Searches of the MEROPS database

Display Known Cleavages for a Protein

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Accession:

Sequence P14780

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Peptide and protein substrates that are thought to be physiologically relevant are indicated by P. Peptide and protein substrates that are not physiologically relevant are indicated by N. How cleavage sites have been identified are indicated by the following evidence codes: NT = N-terminal sequencing, MS = mass spectroscopy, MU = mutation, CS = consensus sequence, LC = liquid chromatography. To see all annotated cleavages for a peptidase, click on the peptidase name.

Cleavage Site	Peptidase	Residue range	Cleavage type	Description	Evidence	Reference
19	unknown peptidase	1-707	P	release of a signal peptide	NT	Sang et al., 1995
28	matrix metallopeptidase-9	20-707	P		NT	Ries et al., 2007
34	matrix metallopeptidase-9	20-707	P			Geurts et al., 2008
57	elastase-2	20-707	P	normal turnover	NT	Jackson et al., 2010
58	elastase-2	20-707	P	normal turnover	NT	Jackson et al., 2010
59	matrix metallopeptidase-1	20-707	P	normal turnover		Sang et al., 1995
59	matrix metallopeptidase-2	20-707	P			Fridman et al., 1995
59	matrix metallopeptidase-9	20-707	P			Fridman et al., 1995
59	matrix metallopeptidase-3	20-707	P	normal turnover		Ogata et al., 1992
59	matrix metallopeptidase-7	20-707	P	release of an amino acid		Sang et al., 1995
59	matrix metallopeptidase-13	20-707	P	release of an amino acid		<%Knauper et al., 1997[]%>
65	enteropeptidase	20-707	P		NT	Vilen et al., 2008
71	matrix metallopeptidase-9	20-707	P			Geurts et al., 2008
72	matrix metallopeptidase-9	1-707	P			Sang et al., 1995
81	matrix metallopeptidase-9	20-707	P			Geurts et al., 2008
92	matrix metallopeptidase-19	20-707	P			Stracke et al., 2000
93	matrix metallopeptidase-1	20-707	P	release of an activation peptide		Sang et al., 1995
93	matrix metallopeptidase-9	20-707	P	release of an activation peptide		Sang et al., 1995
93	matrix metallopeptidase-3	20-707	P			Sang et al., 1995
93	matrix metallopeptidase-26	20-707	P			Zhao et al., 2003
106	matrix metallopeptidase-1	20-707	P	conversion to two-chain form		Sang et al., 1995
106	matrix metallopeptidase-2	20-707	P			Fridman et al., 1995
106	matrix metallopeptidase-3	20-707	P	conversion to two-chain form		Ogata et al., 1992
106	matrix metallopeptidase-10 (Homo sapiens-type)	20-707	P		NT	Nakamura et al., 1998
106	matrix metallopeptidase-7	93-707	P			Sang et al., 1995
106	matrix metallopeptidase-13	20-707	P	conversion to two-chain form		<%Knauper et al., 1997[]%>
106	trypsin 1	20-707	N			Sang et al., 1995
106	trypsin-2 type A	93-707	P			Sorsa et al., 1997
109	thermolysin		N			Okamoto et al., 1997
109	vibriolysin		N			Okamoto et al., 1997
109	pseudolysin		N			Okamoto et al., 1997
135	matrix metallopeptidase-9	107-707	P		MS	Doucet & Overall, 2010
146	matrix metallopeptidase-9	107-707	P		MS	Doucet & Overall, 2010
197	matrix metallopeptidase-9	107-707	P		MS	Doucet & Overall, 2010
324	matrix metallopeptidase-9	107-707	P		MS	Doucet & Overall, 2010
417	matrix metallopeptidase-9	107-707	P		MS	Doucet & Overall, 2010
555	matrix metallopeptidase-9	107-707	P		MS	Doucet & Overall, 2010