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Literature for peptidase C14.009: caspase-8

Summary Gene structure Alignment Tree Sequences Sequence features Distribution Structure Literature Substrates Pharma

(Topics flags: S Structure, A Assay, T Target, K Knockout, P Specificity, E Expression, V Review, M Mutation, R Splicing, I Inhibitor, L Localization, U Therapeutic. To select only the references relevant to a single topic, click the link above. See explanation.)

    2025
  1. Nguyen,L., Ajredini,R., Guo,S., Romano,L.E.L., Tomas,R.F., Bell,L.R., Ranum,P.T., Zu,T., Banez Coronel,M., Kelley,C.P., Redding-Ochoa,J., Nizamis,E., Melloni,A., Connors,T.R., Gaona,A., Thangaraju,K., Pletnikova,O., Clark,H.B., Davidson,B.L., Yachnis,A.T., Golde,T.E., Lou,X., Wang,E.T., Renton,A.E., Goate,A., Valdmanis,P.N., Prokop,S., Troncoso,J.C., Hyman,B.T. and Ranum,L.P.W.
    CASP8 intronic expansion identified by poly-glycine-arginine pathology increases Alzheimer's disease risk
    Proc Natl Acad Sci U S A122, e2416885122-e2416885122. PubMed  Europe PubMed DOI
    2. 2024
  2. Ai,Y., Meng,Y., Yan,B., Zhou,Q. and Wang,X.
    The biochemical pathways of apoptotic, necroptotic, pyroptotic, and ferroptotic cell death
    Mol Cell84, 170-179. PubMed  Europe PubMed DOI  V
  3. Bernabe-Rubio,M. and Watt,F.M.
    Caspase-8-dependent autophagy regulates neutrophil infiltration in oral squamous cell carcinoma
    Proc Natl Acad Sci U S A121, e2406944121-e2406944121. PubMed  Europe PubMed DOI
  4. Chen,H., Lin,Y., Chen,J., Luo,X., Kan,Y., He,Y., Zhu,R., Jin,J., Li,D., Wang,Y. and Han,Z.
    Targeting caspase-8: a new strategy for combating hepatocellular carcinoma
    Front Immunol15, 1501659-1501659. PubMed  Europe PubMed DOI  V
  5. Choudhury,S.M., Sarkar,R., Karki,R. and Kanneganti,T.D.
    A comparative study of apoptosis, pyroptosis, necroptosis, and PANoptosis components in mouse and human cells
    PLoS ONE19, e0299577-e0299577. PubMed  Europe PubMed DOI
  6. Osbron,C.A., Lawson,C., Hanna,N., Koehler,H.S. and Goodman,A.G.
    Caspase-8 activity mediates TNFalpha production and restricts Coxiella burnetii replication during murine macrophage infection
    Infect Immune0005324-e0005324. PubMed  Europe PubMed DOI
    7. 2023
  7. Bazgir,N., Tahvildari,A., Chavoshzade,Z., Jamee,M., Golchehre,Z., Karimi,A., Dara,N., Fallahi,M., Keramatipour,M., Karamzade,A. and Sharafian,S.
    A rare immunological disease, caspase 8 deficiency: case report and literature review
    Allergy Asthma Clin Immunol19, 29-29. PubMed  Europe PubMed DOI
  8. Bozonet,S.M., Magon,N.J., Schwartfeger,A.J., Konigstorfer,A., Heath,S.G., Vissers,M.C.M., Morris,V.K., Gobl,C., Murphy,J.M., Salvesen,G.S. and Hampton,M.B.
