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Literature for peptidase M10.006: matrix metallopeptidase-10 (Homo sapiens-type)

Summary Gene structure Alignment Tree Sequences Sequence features Distribution Structure Literature Substrates Pharma

(Topics flags: S Structure, P Specificity, K Knockout, I Inhibitor, L Localization, V Review. To select only the references relevant to a single topic, click the link above. See explanation.)

    2025
  1. Wei,Y., Xuan,Y., Liu,C., Li,X., Zhang,Y., Shi,C., Li,S., Yang,Q. and Liu,Z.
    Fiber optic surface plasmon resonance sensor for high-sensitivity detection of MMP10, a diagnostic target for Alzheimer's disease
    Opt Express (2025) 33, 38181-38193. PubMed  Europe PubMed DOI  I
    2. 2024
  2. Dibdiakova,K., Majercikova,Z., Galanda,T., Richterova,R., Kolarovszki,B., Racay,P. and Hatok,J.
    Relationship between the Expression of Matrix Metalloproteinases and Their Tissue Inhibitors in Patients with Brain Tumors
    Int J Mol Sci (2024) 25 PubMed  Europe PubMed DOI  PMC  EPMC
    3. 2023
  3. Margetts,P.J.
    Matrix metalloproteinase 10 and the slow demise of the peritoneal membrane
    Kidney Int (2023) 104, 880-882. PubMed  Europe PubMed DOI
    4. 2022
  4. Chi,P.L., Cheng,C.C., Hung,C.C., Wang,M.T., Liu,H.Y., Ke,M.W., Shen,M.C., Lin,K.C., Kuo,S.H., Hsieh,P.P., Wann,S.R. and Huang,W.C.
    MMP-10 from M1 macrophages promotes pulmonary vascular remodeling and pulmonary arterial hypertension
    Int J Biol Sci (2022) 18, 331-348. PubMed  Europe PubMed DOI  PMC  EPMC
  5. Gonzalez-Zamora,J., Hernandez,M., Recalde,S., Bezunartea,J., Montoliu,A., Bilbao-Malave,V., Orbe,J., Rodriguez,J.A., Llorente-Gonzalez,S., Fernandez-Robredo,P. and Garcia-Layana,A.
    Matrix Metalloproteinase 10 Contributes to Choroidal Neovascularisation
    Biomedicines (2022) 10 PubMed  Europe PubMed DOI  PMC  EPMC
  6. Kudelski,J., Mlynarczyk,G., Gudowska-Sawczuk,M., Mroczko,B., Darewicz,B., Bruczko-Goralewska,M. and Romanowicz,L.
    Higher Content but Not Activity of Stromelysin-2 (MMP-10) in Comparison to Stromelysin-1 (MMP-3) in Human Renal Carcinoma
    Int J Environ Res Public Health (2022) 19, 12613-12613. PubMed  Europe PubMed DOI  PMC  EPMC
  7. Raeeszadeh-Sarmazdeh,M., Coban,M., Mahajan,S., Hockla,A., Sankaran,B., Downey,G.P., Radisky,D.C. and Radisky,E.S.
    Engineering of tissue inhibitor of metalloproteinases TIMP-1 for fine discrimination between closely related stromelysins MMP-3 and MMP-10
    J Biol Chem (2022) 298, 101654-101654. PubMed  Europe PubMed DOI  PMC  EPMC
  8. Shigeta,S., Watanabe,Y., Suzuki,F., Nagase,S., Shibuya,Y., Ishibashi,M., Nagai,T., Shiga,N., Toyoshima,M., Tokunaga,H., Shimada,M. and Yaegashi,N.
    MicroRNA-152 Regulates Endometrial Serous Carcinoma Cell Motility by Suppressing Matrix Metalloproteinase 10 Expression
    Tohoku J Exp Med (2022) 256, 249-258. PubMed  Europe PubMed DOI  K
  9. Sun,X. and Liu,Y.
    Matrix Metalloproteinase-10 in Kidney Injury Repair and Disease
    Int J Mol Sci (2022) 23, 2131-2131. PubMed  Europe PubMed DOI  PMC  EPMC  V
  10. Tang,K., Wu,Z., Sun,M., Huang,X., Sun,J., Shi,J., Wang,X., Miao,Z., Gao,P., Song,Y. and Wang,Z.
    Elevated MMP10/13 mediated barrier disruption and NF-kappaB activation aggravate colitis and colon tumorigenesis in both individual or full miR-148/152 family knockout mice
