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Substrates for peptidase M10.006: matrix metallopeptidase-10 (Homo sapiens-type)

Summary Gene structure Alignment Tree Sequences Sequence features Distribution Structure Literature Substrates Pharma

Peptide and protein substrates that are thought to be physiologically relevant are indicated by P. Peptide and protein substrates that are thought to be pathologically relevant are indicated by D. Peptide and protein substrates that are not physiologically relevant are indicated by N. Synthetic substrates are indicated by S. Click on the symbol to show only physiological, non-physiological or synthetic substrates, or here to display all substrates. How cleavage sites have been identified are indicated by the following evidence codes: NT = N-terminal sequencing, MS = mass spectroscopy, MU = mutation, CS = consensus sequence, LC = liquid chromatography. To see all annotated cleavages for a protein substrate, click on the UniProt Accession.

Substrate Uniprot Residue range Cleavage Site Cleavage type Evidence P4 P3 P2 P1 P1' P2' P3' P4' Reference CutDB MERNUM
14-3-3 protein beta/alpha Q9CQV8 21-43 peptide-Ala27+Met-peptide N MS Met Ala Ala Ala Met Lys Ala Val Schlage et al., 2015
14-3-3 protein gamma P61982 20-42 peptide-Ala26+Met-peptide N MS Met Ala Ala Ala Met Lys Asn Val Schlage et al., 2015
14-3-3 protein sigma O70456 1-248 peptide-Phe25+Met-peptide N MS Met Ala Ala Phe Met Lys Ser Ala Schlage et al., 2015
182 kDa tankyrase-1-binding protein P58871 307-402 peptide-Leu390+Leu-peptide N MS Leu Pro Gln Leu Leu Thr Glu Gly Schlage et al., 2015
Acidic leucine-rich nuclear phosphoprotein 32 family member A O35381 138-150 LLPQV+MYLDGYDR N MS Leu Pro Gln Val Met Tyr Leu Asp Schlage et al., 2015
Actin, alpha skeletal muscle P68134 98-118 VAPEEHPTL+LTEAPLNPKANR N MS His Pro Thr Leu Leu Thr Glu Ala Schlage et al., 2015
Actin, cytoplasmic 1 P60710 2-28 peptide-Ala7+Leu-peptide N MS Asp Ile Ala Ala Leu Val Val Asp Schlage et al., 2015
Actin, cytoplasmic 1 P60710 2-28 peptide-Leu8+Val-peptide N MS Ile Ala Ala Leu Val Val Asp Asn Schlage et al., 2015
Actin, cytoplasmic 2 P63260 2-28 peptide-Ala7+Leu-peptide N MS Glu Ile Ala Ala Leu Val Ile Asp Schlage et al., 2015
ADAMTS-like protein 1 Q8BLI0 29-1745 peptide-Asp372+Leu-peptide P MS Met Pro Tyr Asp Leu Tyr His Pro Schlage et al., 2014
aggrecan core protein P16112 17-2415 peptide-Asn360+Phe-peptide P NT Ile Pro Glu Asn Phe Phe Gly Val Fosang et al., 1991
Alpha-actinin-4 {ECO:0000305} P57780 2-41 peptide-Tyr32+Met-peptide N MS Met Gly Asp Tyr Met Ala Gln Glu Schlage et al., 2015
Alpha-actinin-4 {ECO:0000305} P57780 2-41 peptide-Asp31+Tyr-peptide N MS Ser Met Gly Asp Tyr Met Ala Gln Schlage et al., 2015
Alpha-enolase P17182 307-327 FTASAG+IQVVGDDLTVTNPKR N MS Ala Ser Ala Gly Ile Gln Val Val Schlage et al., 2015