    Oxidation of caspase-8 by hypothiocyanous acid enables TNF-mediated necroptosis
    J Biol Chem299, 104792-104792. PubMed  Europe PubMed DOI
  9. Bruning,N., Bonnemann,V. and Watzl,C.
    Analyzing the activity of the proteases granzyme B and caspase-8 inside living cells using fluorescence localization reporters
    Methods Cell Biol178, 13-24. PubMed  Europe PubMed DOI
  10. Contadini,C., Ferri,A., Cirotti,C., Stupack,D. and Barila,D.
    Caspase-8 and Tyrosine Kinases: A Dangerous Liaison in Cancer
    Cancers (Basel)15, PubMed  Europe PubMed DOI  V
  11. Pang,J. and Vince,J.E.
    The role of caspase-8 in inflammatory signalling and pyroptotic cell death
    Semin Immunol70, 101832-101832. PubMed  Europe PubMed DOI  V
  12. Peng,F., Zhu,F., Cao,B. and Peng,L.
    Multidimensional Analysis of PANoptosis-Related Molecule CASP8: Prognostic Significance, Immune Microenvironment Effect, and Therapeutic Implications in Hepatocellular Carcinoma
    Genet Res (Camb)2023, 2406193-2406193. PubMed  Europe PubMed DOI
  13. Sahoo,G., Samal,D., Khandayataray,P. and Murthy,M.K.
    A Review on Caspases: Key Regulators of Biological Activities and Apoptosis
    Mol Neurobiol60, 5805-5837. PubMed  Europe PubMed DOI  V
    14. 2022
  14. Bai,Z.Q., Ma,X., Liu,B., Huang,T. and Hu,K.
    Solution structure of c-FLIP death effector domains
    Biochem Biophys Res Commun617, 1-6. PubMed  Europe PubMed DOI
  15. Geng,S., Gu,L., Zhong,L., Xu,T. and Sun,Y.
    Genomic organization, evolution and functional characterization of caspase-2 and caspase-8 in miiuy croaker (Miichthys miiuy)
    Dev Comp Immunol127, 104308-104308. PubMed  Europe PubMed DOI
  16. Jantaree,P., Chaithongyot,S., Sokolova,O. and Naumann,M.
    USP48 and A20 synergistically promote cell survival in Helicobacter pylori infection
    Cell Mol Life Sci79, 461-461. PubMed  Europe PubMed DOI
  17. Kim,S., Lu,H.C., Steelman,A.J. and Li,J.
    Myeloid caspase-8 restricts RIPK3-dependent proinflammatory IL-1beta production and CD4 T cell activation in autoimmune demyelination
    Proc Natl Acad Sci U S A119, e2117636119-e2117636119. PubMed  Europe PubMed DOI
  18. Mollinedo,F. and Gajate,C.
    Clusters of apoptotic signaling molecule-enriched rafts, CASMERs: membrane platforms for protein assembly in Fas/CD95 signaling and targets in cancer therapy
    Biochem Soc Trans50, 1105-1118. PubMed  Europe PubMed DOI
  19. Rodriguez,D.A., Quarato,G., Liedmann,S., Tummers,B., Zhang,T., Guy,C., Crawford,J.C., Palacios,G., Pelletier,S., Kalkavan,H., Shaw,J.J.P., Fitzgerald,P., Chen,M.J., Balachandran,S. and Green,D.R.
    Caspase-8 and FADD prevent spontaneous ZBP1 expression and necroptosis
    Proc Natl Acad Sci U S A119, e2207240119-e2207240119. PubMed  Europe PubMed DOI
  20. Weir,A. and Vince,J.E.
    No longer married to inflammasome signaling: the diverse interacting pathways leading to pyroptotic cell death
    Biochem J479, 1083-1102. PubMed  Europe PubMed DOI  V
    21. 2021
  21. Du,Y., Taylor,C.G., Aukema,H.M. and Zahradka,P.
    Regulation of docosahexaenoic acid-induced apoptosis of confluent endothelial cells: Contributions of MAPKs and caspases
    Biochim Biophys Acta Mol Cell Biol Lipids1866, 158902-158902. PubMed  Europe PubMed DOI
  22. Fox,J.L., Hughes,M.A., Meng,X., Sarnowska,N.A., Powley,I.R., Jukes-Jones,R., Dinsdale,D., Ragan,T.J., Fairall,L., Schwabe,J.W.R., Morone,N., Cain,K. and MacFarlane,M.
