Searches of the MEROPS database

Display Known Cleavages for a Protein

Please enter a UniProt accession (eg P05067):

Accession:

Sequence P17182

,

Click here to display alignment and conservation of cleavage sites of this sequence with close homologues. This will take a few moments.

Peptide and protein substrates that are thought to be physiologically relevant are indicated by P. Peptide and protein substrates that are not physiologically relevant are indicated by N. How cleavage sites have been identified are indicated by the following evidence codes: NT = N-terminal sequencing, MS = mass spectroscopy, MU = mutation, CS = consensus sequence, LC = liquid chromatography. To see all annotated cleavages for a peptidase, click on the peptidase name.

Cleavage Site	Peptidase	Residue range	Cleavage type	Description	Evidence	Reference
1	unknown peptidase	1-434	P		NT	<%Agarwal et al., 2012[]%>
21	cathepsin E	2-434	P		MS	Impens et al., 2010
23	cathepsin D	2-434	P		MS	Impens et al., 2010
23	cathepsin E	2-434	P		MS	Impens et al., 2010
23	granzyme B (Homo sapiens-type)	2-434	N			Van Damme et al., 2009
23	granzyme B, rodent-type	2-434	P	normal turnover		Van Damme et al., 2009
24	cathepsin D	2-434	P		MS	Impens et al., 2010
24	cathepsin E	2-434	P		MS	Impens et al., 2010
32	trypsin 1	2-434	N			Van Damme et al., 2009
42	cathepsin E	2-434	P		MS	Impens et al., 2010
110	matrix metallopeptidase-2	2-434	N		MS	auf dem Keller et al., 2010
113	cathepsin E	2-434	P		MS	Impens et al., 2010
115	cathepsin D	2-434	P		MS	Impens et al., 2010
116	cathepsin D	2-434	P		MS	Impens et al., 2010
116	cathepsin E	2-434	P		MS	Impens et al., 2010
117	cathepsin E	2-434	P		MS	Impens et al., 2010
167	cathepsin E	2-434	P		MS	Impens et al., 2010
168	cathepsin D	2-434	P		MS	Impens et al., 2010
168	cathepsin E	2-434	P		MS	Impens et al., 2010
171	cathepsin E	2-434	P		MS	Impens et al., 2010
239	cathepsin E	2-434	P		MS	Impens et al., 2010
243	cathepsin D	2-434	P		MS	Impens et al., 2010
243	cathepsin E	2-434	P		MS	Impens et al., 2010
244	cathepsin D	2-434	P		MS	Impens et al., 2010
307	cathepsin D	2-434	P		MS	Impens et al., 2010
312	cathepsin D	2-434	P		MS	Impens et al., 2010
312	cathepsin E	2-434	P		MS	Impens et al., 2010
312	matrix metallopeptidase-2	2-434	N		MS	auf dem Keller et al., 2010
318	granzyme B (Homo sapiens-type)	2-434	N		MS	Van Damme et al., 2009
319	cathepsin E	2-434	P		MS	Impens et al., 2010
380	cathepsin E	2-434	P		MS	Impens et al., 2010
383	cathepsin D	2-434	P		MS	Impens et al., 2010
383	cathepsin E	2-434	P		MS	Impens et al., 2010
383	matrix metallopeptidase-2	2-434	N		MS	auf dem Keller et al., 2010
384	cathepsin D	2-434	P		MS	Impens et al., 2010
384	cathepsin E	2-434	P		MS	Impens et al., 2010
387	cathepsin D	2-434	P		MS	Impens et al., 2010
387	matrix metallopeptidase-2	2-434	N		MS	auf dem Keller et al., 2010
388	cathepsin D	2-434	P		MS	Impens et al., 2010
388	cathepsin E	2-434	P		MS	Impens et al., 2010
388	matrix metallopeptidase-2	2-434	N		MS	auf dem Keller et al., 2010
414	cathepsin D	2-434	P		MS	Impens et al., 2010
414	cathepsin E	2-434	P		MS	Impens et al., 2010
417	cathepsin E	2-434	P		MS	Impens et al., 2010