Amyloid beta precursor like protein 2 {ECO:0000250|UniProtKB:Q06481} Q06335 133-156 peptide-Asp141+Val-peptide N MS Phe Val Ser Asp Val Leu Leu Val Schlage et al., 2015
ATP-citrate synthase Q91V92 827-838 PAS+FMTSICDER N MS '-' Pro Ala Ser Phe Met Thr Ser Schlage et al., 2015
basement membrane-specific heparan sulfate proteoglycan core protein Q05793 22-3707 peptide-Asn2141+Val-peptide N MS Ala Ala Ala Asn Val His Ile Pro Schlage et al., 2015
brevican core protein precursor P55068 23-833 peptide-Ala360+Phe-peptide P His Pro Ser Ala Phe Ser Glu Ala Nakamura et al., 2001 18218
brevican core protein precursor P55068 23-833 peptide-Gln498+Ala-peptide P Pro Pro Ala Gln Ala Val Leu Gln Nakamura et al., 2001 18226
Calpastatin P51125 442-458 SLSESELIGE+LSADFDR N MS Leu Ile Gly Glu Leu Ser Ala Asp Schlage et al., 2015
cCN family member 1 P18406 25-379 peptide-Glu137+Leu-peptide N MS Cys Pro Gln Glu Leu Ser Leu Pro Schlage et al., 2015
Cytoplasmic dynein 1 heavy chain 1 Q9JHU4 35-64 peptide-Ala49+Leu-peptide N MS Ala Pro Ala Ala Leu Glu Ala Ala Schlage et al., 2015
Cytosolic 10-formyltetrahydrofolate dehydrogenase {ECO:0000305|PubMed:31624291} Q8R0Y6 207-225 ETAMINWDQPAE+AIHNWIR N MS Gln Pro Ala Glu Ala Ile His Asn Schlage et al., 2015
dermokine Q6P253 22-517 peptide-Asp179+Tyr-peptide N MS Gly Pro Leu Asp Tyr Glu Thr Asn Schlage et al., 2015
Dermokine Q6P253 311-344 peptide-Ser319+Gly-peptide N MS Ser Gly Gly Ser Gly Gly Ser Gly Schlage et al., 2015
desmocollin-3 P55850 136-896 peptide-Phe611+Asn-peptide N MS Pro Phe Gln Phe Asn Leu Ala Asn Schlage et al., 2015
Dipeptidyl peptidase 3 Q99KK7 368-399 peptide-Gly389+Ile-peptide N MS Ile Pro Ala Gly Ile Asn Ile Pro Schlage et al., 2015
Elongin-C P83940 44-63 AMLSGPGQF+AENETNEVNFR N MS Pro Gly Gln Phe Ala Glu Asn Glu Schlage et al., 2015
Elongin-C P83940 44-63 AMLSGPGQ+FAENETNEVNFR N MS Gly Pro Gly Gln Phe Ala Glu Asn Schlage et al., 2015
Epiplakin {ECO:0000303|PubMed:12791695} Q8R0W0 2703-2717 QVSASE+LCTSGILDR N MS Ser Ala Ser Glu Leu Cys Thr Ser Schlage et al., 2015
Ezrin P26040 413-435 peptide-Glu420+Leu-peptide N MS Leu Ala Ala Glu Leu Ala Glu Tyr Schlage et al., 2015
Ezrin P26040 461-512 peptide-Gly498+Tyr-peptide N MS Glu Pro Met Gly Tyr Ser Ala Glu Schlage et al., 2015
Fascin Q61553 251-271 DELFALEQSCAQ+VVLQAANER N MS Ser Cys Ala Gln Val Val Leu Gln Schlage et al., 2015
fibulin-2 P37889 27-1221 peptide-Gly968+Phe-peptide N MS Cys Ala Ala Gly Phe Leu Leu Ala Schlage et al., 2015
Fibulin-2 P37889 963-987 peptide-Phe969+Leu-peptide N MS Ala Ala Gly Phe Leu Leu Ala Ala Schlage et al., 2015
Fructose-bisphosphate aldolase A P05064 154-173 IGEHTPSALA+IMENANVLAR N MS Ser Ala Leu Ala Ile Met Glu Asn Schlage et al., 2015
Glycogen synthase kinase-3 beta Q9WV60 384-405 peptide-Asn393+Ala-peptide N MS Pro Pro Ala Asn Ala Thr Ala Ala Schlage et al., 2015