    Cryo-EM structural analysis of FADD:Caspase-8 complexes defines the catalytic dimer architecture for co-ordinated control of cell fate
    Nat Commun12, 819-819. PubMed  Europe PubMed DOI
  23. Jiang,M., Qi,L., Li,L., Wu,Y., Song,D. and Li,Y.
    Caspase-8: A key protein of cross-talk signal way in "PANoptosis" in cancer
    Int J Cancer PubMed  Europe PubMed DOI
  24. Lee,S.H., Jung,S., Lee,Y.J., Hyun,M. and Chung,K.C.
    FBXO7 triggers caspase 8-mediated proteolysis of the transcription factor FOXO4 and exacerbates neuronal cytotoxicity
    J Biol Chem297, 101426-101426. PubMed  Europe PubMed DOI
  25. Muendlein,H.I., Connolly,W.M., Magri,Z., Smirnova,I., Ilyukha,V., Gautam,A., Degterev,A. and Poltorak,A.
    ZBP1 promotes LPS-induced cell death and IL-1beta release via RHIM-mediated interactions with RIPK1
    Nat Commun12, 86-86. PubMed  Europe PubMed DOI
  26. Sun,L., Chen,H., Ming,X., Bo,Z., Shin,H.J., Jung,Y.S. and Qian,Y.
    Porcine Epidemic Diarrhea Virus Infection Induces Caspase-8 mediated G3BP1 Cleavage and Subverts Stress Granules to Promote Viral Replication
    J Virol PubMed  Europe PubMed DOI
  27. Xiang,Y.K., Peng,F.H., Guo,Y.Q., Ge,H., Cai,S.Y., Fan,L.X., Peng,Y.X., Wen,H., Wang,Q. and Tao,L.
    Connexin32 Activates Necroptosis via Src-Mediated Inhibition of Caspase 8 in Hepatocellular Carcinoma
    Cancer Sci112, 3507-3519. PubMed  Europe PubMed DOI
  28. Zhang,L.S., Xu,H.L., Xia,Y., Bi,J.P., Zhang,C.Z., Xi,Z., Li,L.Y. and Zhang,Z.S.
    Real-time monitoring of caspase-3/8 activity by self-assembling nanofiber probes in living cells
    Chem Commun (Camb)57, 797-800. PubMed  Europe PubMed DOI
  29. Zhu,Y., Zhou,J., Niu,P., Chen,H. and Shi,D.
    Cardamonin inhibits cell proliferation by caspase-mediated cleavage of Raptor
    Naunyn Schmiedebergs Arch Pharmacol394, 809-817. PubMed  Europe PubMed DOI  I
  30. Zou,J., Xia,H., Zhang,C., Xu,H., Tang,Q., Zhu,G., Li,J. and Bi,F.
    Casp8 acts through A20 to inhibit PD-L1 expression: The mechanism and its implication in immunotherapy
    Cancer Sci112, 2664-2678. PubMed  Europe PubMed DOI
    31. 2020
  31. Ashida,H., Sasakawa,C. and Suzuki,T.
    A unique bacterial tactic to circumvent the cell death crosstalk induced by blockade of caspase-8
    EMBO Je104469-e104469. PubMed  Europe PubMed DOI
  32. Cui,X.Y., Park,S.H. and Park,W.H.
    Auranofin inhibits the proliferation of lung cancer cells via necrosis and caspasedependent apoptosis
    Oncol Rep44, 2715-2724. PubMed  Europe PubMed DOI  I
  33. de Vasconcelos,N.M., Van Opdenbosch,N., Van Gorp,H., Martin-Perez,R., Zecchin,A., Vandenabeele,P. and Lamkanfi,M.
    An Apoptotic Caspase Network Safeguards Cell Death Induction in Pyroptotic Macrophages
    Cell Rep32, 107959-107959. PubMed  Europe PubMed DOI
  34. Eslami,F., Mahdavi,M., Babaei,E., Hussen,B.M., Mostafavi,H., Shahbazi,A. and Hidayat,H.J.
    Down-regulation of Survivin and Bcl-2 concomitant with the activation of caspase-3 as a mechanism of apoptotic death in KG1a and K562 cells upon exposure to a derivative from ciprofloxacin family