    Cancer Lett (2022) 529, 53-69. PubMed  Europe PubMed DOI
  11. Tian,Y., Zheng,G., Xie,H., Guo,Y., Zeng,H., Fu,Y. and Liu,X.
    Study on the Mechanism of circRNA-0024103 Reducing Endothelial Cell Injury by Regulating miR-363/MMP-10
    Contrast Media Mol Imaging (2022) 2022, 1709325-1709325. PubMed  Europe PubMed DOI  PMC  EPMC
  12. Zhang,D., Deng,X., Liu,Y., Zhang,Y., Wang,H., Zhang,M., Fang,Q., Yi,C., Zhao,X., Ma,T., Wu,C. and Chen,J.
    MMP-10 Deficiency Effects Differentiation and Death of Chondrocytes Associated with Endochondral Osteogenesis in an Endemic Osteoarthritis
    Cartilage (2022) 13, 19476035221109226-19476035221109226. PubMed  Europe PubMed DOI  PMC  EPMC  K
    13. 2021
  13. Bae,S., Lim,J.W. and Kim,H.
    beta-Carotene Inhibits Expression of Matrix Metalloproteinase-10 and Invasion in Helicobacter pylori-Infected Gastric Epithelial Cells
    Molecules (2021) 26, 1567-1567. PubMed  Europe PubMed DOI  PMC  EPMC
  14. Baraibar-Churio,A., Bobadilla,M., Machado,F.J.D., Sainz,N., Roncal,C., Abizanda,G., Prosper,F., Orbe,J. and Perez-Ruiz,A.
    Deficiency of MMP-10 Aggravates the Diseased Phenotype of Aged Dystrophic Mice
    Life (Basel) (2021) 11, 1398-1398. PubMed  Europe PubMed DOI  PMC  EPMC
  15. Bassiouni,W., Ali,M.A.M. and Schulz,R.
    Multifunctional intracellular matrix metalloproteinases: implications in disease
    FEBS J (2021) 288, 7162-7182. PubMed  Europe PubMed DOI  V
  16. Kudelski,J., Mlynarczyk,G., Gudowska-Sawczuk,M., Mroczko,B., Darewicz,B., Bruczko-Goralewska,M., Sobolewski,K. and Romanowicz,L.
    Enhanced Expression but Decreased Specific Activity of Matrix Metalloproteinase 10 (MMP-10) in Comparison with Matrix Metalloproteinase 3 (MMP-3) in Human Urinary Bladder Carcinoma
    J Clin Med (2021) 10, 3683-3683. PubMed  Europe PubMed DOI  PMC  EPMC
  17. Nakagawa,M., Shirasugi,M., Yamamoto,T., Nakaya,T. and Kanamura,N.
    Long-term exposure to butyric acid induces excessive production of matrix metalloproteases in human gingival fibroblasts
    Arch Oral Biol (2021) 123, 105035-105035. PubMed  Europe PubMed DOI  L
  18. Valdes-Fernandez,J., Lopez-Martinez,T., Ripalda-Cemborain,P., Calvo,I.A., Saez,B., Romero-Torrecilla,J.A., Aldazabal,J., Muinos-Lopez,E., Montiel,V., Orbe,J., Rodriguez,J.A., Paramo,J.A., Prosper,F. and Granero-Molto,F.
    Molecular and Cellular Mechanisms of Delayed Fracture Healing in Mmp10 (Stromelysin 2) Knockout Mice
    J Bone Miner Res (2021) 36, 2203-2213. PubMed  Europe PubMed DOI
  19. Zuo,Y., Wang,C., Sun,X., Hu,C., Liu,J., Hong,X., Shen,W., Nie,J., Hou,F.F., Zhou,L. and Liu,Y.
    Identification of matrix metalloproteinase-10 as a key mediator of podocyte injury and proteinuria
    Kidney Int (2021) 100, 837-849. PubMed  Europe PubMed DOI  K
    20. 2020
  20. El Ashry,E.S.H., Awad,L.F., Teleb,M., Ibrahim,N.A., Abu-Serie,M.M. and Abd Al Moaty,M.N.
    Structure-based design and optimization of pyrimidine- and 1,2,4-triazolo[4,3-a]pyrimidine-based matrix metalloproteinase-10/13 inhibitors via Dimroth rearrangement towards targeted polypharmacology
    Bioorg Chem (2020) 96, 103616-103616. PubMed  Europe PubMed DOI  I
  21. Moffitt,L.R., Bilandzic,M., Wilson,A.L., Chen,Y., Gorrell,M.D., Oehler,M.K., Plebanski,M. and Stephens,A.N.
    Hypoxia Regulates DPP4 Expression, Proteolytic Inactivation, and Shedding from Ovarian Cancer Cells
