PDBsum entry 1p7v

Hydrolase

PDB id: 1p7v

Contents

Protein chain

279 a.a. *

Ligands

PRO-ALA-PRO-PHE-ALA-ALA-ALA

NO3 ×3

Metals

_CA ×2

Waters ×452

* Residue conservation analysis

PDB id:

1p7v

Name:

Hydrolase

Title:

Structure of a complex formed between proteinase k and a designed heptapeptide inhibitor pro-ala-pro-phe-ala-ala-ala at atomic resolution

Structure:

Proteinase k. Chain: a. Synonym: tritirachium alkaline proteinase, endopeptidase k. Inhibitor peptide. Chain: b. Engineered: yes

Source:

Engyodontium album. Organism_taxid: 37998. Synthetic: yes

Biol. unit:

Dimer (from PQS)

Resolution:

1.08Å R-factor: 0.120 R-free: 0.140

Authors:

S.Bilgrami,P.Kaur,V.Chandra,S.Banumathi,M.Perbandt,C.Betzel,T.P.Singh

Key ref:

S.Bilgrami et al. Structure of a complex formed between proteinase k and a designed heptapeptide inhibitor pro-Ala-Pro-Phe-Ala-Ala-Ala at atomic resolution. To be published, .

Date:

06-May-03 Release date: 18-May-04

Protein chain

P06873  (PRTK_PARAQ) -  Proteinase K from Parengyodontium album

Seq: 384 a.a.

Struc: 279 a.a.*

* PDB and UniProt seqs differ at 1 residue position (black cross)

Enzyme reactions

• Enzyme class: E.C.3.4.21.64 - peptidase K.
• Reaction: Hydrolysis of keratin and of other proteins, with subtilisin-like specificity. Hydrolyzes peptides amides.