    Toxicol Appl Pharmacol409, 115331-115331. PubMed  Europe PubMed DOI
  35. Fathi,E. and Vietor,I.
    Mesenchymal stem cells promote caspase expression in Molt-4 leukemia cells via GSK-3alpha/beta and ERK1/2 signaling pathways as a therapeutic strategy
    Curr Gene Ther PubMed  Europe PubMed DOI
  36. Fu,S., Ding,M., Wang,J., Yin,X., Zhou,E., Kong,L., Tu,X., Guo,Z., Wang,A., Huang,Y. and Ye,J.
    Identification and functional characterization of three caspases in Takifugu obscurus in response to bacterial infection
    Fish Shellfish Immunol PubMed  Europe PubMed DOI  I
  37. Gao,H., Wen,N., Xu,X., Hong,G. and Lai,X.
    [Endoplasmic reticulum stress enhances tumor necrosis factor-alpha expression in rat Kupffer cells to trigger hepatic stellate apoptosis cell through TNFR/caspase-8 pathway]
    Nan Fang Yi Ke Da Xue Xue Bao40, 632-639. PubMed  Europe PubMed DOI
  38. Hong,W., Gu,Y., Guan,R., Xie,D., Zhou,H. and Yu,M.
    Pan-cancer analysis of the CASP gene family in relation to survival, tumor-infiltrating immune cells and therapeutic targets
    Genomics PubMed  Europe PubMed DOI
  39. Israelov,H., Ravid,O., Atrakchi,D., Rand,D., Elhaik,S., Bresler,Y., Twitto-Greenberg,R., Omesi,L., Liraz-Zaltsman,S., Gosselet,F., Schnaider Beeri,M. and Cooper,I.
    Caspase-1 has a critical role in blood-brain barrier injury and its inhibition contributes to multifaceted repair
    J Neuroinflammation17, 267-267. PubMed  Europe PubMed DOI  I
  40. Ivanisenko,N.V. and Lavrik,I.N.
    Mathematical Modeling Reveals the Importance of the DED Filament Composition in the Effects of Small Molecules Targeting Caspase-8/c-FLIPL Heterodimer
    Biochemistry (Mosc)85, 1134-1144. PubMed  Europe PubMed DOI
  41. Jin,Q., Lin,C., Zhu,X., Cao,Y., Guo,C. and Wang,L.
    (125)I seeds irradiation inhibits tumor growth and induces apoptosis by Ki-67, P21, survivin, livin and caspase-9 expression in lung carcinoma xenografts
    Radiat Oncol15, 238-238. PubMed  Europe PubMed DOI
  42. Lee,S.E., Okhlopkova,Z., Lim,C. and Cho,S.
    Dracocephalum palmatum Stephan extract induces apoptosis in human prostate cancer cells via the caspase-8-mediated extrinsic pathway
    Chin J Nat Med18, 793-800. PubMed  Europe PubMed DOI
  43. Lees,A., McIntyre,A.J., Crawford,N.T., Falcone,F., McCann,C., Holohan,C., Quinn,G.P., Roberts,J.Z., Sessler,T., Gallagher,P.F., Gregg,G.M.A., McAllister,K., McLaughlin,K.M., Allen,W.L., Egan,L.J., Ryan,A.E., Labonte-Wilson,M.J., Dunne,P.D., Wappett,M., Coyle,V.M., Johnston,P.G., Kerr,E.M., Longley,D.B. and McDade,S.S.
    The pseudo-caspase FLIP(L) regulates cell fate following p53 activation
    Proc Natl Acad Sci U S A117, 17808-17819. PubMed  Europe PubMed DOI
  44. Li,S., Zhang,Y., Guan,Z., Li,H., Ye,M., Chen,X., Shen,J., Zhou,Y., Shi,Z.L., Zhou,P. and Peng,K.
    SARS-CoV-2 triggers inflammatory responses and cell death through caspase-8 activation
    Signal Transduct Target Ther5, 235-235. PubMed  Europe PubMed DOI
  45. Lorente,L., Martin,M.M., Ortiz-Lopez,R., Gonzalez-Rivero,A.F., Perez-Cejas,A., Martin,M., Gonzalez,V., Perez,A., Rodin,M. and Jimenez,A.
