Merops Switch to
Inhibitors

Peptidase

Family Clan SEARCHES BLAST
MEROPS SUBMISSIONS

Other
information

Substrates for peptidase C14.009: caspase-8

Summary Gene structure Alignment Tree Sequences Sequence features Distribution Structure Literature Substrates Pharma

Peptide and protein substrates that are thought to be physiologically relevant are indicated by P. Peptide and protein substrates that are thought to be pathologically relevant are indicated by D. Peptide and protein substrates that are not physiologically relevant are indicated by N. Synthetic substrates are indicated by S. Click on the symbol to show only physiological, non-physiological or synthetic substrates, or here to display all substrates. How cleavage sites have been identified are indicated by the following evidence codes: NT = N-terminal sequencing, MS = mass spectroscopy, MU = mutation, CS = consensus sequence, LC = liquid chromatography. To see all annotated cleavages for a protein substrate, click on the UniProt Accession.

Substrate Uniprot Residue range Cleavage Site Cleavage type Evidence P4 P3 P2 P1 P1' P2' P3' P4' Reference CutDB MERNUM
14-3-3 protein theta P27348 1-245 peptide-Asp238+Ala-peptide P Glu Glu Cys Asp Ala Ala Glu Gly Nomura et al., 2003 19282
Ac-Asp-Glu-Val-Asp-NHMec Ac-Asp-Glu-Val-Asp+NHMec S Asp Glu Val Asp AMC - - - Garcia-Calvo et al., 1999
AKAP1 A-kinase anchor protein 1 precursor Q92667 30-903 peptide-Asp582+Ser-peptide P Asp Ser Val Asp Ser Cys Cys Ser Yoo et al., 2008 21689
atrophin-1 P54259 1-1185 peptide-Asp109+Gly-peptide P Asp Ser Leu Asp Gly Arg Ser Leu
B-cell receptor-associated protein 31 P51572 2-246 peptide-Asp237+Gly-peptide P Ala Ala Val Asp Gly Pro Met Asp Maatta et al., 2000 23788
B-cell receptor-associated protein 31 P51572 2-246 peptide-Asp164+Gly-peptide P Ala Ala Val Asp Gly Gly Lys Leu Breckenridge et al., 2003 23789
BH3-interacting domain death agonist (BID) P70444 1-195 peptide-Asp59+Gly-peptide P Leu Gln Thr Asp Gly Ser Gln Ala Stoka et al., 2001
BH3-interacting domain death agonist (BID) P55957 1-195 peptide-Asp60+Gly-peptide P Leu Gln Thr Asp Gly Asn Arg Ser Deqli Esposti et al., 2003 20456
BH3-interacting domain death agonist (BID) P55957 1-195 peptide-Asp75+Ser-peptide P Ile Glu Ala Asp Ser Glu Ser Gln Deqli Esposti et al., 2003
CASP8 and FADD-like apoptosis regulator subunit p43 O15519 1-480 peptide-Asp376+Gly-peptide P Leu Glu Val Asp Gly Pro Ala Met Niikura et al., 2002 3965
caspase-13 precursor O75601 1-377 peptide-Asp289+Ala-peptide P Leu Glu Glu Asp Ala Val Tyr Lys Humke et al., 1998 17986
caspase-3 precursor P42574 1-277 peptide-Asp175+Ser-peptide P Ile Glu Thr Asp Ser Gly Val Asp Rank et al., 2001 3962
caspase-3 precursor P42574 1-277 peptide-Asp28+Ser-peptide P Glu Ser Met Asp Ser Gly Ile Ser Rank et al., 2001
caspase-8 precursor Q14790 1-479 peptide-Asp384+Leu-peptide P Leu Glu Met Asp Leu Ser Ser Pro Srinivasula et al., 1996
caspase-8 precursor Q14790 1-479 peptide-Asp210+Ser-peptide P Thr Ile Ser Asp Ser Pro Arg Glu Srinivasula et al., 1996
caspase-8 precursor Q14790 1-479 peptide-Asp216+Ser-peptide P Arg Glu Gln Asp Ser Glu Ser Gln Srinivasula et al., 1996
caspase-8 precursor Q14790 1-479 peptide-Asp374+Ser-peptide P Val Glu Thr Asp Ser Glu Glu Gln Srinivasula et al., 1996 3979
Caspase-9 P55211 1-416 Peptide-Asp315+Ala-Peptide P CS Pro Glu Pro Asp Ala Thr Pro Phe McDonnell et al., 2003
Caspase-9 P55211 1-416 Peptide-Asp330+Ala-Peptide P CS Asp Gln Leu Asp Ala Ile Ser Ser McDonnell et al., 2003
