Structure for peptidase S08.054: endopeptidase K

Summary Alignment Sequences Sequence features Distribution Structure Literature Substrates

PDB	Organism	Resolution	Comment
2PRK	Engyodontium album	1.50 Å	mature
Catalytic residues are shown in ball-and-stick representation: Asp144 in pink, His174 in purple and Ser329 in orange. The structural calcium ions are shown as yellow CPK spheres.

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TERTIARY STRUCTURE DATA
Comment	Resolution	PDB	PDBe	SCOP	CATH	PDBSum	Proteopedia	Reference
Engyodontium album
complex with lactoferrin fragment	2.44 Å	1BJR	1BJR	1BJR	1BJR	1BJR	1BJR	Singh et al., 1998
in anhydrous organic solvent at 70 celsius	2.20 Å	1CNM	1CNM	1CNM	1CNM	1CNM	1CNM	Gupta et al., 2000
enhanced activity through three-phase partitioning	1.55 Å	1EGQ	1EGQ	1EGQ	1EGQ	1EGQ	1EGQ	Singh et al., 2001
complex with Hg2+	1.80 Å	1HT3	1HT3	1HT3	1HT3	1HT3	1HT3	Gourinath et al., 2001
mature peptidase	0.98 Å	1IC6	1IC6	1IC6	1IC6	1IC6	1IC6	Betzel et al., 2001
complex with melanin monomers	2.02 Å	1OYO	1OYO	1OYO	1OYO	1OYO	1OYO
complex with heptapeptide inhibitor Pro-Ala-Pro-Phe-Ala-Ala-Ala	1.08 Å	1P7V	1P7V	1P7V	1P7V	1P7V	1P7V
complex with a designed heptapeptide inhibitor Pro-Ala-Pro-Phe-Ala-Ser-Ala	1.02 Å	1P7W	1P7W	1P7W	1P7W	1P7W	1P7W
complex with N-Ac-Pro-Ala-Pro-Phe-D-Ala-Ala-NH2	2.20 Å	1PEK	1PEK	1PEK	1PEK	1PEK	1PEK	Betzel et al., 1993
strategy to design inhibitors: structure of a complex of proteinase k with a designed octapeptide inhibitor n-ac- pro-ala-pro-phe-dala-ala-ala-ala-nh2 at 2.5a resolution	2.50 Å	1PFG	1PFG	1PFG	1PFG	1PFG	1PFG	Saxena et al., 1996
structure of a ternary complex of proteinase k, mercury and a substrate-analogue hexapeptide at 2.2 a resolution	2.20 Å	1PJ8	1PJ8	1PJ8	1PJ8	1PJ8	1PJ8	Saxena et al., 1996
complex with mercury	2.40 Å	1PTK	1PTK	1PTK	1PTK	1PTK	1PTK	Muller & Saenger, 1993
complex with human lactoferrin fragment	2.90 Å	2DP4	2DP4	2DP4	2DP4	2DP4	2DP4
complex with a specific lactoferrin peptide Val-Leu-Leu-His	1.93 Å	2DQK	2DQK	2DQK	2DQK	2DQK	2DQK
complex with a synthetic peptide Leu-Leu-Phe-Asn-Asp	1.67 Å	2DUJ	2DUJ	2DUJ	2DUJ	2DUJ	2DUJ
anomalous substructure of proteinase k	2.14 Å	2G4V	2G4V	2G4V	2G4V	2G4V	2G4V	Mueller-Dieckmann et al., 2007
complex with inhibitory lactoferrin octapeptide Gly-Asp-Glu-Gln-Gly-Glu-Asn-Lys	2.15 Å	2HD4	2HD4	2HD4	2HD4	2HD4	2HD4
complex with a synthetic peptide Lys-Leu-Lys-Leu-Leu-Val-Val-Ile-Arg-Leu-Lys	1.69 Å	2HPZ	2HPZ	2HPZ	2HPZ	2HPZ	2HPZ
mature peptidase	1.27 Å	2ID8	2ID8	2ID8	2ID8	2ID8	2ID8	Wang et al., 2006
calcium-free form	1.50 Å	2PKC	2PKC	2PKC	2PKC	2PKC	2PKC	Muller et al., 1994
structure of serine proteinase k complex with a highly flexible hydrophobic peptide at 1.8a resolution	1.82 Å	2PQ2	2PQ2	2PQ2	2PQ2	2PQ2	2PQ2
mature peptidase	1.50 Å	2PRK	2PRK	2PRK	2PRK	2PRK	2PRK	Betzel et al., 1988
