covington,M.B., Qian,M., Vaddi,K., Newton,R.C., Trzaskos,J.M., Christ,D.D., Galya,L., Scholz,T., Marshall,W. and Duan,J.J. alpha,beta-Cyclic-beta-benzamido hydroxamic acids: novel oxaspiro[4.4]nonane templates for the discovery of potent, selective, orally bioavailable inhibitors of tumor necrosis factor-alpha converting enzyme (TACE) Bioorg Med Chem Lett (2008) 18, 1288-1292. PubMed Europe PubMed DOI I
Ott,G.R., Asakawa,N., Lu,Z., Anand,R., Liu,R.Q., Covington,M.B., Vaddi,K., Qian,M., Newton,R.C., Christ,D.D., Trzaskos,J.M. and Duan,J.J. Potent, exceptionally selective, orally bioavailable inhibitors of TNF-alpha converting enzyme (TACE): novel 2-substituted-1H-benzo[d]imidazol-1-yl)methyl)benzamide P1' substituents Bioorg Med Chem Lett (2008) 18, 1577-1582. PubMed Europe PubMed DOI I
Postina,R. A closer look at alpha-secretase Curr Alzheimer Res (2008) 5, 179-186. PubMed Europe PubMed DOI
Swendeman,S., Mendelson,K., Weskamp,G., Horiuchi,K., Deutsch,U., Scherle,P., Hooper,A., Rafii,S. and Blobel,C.P. VEGF-A stimulates ADAM17-dependent shedding of VEGFR2 and crosstalk between VEGFR2 and ERK signaling Circ Res (2008) 103, 916-918. PubMed Europe PubMed DOI PMC EPMC
Wang,Y., Papamichelakis,M., Chew,W., Sellstedt,J., Noureldin,R., Tadayon,S., Daigneault,S., Galante,R.J. and Sun,J. Development of a suitable process for the preparation of a TNF-alpha converting enzyme inhibitor, WAY-281418 Org Process Res Dev (2008) 12, 1253-1260. DOI I
Wisniewska,M., Goettig,P., Maskos,K., Belouski,E., Winters,D., Hecht,R., Black,R. and Bode,W. Structural determinants of the ADAM inhibition by TIMP-3: crystal structure of the TACE-N-TIMP-3 complex J Mol Biol (2008) 381, 1307-1319. PubMed Europe PubMed DOI S
Zhu,Z., Mazzola,R., Sinning,L., McKittrick,B., Niu,X., Lundell,D., Sun,J., Orth,P., Guo,Z., Madison,V., Ingram,R. and Beyer,B.M. Discovery of novel hydroxamates as highly potent tumor necrosis factor-alpha converting enzyme inhibitors: part I - discovery of two binding modes J Med Chem (2008) 51, 725-736. PubMed Europe PubMed DOI I

2007

Duan,J.J., Chen,L., Lu,Z., Jiang,B., Asakawa,N., Sheppeck,J.E., Liu,R.Q., Covington,M.B., Pitts,W., Kim,S.H. and Decicco,C.P. Discovery of low nanomolar non-hydroxamate inhibitors of tumor necrosis factor-alpha converting enzyme (TACE) Bioorg Med Chem Lett (2007) 17, 266-271. PubMed Europe PubMed DOI I
Gardiner,E.E., Karunakaran,D., Shen,Y., Arthur,J.F., Andrews,R.K. and Berndt,M.C. Controlled shedding of platelet glycoprotein (GP)VI and GPIb-IX-V by ADAM family metalloproteinases J Thromb Haemost (2007) 5, 1530-1537. PubMed Europe PubMed DOI
Gilmore,J.L., King,B.W., Asakawa,N., Harrison,K., Tebben,A., Sheppeck,J.E., Liu,R.Q., Covington,M. and Duan,J.J. Synthesis and structure-activity relationship of a novel, non-hydroxamate series of TNF-alpha converting enzyme inhibitors Bioorg Med Chem Lett (2007) 17, 4678-4682. PubMed Europe PubMed DOI I
Horiuchi,K., Kimura,T., Miyamoto,T., Takaishi,H., Okada,Y., Toyama,Y. and Blobel,C.P. Cutting edge: TNF-alpha-converting enzyme (TACE/ADAM17) inactivation in mouse myeloid cells prevents lethality from endotoxin shock J Immunol (2007) 179, 2686-2689. PubMed Europe PubMed K
Huang,A., Joseph-McCarthy,D., Lovering,F., Sun,L., Wang,W., Xu,W., Zhu,Y., Cui,J., Zhang,Y. and Levin,J.I. Structure-based design of TACE selective inhibitors: manipulations in the S1'-S3' pocket Bioorg Med Chem (2007) 15, 6170-6181. PubMed Europe PubMed DOI S I
Katakowski,M., Chen,J., Zhang,Z.G., Santra,M., Wang,Y. and Chopp,M. Stroke-induced subventricular zone proliferation is promoted by tumor necrosis factor-alpha-converting enzyme protease activity J Cereb Blood Flow Metab (2007) 27, 669-678. PubMed Europe PubMed DOI I
Li,N., Boyd,K., Dempsey,P.J. and Vignali,D.A. Non-cell autonomous expression of TNF-alpha-converting enzyme ADAM17 is required for normal lymphocyte development J Immunol (2007) 178, 4214-4221. PubMed Europe PubMed K
Moss,M.L. and Rasmussen,F.H. Fluorescent substrates for the proteinases ADAM17, ADAM10, ADAM8, and ADAM12 useful for high-throughput inhibitor screening Anal Biochem (2007) 366, 144-148. PubMed Europe PubMed DOI A I
QU,D., Wang,Y., Esmon,N.L. and Esmon,C.T. Regulated endothelial protein C receptor shedding is mediated by tumor necrosis factor-alpha converting enzyme/ADAM17 J Thromb Haemost (2007) 5, 395-402. PubMed Europe PubMed DOI
Serino,M., Menghini,R., Fiorentino,L., Amoruso,R., Mauriello,A., Lauro,D., Sbraccia,P., Hribal,M.L., Lauro,R. and Federici,M. Mice heterozygous for tumor necrosis factor-alpha converting enzyme are protected from obesity-induced insulin resistance and diabetes Diabetes (2007) 56, 2541-2546. PubMed Europe PubMed DOI K
Sheppeck,J.E., Gilmore,J.L., Yang,A., Chen,X.T., Xue,C.B., Roderick,J., Liu,R.Q., Covington,M.B., Decicco,C.P. and Duan,J.J. Discovery of novel hydantoins as selective non-hydroxamate inhibitors of tumor necrosis factor-alpha converting enzyme (TACE) Bioorg Med Chem Lett (2007) 17, 1413-1417. PubMed Europe PubMed DOI I
Sheppeck,J.E., Gilmore,J.L., Tebben,A., Xue,C.B., Liu,R.Q., Decicco,C.P. and Duan,J.J. Hydantoins, triazolones, and imidazolones as selective non-hydroxamate inhibitors of tumor necrosis factor-alpha converting enzyme (TACE) Bioorg Med Chem Lett (2007) 17, 2769-2774. PubMed Europe PubMed DOI I
Solomon,A., Akabayov,B., Frenkel,A., Milla,M.E. and Sagi,I. Key feature of the catalytic cycle of TNF-alpha converting enzyme involves communication between distal protein sites and the enzyme catalytic core Proc Natl Acad Sci U S A (2007) 104, 4931-4936. PubMed Europe PubMed DOI PMC EPMC

