Searches of the MEROPS database

Display Known Cleavages for a Protein

Please enter a UniProt accession (eg P05067):

Accession:

Sequence P63260

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Peptide and protein substrates that are thought to be physiologically relevant are indicated by P. Peptide and protein substrates that are not physiologically relevant are indicated by N. How cleavage sites have been identified are indicated by the following evidence codes: NT = N-terminal sequencing, MS = mass spectroscopy, MU = mutation, CS = consensus sequence, LC = liquid chromatography. To see all annotated cleavages for a peptidase, click on the peptidase name.

Cleavage Site	Peptidase	Residue range	Cleavage type	Description	Evidence	Reference
1	unknown peptidase	1-375	P		NT	<%Agarwal et al., 2012[]%>
4	cathepsin E	1-375	P		MS	Impens et al., 2010
6	cathepsin E	1-375	P		MS	Impens et al., 2010
7	cathepsin D	1-375	P		MS	Impens et al., 2010
7	cathepsin E	1-375	P		MS	Impens et al., 2010
7	matrix metallopeptidase-2	2-375	N		MS	Prudova et al., 2010
8	cathepsin D	1-375	P		MS	Impens et al., 2010
8	cathepsin E	1-375	P		MS	Impens et al., 2010
11	caspase-1	2-375	P	normal turnover	MS	Lamkanfi et al., 2008
104	cathepsin D	1-375	P		MS	Impens et al., 2010
104	cathepsin E	1-375	P		MS	Impens et al., 2010
136	cathepsin E	1-375	P		MS	Impens et al., 2010
244	caspase-1	2-375	P		MS	Lamkanfi et al., 2008