complex with alanine boronic acid	0.83 Å	2PWA	2PWA	2PWA	2PWA	2PWA	2PWA
complex with coumarin	1.90 Å	2PWB	2PWB	2PWB	2PWB	2PWB	2PWB
complex with auramine	1.79 Å	2PYZ	2PYZ	2PYZ	2PYZ	2PYZ	2PYZ
sad structure solution of proteinase k grown in selenate solution	0.94 Å	2V8B	2V8B	2V8B	2V8B	2V8B	2V8B
mature peptidase	1.10 Å	3AJ8	3AJ8	3AJ8	3AJ8	3AJ8	3AJ8	Chatake et al., 2011
mature peptidase	1.10 Å	3AJ9	3AJ9	3AJ9	3AJ9	3AJ9	3AJ9	Chatake et al., 2011
proteinase k by lb nanotemplate method before high x-ray dose on esrf id23-1 beamline	1.43 Å	3D9Q	3D9Q	3D9Q	3D9Q	3D9Q	3D9Q	Pechkova et al., 2009
proteinase k by lb nanotemplate method after the first step of high x-ray dose on esrf id23-1 beamline	1.70 Å	3DDZ	3DDZ	3DDZ	3DDZ	3DDZ	3DDZ	Pechkova et al., 2009
proteinase k by lb nanotemplate method after the second step of high x-ray dose on esrf id23-1 beamline	1.90 Å	3DE0	3DE0	3DE0	3DE0	3DE0	3DE0	Pechkova et al., 2009
proteinase k by lb nanotemplate method after the third step of high x-ray dose on esrf id23-1 beamline	2.00 Å	3DE1	3DE1	3DE1	3DE1	3DE1	3DE1	Pechkova et al., 2009
proteinase k by lb nanotemplate method after the fourth step of high x-ray dose on esrf id23-1 beamline	2.10 Å	3DE2	3DE2	3DE2	3DE2	3DE2	3DE2	Pechkova et al., 2009
proteinase k by classical hanging drop method before high x- ray dose on esrf id23-1 beamline	1.43 Å	3DE3	3DE3	3DE3	3DE3	3DE3	3DE3	Pechkova et al., 2009
proteinase k by classical hanging drop method after the first step of high x-ray dose on esrf id23-1 beamline	1.80 Å	3DE4	3DE4	3DE4	3DE4	3DE4	3DE4	Pechkova et al., 2009
roteinase k by classical hanging drop method after the second step of high x-ray dose on esrf id23-1 beamline	2.10 Å	3DE5	3DE5	3DE5	3DE5	3DE5	3DE5	Pechkova et al., 2009
proteinase k by classical hanging drop method after the third step of high x-ray dose on esrf id23-1 beamline	2.20 Å	3DE6	3DE6	3DE6	3DE6	3DE6	3DE6	Pechkova et al., 2009
proteinase k by classical hanging drop method after the fourth step of high x-ray dose on esrf id23-1 beamline	2.30 Å	3DE7	3DE7	3DE7	3DE7	3DE7	3DE7	Pechkova et al., 2009
mature peptidase	1.02 Å	3DVQ	3DVQ	3DVQ	3DVQ	3DVQ	3DVQ
mature peptidase	1.02 Å	3DVR	3DVR	3DVR	3DVR	3DVR	3DVR
mature peptidase	1.02 Å	3DVS	3DVS	3DVS	3DVS	3DVS	3DVS
mature peptidase	1.03 Å	3DW1	3DW1	3DW1	3DW1	3DW1	3DW1
mature peptidase	0.99 Å	3DW3	3DW3	3DW3	3DW3	3DW3	3DW3
mature peptidase	0.99 Å	3DWE	3DWE	3DWE	3DWE	3DWE	3DWE
complex with digalacturonic acid	1.32 Å	3DYB	3DYB	3DYB	3DYB	3DYB	3DYB	Larson et al., 2009
complex with the mad triangle b3c	1.50 Å	3GT3	3GT3	3GT3	3GT3	3GT3	3GT3
complex with the magic triangle i3c	1.76 Å	3GT4	3GT4	3GT4	3GT4	3GT4	3GT4
mature peptidase	1.00 Å	3I2Y	3I2Y	3I2Y	3I2Y	3I2Y	3I2Y
mature peptidase	0.99 Å	3I30	3I30	3I30	3I30	3I30	3I30
mature peptidase	1.00 Å	3I34	3I34	3I34	3I34	3I34	3I34
mature peptidase	1.00 Å	3I37	3I37	3I37	3I37	3I37	3I37