2006

[YEAR:5-10-2006]Canault,M., Peiretti,F., Kopp,F., Bonardo,B., Bonzi,M.F., Coudeyre,J.C., Alessi,M.C., Juhan-Vague,I. and Nalbone,G. The TNF alpha converting enzyme (TACE/ADAM17) is expressed in the atherosclerotic lesions of apolipoprotein E-deficient mice: possible contribution to elevated plasma levels of soluble TNF alpha receptors Atherosclerosis (5-10-2006) 187, 82-91. PubMed Europe PubMed DOI
[YEAR:7-11-2006]Cherney,R.J., King,B.W., Gilmore,J.L., Liu,R.Q., Covington,M.B., Duan,J.J. and Decicco,C.P. Conversion of potent MMP inhibitors into selective TACE inhibitors Bioorg Med Chem Lett (7-11-2006) 16, 1028-1031. PubMed Europe PubMed DOI I
[YEAR:31-5-2006]Gooz,M., Gooz,P., Luttrell,L.M. and Raymond,J.R. 5-HT2A receptor induces ERK phosphorylation and proliferation through ADAM-17 tumor necrosis factor-alpha-converting enzyme (TACE) activation and heparin-bound epidermal growth factor-like growth factor (HB-EGF) shedding in mesangial cells J Biol Chem (31-5-2006) 281, 21004-21012. PubMed Europe PubMed DOI
[YEAR:3-2-2006]Ingram,R.N., Orth,P., Strickland,C.L., Le,H.V., Madison,V. and Beyer,B.M. Stabilization of the autoproteolysis of TNF-alpha converting enzyme (TACE) results in a novel crystal form suitable for structure-based drug design studies Protein Eng Des Sel (3-2-2006) 19, 155-161. PubMed Europe PubMed DOI
Kalus,I., Bormann,U., Mzoughi,M., Schachner,M. and Kleene,R. Proteolytic cleavage of the neural cell adhesion molecule by ADAM17/TACE is involved in neurite outgrowth J Neurochem (2006) 98, 78-88. PubMed Europe PubMed DOI
Milla,M.E., Gonzales,P.E. and Leonard,J.D. The TACE zymogen: re-examining the role of the cysteine switch Cell Biochem Biophys (2006) 44, 342-348. PubMed Europe PubMed DOI I
[YEAR:15-12-2006]Tang,Z.Y., Loss,G., Carmody,I. and Cohen,A.J. TIMP-3 ameliorates hepatic ischemia/reperfusion injury through inhibition of tumor necrosis factor-alpha-converting enzyme activity in rats Transplantation (15-12-2006) 82, 1518-1523. PubMed Europe PubMed DOI
Tellier,E., Canault,M., Rebsomen,L., Bonardo,B., Juhan-Vague,I., Nalbone,G. and Peiretti,F. The shedding activity of ADAM17 is sequestered in lipid rafts Exp Cell Res (2006) 312, 3969-3980. PubMed Europe PubMed DOI

2005

[YEAR:27-6-2005]Lambert,D.W., Yarski,M., Warner,F.J., Thornhill,P., Parkin,E.T., Smith,A.I., Hooper,N.M. and Turner,A.J. Tumor necrosis factor-alpha convertase (ADAM17) mediates regulated ectodomain shedding of the severe-acute respiratory syndrome-coronavirus (SARS-CoV) receptor, angiotensin-converting enzyme-2 (ACE2) J Biol Chem (27-6-2005) 280, 30113-30119. PubMed Europe PubMed DOI
Lambert,M.H., Blackburn,R.K., Seaton,T.D., Kassel,D.B., Kinder,D.S., Leesnitzer,M.A., Bickett,D.M., Warner,J.R., Andersen,M.W., Badiang,J.G., Cowan,D.J., Gaul,M.D., Petrov,K.G., Rabinowitz,M.H., Wiethe,R.W., Becherer,J.D., McDougald,D.L., Musso,D.L., Andrews,R.C. and Moss,M.L. Substrate specificity and novel selective inhibitors of TNF-alpha converting enzyme (TACE) from two-dimensional substrate mapping Comb Chem High Throughput Screen (2005) 8, 327-339. PubMed Europe PubMed DOI P
Leonard,J.D., Lin,F. and Milla,M.E. Chaperone-like properties of the prodomain of TNFalpha-converting enzyme (TACE) and the functional role of its cysteine switch Biochem J (2005) 387, 797-805. PubMed Europe PubMed DOI PMC EPMC
Soond,S.M., Everson,B., Riches,D.W. and Murphy,G. ERK-mediated phosphorylation of Thr735 in TNFalpha-converting enzyme and its potential role in TACE protein trafficking J Cell Sci (2005) 118, 2371-2380. PubMed Europe PubMed DOI

