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PDBsum entry 4zar
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Hydrolase/hydrolase inhibitor
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PDB id
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4zar
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PDB id:
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| Name: |
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Hydrolase/hydrolase inhibitor
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Title:
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Crystal structure of proteinase k from engyodontium albuminhibited by methoxysuccinyl-ala-ala-pro-phe-chloromethyl ketone at 1.15 a resolution
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Structure:
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Proteinase k. Chain: a. Fragment: unp residues 106-384. Synonym: endopeptidase k,tritirachium alkaline proteinase. Engineered: yes. Methoxysuccinyl-ala-ala-pro-phe-chloromethyl ketone, bound form. Chain: b. Engineered: yes
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Source:
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Engyodontium album. Organism_taxid: 37998. Expressed in: escherichia coli. Expression_system_taxid: 562. Synthetic: yes. Synthetic construct. Organism_taxid: 32630
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Resolution:
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1.15Å
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R-factor:
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0.112
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R-free:
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0.135
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Authors:
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M.R.Sawaya,D.Cascio,M.Collazo,C.Bond,A.Cohen,A.Denicola,K.Eden, K.Jain,C.Leung,N.Lubock,J.Mccormick,J.Rosinski,L.Spiegelman,Y.Athar, N.Tibrewal,J.Winter,S.Solomon
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Key ref:
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M.R.Sawaya
et al.
Crystal structure of proteinase k from engyodontium a inhibited by methoxysuccinyl-Ala-Ala-Pro-Phe-Chlorome ketone at 1.15 a resolution.
To be published,
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Date:
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14-Apr-15
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Release date:
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06-May-15
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PROCHECK
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Headers
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References
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P06873
(PRTK_PARAQ) -
Proteinase K from Parengyodontium album
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Seq:
Struc:
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384 a.a.
279 a.a.*
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Key: |
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PfamA domain |
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Secondary structure |
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CATH domain |
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*
PDB and UniProt seqs differ
at 1 residue position (black
cross)
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Enzyme class:
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E.C.3.4.21.64
- peptidase K.
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Reaction:
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Hydrolysis of keratin and of other proteins, with subtilisin-like specificity. Hydrolyzes peptides amides.
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Links
