Searches of the MEROPS database

Display Known Cleavages for a Protein

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Accession:

Sequence P16112

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Peptide and protein substrates that are thought to be physiologically relevant are indicated by P. Peptide and protein substrates that are not physiologically relevant are indicated by N. How cleavage sites have been identified are indicated by the following evidence codes: NT = N-terminal sequencing, MS = mass spectroscopy, MU = mutation, CS = consensus sequence, LC = liquid chromatography. To see all annotated cleavages for a peptidase, click on the peptidase name.

Cleavage Site	Peptidase	Residue range	Cleavage type	Description	Evidence	Reference
16	unknown peptidase	1-2316	P	release of a signal peptide	NT	Ilic et al., 1995
360	matrix metallopeptidase-1	17-2415	P	normal turnover		Fosang et al., 1996
360	matrix metallopeptidase-8	17-2415	P	normal turnover		Fosang et al., 1996
360	matrix metallopeptidase-2	17-2415	P	normal turnover		Fosang et al., 1992
360	matrix metallopeptidase-9	17-2415	P	normal turnover		Fosang et al., 1992
360	matrix metallopeptidase-3	17-2415	P	normal turnover		Fosang et al., 1992
360	matrix metallopeptidase-10 (Homo sapiens-type)	17-2415	P		NT	Fosang et al., 1991
360	matrix metallopeptidase-7	17-2415	P	normal turnover		Fosang et al., 1992
360	matrix metallopeptidase-13	17-2415	P	normal turnover		Leeman et al., 2002
360	membrane-type matrix metallopeptidase-1	17-2415	P			Fosang et al., 1998
360	matrix metallopeptidase-20	17-2415	P			Stracke et al., 2000
360	matrix metallopeptidase-19	17-2415	P			Sedlacek, 2004
360	atrolysin C	17-2415	N			Fox, 2004
360	ADAMTS4 peptidase	17-2415	P			Westling et al., 2002
360	ADAMTS1 peptidase	17-2415	P			Rodgriguez-Manzaneque et al., 2002
363	cathepsin B	17-2415	P	normal turnover		Fosang et al., 1992
373	membrane-type matrix metallopeptidase-1	17-2415	P			Fosang et al., 1998
375	HtrA1 peptidase (Homo sapiens-type)	17-2415	P		NT	Chamberland et al., 2009
392	matrix metallopeptidase-8	17-2415	P	conversion to two-chain form		Fosang et al., 1996
392	atrolysin C	17-2415	N			Tortorella et al., 1998
392	ADAMTS4 peptidase	17-2415	P			Westling et al., 2002
392	ADAMTS1 peptidase	17-2415	P			Rodgriguez-Manzaneque et al., 2002
392	ADAMTS5 peptidase	17-2415	P			Westling et al., 2002
392	ADAMTS8 peptidase	17-2415	P		AB	Collins-Racie et al., 2004
394	plasmin	17-2415	P			Fosang et al., 1998
396	matrix metallopeptidase-3	17-2415	P	normal turnover		Fosang et al., 1996
397	elastase-2	17-2415	P	normal turnover		Fosang et al., 1992
397	urokinase-type plasminogen activator	17-2415	P			Fosang et al., 1998
403	matrix metallopeptidase-13	17-2415	P			Fosang et al., 1998
460	matrix metallopeptidase-1	17-2415	P	normal turnover		Fosang et al., 1996
460	matrix metallopeptidase-8	17-2415	P	normal turnover		Fosang et al., 1996
460	matrix metallopeptidase-2	17-2415	P	normal turnover		Fosang et al., 1998
460	matrix metallopeptidase-7	17-2415	P	normal turnover		Fosang et al., 1992
460	matrix metallopeptidase-13	17-2415	P	normal turnover		Fosang et al., 1996
460	membrane-type matrix metallopeptidase-1	17-2415	P			Fosang et al., 1998
1564	ADAMTS4 peptidase	17-2415	P			Wayne et al., 2007
1564	ADAMTS1 peptidase	17-2415	P			Rodgriguez-Manzaneque et al., 2002
1733	ADAMTS1 peptidase	17-2415	P			Rodgriguez-Manzaneque et al., 2002
1734	ADAMTS4 peptidase	17-2415	P			Wayne et al., 2007
1838	ADAMTS4 peptidase	17-2415	P			Wayne et al., 2007
1838	ADAMTS1 peptidase	1817-1843	P		CS	Sandy et al., 2001
1938	ADAMTS4 peptidase	17-2415	P			Wayne et al., 2007
1938	ADAMTS1 peptidase	17-2415	P			Rodgriguez-Manzaneque et al., 2002