2004

Allinson,T.M., Parkin,E.T., Condon,T.P., Schwager,S.L., Sturrock,E.D., Turner,A.J. and Hooper,N.M. The role of ADAM10 and ADAM17 in the ectodomain shedding of angiotensin converting enzyme and the amyloid precursor protein Eur J Biochem (2004) 271, 2539-2547. PubMed Europe PubMed DOI
Black,R.A. Tumor necrosis factor alpha-converting enzyme [ISSN:0-12-079610-4] (2004) 2, 726-729. V
[YEAR:18-11-2004]Cruz,A.C., Frank,B.T., Edwards,S.T., Dazin,P.F., Peschon,J.J. and Fang,K.C. Tumor necrosis factor-alpha-converting enzyme controls surface expression of c-Kit and survival of embryonic stem cell-derived mast cells J Biol Chem (18-11-2004) 279, 5612-5620. PubMed Europe PubMed DOI
[YEAR:20-4-2004]Gonzales,P.E., Solomon,A., Miller,A.B., Leesnitzer,M.A., Sagi,I. and Milla,M.E. Inhibition of the tumor necrosis factor-alpha-converting enzyme by its pro domain J Biol Chem (20-4-2004) 279, 31638-31645. PubMed Europe PubMed DOI
Hinkle,C.L., Sunnarborg,S.W., Loiselle,D., Parker,C.E., Stevenson,M., Russell,W.E. and Lee,D.C. Selective roles for tumor necrosis factor alpha-converting enzyme/ADAM17 in the shedding of the epidermal growth factor receptor ligand family: the juxtamembrane stalk determines cleavage efficiency J Biol Chem (2004) 279, 24179-24188. PubMed Europe PubMed DOI
Kamei,N., Tanaka,T., Kawai,K., Miyawaki,K., Okuyama,A., Murakami,Y., Arakawa,Y., Haino,M., Harada,T. and Shimano,M. Reverse hydroxamate-based selective TACE inhibitors Bioorg Med Chem Lett (2004) 14, 2897-2900. PubMed Europe PubMed DOI I
[YEAR:12-8-2004]Lee,M.H., Rapti,M. and Murphy,G. Delineating the molecular basis of the inactivity of tissue inhibitor of metalloproteinase-2 against tumor necrosis factor-alpha-converting enzyme J Biol Chem (12-8-2004) 279, 45121-45129. PubMed Europe PubMed DOI
[YEAR:15-5-2004]Neumann,U., Kubota,H., Frei,K., Ganu,V. and Leppert,D. Characterization of Mca-Lys-Pro-Leu-Gly-Leu-Dpa-Ala-Arg-NH2, a fluorogenic substrate with increased specificity constants for collagenases and tumor necrosis factor converting enzyme Anal Biochem (15-5-2004) 328, 166-173. PubMed Europe PubMed DOI A
[YEAR:1-3-2004]Sahin,U., Weskamp,G., Kelly,K., Zhou,H.M., Higashiyama,S., Peschon,J., Hartmann,D., Saftig,P. and Blobel,C.P. Distinct roles for ADAM10 and ADAM17 in ectodomain shedding of six EGFR ligands J Cell Biol (1-3-2004) 164, 769-779. PubMed Europe PubMed DOI PMC EPMC
[YEAR:26-8-2004]Schafer,B., Marg,B., Gschwind,A. and Ullrich,A. Distinct ADAM metalloproteinases regulate G protein-coupled receptor-induced cell proliferation and survival J Biol Chem (26-8-2004) 279, 47929-47938. PubMed Europe PubMed DOI
[YEAR:23-7-2004]Solomon,A., Rosenblum,G., Gonzales,P.E., Leonard,J.D., Mobashery,S., Milla,M.E. and Sagi,I. Pronounced diversity in electronic and chemical properties between the catalytic zinc sites of tumor necrosis factor-alpha-converting enzyme and matrix metalloproteinases despite their high structural similarity J Biol Chem (23-7-2004) 279, 31646-31654. PubMed Europe PubMed DOI I
[YEAR:5-4-2004]Valeva,A., Walev,I., Weis,S., Boukhallouk,F., Wassenaar,T.M., Endres,K., Fahrenholz,F., Bhakdi,S. and Zitzer,A. A cellular metalloproteinase activates Vibrio cholerae pro-cytolysin J Biol Chem (5-4-2004) 279, 25143-25148. PubMed Europe PubMed DOI
[YEAR:24-11-2004]Weskamp,G., Schlondorff,J., Lum,L., Becherer,J.D., Kim,T.W., Saftig,P., Hartmann,D., Murphy,G. and Blobel,C.P. Evidence for a critical role of the tumor necrosis factor alpha convertase (TACE) in ectodomain shedding of the p75 neurotrophin receptor (p75NTR) J Biol Chem (24-11-2004) 279, 4241-4249. PubMed Europe PubMed DOI
Wolfsberg,T.G. and White,J.M. ADAM metalloproteinases [ISSN:0-12-079610-4] (2004) 2, 709-714. V
[YEAR:6-9-2004]Xue,C.B., Chen,X.T., He,X., Roderick,J., Corbett,R.L., Ghavimi,B., Liu,R.Q., Covington,M.B., Qian,M., Ribadeneira,M.D., Vaddi,K., Trzaskos,J., Newton,R.C., Duan,J.J. and Decicco,C.P. Synthesis and structure-activity relationship of a novel sulfone series of TNF-alpha converting enzyme inhibitors Bioorg Med Chem Lett (6-9-2004) 14, 4453-4459. PubMed Europe PubMed DOI I
[YEAR:23-1-2004]Zhang,Y., Xu,J., Levin,J., Hegen,M., Li,G., Robertshaw,H., Brennan,F., Cummons,T., Clarke,D., Vansell,N., Nickerson-Nutter,C., Barone,D., Mohler,K., Black,R., Skotnicki,J., Gibbons,J., Feldmann,M., Frost,P., Larsen,G. and Lin,L.L. Identification and characterization of 4-[[4-(2-butynyloxy)phenyl]sulfonyl]-N-hydroxy-2,2-dimethyl-(3S)thiomorpho linecarboxamide (TMI-1), a novel dual tumor necrosis factor-alpha-converting enzyme/matrix metalloprotease inhibitor for the treatment of rheumatoid arthritis J Pharmacol Exp Ther (23-1-2004) 309, 348-355. PubMed Europe PubMed DOI I
[YEAR:20-12-2004]Zhang,Y., Hegen,M., Xu,J., Keith,J.C., Jr., Jin,G., Du,X., Cummons,T., Sheppard,B.J., Sun,L., Zhu,Y., Rao,V.R., Wang,Q., Xu,W., Cowling,R., Nickerson-Nutter,C.L., Gibbons,J., Skotnicki,J., Lin,L.L. and Levin,J. Characterization of (2R, 3S)-2-([[4-(2-butynyloxy)phenyl]sulfonyl]amino)-N,3-dihydroxybutanamide, a potent and selective inhibitor of TNF-alpha converting enzyme Int Immunopharmacol (20-12-2004) 4, 1845-1857. PubMed Europe PubMed DOI I
[YEAR:2-8-2004]Zheng,Y., Saftig,P., Hartmann,D. and Blobel,C. Evaluation of the contribution of different ADAMs to tumor necrosis factor alpha (TNFalpha) shedding and of the function of the TNFalpha ectodomain in ensuring selective stimulated shedding by the TNFalpha convertase (TACE/ADAM17) J Biol Chem (2-8-2004) 279, 42898-42906. PubMed Europe PubMed DOI