Heat shock 70 kDa protein 4 Q61316 85-110 peptide-Asp90+Ile-peptide N MS Leu Ala Tyr Asp Ile Val Gln Leu Schlage et al., 2015
Heat shock protein 105 kDa Q61699 592-609 VVNVELPVEAN+LVWQLGR N MS Val Glu Ala Asn Leu Val Trp Gln Schlage et al., 2015
Heterogeneous nuclear ribonucleoproteins A2/B1 O88569 114-129 LFVGG+IKEDTEEHHLR N MS Phe Val Gly Gly Ile Lys Glu Asp Schlage et al., 2015
huntingtin P42858 1-3142 peptide-Gly402+Gln-peptide P NT Gly Gly Ile Gly Gln Leu Thr Ala Miller et al., 2010
hyaluronan and proteoglycan link protein 1 P10915 16-354 peptide-Leu40+Leu-peptide P Gly Pro His Leu Leu Val Glu Ala Nguyen et al., 1993 3609
hyaluronan and proteoglycan link protein 1 P10915 16-354 peptide-His31+Ile-peptide P Arg Ala Ile His Ile Gln Ala Glu Nguyen et al., 1993 3608
integrin alpha-6 Q61739 24-1091 peptide-Ser517+Ile-peptide N MS Pro Pro Ile Ser Ile Leu Gly Ile Schlage et al., 2015
Mannose-6-phosphate isomerase Q924M7 45-56 PYAE+LWMGTHPR N MS Pro Tyr Ala Glu Leu Trp Met Gly Schlage et al., 2015
Matrix metalloproteinase-9 P14780 20-707 peptide-Arg106+Phe-peptide P NT Asp Leu Gly Arg Phe Gln Thr Phe Nakamura et al., 1998 3607
Mca-Pro-Ala-Ala-Leu-Val-Ala-Lys(Dnp)-NH2 Mca-Pro-Ala-Ala+Leu-Val-Ala-Lys(Dnp)-NH2 S Mca Pro Ala Ala Leu Val Ala Lyd Schlage et al., 2015
Mca-Pro-Ala-Asn-Leu-Val-Ala-Lys(Dnp)-NH2 Mca-Pro-Ala-Asn+Leu-Val-Ala-Lys(Dnp)-NH2 S Mca Pro Ala Asn Leu Val Ala Lyd Schlage et al., 2015
Mca-Pro-Ala-Glu-Leu-Val-Ala-Lys(Dnp)-NH2 Mca-Pro-Ala-Glu+Leu-Val-Ala-Lys(Dnp)-NH2 S Mca Pro Ala Glu Leu Val Ala Lyd Schlage et al., 2015
Microtubule-associated protein 6 Q7TSJ2 255-279 peptide-Gln260+Ser-peptide N MS Pro Pro Ala Gln Ser Gln Thr Gln Schlage et al., 2015
myelin basic protein isoform 1 P02686 135-304 peptide-Ser111+Leu-peptide P MS Arg Gly Leu Ser Leu Ser Arg Phe Shiryaev et al., 2009 25405
myelin basic protein isoform 1 P02686 135-304 peptide-Ala169+Arg-peptide P MS Ser Pro Met Ala Arg Arg Gly Gly Shiryaev et al., 2009 25406
myelin basic protein isoform 1 P04370 1-246 peptide-Lys205+Ser-peptide P MS Leu Pro Gln Lys Ser Gln His Gly Shiryaev et al., 2009 25524
myelin basic protein isoform 1 P04370 1-246 peptide-Pro203+Gln-peptide P MS Gly Ser Leu Pro Gln Lys Ser Gln Shiryaev et al., 2009 25525
myelin basic protein isoform 1 P04370 1-246 peptide-Glu116+Leu-peptide P MS Glu Ser Asp Glu Leu Gln Thr Ile Shiryaev et al., 2009 25526
myelin basic protein isoform 1 P04370 1-246 peptide-Asn75+Asn-peptide P MS Asp Pro Lys Asn Asn Trp Gln Gly Shiryaev et al., 2009 25527
myelin basic protein isoform 2 P04370-2 1-190 peptide-Lys34+Leu-peptide P MS Ser Val Gly Lys Leu Ser Gln Thr Shiryaev et al., 2009 25431
myelin basic protein isoform 2 P04370-2 1-190 peptide-Gln142+Arg-peptide P MS Arg Pro Ser Gln Arg Ser Lys Tyr Shiryaev et al., 2009 25432