mature peptidase	1.55 Å	3L1K	3L1K	3L1K	3L1K	3L1K	3L1K
mature peptidase	2.26 Å	3OSZ	3OSZ	3OSZ	3OSZ	3OSZ	3OSZ
complex with inhibitor MeOSuc-Ala-Ala-Pro-Ala-chloromethyl ketone	2.20 Å	3PRK	3PRK	3PRK	3PRK	3PRK	3PRK	Wolf et al., 1991
mature peptidase	1.30 Å	3PTL	3PTL	3PTL	3PTL	3PTL	3PTL
mature peptidase	1.80 Å	3Q40	3Q40	3Q40	3Q40	3Q40	3Q40
mature peptidase	1.77 Å	3Q5G	3Q5G	3Q5G	3Q5G	3Q5G	3Q5G
mature peptidase	1.10 Å	3QMP	3QMP	3QMP	3QMP	3QMP	3QMP
mature peptidase	1.60 Å	4B5L	4B5L	4B5L	4B5L	4B5L	4B5L
mature peptidase	1.80 Å	4DJ5	4DJ5	4DJ5	4DJ5	4DJ5	4DJ5	Pechkova et al., 2012
mature peptidase	1.05 Å	4FON	4FON	4FON	4FON	4FON	4FON
mature peptidase	1.90 Å	4WOB	4WOB	4WOB	4WOB	4WOB	4WOB	Guo et al., 2015
mature peptidase	1.60 Å	4WOC	4WOC	4WOC	4WOC	4WOC	4WOC	Guo et al., 2015
mature peptidase	1.15 Å	4ZAR	4ZAR	4ZAR	4ZAR	4ZAR	4ZAR
crystal structure of proteinase k processed with the crystaldirect automated mounting and cryo-cooling technology	1.01 Å	5AMX	5AMX	5AMX	5AMX	5AMX	5AMX
mature peptidase	1.45 Å	5AVJ	5AVJ	5AVJ	5AVJ	5AVJ	5AVJ
mature peptidase	1.45 Å	5AVK	5AVK	5AVK	5AVK	5AVK	5AVK
mature peptidase	2.30 Å	5B1D	5B1D	5B1D	5B1D	5B1D	5B1D
mature peptidase	2.30 Å	5B1E	5B1E	5B1E	5B1E	5B1E	5B1E
mature peptidase	1.45 Å	5CW1	5CW1	5CW1	5CW1	5CW1	5CW1
mature peptidase	1.75 Å	5I9S	5I9S	5I9S	5I9S	5I9S	5I9S
microed structure of proteinase k at 1.6 a resolution	1.60 Å	5K7S	5K7S	5K7S	5K7S	5K7S	5K7S
mature peptidase	1.20 Å	5KXU	5KXU	5KXU	5KXU	5KXU	5KXU
mature peptidase	0.98 Å	5KXV	5KXV	5KXV	5KXV	5KXV	5KXV
single-shot pink beam serial crystallography: proteinase k	2.21 Å	5MJL	5MJL	5MJL	5MJL	5MJL	5MJL
serial millisecond crystallography of membrane and soluble protein micro-crystals using synchrotron radiation	2.65 Å	5UVL	5UVL	5UVL	5UVL	5UVL	5UVL
using sound pulses to solve the crystal harvesting bottleneck	1.71 Å	5WHW	5WHW	5WHW	5WHW	5WHW	5WHW
using sound pulses to solve the crystal harvesting bottleneck	1.50 Å	5WJG	5WJG	5WJG	5WJG	5WJG	5WJG
using sound pulses to solve the crystal harvesting bottleneck	1.63 Å	5WJH	5WJH	5WJH	5WJH	5WJH	5WJH
crystal structure of proteinase k from engyodontium album	1.50 Å	5WRC	5WRC	5WRC	5WRC	5WRC	5WRC
mature peptidase	1.71 Å	6CL7	6CL7	6CL7	6CL7	6CL7	6CL7
mature peptidase	2.00 Å	6CL8	6CL8	6CL8	6CL8	6CL8	6CL8
mature peptidase	2.20 Å	6CL9	6CL9	6CL9	6CL9	6CL9	6CL9
mature peptidase	2.80 Å	6CLA	6CLA	6CLA	6CLA	6CLA	6CLA
mature peptidase	3.20 Å	6CLB	6CLB	6CLB	6CLB	6CLB	6CLB
proteinase~k siras phased structure of room-temperature, serially collected synchrotron data	1.90 Å	6FJS	6FJS	6FJS	6FJS	6FJS	6FJS
high-viscosity injector-based pink beam serial crystallography of micro-crystals at a synchrotron radiation source.	1.80 Å	6MH6	6MH6	6MH6	6MH6	6MH6	6MH6
microed structure of proteinase k at 2.75a resolution from a single milled crystal.	2.75 Å	6N4U	6N4U	6N4U	6N4U	6N4U	6N4U