2003

[YEAR:31-1-2003]Asai,M., Hattori,C., Szabo,B., Sasagawa,N., Maruyama,K., Tanuma,S. and Ishiura,S. Putative function of ADAM9, ADAM10, and ADAM17 as APP alpha-secretase Biochem Biophys Res Commun (31-1-2003) 301, 231-235. PubMed Europe PubMed DOI
[YEAR:3-3-2003]Borrell-Pages,M., Rojo,F., Albanell,J., Baselga,J. and Arribas,J. TACE is required for the activation of the EGFR by TGF-alpha in tumors EMBO J (3-3-2003) 22, 1114-1124. PubMed Europe PubMed DOI PMC EPMC
[YEAR:8-5-2003]Cherney,R.J., Duan,J.J., Voss,M.E., Chen,L., Wang,L., Meyer,D.T., Wasserman,Z.R., Hardman,K.D., Liu,R.Q., Covington,M.B., Qian,M., Mandlekar,S., Christ,D.D., Trzaskos,J.M., Newton,R.C., Magolda,R.L., Wexler,R.R. and Decicco,C.P. Design, synthesis, and evaluation of benzothiadiazepine hydroxamates as selective tumor necrosis factor-alpha converting enzyme inhibitors J Med Chem (8-5-2003) 46, 1811-1823. PubMed Europe PubMed DOI I
[YEAR:22-8-2003]Doedens,J.R., Mahimkar,R.M. and Black,R.A. TACE/ADAM-17 enzymatic activity is increased in response to cellular stimulation Biochem Biophys Res Commun (22-8-2003) 308, 331-338. PubMed Europe PubMed DOI
[YEAR:16-6-2003]Duan,J.J., Lu,Z., Xue,C.B., He,X., Seng,J.L., Roderick,J.J., Wasserman,Z.R., Liu,R.Q., Covington,M.B., Magolda,R.L., Newton,R.C., Trzaskos,J.M. and Decicco,C.P. Discovery of N-hydroxy-2-(2-oxo-3-pyrrolidinyl)acetamides as potent and selective inhibitors of tumor necrosis factor-alpha converting enzyme (TACE) Bioorg Med Chem Lett (16-6-2003) 13, 2035-2040. PubMed Europe PubMed DOI I
Kieseier,B.C., Pischel,H., Neuen-Jacob,E., Tourtellotte,W.W. and Hartung,H.P. ADAM-10 and ADAM-17 in the inflamed human CNS Glia (2003) 42, 398-405. PubMed Europe PubMed DOI
[YEAR:5-9-2003]LaVoie,M.J. and Selkoe,D.J. The Notch ligands, Jagged and Delta, are sequentially processed by alpha-secretase and presenilin/gamma-secretase and release signaling fragments J Biol Chem (5-9-2003) 278, 34427-34437. PubMed Europe PubMed DOI
[YEAR:15-4-2003]Lee,M.H., Dodds,P., Verma,V., Maskos,K., Knauper,V. and Murphy,G. Tailoring tissue inhibitor of metalloproteinases-3 to overcome the weakening effects of the cysteine-rich domains of tumour necrosis factor-alpha converting enzyme Biochem J (15-4-2003) 371, 369-376. PubMed Europe PubMed DOI PMC EPMC
[YEAR:1-5-2003]Peiretti,F., Canault,M., Deprez-Beauclair,P., Berthet,V., Bonardo,B., Juhan-Vague,I. and Nalbone,G. Intracellular maturation and transport of tumor necrosis factor alpha converting enzyme Exp Cell Res (1-5-2003) 285, 278-285. PubMed Europe PubMed DOI
Skotnicki,J.S., DiGrandi,M.J. and Levin,J.I. Design strategies for the identification of MMP-13 and TACE inhibitors Curr Opin Drug Discov Devel (2003) 6, 742-759. PubMed Europe PubMed I
[YEAR:20-11-2003]Srour,N., Lebel,A., McMahon,S., Fournier,I., Fugere,M., Day,R. and Dubois,C.M. TACE/ADAM-17 maturation and activation of sheddase activity require proprotein convertase activity FEBS Lett (20-11-2003) 554, 275-283. PubMed Europe PubMed DOI
[YEAR:31-1-2003]Thathiah,A., Blobel,C.P. and Carson,D.D. Tumor necrosis factor-alpha converting enzyme/ADAM 17 mediates MUC1 shedding J Biol Chem (31-1-2003) 278, 3386-3394. PubMed Europe PubMed DOI
[YEAR:15-12-2003]Xue,C.B., He,X., Roderick,J., Corbett,R.L., Duan,J.J., Liu,R.Q., Covington,M.B., Newton,R.C., Trzaskos,J.M., Magolda,R.L., Wexler,R.R. and Decicco,C.P. Rational design, synthesis and structure-activity relationships of a cyclic succinate series of TNF-alpha converting enzyme inhibitors. Part 1: lead identification Bioorg Med Chem Lett (15-12-2003) 13, 4293-4297. PubMed Europe PubMed DOI I

