Merops Switch to
Inhibitors

Peptidase

Family Clan SEARCHES BLAST
MEROPS SUBMISSIONS

Other
information

Literature for peptidase M10.006: matrix metallopeptidase-10 (Homo sapiens-type)

Summary Gene structure Alignment Tree Sequences Sequence features Distribution Structure Literature Substrates Pharma

(Topics flags: S Structure, P Specificity, K Knockout, I Inhibitor, L Localization, V Review. To select only the references relevant to a single topic, click the link above. See explanation.)

    2025
  1. Wei,Y., Xuan,Y., Liu,C., Li,X., Zhang,Y., Shi,C., Li,S., Yang,Q. and Liu,Z.<br>Fiber optic surface plasmon resonance sensor for high-sensitivity detection of MMP10, a diagnostic target for Alzheimer's disease<br>Opt Express (2025) 33, 38181-38193. PubMed  Europe PubMed DOI  I
    2. 2024
  2. Dibdiakova,K., Majercikova,Z., Galanda,T., Richterova,R., Kolarovszki,B., Racay,P. and Hatok,J.<br>Relationship between the Expression of Matrix Metalloproteinases and Their Tissue Inhibitors in Patients with Brain Tumors<br>Int J Mol Sci (2024) 25 PubMed  Europe PubMed DOI  PMC  EPMC
    3. 2023
  3. Margetts,P.J.<br>Matrix metalloproteinase 10 and the slow demise of the peritoneal membrane<br>Kidney Int (2023) 104, 880-882. PubMed  Europe PubMed DOI
    4. 2022
  4. Chi,P.L., Cheng,C.C., Hung,C.C., Wang,M.T., Liu,H.Y., Ke,M.W., Shen,M.C., Lin,K.C., Kuo,S.H., Hsieh,P.P., Wann,S.R. and Huang,W.C.<br>MMP-10 from M1 macrophages promotes pulmonary vascular remodeling and pulmonary arterial hypertension<br>Int J Biol Sci (2022) 18, 331-348. PubMed  Europe PubMed DOI  PMC  EPMC
  5. Gonzalez-Zamora,J., Hernandez,M., Recalde,S., Bezunartea,J., Montoliu,A., Bilbao-Malave,V., Orbe,J., Rodriguez,J.A., Llorente-Gonzalez,S., Fernandez-Robredo,P. and Garcia-Layana,A.<br>Matrix Metalloproteinase 10 Contributes to Choroidal Neovascularisation<br>Biomedicines (2022) 10 PubMed  Europe PubMed DOI  PMC  EPMC
  6. Kudelski,J., Mlynarczyk,G., Gudowska-Sawczuk,M., Mroczko,B., Darewicz,B., Bruczko-Goralewska,M. and Romanowicz,L.<br>Higher Content but Not Activity of Stromelysin-2 (MMP-10) in Comparison to Stromelysin-1 (MMP-3) in Human Renal Carcinoma<br>Int J Environ Res Public Health (2022) 19, 12613-12613. PubMed  Europe PubMed DOI  PMC  EPMC
  7. Raeeszadeh-Sarmazdeh,M., Coban,M., Mahajan,S., Hockla,A., Sankaran,B., Downey,G.P., Radisky,D.C. and Radisky,E.S.<br>Engineering of tissue inhibitor of metalloproteinases TIMP-1 for fine discrimination between closely related stromelysins MMP-3 and MMP-10<br>J Biol Chem (2022) 298, 101654-101654. PubMed  Europe PubMed DOI  PMC  EPMC
  8. Shigeta,S., Watanabe,Y., Suzuki,F., Nagase,S., Shibuya,Y., Ishibashi,M., Nagai,T., Shiga,N., Toyoshima,M., Tokunaga,H., Shimada,M. and Yaegashi,N.<br>MicroRNA-152 Regulates Endometrial Serous Carcinoma Cell Motility by Suppressing Matrix Metalloproteinase 10 Expression<br>Tohoku J Exp Med (2022) 256, 249-258. PubMed  Europe PubMed DOI  K
  9. Sun,X. and Liu,Y.<br>Matrix Metalloproteinase-10 in Kidney Injury Repair and Disease<br>Int J Mol Sci (2022) 23, 2131-2131. PubMed  Europe PubMed DOI  PMC  EPMC  V
  10. Tang,K., Wu,Z., Sun,M., Huang,X., Sun,J., Shi,J., Wang,X., Miao,Z., Gao,P., Song,Y. and Wang,Z.<br>Elevated MMP10/13 mediated barrier disruption and NF-kappaB activation aggravate colitis and colon tumorigenesis in both individual or full miR-148/152 family knockout mice<br>Cancer Lett (2022) 529, 53-69. PubMed  Europe PubMed DOI