    Int J Mol Sci (2020) 21 PubMed  Europe PubMed DOI  PMC  EPMC
  22. Razai,A.S., Eckelman,B.P. and Salvesen,G.S.
    Selective inhibition of matrix metalloproteinase 10 (MMP10) with a single-domain antibody
    J Biol Chem (2020) 295, 2464-2472. PubMed  Europe PubMed DOI
    23. 2019
  23. Mirastschijski,U., Dinesh,N., Baskaran,S., Wedekind,D., Gavrilovic,J., Murray,M.Y., Bevan,D. and Kelm,S.
    Novel specific human and mouse stromelysin-1 (MMP-3) and stromelysin-2 (MMP-10) antibodies for biochemical and immunohistochemical analyses
    Wound Repair Regen (2019) 27, 309-323. PubMed  Europe PubMed DOI
    24. 2017
  24. Vandivort,T.C., Birkland,T.P., Domiciano,T.P., Mitra,S., Kavanagh,T.J. and Parks,W.C.
    Stromelysin-2 (MMP-10) facilitates clearance and moderates inflammation and cell death following lung exposure to long multiwalled carbon nanotubes
    Int J Nanomedicine (2017) 12, 1019-1031. PubMed  Europe PubMed DOI  PMC  EPMC  K
    25. 2016
  25. McMahan,R.S., Birkland,T.P., Smigiel,K.S., Vandivort,T.C., Rohani,M.G., Manicone,A.M., McGuire,J.K., Gharib,S.A. and Parks,W.C.
    Stromelysin-2 (MMP10) moderates inflammation by controlling macrophage activation
    J Immunol (2016) 197, 899-909. PubMed  Europe PubMed DOI
    26. 2015
  26. Rohani,M.G., McMahan,R.S., Razumova,M.V., Hertz,A.L., Cieslewicz,M., Pun,S.H., Regnier,M., Wang,Y., Birkland,T.P. and Parks,W.C.
    MMP-10 regulates collagenolytic activity of alternatively activated resident macrophages
    J Invest Dermatol (2015) 135, 2377-2384. PubMed  Europe PubMed DOI
  27. Schlage,P., Kockmann,T., Sabino,F., Kizhakkedathu,J.N. and auf dem Keller,U.
    Matrix metalloproteinase 10 degradomics in keratinocytes and epidermal tissue identifies bioactive substrates with pleiotropic functions
    Mol Cell Proteomics (2015) 14, 3234-3246. PubMed  Europe PubMed DOI  P
    28. 2014
  28. Bobadilla,M., Sáinz,N., Rodriguez,J.A., Abizanda,G., Orbe,J., de,M.A., García Verdugo,J.M., Páramo,J.A., Prósper,F. and Pérez-Ruiz,A.
    MMP-10 is required for efficient muscle regeneration in mouse models of injury and muscular dystrophy
    Stem Cells (2014) 32, 447-461. PubMed  Europe PubMed
  29. Schlage,P., Egli,F.E., Nanni,P., Wang,L.W., Kizhakkedathu,J.N., Apte,S.S. and Keller,U.A.
    Time-resolved analysis of the matrix metalloproteinase 10 substrate degradome
    Mol Cell Proteomics (2014) 13, 580-593. PubMed  Europe PubMed DOI
    30. 2013
  30. Murray,M.Y., Birkland,T.P., Howe,J.D., Rowan,A.D., Fidock,M., Parks,W.C. and Gavrilovic,J.
    Macrophage migration and invasion is regulated by MMP10 expression
    PLoS ONE (2013) 8, e63555-e63555. PubMed  Europe PubMed DOI  PMC  EPMC
    31. 2012
  31. Batra,J., Robinson,J., Soares,A.S., Fields,A.P., Radisky,D.C. and Radisky,E.S.
    Matrix metalloproteinase-10 (MMP-10) interaction with tissue inhibitors of metalloproteinases TIMP-1 and TIMP-2: binding studies and crystal structure
    J Biol Chem (2012) 287, 15935-15946. PubMed  Europe PubMed DOI  S
  32. Fingleton,B.
    Matrix metallopeptidase-10/stromelysin 2
    [ISSN:978-0-12-407744-7] (2012) 3, 774-778. DOI
    33. 2010
  33. Miller,J.P., Holcomb,J., Al-Ramahi,I., de Haro,M., Gafni,J., Zhang,N., Kim,E., Sanhueza,M., Torcassi,C., Kwak,S., Botas,J., Hughes,R.E. and Ellerby,L.M.