2002

Beck,G., Bottomley,G., Bradshaw,D., Brewster,M., Broadhurst,M., Devos,R., Hill,C., Johnson,W., Kim,H.J., Kirtland,S., Kneer,J., Lad,N., Mackenzie,R., Martin,R., Nixon,J., Price,G., Rodwell,A., Rose,F., Tang,J.P., Walter,D.S., Wilson,K. and Worth,E. (E)-2(R)-[1(S)-(Hydroxycarbamoyl)-4-phenyl-3-butenyl]-2'-isobutyl-2'-(meth anesulfonyl)-4-methylvalerohydrazide (Ro 32-7315), a selective and orally active inhibitor of tumor necrosis factor-alpha convertase J Pharmacol Exp Ther (2002) 302, 390-396. PubMed Europe PubMed DOI I
Black,R.A. Tumor necrosis factor-alpha converting enzyme Int J Biochem Cell Biol (2002) 34, 1-5. PubMed Europe PubMed DOI
Chen,Y., Diener,K., Patel,I.R., Kawooya,J.K., Martin,G.A., Yamdagni,P., Zhang,X., Sandrasalphaa,A., Sahasrabudhe,S. and Busch,S.J. Phage display of functional human TNF-alpha converting enzyme catalytic domain: a rapid method for the production of stabilized proteolytic proteins for assay development and high-throughput screening J Biomol Screen (2002) 7, 433-440. PubMed Europe PubMed DOI A
[YEAR:7-11-2002]Duan,J.J., Chen,L., Wasserman,Z.R., Lu,Z., Liu,R.Q., Covington,M.B., Qian,M., Hardman,K.D., Magolda,R.L., Newton,R.C., Christ,D.D., Wexler,R.R. and Decicco,C.P. Discovery of gamma-lactam hydroxamic acids as selective inhibitors of tumor necrosis factor alpha converting enzyme: design, synthesis, and structure-activity relationships J Med Chem (7-11-2002) 45, 4954-4957. PubMed Europe PubMed DOI I
Hooper,N.M. and Turner,A.J. The search for alpha-secretase and its potential as a therapeutic approach to Alzheimer s disease Curr Med Chem (2002) 9, 1107-1119. PubMed Europe PubMed I
[YEAR:15-3-2002]Jin,G., Huang,X., Black,R., Wolfson,M., Rauch,C., McGregor,H., Ellestad,G. and Cowling,R. A continuous fluorimetric assay for tumor necrosis factor-alpha converting enzyme Anal Biochem (15-3-2002) 302, 269-275. PubMed Europe PubMed DOI A
[YEAR:5-6-2002]Lee,M.H., Verma,V., Maskos,K., Becherer,J.D., Knauper,V., Dodds,P., Amour,A. and Murphy,G. The C-terminal domains of TACE weaken the inhibitory action of N-TIMP-3 FEBS Lett (5-6-2002) 520, 102-106. PubMed Europe PubMed DOI
[YEAR:20-5-2002]Letavic,M.A., Axt,M.Z., Barberia,J.T., Carty,T.J., Danley,D.E., Geoghegan,K.F., Halim,N.S., Hoth,L.R., Kamath,A.V., Laird,E.R., Lopresti-Morrow,L.L., McClure,K.F., Mitchell,P.G., Natarajan,V., Noe,M.C., Pandit,J., Reeves,L., Schulte,G.K., Snow,S.L., Sweeney,F.J., Tan,D.H. and Yu,C.H. Synthesis and biological activity of selective pipecolic acid-based TNF-alpha converting enzyme (TACE) inhibitors Bioorg Med Chem Lett (20-5-2002) 12, 1387-1390. PubMed Europe PubMed DOI I
[YEAR:30-7-2002]Mohan,M.J., Seaton,T., Mitchell,J., Howe,A., Blackburn,K., Burkhart,W., Moyer,M., Patel,I., Waitt,G.M., Becherer,J.D., Moss,M.L. and Milla,M.E. The tumor necrosis factor-alpha converting enzyme (TACE): a unique metalloproteinase with highly defined substrate selectivity Biochemistry (30-7-2002) 41, 9462-9469. PubMed Europe PubMed DOI
[YEAR:12-4-2002]Sunnarborg,S.W., Hinkle,C.L., Stevenson,M., Russell,W.E., Raska,C.S., Peschon,J.J., Castner,B.J., Gerhart,M.J., Paxton,R.J., Black,R.A. and Lee,D.C. Tumor necrosis factor-alpha converting enzyme (TACE) regulates epidermal growth factor receptor ligand availability J Biol Chem (12-4-2002) 277, 12838-12845. PubMed Europe PubMed DOI
[YEAR:27-12-2002]Wang,X., He,K., Gerhart,M., Huang,Y., Jiang,J., Paxton,R.J., Yang,S., Lu,C., Menon,R.K., Black,R.A., Baumann,G. and Frank,S.J. Metalloprotease-mediated GH receptor proteolysis and GHBP shedding. Determination of extracellular domain stem region cleavage site J Biol Chem (27-12-2002) 277, 50510-50519. PubMed Europe PubMed DOI
Zheng,Y., Schlondorff,J. and Blobel,C.P. Evidence for regulation of the tumor necrosis factor alpha-convertase (TACE) by protein-tyrosine phosphatase PTPH1 J Biol Chem (2002) 277, 42463-42470. PubMed Europe PubMed DOI