choline-phosphate cytidylyltransferase A P49585 1-367 peptide-Asp28+Gly-peptide P Thr Glu Glu Asp Gly Val Pro Ser Lagace et al., 2002 3987
cytosolic phospholipase A2 P47712 1-749 peptide-Asp522+Ala-peptide P CS Asp Glu Leu Asp Ala Ala Val Ala Luschen et al., 1999
dihydrolipoyllysine-residue acetyltransferase component of pyruvate dehydrogenase complex, mitochondrial P10515 87-647 peptide-Asp131+Lys-peptide P Val Glu Thr Asp Lys Ala Thr Val Matsumura et al., 2002 19916
dihydrolipoyllysine-residue acetyltransferase component of pyruvate dehydrogenase complex, mitochondrial P10515 87-647 peptide-Asp258+Lys-peptide P Ile Glu Thr Asp Lys Ala Thr Ile Matsumura et al., 2002
erythroid transcription factor P15976 1-413 peptide-Asp125+Gly-peptide P Glu Asp Leu Asp Gly Lys Gly Ser Maria et al., 1999 19894
eukaryotic translation initiation factor 2 subunit 1 P05198 2-315 peptide-Asp301+Gly-peptide P Ala Glu Val Asp Gly Asp Asp Asp Marissen et al., 2000 3983
fragile X mental retardation syndrome-related protein 2 P51116 1-673 peptide-Asp567+Gly-peptide N Leu Glu Ser Asp Gly Pro Asn Met Ju et al., 2007 23427
general vesicular transport factor p115 O60763 1-962 peptide-Asp757+Ser-peptide P Thr Glu Lys Asp Ser Met Ile Glu Chiu et al., 2002 3985
GRIA1 P42261 19-906 peptide-Asp882+Phe-peptide P Val Ser His Asp Phe Pro Lys Ser Meyer et al., 2002 18910
histone deacetylase 7 Q8WUI4 1-952 peptide-Asp412+Gly-peptide P Leu Glu Thr Asp Gly Gly Gly Pro Scott et al., 2008 20769
Histone deacetylase 7 Q8C2B3 1-938 Peptide-Asp405+Gly-Peptide P CS Leu Glu Thr Asp Gly Gly Gly Val Scott et al., 2008
hsc70-interacting protein Q99L47 1-371 peptide-Asp83+Asn-peptide P Leu Glu Ile Asp Asn Glu Gly Val Caruso & Reiners, 2006
interferon-induced helicase C domain-containing protein 1 Q8R5F7 1-1025 peptide-Asp251+Ser-peptide P Ser Cys Thr Asp Ser Ser Val Thr Kovacsovics et al., 2002 19865
interferon-induced, double-stranded RNA-activated protein kinase P19525 1-551 peptide-Asp251+Met-peptide P Asp Leu Pro Asp Met Lys Glu Thr Saelens et al., 2001 3970
matrin-3 P43243 633-704 peptide-Asp680+Leu-peptide N CS Asp Glu Thr Asp Leu Ala Asn Leu Valencia et al., 2007 20141
Membrane-associated guanylate kinase, WW and PDZ domain-containing protein 1 Q96QZ7 1-1491 Peptide-Asp782+Ser-Peptide P CS Asp Gln Thr Asp Ser Ser Gly Gln Ivanova et al., 2011
microtubule-associated protein tau P10636 2-758 peptide-Asp421+Pro-peptide P Gly Ser Ser Asp Pro Leu Ile Gln Gamblin et al., 2003
microtubule-associated protein tau P10636 2-758 peptide-Asp738+Ser-peptide P Asp Met Val Asp Ser Pro Gln Leu Gamblin et al., 2003 26389
myocyte-specific enhancer factor 2A Q02078 1-507 peptide-Asp176+Ser-peptide P Thr Leu Thr Asp Ser Ser Met Leu Okamoto et al., 2002 23812
nEDD4-binding protein 1 O75113 1-896 peptide-Asp424+Ser-peptide P NT Leu Thr Thr Asp Ser Thr Pro Lys Shi et al., 2021
nEDD4-binding protein 1 O75113 1-896 peptide-Asp490+Gly-peptide P NT Pro Glu Thr Asp Gly Leu Ser Pro Shi et al., 2021
osteopontin P10451 17-314 peptide-Asp157+Gly-peptide P MU Asp Thr Tyr Asp Gly Arg Gly Asp Kim et al., 2009
osteopontin P10451 17-314 peptide-Asp135+Phe-peptide P MU Leu Val Thr Asp Phe Pro Thr Asp Kim et al., 2009
parkin O60260 1-465 peptide-Asp126+Ser-peptide P Leu His Thr Asp Ser Arg Lys Asp Kahns et al., 2003 19302
plectin-1 Q15149 1-4684 peptide-Asp2395+Lys-peptide P Ile Leu Arg Asp Lys Asp Asn Thr Stegh et al., 2000 23769
plectin-1 Q15149 1-4684 peptide-Asp2397+Asn-peptide P Arg Asp Lys Asp Asn Thr Gln Arg Stegh et al., 2000 3976
poly [ADP-ribose] polymerase 2 O88554 1-559 peptide-Asp187+Tyr-peptide P NT Leu Gln Met Asp Tyr Ala Ala Ser Benchoua et al., 2002 18909