    Matrix metalloproteinases are modifiers of huntingtin proteolysis and toxicity in Huntington's disease
    Neuron (2010) 67, 199-212. PubMed  Europe PubMed DOI  PMC  EPMC
    34. 2009
  34. Lijnen,H.R., Van Hoef,B., Rodriguez,J.A. and Paramo,J.A.
    Stromelysin-2 (MMP-10) deficiency does not affect adipose tissue formation in a mouse model of nutritionally induced obesity
    Biochem Biophys Res Commun (2009) 389, 378-381. PubMed  Europe PubMed DOI  K
  35. Wu,X. and Pan,Y.
    Molecular characterization, mapping, and haplotype analysis of porcine matrix metalloproteinase genes MMP1 and MMP10
    Biochem Genet (2009) 47, 763-774. PubMed  Europe PubMed DOI
    36. 2004
  36. [YEAR:20-2-2004]Bertini,I., Calderone,V., Fragai,M., Luchinat,C., Mangani,S. and Terni,B.
    Crystal structure of the catalytic domain of human matrix metalloproteinase 10
    J Mol Biol (20-2-2004) 336, 707-716. PubMed  Europe PubMed DOI  S  I
  37. Gill,J.H., Kirwan,I.G., Seargent,J.M., Martin,S.W., Tijani,S., Anikin,V.A., Mearns,A.J., Bibby,M.C., Anthoney,A. and Loadman,P.M.
    MMP-10 is overexpressed, proteolytically active, and a potential target for therapeutic intervention in human lung carcinomas
    Neoplasia (2004) 6, 777-785. PubMed  Europe PubMed DOI  PMC  EPMC
  38. Matrisian,L.M.
    Stromelysin 2
    [ISSN:0-12-079610-4] (2004) 2, 523-526.  V
    39. 1998
  39. [YEAR:1-4-1998]Nakamura,H., Fujii,Y., Ohuchi,E., Yamamoto,E. and Okada,Y.
    Activation of the precursor of human stromelysin 2 and its interactions with other matrix metalloproteinases
    Eur J Biochem (1-4-1998) 253, 67-75. PubMed  Europe PubMed
    40. 1996
  40. Knauper,V., Murphy,G. and Tschesche,H.
    Activation of human neutrophil procollagenase by stromelysin 2
    Eur J Biochem (1996) 235, 187-191. PubMed  Europe PubMed
    41. 1995
  41. Nagase,H.
    Human stromelysins 1 and 2
    Methods Enzymol (1995) 248, 449-470. PubMed  Europe PubMed DOI  V
    42. 1994
  42. Conca,W. and Willmroth,F.
    Human T lymphocytes express a member of the matrix metalloproteinase gene family
    Arthritis Rheum (1994) 37, 951-956. PubMed  Europe PubMed DOI
    43. 1993
  43. Formstone,C.J., Byrd,P.J., Ambrose,H.J., Riley,J.H., Hernandez,D., McConville,C.M. and Taylor,A.M.
    The order and orientation of a cluster of metalloproteinase genes, stromelysin 2, collagenase, and stromelysin, together with D11S385, on chromosome 11q22-q23
    Genomics (1993) 16, 289-291. PubMed  Europe PubMed DOI
  44. Sanchez-Lopez,R., Alexander,C.M., Behrendtsen,O., Breathnach,R. and Werb,Z.
    Role of zinc-binding- and hemopexin domain-encoded sequences in the substrate specificity of collagenase and stromelysin- 2 as revealed by chimeric proteins
    J Biol Chem (1993) 268, 7238-7247. PubMed  Europe PubMed
  45. [YEAR:15-8-1993]Windsor,L.J., Grenett,H., Birkedal-Hansen,B., Bodden,M.K., Engler,J.A. and Birkedal-Hansen,H.
    Cell type-specific regulation of SL-1 and SL-2 genes. Induction of the SL-2 gene but not the SL-1 gene by human keratinocytes in response to cytokines and phorbolesters
    J Biol Chem (15-8-1993) 268, 17341-17347. PubMed  Europe PubMed
    46. 1991
  46. Woessner,J.F., Jr.
    Matrix metalloproteinases and their inhibitors in connective tissue remodeling
    FASEB J (1991) 5, 2145-2154. PubMed  Europe PubMed
    47. 1988
  47. Sanchez-Lopez,R., Nicholson,R., Gesnel,M.C., Matrisian,L.M. and Breathnach,R.
    Structure-function relationships in the collagenase family member transin
    J Biol Chem (1988) 263, 11892-11899. PubMed  Europe PubMed
    48. 1987
  48. Breathnach,R., Matrisian,L.M., Gesnel,M.C., Staub,A. and Leroy,P.
    Sequences coding for part of oncogene-induced transin are highly conserved in a related rat gene
    Nucleic Acids Res (1987) 15, 1139-1151. PubMed  Europe PubMed  PMC  EPMC

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