2001

Dominguez,D.I., De Strooper,B. and Annaert,W. Secretases as therapeutic targets for the treatment of Alzheimer's disease Amyloid (2001) 8, 124-142. PubMed Europe PubMed
[YEAR:12-10-2001]Garton,K.J., Gough,P.J., Blobel,C.P., Murphy,G., Greaves,D.R., Dempsey,P.J. and Raines,E.W. Tumor necrosis factor-alpha-converting enzyme (ADAM17) mediates the cleavage and shedding of fractalkine (CX3CL1) J Biol Chem (12-10-2001) 276, 37993-38001. PubMed Europe PubMed DOI
Goddard,D.R., Bunning,R.A.D. and Woodroofe,M.N. Astrocyte and endothelial cell expression of ADAM 17 (TACE) in adult human CNS Glia (2001) 34, 267-271. PubMed Europe PubMed DOI
Holms,J., Mast,K., Marcotte,P., Elmore,I., Li,J.L., Pease,L., Glaser,K., Morgan,D., Michaelides,M. and Davidsen,S. Discovery of selective hydroxamic acid inhibitors of tumor necrosis factor-alpha converting enzyme Bioorg Med Chem Lett (2001) 11, 2907-2910. PubMed Europe PubMed DOI I
Hurtado,O., Cardenas,A., Lizasoain,I., Bosca,L., Leza,J.C., Lorenzo,P. and Moro,M.A. Up-regulation of TNF-alpha convertase (TACE/ADAM17) after oxygen-glucose deprivation in rat forebrain slices Neuropharmacology (2001) 40, 1094-1102. PubMed Europe PubMed DOI I
Itai,T., Tanaka,M. and Nagata,S. Processing of tumor necrosis factor by the membrane-bound TNF-alpha-converting enzyme, but not its truncated soluble form Eur J Biochem (2001) 268, 2074-2082. PubMed Europe PubMed DOI
[YEAR:26-1-2001]Lee,M.H., Knauper,V., Becherer,J.D. and Murphy,G. Full-length and N-TIMP-3 display equal inhibitory activities toward TNF-alpha convertase Biochem Biophys Res Commun (26-1-2001) 280, 945-950. PubMed Europe PubMed DOI
[YEAR:1-4-2001]Moss,M.L., White,J.M., Lambert,M.H. and Andrews,R.C. TACE and other ADAM proteases as targets for drug discovery Drug Discov Today (1-4-2001) 6, 417-426. PubMed Europe PubMed
Musso,D.L., Andersen,M.W., Andrews,R.C., Austin,R., Beaudet,E.J., Becherer,J.D., Bubacz,D.G., Bickett,D.M., Chan,J.H., Conway,J.G., Cowan,D.J., Gaul,M.D., Glennon,K.C., Hedeen,K.M., Lambert,M.H., Leesnitzer,M.A., McDougald,D.L., Mitchell,J.L., Moss,M.L., Rabinowitz,M.H., Rizzolio,M.C., Schaller,L.T., Stanford,J.B., Tippin,T., Warner,J.R., Whitesell,L.G. and Wiethe,R.W. N-hydroxyformamide peptidomimetics as TACE/matrix metalloprotease inhibitors: oral activity via P1' isobutyl substitution Bioorg Med Chem Lett (2001) 11, 2147-2151. PubMed Europe PubMed DOI I
Newton,R.C., Solomon,K.A., Covington,M.B., Decicco,C.P., Haley,P.J., Friedman,S.M. and Vaddi,K. Biology of TACE inhibition Ann Rheum Dis (2001) 60 Suppl 3, iii25-iii32. PubMed Europe PubMed PMC EPMC
Ohta,S., Harigai,M., Tanaka,M., Kawaguchi,Y., Sugiura,T., Takagi,K., Fukasawa,C., Hara,M. and Kamatani,N. Tumor necrosis factor-alpha (TNF-alpha) converting enzyme contributes to production of TNF-alpha in synovial tissues from patients with rheumatoid arthritis J Rheumatol (2001) 28, 1756-1763. PubMed Europe PubMed
[YEAR:22-11-2001]Rabinowitz,M.H., Andrews,R.C., Becherer,J.D., Bickett,D.M., Bubacz,D.G., Conway,J.G., Cowan,D.J., Gaul,M., Glennon,K., Lambert,M.H., Leesnitzer,M.A., McDougald,D.L., Moss,M.L., Musso,D.L. and Rizzolio,M.C. Design of selective and soluble inhibitors of tumor necrosis factor-alpha converting enzyme (TACE) J Med Chem (22-11-2001) 44, 4252-4267. PubMed Europe PubMed DOI I
[YEAR:1-2-2001]Rovida,E., Paccagnini,A., Del Rosso,M., Peschon,J. and Dello Sbarba,P. TNF-alpha-converting enzyme cleaves the macrophage colony-stimulating factor receptor in macrophages undergoing activation J Immunol (1-2-2001) 166, 1583-1589. PubMed Europe PubMed
[YEAR:30-11-2001]Tsou,C.L., Haskell,C.A. and Charo,I.F. Tumor necrosis factor-alpha-converting enzyme mediates the inducible cleavage of fractalkine J Biol Chem (30-11-2001) 276, 44622-44626. PubMed Europe PubMed DOI
[YEAR:1-4-2001]Zhao,J., Chen,H., Peschon,J.J., Shi,W., Zhang,Y., Frank,S.J. and Warburton,D. Pulmonary hypoplasia in mice lacking tumor necrosis factor-alpha converting enzyme indicates an indispensable role for cell surface protein shedding during embryonic lung branching morphogenesis Dev Biol (1-4-2001) 232, 204-218. PubMed Europe PubMed DOI K

