Searches of the MEROPS database

Display Known Cleavages for a Protein

Please enter a UniProt accession (eg P05067):

Accession:

Sequence P42574

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Peptide and protein substrates that are thought to be physiologically relevant are indicated by P. Peptide and protein substrates that are not physiologically relevant are indicated by N. How cleavage sites have been identified are indicated by the following evidence codes: NT = N-terminal sequencing, MS = mass spectroscopy, MU = mutation, CS = consensus sequence, LC = liquid chromatography. To see all annotated cleavages for a peptidase, click on the peptidase name.

Cleavage Site	Peptidase	Residue range	Cleavage type	Description	Evidence	Reference
7	calpain-1	1-277	P			Wolf et al., 1999
9	caspase-3	1-277	P	release of an activation peptide		Kamada et al., 1997
9	caspase-10	1-277	P			Fernandes-Alnemri et al., 1996
28	caspase-3	1-277	P			Meergans et al., 2001
28	caspase-8	1-277	P			Rank et al., 2001
175	caspase-3	1-277	P	release of a protein domain		Kamada et al., 1997
175	caspase-6	29-277	P			Cohen, 1997
175	caspase-4	29-277	P			Kamada et al., 1997
175	caspase-8	1-277	P			Rank et al., 2001
175	caspase-9		P			Zou et al., 1997
175	caspase-10	1-277	P			Fernandes-Alnemri et al., 1996
175	caspase-11	1-277	P			Kang et al., 2000
175	granzyme B (Homo sapiens-type)	29-277	P			Casciola-Rosen et al., 2007
175	granzyme B, rodent-type	29-277	N			Casciola-Rosen et al., 2007