Searches of the MEROPS database

Display Known Cleavages for a Protein

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Accession:

Sequence P02686

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Peptide and protein substrates that are thought to be physiologically relevant are indicated by P. Peptide and protein substrates that are not physiologically relevant are indicated by N. How cleavage sites have been identified are indicated by the following evidence codes: NT = N-terminal sequencing, MS = mass spectroscopy, MU = mutation, CS = consensus sequence, LC = liquid chromatography. To see all annotated cleavages for a peptidase, click on the peptidase name.

Cleavage Site	Peptidase	Residue range	Cleavage type	Description	Evidence	Reference
135	unknown peptidase	135-304	P		NT	Beck et al., 2001
136	unknown peptidase	135-304	P		NT	Beck et al., 2001
137	unknown peptidase	135-304	P		NT	Beck et al., 2001
141	unknown peptidase	135-304	P		NT	Beck et al., 2001
148	matrix metallopeptidase-8	135-304	P			Shiryaev et al., 2009
148	matrix metallopeptidase-2	135-304	P			Shiryaev et al., 2009
148	matrix metallopeptidase-9	135-304	P			Shiryaev et al., 2009
148	membrane-type matrix metallopeptidase-6	135-304	P			Shiryaev et al., 2009
149	cathepsin S	135-304	P	normal turnover		Beck et al., 2001
150	unknown peptidase	135-304	P		NT	Beck et al., 2001
151	unknown peptidase	135-304	P		NT	Beck et al., 2001
152	calpain-2	135-304	P			Banik et al., 1994
153	unknown peptidase	135-304	P		NT	Beck et al., 2001
157	calpain-2	135-304	P			Banik et al., 1994
159	mesotrypsin	135-304	P			Medveczky et al., 2006
159	kallikrein-related peptidase 6	156-162	N		CS	Angelo et al., 2006
161	calpain-2	135-304	P			Banik et al., 1994
165	kallikrein-related peptidase 6	162-168	N		CS	Angelo et al., 2006
166	matrix metallopeptidase-2	135-304	P		MS	Shiryaev et al., 2009
166	matrix metallopeptidase-9	135-304	P			Shiryaev et al., 2009
167	kallikrein-related peptidase 6	164-170	N		CS	Angelo et al., 2006
173	cathepsin S	135-304	P	normal turnover		Beck et al., 2001
177	matrix metallopeptidase-2	135-304	P			Shiryaev et al., 2009
177	kallikrein-related peptidase 6	174-180	N		CS	Angelo et al., 2006
178	cathepsin D	135-304	P	normal turnover		Beck et al., 2001
180	cathepsin S	135-304	P	normal turnover		Beck et al., 2001
183	calpain-2	135-304	P			Banik et al., 1994
183	kallikrein-related peptidase 6	180-186	N		CS	Angelo et al., 2006
188	kallikrein-related peptidase 6	185-191	N		CS	Angelo et al., 2006
188	flavivirin	134-304	P		MS	Shiryaev et al., 2006
193	calpain-2	135-304	P		NT	Banik et al., 1994
199	cathepsin S	135-304	P	normal turnover		Beck et al., 2001
199	mesotrypsin	135-304	P			Medveczky et al., 2006
199	kallikrein-related peptidase 6	196-202	N		CS	Angelo et al., 2006
200	unknown peptidase	135-304	P		NT	Beck et al., 2001
202	unknown peptidase	135-304	N		NT	Beck et al., 2001
203	unknown peptidase	135-304	P		NT	Beck et al., 2001
204	calpain-2	135-304	P			Banik et al., 1994
213	mesotrypsin	134-304	P			Medveczky et al., 2006
213	kallikrein-related peptidase 6	210-216	N		CS	Angelo et al., 2006
218	unknown peptidase	135-304	P		NT	Beck et al., 2001
222	cathepsin S	135-304	P	normal turnover		Beck et al., 2001
223	cathepsin D	135-304	P	normal turnover		Beck et al., 2001
223	matrix metallopeptidase-8	135-304	P			Shiryaev et al., 2009
223	matrix metallopeptidase-12	135-304	P			Shiryaev et al., 2009
223	membrane-type matrix metallopeptidase-1	135-304	P			Shiryaev et al., 2009
223	membrane-type matrix metallopeptidase-6	135-304	P			Shiryaev et al., 2009
224	matrix metallopeptidase-8	135-304	P			Shiryaev et al., 2009
224	matrix metallopeptidase-2	135-304	P			Shiryaev et al., 2009
224	matrix metallopeptidase-9	135-304	P		MS	Shiryaev et al., 2009
224	cathepsin G	1-304	P			Burster et al., 2004
225	cathepsin L	135-304	P	normal turnover		Beck et al., 2001
225	cathepsin S	135-304	P	normal turnover		Beck et al., 2001
226	legumain, animal-type	1-304	P	normal turnover		Burster et al., 2004