2000

Novel N-hydroxamic acid hydrazide inhibitors of TNF-alpha synthesis Expert Opin Ther Pat (2000) 10, 1617-1621. V I
[YEAR:12-5-2000]Reddy,P., Slack,J.L., Davis,R., Cerretti,D.P., Kozlosky,C.J., Blanton,R.A., Shows,D., Peschon,J.J. and Black,R.A. Functional analysis of the domain structure of tumor necrosis factor-alpha converting enzyme J Biol Chem (12-5-2000) 275, 14608-14614. PubMed Europe PubMed DOI
[YEAR:1-4-2000]Schlondorff,J., Becherer,J.D. and Blobel,C.P. Intracellular maturation and localization of the tumour necrosis factor alpha convertase (TACE) Biochem J (1-4-2000) 347, 131-138. PubMed Europe PubMed DOI PMC EPMC
Zhang,Y., Jiang,J., Black,R.A., Baumann,G. and Frank,S.J. Tumor necrosis factor-alpha converting enzyme (TACE) is a growth hormone binding protein (GHBP) sheddase: The metalloprotease TACE/ADAM-17 is critical for (PMA-induced) GH receptor proteolysis and GHBP generation Endocrinology (2000) 141, 4342-4348. PubMed Europe PubMed DOI

1999

[YEAR:18-11-1999]Barlaam,B., Bird,T.G., Lambert-Van Der Brempt,C., Campbell,D., Foster,S.J. and Maciewicz,R. New alpha-substituted succinate-based hydroxamic acids as TNFalpha convertase inhibitors J Med Chem (18-11-1999) 42, 4890-4908. PubMed Europe PubMed DOI I
[YEAR:1-10-1999]Dekkers,P.E., Lauw,F.N., ten Hove,T., te Velde,A.A., Lumley,P., Becherer,D., van Deventer,S.J. and van der Poll,T. The effect of a metalloproteinase inhibitor (GI5402) on tumor necrosis factor-alpha (TNF-alpha) and TNF-alpha receptors during human endotoxemia Blood (1-10-1999) 94, 2252-2258. PubMed Europe PubMed
[YEAR:22-10-1999]Milla,M.E., Leesnitzer,M.A., Moss,M.L., Clay,W.C., Carter,H.L., Miller,A.B., Su,J.L., Lambert,M.H., Willard,D.H., Sheeley,D.M., Kost,T.A., Burkhart,W., Moyer,M., Blackburn,R.K., Pahel,G.L., Mitchell,J.L., Hoffman,C.R. and Becherer,J.D. Specific sequence elements are required for the expression of functional tumor necrosis factor-alpha-converting enzyme (TACE) J Biol Chem (22-10-1999) 274, 30563-30570. PubMed Europe PubMed DOI
[YEAR:11-6-1999]Mizui,Y., Yamazaki,K., Sagane,K. and Tanaka,I. cDNA cloning of mouse tumor necrosis factor-alpha converting enzyme (TACE) and partial analysis of its promoter Gene (11-6-1999) 233, 67-74. PubMed Europe PubMed DOI
[YEAR:1-11-1999]Nelson,K.K., Schlondorff,J. and Blobel,C.P. Evidence for an interaction of the metalloprotease-disintegrin tumour necrosis factor alpha convertase (TACE) with mitotic arrest deficient 2 (MAD2), and of the metalloprotease-disintegrin MDC9 with a novel MAD2-related protein, MAD2beta Biochem J (1-11-1999) 343, 673-680. PubMed Europe PubMed DOI PMC EPMC
[YEAR:15-10-1999]Solomon,K.A., Pesti,N., Wu,G. and Newton,R.C. Cutting edge: A dominant negative form of TNF-alpha converting enzyme inhibits ProTNF and TNFRII secretion J Immunol (15-10-1999) 163, 4105-4108. PubMed Europe PubMed