myelin basic protein isoform 2 P04370-2 1-190 peptide-Tyr146+Leu-peptide P MS Arg Ser Lys Tyr Leu Ala Thr Ala Shiryaev et al., 2009 25433
myelin basic protein isoform 2 P04370-2 1-190 peptide-His164+Arg-peptide P MS Leu Pro Arg His Arg Asp Thr Gly Shiryaev et al., 2009 25434
NEDD8-activating enzyme E1 regulatory subunit Q8VBW6 271-293 peptide-Ser284+Ile-peptide N MS Ile Pro Ser Ser Ile Glu Asp Ile Schlage et al., 2015
Neutrophil collagenase precursor P22894 21-467 peptide-Gly98+Phe-peptide P NT Asp Ser Gly Gly Phe Met Leu Thr Knäuper et al., 1996 3610
NHL repeat-containing protein 2 Q8BZW8 216-237 peptide-Pro222+Leu-peptide N MS Pro Pro Ser Pro Leu Leu Phe Pro Schlage et al., 2015
Nucleoside diphosphate kinase B Q01768 67-88 peptide-Met76+Val-peptide N MS Val Val Ala Met Val Trp Glu Gly Schlage et al., 2015
Osteoclast-stimulating factor 1 Q62422 58-83 peptide-Asn64+Tyr-peptide N MS Ile Pro Ser Asn Tyr Val Ala Glu Schlage et al., 2015
Peptidyl-prolyl cis-trans isomerase A P17742 56-69 IIPGF+MCQGGDFTR N MS Ile Pro Gly Phe Met Cys Gln Gly Schlage et al., 2015
Perilipin-3 Q9DBG5 123-150 peptide-Glu134+Met-peptide N MS Gly Ala Gln Glu Met Val Ser Ser Schlage et al., 2015
phosphatidylethanolamine-binding protein 1 P70296 2-187 peptide-Cys13+Leu-peptide N MS Gly Pro Leu Cys Leu Gln Glu Val Schlage et al., 2015
Phosphoacetylglucosamine mutase {ECO:0000305} Q9CYR6 75-103 peptide-Glu81+Met-peptide N MS Pro Leu Gly Glu Met Leu Ala Pro Schlage et al., 2015
Phosphoglycerate kinase 1 P09411 333-350 QIVWNGPVG+VFEWEAFAR N MS Gly Pro Val Gly Val Phe Glu Trp Schlage et al., 2015
Phosphoglycerate kinase 2 P09041 147-171 peptide-Ala152+Ser-peptide N MS Ala Phe Gln Ala Ser Leu Ser Lys Schlage et al., 2015
Plectin Q9QXR9 3454-3469 APVPAS+ELLDAKILSR N MS Val Pro Ala Ser Glu Leu Leu Asp Schlage et al., 2015
Plectin Q9QXR9 3123-3146 peptide-Glu3129+Leu-peptide N MS Pro Ala Ala Glu Leu Leu Asp Ser Schlage et al., 2015
Plectin Q9QXR9 2496-2511 EQMAQQ+LVEETQGFQR N MS Met Ala Gln Gln Leu Val Glu Glu Schlage et al., 2015
PRKC apoptosis WT1 regulator protein Q925B0 155-180 peptide-Glu165+Cys-peptide N MS Pro Ala Ala Glu Cys Leu Asp Glu Schlage et al., 2015
PRKC apoptosis WT1 regulator protein Q925B0 47-92 peptide-Ala80+Leu-peptide N MS Ala Pro Gly Ala Leu Asn Cys Ala Schlage et al., 2015
prolactin-2C3 P04768 30-224 peptide-Trp179+Phe-peptide N MS Asn Pro Ala Trp Phe Leu Gln Ser Schlage et al., 2015
Prolactin-2C3 P04768 176-189 NPAWF+LQSDNEDAR N MS Pro Ala Trp Phe Leu Gln Ser Asp Schlage et al., 2015
Prolyl endopeptidase Q9QUR6 622-643 peptide-Met633+Leu-peptide N MS Tyr Pro Ser Met Leu Leu Leu Thr Schlage et al., 2015
prosaposin Q61207 17-557 peptide-Pro169+Phe-peptide N MS Val Val Ala Pro Phe Met Ser Asn Schlage et al., 2015
prosaposin Q61207 17-557 peptide-Lys520+Leu-peptide N MS Ser Ala Tyr Lys Leu Leu Leu Gly Schlage et al., 2015
