$VAR1 = undef;

Summary for peptidase M10.006: matrix metallopeptidase-10 (Homo sapiens-type)

Names
MEROPS Name	matrix metallopeptidase-10 (Homo sapiens-type)
Other names	matrix metalloproteinase 10, MMP-10, stromelysin 2, transin-2 (Homo sapiens-type)

Domain architecture

MEROPS Classification
Classification	Clan MA >> Subclan MA(M) >> Family M10 >> Subfamily A >> M10.006
Holotype	matrix metallopeptidase-10 (Homo sapiens-type), Uniprot accession P09238 (peptidase unit: 97-278), MERNUM MER0001072
History	Identifier created: Handbook of Proteolytic Enzymes (1998) Academic Press, London.

Activity
Catalytic type	Metallo
Peplist	Included in the Peplist with identifier PL00159
NC-IUBMB	Subclass 3.4 (Peptidases) >> Sub-subclass 3.4.24 (Metalloendopeptidases) >> Peptidase 3.4.24.22
Enzymology	BRENDA database
Proteolytic events	CutDB database (16 cleavages)
Activity status	human: active (Matrisian, 2004) mouse: active (Gack et al., 1994)
Physiology	Role in turnover of extracellular matrix proteins.
Other databases	WIKIPEDIA	http://en.wikipedia.org/wiki/MMP10
Cleavage site specificity	Explanations of how to interpret the following cleavage site sequence logo and specificity matrix can be found here.
Cleavage pattern	-/Pa/a/-l/-/-/- (based on 103 cleavages)

Specificity matrix

Amino acid	P4	P3	P2	P1	P1'	P2'	P3'	P4'
Gly	11	5	13	9	1	2	5	11
Pro	13	49	0	4	0	0	0	9
Ala	8	20	38	17	4	4	18	13
Val	6	5	1	1	9	18	3	8
Leu	7	2	8	5	33	18	11	4
Ile	6	4	3	0	15	4	4	3
Met	6	2	3	3	9	5	1	0
Phe	2	3	1	6	11	2	1	2
Tyr	1	2	4	3	5	2	0	2
Trp	0	0	1	1	0	3	1	1
Ser	11	6	8	7	5	9	9	6
Thr	0	0	2	0	1	4	10	5
Cys	2	1	0	2	1	2	2	0
Asn	1	0	1	8	2	3	3	8
Gln	2	1	10	8	2	12	9	6
Asp	4	0	2	6	0	1	5	9
Glu	5	1	4	17	2	4	15	9
Lys	0	0	2	3	0	7	1	2
Arg	5	0	1	1	3	1	1	1
His	5	1	1	2	0	1	4	1

Human genetics
Gene symbol	Locus	Megabases	Ensembl	Entrez gene	Gene Cards	OMIM
MMP10	11q22.3-q23		ENSG00000166670	4319	MMP10	185260