1998

[YEAR:11-9-1998]Amour,A., Slocombe,P.M., Webster,A., Butler,M., Knight,C.G., Smith,B.J., Stephens,P.E., Shelley,C., Hutton,M., Knauper,V., Docherty,A.J. and Murphy,G. TNF-alpha converting enzyme (TACE) is inhibited by TIMP-3 FEBS Lett (11-9-1998) 435, 39-44. PubMed Europe PubMed DOI
Black,R.A. and White,J.M. ADAMs: focus on the protease domain Curr Opin Cell Biol (1998) 10, 654-659. PubMed Europe PubMed DOI
[YEAR:23-10-1998]Buxbaum,J.D., Liu,K.N., Luo,Y., Slack,J.L., Stocking,K.L., Peschon,J.J., Johnson,R.S., Castner,B.J., Cerretti,D.P. and Black,R.A. Evidence that tumor necrosis factor alpha converting enzyme is involved in regulated alpha-secretase cleavage of the Alzheimer amyloid protein precursor J Biol Chem (23-10-1998) 273, 27765-27767. PubMed Europe PubMed DOI K
Clarke,H.R., Wolfson,M.F., Rauch,C.T., Castner,B.J., Huang,C.P., Gerhart,M.J., Johnson,R.S., Cerretti,D.P., Paxton,R.J., Price,V.L. and Black,R.A. Expression and purification of correctly processed, active human TACE catalytic domain in Saccharomyces cerevisiae Protein Expr Purif (1998) 13, 104-110. PubMed Europe PubMed DOI E
[YEAR:31-3-1998]Maskos,K., Fernandez-Catalan,C., Huber,R., Bourenkov,G.P., Bartunik,H., Ellestad,G.A., Reddy,P., Wolfson,M.F., Rauch,C.T., Castner,B.J., Davis,R., Clarke,H.R., Petersen,M., Fitzner,J.N., Cerretti,D.P., March,C.J., Paxton,R.J., Black,R.A. and Bode,W. Crystal structure of the catalytic domain of human tumor necrosis factor-alpha-converting enzyme Proc Natl Acad Sci U S A (31-3-1998) 95, 3408-3412. PubMed Europe PubMed DOI PMC EPMC S
[YEAR:1-5-1998]Patel,I.R., Attur,M.G., Patel,R.N., Stuchin,S.A., Abagyan,R.A., Abramson,S.B. and Amin,A.R. TNF-alpha convertase enzyme from human arthritis-affected cartilage: Isolation of cDNA by differential display, expression of the active enzyme, and regulation of TNF-alpha J Immunol (1-5-1998) 160, 4570-4579. PubMed Europe PubMed
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1997

Black,R.A., Rauch,C.T., Kozlosky,C.J., Peschon,J.J., Slack,J.L., Wolfson,M.F., Castner,B.J., Stocking,K.L., Reddy,P., Srinivasan,S., Nelson,N., Boiani,N., Schooley,K.A., Gerhart,M., Davis,R., Fitzner,J.N., Johnson,R.S., Paxton,R.J., March,C.J. and Cerretti,D.P. A metalloproteinase disintegrin that releases tumour-necrosis factor-alpha from cells Nature (1997) 385, 729-733. PubMed Europe PubMed DOI
Moss,M.L., Jin,S.L., Becherer,J.D., Bickett,D.M., Burkhart,W., Chen,W.J., Hassler,D., Leesnitzer,M.T., McGeehan,G., Milla,M., Moyer,M., Rocque,W., Seaton,T., Schoenen,F., Warner,J. and Willard,D. Structural features and biochemical properties of TNF-alpha converting enzyme (TACE) J Neuroimmunol (1997) 72, 127-129. PubMed Europe PubMed DOI
Moss,M.L., Jin,S.L., Milla,M.E., Bickett,D.M., Burkhart,W., Carter,H.L., Chen,W.J., Clay,W.C., Didsbury,J.R., Hassler,D., Hoffman,C.R., Kost,T.A., Lambert,M.H., Leesnitzer,M.A., McCauley,P., McGeehan,G., Mitchell,J., Moyer,M., Pahel,G., Rocque,W., Overton,L.K., Schoenen,F., Seaton,T., Su,J.L. and Becherer,J.D. Cloning of a disintegrin metalloproteinase that processes precursor tumour-necrosis factor-alpha Nature (1997) 385, 733-736. PubMed Europe PubMed DOI
Robache-Gallea,S., Bruneau,J.M., Robbe,H., Morand,V., Capdevila,C., Bhatnagar,N., Chouaib,S. and Roman-Roman,S. Partial purification and characterization of a tumor necrosis factor-alpha converting activity Eur J Immunol (1997) 27, 1275-1282. PubMed Europe PubMed DOI
Solorzano,C.C., Ksontini,R., Pruitt,J.H., Auffenberg,T., Tannahill,C., Galardy,R.E., Schultz,G.P., MacKay,S.L., Copeland,E.M., III and Moldawer,L.L. A matrix metalloproteinase inhibitor prevents processing of tumor necrosis factor alpha (TNFalpha) and abrogates endotoxin-induced lethality Shock (1997) 7, 427-431. PubMed Europe PubMed I
Van Dyk,D.E., Marchand,P., Bruckner,R.C., Fox,J.W., Jaffee,B.D., Gunyuzlu,P.L., Davis,G.L., Nurnberg,S., Covington,M., Decicco,C.P., Trzaskos,J.M., Magolda,R.L. and Copeland,R.A. Comparison of snake venom reprolysin and matrix metalloproteinases as models of TNF-alpha converting enzyme Bioorg Med Chem Lett (1997) 7, 1219-1224. DOI I

1996

Williams,L.M., Gibbons,D.L., Gearing,A., Maini,R.N., Feldmann,M. and Brennan,F.M. Paradoxical effects of a synthetic metalloproteinase inhibitor that blocks both p55 and p75 TNF receptor shedding and TNF alpha processing in RA synovial membrane cell cultures J Clin Invest (1996) 97, 2833-2841. PubMed Europe PubMed DOI PMC EPMC I

1995

Robache-Gallea,S., Morand,V., Bruneau,J.M., Schoot,B., Tagat,E., Realo,E., Chouaib,S. and Roman-Roman,S. In vitro processing of human tumor necrosis factor-alpha J Biol Chem (1995) 270, 23688-23692. PubMed Europe PubMed DOI

1994

[YEAR:21-7-1994]Mohler,K.M., Sleath,P.R., Fitzner,J.N., Cerretti,D.P., Alderson,M., Kerwar,S.S., Torrance,D.S., Otten-Evans,C., Greenstreet,T. and Weerawarna,K. Protection against a lethal dose of endotoxin by an inhibitor of tumour necrosis factor processing Nature (21-7-1994) 370, 218-220. PubMed Europe PubMed DOI I