  11. Tian,Y., Zheng,G., Xie,H., Guo,Y., Zeng,H., Fu,Y. and Liu,X.<br>Study on the Mechanism of circRNA-0024103 Reducing Endothelial Cell Injury by Regulating miR-363/MMP-10<br>Contrast Media Mol Imaging (2022) 2022, 1709325-1709325. PubMed  Europe PubMed DOI  PMC  EPMC
  12. Zhang,D., Deng,X., Liu,Y., Zhang,Y., Wang,H., Zhang,M., Fang,Q., Yi,C., Zhao,X., Ma,T., Wu,C. and Chen,J.<br>MMP-10 Deficiency Effects Differentiation and Death of Chondrocytes Associated with Endochondral Osteogenesis in an Endemic Osteoarthritis<br>Cartilage (2022) 13, 19476035221109226-19476035221109226. PubMed  Europe PubMed DOI  PMC  EPMC  K
    13. 2021
  13. Bae,S., Lim,J.W. and Kim,H.<br>beta-Carotene Inhibits Expression of Matrix Metalloproteinase-10 and Invasion in Helicobacter pylori-Infected Gastric Epithelial Cells<br>Molecules (2021) 26, 1567-1567. PubMed  Europe PubMed DOI  PMC  EPMC
  14. Baraibar-Churio,A., Bobadilla,M., Machado,F.J.D., Sainz,N., Roncal,C., Abizanda,G., Prosper,F., Orbe,J. and Perez-Ruiz,A.<br>Deficiency of MMP-10 Aggravates the Diseased Phenotype of Aged Dystrophic Mice<br>Life (Basel) (2021) 11, 1398-1398. PubMed  Europe PubMed DOI  PMC  EPMC
  15. Bassiouni,W., Ali,M.A.M. and Schulz,R.<br>Multifunctional intracellular matrix metalloproteinases: implications in disease<br>FEBS J (2021) 288, 7162-7182. PubMed  Europe PubMed DOI  V
  16. Kudelski,J., Mlynarczyk,G., Gudowska-Sawczuk,M., Mroczko,B., Darewicz,B., Bruczko-Goralewska,M., Sobolewski,K. and Romanowicz,L.<br>Enhanced Expression but Decreased Specific Activity of Matrix Metalloproteinase 10 (MMP-10) in Comparison with Matrix Metalloproteinase 3 (MMP-3) in Human Urinary Bladder Carcinoma<br>J Clin Med (2021) 10, 3683-3683. PubMed  Europe PubMed DOI  PMC  EPMC
  17. Nakagawa,M., Shirasugi,M., Yamamoto,T., Nakaya,T. and Kanamura,N.<br>Long-term exposure to butyric acid induces excessive production of matrix metalloproteases in human gingival fibroblasts<br>Arch Oral Biol (2021) 123, 105035-105035. PubMed  Europe PubMed DOI  L
  18. Valdes-Fernandez,J., Lopez-Martinez,T., Ripalda-Cemborain,P., Calvo,I.A., Saez,B., Romero-Torrecilla,J.A., Aldazabal,J., Muinos-Lopez,E., Montiel,V., Orbe,J., Rodriguez,J.A., Paramo,J.A., Prosper,F. and Granero-Molto,F.<br>Molecular and Cellular Mechanisms of Delayed Fracture Healing in Mmp10 (Stromelysin 2) Knockout Mice<br>J Bone Miner Res (2021) 36, 2203-2213. PubMed  Europe PubMed DOI
  19. Zuo,Y., Wang,C., Sun,X., Hu,C., Liu,J., Hong,X., Shen,W., Nie,J., Hou,F.F., Zhou,L. and Liu,Y.<br>Identification of matrix metalloproteinase-10 as a key mediator of podocyte injury and proteinuria<br>Kidney Int (2021) 100, 837-849. PubMed  Europe PubMed DOI  K
    20. 2020
  20. El Ashry,E.S.H., Awad,L.F., Teleb,M., Ibrahim,N.A., Abu-Serie,M.M. and Abd Al Moaty,M.N.<br>Structure-based design and optimization of pyrimidine- and 1,2,4-triazolo[4,3-a]pyrimidine-based matrix metalloproteinase-10/13 inhibitors via Dimroth rearrangement towards targeted polypharmacology<br>Bioorg Chem (2020) 96, 103616-103616. PubMed  Europe PubMed DOI  I
  21. Moffitt,L.R., Bilandzic,M., Wilson,A.L., Chen,Y., Gorrell,M.D., Oehler,M.K., Plebanski,M. and Stephens,A.N.<br>Hypoxia Regulates DPP4 Expression, Proteolytic Inactivation, and Shedding from Ovarian Cancer Cells<br>Int J Mol Sci (2020) 21 PubMed  Europe PubMed DOI  PMC  EPMC
  22. Razai,A.S., Eckelman,B.P. and Salvesen,G.S.<br>Selective inhibition of matrix metalloproteinase 10 (MMP10) with a single-domain antibody<br>J Biol Chem (2020) 295, 2464-2472. PubMed  Europe PubMed DOI
