Searches of the MEROPS database

Display Known Cleavages for a Protein

Please enter a UniProt accession (eg P05067):

Accession:

Sequence P42858

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Peptide and protein substrates that are thought to be physiologically relevant are indicated by P. Peptide and protein substrates that are not physiologically relevant are indicated by N. How cleavage sites have been identified are indicated by the following evidence codes: NT = N-terminal sequencing, MS = mass spectroscopy, MU = mutation, CS = consensus sequence, LC = liquid chromatography. To see all annotated cleavages for a peptidase, click on the peptidase name.

Cleavage Site	Peptidase	Residue range	Cleavage type	Description	Evidence	Reference
402	matrix metallopeptidase-10 (Homo sapiens-type)	1-3142	P		NT	Miller et al., 2010
467	calpain-1	1-3142	P			Gafni et al., 2004
467	calpain-2	1-3142	P			Gafni et al., 2004
511	caspase-3	1-3142	P			Wellington et al., 2000
528	caspase-3	1-3142	P	normal turnover		Wellington et al., 2000
534	calpain-1	1-3142	P			Gafni et al., 2004
534	calpain-2	1-3142	P			Gafni et al., 2004
550	caspase-3	1-3142	P			Wellington et al., 2000
550	caspase-2	1-3142	P			Wellington et al., 2000
584	caspase-3	1-3142	P	normal turnover		Wellington et al., 2000
584	caspase-6	1-3142	P			Wellington et al., 2000
587	unknown peptidase	1-3142	P		NT	<%Agarwal et al., 2012[]%>