Protein Niban 1 {ECO:0000305} Q3UW53 741-759 IHPEASHPAA+IQQDSCEER N MS His Pro Ala Ala Ile Gln Gln Asp Schlage et al., 2015
Protein-glutamine gamma-glutamyltransferase 2 {ECO:0000305} P21981 388-406 YDAPFVFAE+VNADVVDWIR N MS Val Phe Ala Glu Val Asn Ala Asp Schlage et al., 2015
QF-24 Mca-Pro-Leu-Gly+Leu-Dpa-Ala-Arg-NH2 S Mca Pro Leu Gly Leu Dpa Ala Arg Matrisian, 2004
Ribonuclease inhibitor Q91VI7 165-183 AD+FKELVLSNNDLHEPGVR N MS '-' '-' Ala Asp Phe Lys Glu Leu Schlage et al., 2015
Scaffold attachment factor B1 D3YXK2 2-29 peptide-Ala18+Val-peptide N MS Gly Ala Ala Ala Val Ser Ser Ala Schlage et al., 2015
Septin-2 P42208 4-29 peptide-Gln8+Phe-peptide N MS Gln Pro Thr Gln Phe Ile Asn Pro Schlage et al., 2015
serine protease HTRA1 Q9R118 23-480 peptide-Ala34+Thr-peptide N MS Ala Pro Ala Ala Thr Val Cys Pro Schlage et al., 2015
Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A beta isoform Q7TNP2 61-117 peptide-Glu106+Ser-peptide N MS Pro Pro Leu Glu Ser Leu Ala Thr Schlage et al., 2015
Sorting nexin-2 Q9CWK8 347-362 SAA+MLGNSEDHTALSR N MS '-' Ser Ala Ala Met Leu Gly Asn Schlage et al., 2015
Spermidine synthase Q64674 23-44 peptide-Leu33+Ser-peptide N MS Gly Gln Ala Leu Ser Leu Gln Val Schlage et al., 2015
syndecan-4 O35988 24-198 peptide-Pro77+Glu-peptide N MS Arg Pro Phe Pro Glu Val Ile Glu Schlage et al., 2015
Transitional endoplasmic reticulum ATPase Q01853 165-191 peptide-Cys174+Ile-peptide N MS Ser Pro Tyr Cys Ile Val Ala Pro Schlage et al., 2015
Triosephosphate isomerase P17751 70-99 peptide-Met83+Ile-peptide N MS Ser Pro Gly Met Ile Lys Asp Leu Schlage et al., 2015
Tropomyosin alpha-1 chain P58771 141-160 MEIQE+IQLKEAKHIAEDADR N MS Glu Ile Gln Glu Ile Gln Leu Lys Schlage et al., 2015
Tubulin alpha-8 chain Q9JJZ2 85-105 QLFHPEQ+LITGKEDAANNYAR N MS His Pro Glu Gln Leu Ile Thr Gly Schlage et al., 2015
Tumor protein D52 Q62393 50-79 peptide-Ala69+Leu-peptide N MS Ala Pro Glu Ala Leu Thr Glu Glu Schlage et al., 2015
UV excision repair protein RAD23 homolog A P54726 123-149 peptide-Ser136+Ile-peptide N MS Ser Pro Glu Ser Ile Ser Gly Ser Schlage et al., 2015
UV excision repair protein RAD23 homolog B P54728 309-379 peptide-Tyr366+Ile-peptide N MS His Met Asn Tyr Ile Gln Val Thr Schlage et al., 2015
UV excision repair protein RAD23 homolog B P54728 309-379 peptide-Asn365+Tyr-peptide N MS Gly His Met Asn Tyr Ile Gln Val Schlage et al., 2015
V-type proton ATPase subunit B, brain isoform Q3U9Z0 68-82 YAE+IVHLTLPDGTKR N MS '-' Tyr Ala Glu Ile Val His Leu Schlage et al., 2015
V-type proton ATPase subunit G 1 Q9CR51 59-78 EAAA+LGSHGSCSSEVEKETR N MS Glu Ala Ala Ala Leu Gly Ser His Schlage et al., 2015
Valine--tRNA ligase Q9Z1Q9 1230-1250 VPLE+VQEADEAKLQQTEAELR N MS Val Pro Leu Glu Val Gln Glu Ala Schlage et al., 2015

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