    23. 2019
  23. Mirastschijski,U., Dinesh,N., Baskaran,S., Wedekind,D., Gavrilovic,J., Murray,M.Y., Bevan,D. and Kelm,S.<br>Novel specific human and mouse stromelysin-1 (MMP-3) and stromelysin-2 (MMP-10) antibodies for biochemical and immunohistochemical analyses<br>Wound Repair Regen (2019) 27, 309-323. PubMed  Europe PubMed DOI
    24. 2017
  24. Vandivort,T.C., Birkland,T.P., Domiciano,T.P., Mitra,S., Kavanagh,T.J. and Parks,W.C.<br>Stromelysin-2 (MMP-10) facilitates clearance and moderates inflammation and cell death following lung exposure to long multiwalled carbon nanotubes<br>Int J Nanomedicine (2017) 12, 1019-1031. PubMed  Europe PubMed DOI  PMC  EPMC  K
    25. 2016
  25. McMahan,R.S., Birkland,T.P., Smigiel,K.S., Vandivort,T.C., Rohani,M.G., Manicone,A.M., McGuire,J.K., Gharib,S.A. and Parks,W.C.<br>Stromelysin-2 (MMP10) moderates inflammation by controlling macrophage activation<br>J Immunol (2016) 197, 899-909. PubMed  Europe PubMed DOI
    26. 2015
  26. Rohani,M.G., McMahan,R.S., Razumova,M.V., Hertz,A.L., Cieslewicz,M., Pun,S.H., Regnier,M., Wang,Y., Birkland,T.P. and Parks,W.C.<br>MMP-10 regulates collagenolytic activity of alternatively activated resident macrophages<br>J Invest Dermatol (2015) 135, 2377-2384. PubMed  Europe PubMed DOI
  27. Schlage,P., Kockmann,T., Sabino,F., Kizhakkedathu,J.N. and auf dem Keller,U.<br>Matrix metalloproteinase 10 degradomics in keratinocytes and epidermal tissue identifies bioactive substrates with pleiotropic functions<br>Mol Cell Proteomics (2015) 14, 3234-3246. PubMed  Europe PubMed DOI  P
    28. 2014
  28. Bobadilla,M., Sáinz,N., Rodriguez,J.A., Abizanda,G., Orbe,J., de,M.A., García Verdugo,J.M., Páramo,J.A., Prósper,F. and Pérez-Ruiz,A.<br>MMP-10 is required for efficient muscle regeneration in mouse models of injury and muscular dystrophy<br>Stem Cells (2014) 32, 447-461. PubMed  Europe PubMed
  29. Schlage,P., Egli,F.E., Nanni,P., Wang,L.W., Kizhakkedathu,J.N., Apte,S.S. and Keller,U.A.<br>Time-resolved analysis of the matrix metalloproteinase 10 substrate degradome<br>Mol Cell Proteomics (2014) 13, 580-593. PubMed  Europe PubMed DOI
    30. 2013
  30. Murray,M.Y., Birkland,T.P., Howe,J.D., Rowan,A.D., Fidock,M., Parks,W.C. and Gavrilovic,J.<br>Macrophage migration and invasion is regulated by MMP10 expression<br>PLoS ONE (2013) 8, e63555-e63555. PubMed  Europe PubMed DOI  PMC  EPMC
    31. 2012
  31. Batra,J., Robinson,J., Soares,A.S., Fields,A.P., Radisky,D.C. and Radisky,E.S.<br>Matrix metalloproteinase-10 (MMP-10) interaction with tissue inhibitors of metalloproteinases TIMP-1 and TIMP-2: binding studies and crystal structure<br>J Biol Chem (2012) 287, 15935-15946. PubMed  Europe PubMed DOI  S
  32. Fingleton,B.<br>Matrix metallopeptidase-10/stromelysin 2<br>[ISSN:978-0-12-407744-7] (2012) 3, 774-778. DOI
    33. 2010
  33. Miller,J.P., Holcomb,J., Al-Ramahi,I., de Haro,M., Gafni,J., Zhang,N., Kim,E., Sanhueza,M., Torcassi,C., Kwak,S., Botas,J., Hughes,R.E. and Ellerby,L.M.<br>Matrix metalloproteinases are modifiers of huntingtin proteolysis and toxicity in Huntington's disease<br>Neuron (2010) 67, 199-212. PubMed  Europe PubMed DOI  PMC  EPMC
    34. 2009
  34. Lijnen,H.R., Van Hoef,B., Rodriguez,J.A. and Paramo,J.A.<br>Stromelysin-2 (MMP-10) deficiency does not affect adipose tissue formation in a mouse model of nutritionally induced obesity<br>Biochem Biophys Res Commun (2009) 389, 378-381. PubMed  Europe PubMed DOI  K