poly [ADP-ribose] polymerase 2 O88554 1-559 peptide-Asp120+Ala-peptide P MU Leu Glu Asp Asp Ala Gln Arg Asn Benchoua et al., 2002 18908
presenilin 1 P49768 1-467 peptide-Asp333+Gly-peptide P Glu Asn Asp Asp Gly Gly Phe Ser van de Craen et al., 1999 3974
presenilin 1 P49768 1-467 peptide-Asp345+Ser-peptide P Ala Gln Arg Asp Ser His Leu Gly van de Craen et al., 1999
presenilin 2 P49810 1-448 peptide-Asp326+Ser-peptide P Asp Ser Tyr Asp Ser Phe Gly Glu van de Craen et al., 1999 3938
presenilin 2 P49810 298-448 peptide-Asp326+Ser-peptide P Met Glu Glu Asp Ser Tyr Asp Ser van de Craen et al., 1999 3975
protein kinase C zeta type Q05513 1-592 peptide-Asp210+Gly-peptide P Glu Glu Thr Asp Gly Ile Ala Tyr Smith et al., 2000 19391
ras GTPase-activating protein-binding protein 1 A0A480DPE1 1-465 peptide-Asp168+Asp-peptide P NT Val Val Pro Asp Asp Ser Gly Thr Sun et al., 2021
ras GTPase-activating protein-binding protein 1 A0A480DPE1 1-465 peptide-Asp169+Ser-peptide P NT Val Pro Asp Asp Ser Gly Thr Phe Sun et al., 2021
receptor tyrosine-protein kinase erbB-2 P04626 23-1255 peptide-Asp1016+Leu-peptide P Asp Met Gly Asp Leu Val Asp Ala Strohecker et al., 2008 20672
receptor tyrosine-protein kinase erbB-2 P04626 23-1255 peptide-Asp1019+Ala-peptide P Asp Leu Val Asp Ala Glu Glu Tyr Strohecker et al., 2008 20673
receptor tyrosine-protein kinase erbB-2 P04626 23-1255 peptide-Asp1125+Gly-peptide P Ser Glu Thr Asp Gly Tyr Val Ala Strohecker et al., 2008 20674
receptor tyrosine-protein kinase erbB-2 P04626 23-1255 peptide-Asp1087+Gly-peptide P Asp Val Phe Asp Gly Asp Leu Gly Strohecker et al., 2008 20675
receptor-interacting serine/threonine-protein kinase 1 Q13546 1-671 peptide-Asp324+Cys-peptide P Leu Gln Leu Asp Cys Val Ala Val Kim et al., 2000 3957
retinoblastoma-associated protein P06400 1-928 peptide-Asp349+Ser-peptide P CS Asp Ser Ile Asp Ser Phe Glu Thr Lemaire et al., 2005
serine/threonine-protein kinase 24 Q9Y6E0 1-443 peptide-Asp325+Gly-peptide P Ala Glu Thr Asp Gly Gln Ala Ser Johnston et al., 2000
serine/threonine-protein kinase DCAMKL1 Q9JLM8 1-756 peptide-Asp369+Gly-peptide P Asp Glu Asn Asp Gly Pro Gly Glu Kruidering et al., 2001
Serine/threonine-protein kinase DCLK1 O08875 1-433 Peptide-Asp62+Gly-Peptide P CS Asp Glu Asn Asp Gly Pro Gly Glu Kruidering et al., 2001
serpin A3-1 Q9TTE1 25-411 peptide-Asp395+Thr-peptide P MU Val Leu Lys Asp Thr Gln Ser Ile Herrera-Mendez et al., 2009
small nuclear ribonucleoprotein F P62306 2-86 peptide-Asp81+Gly-peptide P Glu Glu Glu Asp Gly Glu Met Arg Malmegrim de Farias et al., 2003 20166
T-cell acute lymphocytic leukemia 1 P17542 1-331 peptide-Asp180+Gly-peptide P Glu Ile Thr Asp Gly Pro His Thr Zeuner et al., 2003 20385
T-cell acute lymphocytic leukemia 1 P17542 1-331 peptide-Asp296+Gly-peptide P Ser Ser Leu Asp Gly Ala Ala Ser Zeuner et al., 2003 20386
TNF receptor-associated factor 1 Q13077 1-416 peptide-Asp163+Cys-peptide P Leu Glu Val Asp Cys Tyr Arg Ala Irmler et al., 2000 20038
tyrosine-protein kinase ABL1 P00519 1-1130 peptide-Asp546+Val-peptide P Asp Thr Thr Asp Val Pro Glu Met Barilà et al., 2003 23790
tyrosine-protein kinase ABL1 P00519 1-1130 peptide-Asp625+Gly-peptide P Arg Glu Met Asp Gly Gln Pro Glu Barilà et al., 2003 23795
tyrosine-protein kinase ABL1 P00519 1-1130 peptide-Asp939+Ala-peptide P Ser Leu Val Asp Ala Val Asn Ser Barilà et al., 2003 20917
vimentin P08670 2-466 peptide-Asp259+Val-peptide P Ile Asp Val Asp Val Ser Lys Pro Morishima, 1999 3973

feedback
Page created 8-September-2023

EMBL-EBI logo

© 2025 EBI
Terms of use