226	matrix metallopeptidase-8	135-304	P			Shiryaev et al., 2009
226	matrix metallopeptidase-2	135-304	P			Shiryaev et al., 2009
226	matrix metallopeptidase-9	135-304	P			Shiryaev et al., 2009
227	unknown peptidase	135-304	P		NT	Beck et al., 2001
228	calpain-2	135-304	P		NT	Banik et al., 1994
230	matrix metallopeptidase-2	135-304	P			Shiryaev et al., 2009
230	matrix metallopeptidase-9	135-304	P			Shiryaev et al., 2009
231	calpain-2	135-304	P		NT	Banik et al., 1994
231	mesotrypsin	134-304	P			Medveczky et al., 2006
231	kallikrein-related peptidase 6	228-234	N		CS	Angelo et al., 2006
235	matrix metallopeptidase-9	135-304	P			Shiryaev et al., 2009
235	membrane-type matrix metallopeptidase-6	135-304	P			Shiryaev et al., 2009
241	mesotrypsin	214-304	P		MS	Medveczky et al., 2006
241	kallikrein-related peptidase 6	238-244	N		CS	Angelo et al., 2006
241	flavivirin	134-304	P		NT	Shiryaev et al., 2006
242	matrix metallopeptidase-8	135-304	P			Shiryaev et al., 2009
242	matrix metallopeptidase-2	135-304	P			Shiryaev et al., 2009
242	membrane-type matrix metallopeptidase-1	135-304	P			Shiryaev et al., 2009
242	membrane-type matrix metallopeptidase-6	135-304	P			Shiryaev et al., 2009
244	cathepsin L	135-304	P	normal turnover		Beck et al., 2001
244	cathepsin S	135-304	P	normal turnover		Beck et al., 2001
244	calpain-2	135-304	P			Banik et al., 1994
244	matrix metallopeptidase-2	135-304	P			Shiryaev et al., 2009
244	matrix metallopeptidase-9	1-304	P			Proost et al., 1993
244	matrix metallopeptidase-10 (Homo sapiens-type)	135-304	P			Shiryaev et al., 2009
244	matrix metallopeptidase-12	135-304	P			Shiryaev et al., 2009
244	membrane-type matrix metallopeptidase-1	135-304	P			Shiryaev et al., 2009
244	membrane-type matrix metallopeptidase-6	135-304	P			Shiryaev et al., 2009
246	unknown peptidase	135-304	P		NT	Beck et al., 2001
247	kallikrein-related peptidase 6	244-250	N		CS	Angelo et al., 2006
248	matrix metallopeptidase-9	1-304	P			Proost et al., 1993
248	cathepsin G	1-304	P			Burster et al., 2004
249	cathepsin S	135-304	P	normal turnover		Beck et al., 2001
260	cathepsin S	135-304	P	normal turnover		Beck et al., 2001
261	cathepsin S	135-304	P	normal turnover		Beck et al., 2001
262	cathepsin S	135-304	P	normal turnover		Beck et al., 2001
264	kallikrein-related peptidase 6	261-267	N		CS	Angelo et al., 2006
265	calpain-2	135-304	P			Medveczky et al., 2006
266	unknown peptidase	135-304	P		NT	Beck et al., 2001
267	matrix metallopeptidase-8	135-304	P			Shiryaev et al., 2009
267	matrix metallopeptidase-2	135-304	P			Shiryaev et al., 2009
267	matrix metallopeptidase-9	135-304	P			Proost et al., 1993
267	membrane-type matrix metallopeptidase-6	135-304	P			Shiryaev et al., 2009
276	cathepsin S	135-304	P	normal turnover		Beck et al., 2001
276	trypsin 1	135-304	N		MS	Medveczky et al., 2006
277	unknown peptidase	135-304	P		NT	Beck et al., 2001
279	cathepsin S	135-304	P	normal turnover		Beck et al., 2001
279	calpain-2	135-304	P			Banik et al., 1994
284	unknown peptidase	135-304	P		NT	Beck et al., 2001
285	unknown peptidase	135-304	P		NT	Beck et al., 2001
286	matrix metallopeptidase-8	135-304	P			Shiryaev et al., 2009
286	matrix metallopeptidase-2	135-304	P			Shiryaev et al., 2009
286	matrix metallopeptidase-9	135-304	P			Shiryaev et al., 2009
286	membrane-type matrix metallopeptidase-6	135-304	P			Shiryaev et al., 2009
287	unknown peptidase	135-304	P		NT	Beck et al., 2001
289	cathepsin S	135-304	P	normal turnover		Beck et al., 2001
290	calpain-2	135-304	P			Banik et al., 1994
293	kallikrein-related peptidase 6	290-296	N		CS	Angelo et al., 2006
294	unknown peptidase	135-304	P		NT	Beck et al., 2001
296	kallikrein-related peptidase 6	293-299	N		CS	Angelo et al., 2006
302	matrix metallopeptidase-10 (Homo sapiens-type)	135-304	P			Shiryaev et al., 2009
302	matrix metallopeptidase-12	135-304	P			Shiryaev et al., 2009
302	membrane-type matrix metallopeptidase-1	135-304	P			Shiryaev et al., 2009
302	membrane-type matrix metallopeptidase-6	135-304	P			Shiryaev et al., 2009
303	unknown peptidase	135-304	P		NT	Beck et al., 2001