  35. Wu,X. and Pan,Y.<br>Molecular characterization, mapping, and haplotype analysis of porcine matrix metalloproteinase genes MMP1 and MMP10<br>Biochem Genet (2009) 47, 763-774. PubMed  Europe PubMed DOI
    36. 2004
  36. [YEAR:20-2-2004]Bertini,I., Calderone,V., Fragai,M., Luchinat,C., Mangani,S. and Terni,B.<br>Crystal structure of the catalytic domain of human matrix metalloproteinase 10<br>J Mol Biol (20-2-2004) 336, 707-716. PubMed  Europe PubMed DOI  S  I
  37. Gill,J.H., Kirwan,I.G., Seargent,J.M., Martin,S.W., Tijani,S., Anikin,V.A., Mearns,A.J., Bibby,M.C., Anthoney,A. and Loadman,P.M.<br>MMP-10 is overexpressed, proteolytically active, and a potential target for therapeutic intervention in human lung carcinomas<br>Neoplasia (2004) 6, 777-785. PubMed  Europe PubMed DOI  PMC  EPMC
  38. Matrisian,L.M.<br>Stromelysin 2<br>[ISSN:0-12-079610-4] (2004) 2, 523-526.  V
    39. 1998
  39. [YEAR:1-4-1998]Nakamura,H., Fujii,Y., Ohuchi,E., Yamamoto,E. and Okada,Y.<br>Activation of the precursor of human stromelysin 2 and its interactions with other matrix metalloproteinases<br>Eur J Biochem (1-4-1998) 253, 67-75. PubMed  Europe PubMed
    40. 1996
  40. Knauper,V., Murphy,G. and Tschesche,H.<br>Activation of human neutrophil procollagenase by stromelysin 2<br>Eur J Biochem (1996) 235, 187-191. PubMed  Europe PubMed
    41. 1995
  41. Nagase,H.<br>Human stromelysins 1 and 2<br>Methods Enzymol (1995) 248, 449-470. PubMed  Europe PubMed DOI  V
    42. 1994
  42. Conca,W. and Willmroth,F.<br>Human T lymphocytes express a member of the matrix metalloproteinase gene family<br>Arthritis Rheum (1994) 37, 951-956. PubMed  Europe PubMed DOI
    43. 1993
  43. Formstone,C.J., Byrd,P.J., Ambrose,H.J., Riley,J.H., Hernandez,D., McConville,C.M. and Taylor,A.M.<br>The order and orientation of a cluster of metalloproteinase genes, stromelysin 2, collagenase, and stromelysin, together with D11S385, on chromosome 11q22-q23<br>Genomics (1993) 16, 289-291. PubMed  Europe PubMed DOI
  44. Sanchez-Lopez,R., Alexander,C.M., Behrendtsen,O., Breathnach,R. and Werb,Z.<br>Role of zinc-binding- and hemopexin domain-encoded sequences in the substrate specificity of collagenase and stromelysin- 2 as revealed by chimeric proteins<br>J Biol Chem (1993) 268, 7238-7247. PubMed  Europe PubMed
  45. [YEAR:15-8-1993]Windsor,L.J., Grenett,H., Birkedal-Hansen,B., Bodden,M.K., Engler,J.A. and Birkedal-Hansen,H.<br>Cell type-specific regulation of SL-1 and SL-2 genes. Induction of the SL-2 gene but not the SL-1 gene by human keratinocytes in response to cytokines and phorbolesters<br>J Biol Chem (15-8-1993) 268, 17341-17347. PubMed  Europe PubMed
    46. 1991
  46. Woessner,J.F., Jr.<br>Matrix metalloproteinases and their inhibitors in connective tissue remodeling<br>FASEB J (1991) 5, 2145-2154. PubMed  Europe PubMed
    47. 1988
  47. Sanchez-Lopez,R., Nicholson,R., Gesnel,M.C., Matrisian,L.M. and Breathnach,R.<br>Structure-function relationships in the collagenase family member transin<br>J Biol Chem (1988) 263, 11892-11899. PubMed  Europe PubMed
    48. 1987
  48. Breathnach,R., Matrisian,L.M., Gesnel,M.C., Staub,A. and Leroy,P.<br>Sequences coding for part of oncogene-induced transin are highly conserved in a related rat gene<br>Nucleic Acids Res (1987) 15, 1139-1151. PubMed  Europe PubMed  PMC  EPMC

feedback
Page created 8-September-2023

EMBL-EBI logo

© 2025 EBI
Terms of use