    Blood caspase-8 concentrations and mortality among septic patients
    Med Intensiva PubMed  Europe PubMed DOI
  46. Mandal,R., Barron,J.C., Kostova,I., Becker,S. and Strebhardt,K.
    Caspase-8: the double-edged sword
    Biochim Biophys Acta Rev Cancer1873, 188357-188357. PubMed  Europe PubMed DOI
  47. Pereira,L.M.N., Assis,P.A., de Araujo,N.M., Durso,D.F., Junqueira,C., Ataide,M.A., Pereira,D.B., Lien,E., Fitzgerald,K.A., Zamboni,D.S., Golenbock,D.T. and Gazzinelli,R.T.
    Author Correction: Caspase-8 mediates inflammation and disease in rodent malaria
    Nat Commun11, 5673-5673. PubMed  Europe PubMed DOI
  48. Rashidbaghan,A., Mostafaie,A., Yazdani,Y. and Mansouri,K.
    Urtica dioica agglutinin (a plant lectin) has a caspase-dependent apoptosis induction effect on the acute lymphoblastic leukemia cell line
    Cell Mol Biol (Noisy-le-grand)66, 121-126. PubMed  Europe PubMed
  49. Soni,U.K., Chadchan,S.B., Joshi,A., Kumar,V., Maurya,V.K., Verma,R.K. and Jha,R.K.
    Poly(ADP-ribose) polymerase-2 is essential for endometrial receptivity and blastocyst implantation, and regulated by caspase-8
    Mol Cell Endocrinol110946-110946. PubMed  Europe PubMed DOI
  50. Sun,H., Zong,H. and Wu,G.
    2Hydroxypropylbetacyclodextrin blocks autophagy flux and triggers caspase8mediated apoptotic cascades in HepG2 cells
    Mol Med Rep22, 1901-1909. PubMed  Europe PubMed DOI
  51. Willson,J.
    A matter of life and death for caspase 8
    Nat Rev Mol Cell Biol21, 63-63. PubMed  Europe PubMed DOI
  52. Wolin,I.A.V., Heinrich,I.A., Nascimento,A.P.M., Welter,P.G., Sosa,L.D.V., De Paul,A.L., Zanotto-Filho,A., Nedel,C.B., Lima,L.D., Osterne,V.J.S., Pinto-Junior,V.R., Nascimento,K.S., Cavada,B.S. and Leal,R.B.
    ConBr lectin modulates MAPKs and Akt pathways and triggers autophagic glioma cell death by a mechanism dependent upon caspase-8 activation
    Biochimie180, 186-204. PubMed  Europe PubMed DOI
  53. Xie,B., Yao,Q., Xiang,J. and Minh,D.D.L.
    A Structural Model for Bax2-Mediated Activation of Caspase 8-Dependent Apoptosis
    Int J Mol Sci21, PubMed  Europe PubMed DOI
  54. Yu,H., Sun,Q., Yun,F., Xu,X., Ding,F., Li,S. and Zhao,P.
    XCHD Inhibits C6 Cell Growth Primarily via the p53/Caspase Pathway
    Evid Based Complement Alternat Med2020, 7973639-7973639. PubMed  Europe PubMed DOI
  55. Zhang,Y., Zhou,G., Chen,Z., Guan,W., Zhang,J., Bi,M., Wang,F., You,X., Liao,Y., Zheng,S., Xu,K. and Yang,H.
    Si-Wu-Tang Alleviates Nonalcoholic Fatty Liver Disease via Blocking TLR4-JNK and Caspase-8-GSDMD Signaling Pathways
    Evid Based Complement Alternat Med2020, 8786424-8786424. PubMed  Europe PubMed DOI
  56. Zhang,Y., Zhou,G., Chen,Z., Guan,W., Zhang,J., Bi,M., Wang,F., You,X., Liao,Y., Zheng,S., Xu,K. and Yang,H.
    Si-Wu-Tang Alleviates Nonalcoholic Fatty Liver Disease via Blocking TLR4-JNK and Caspase-8-GSDMD Signaling Pathways
    Evid Based Complement Alternat Med2020, 8786424-8786424. PubMed  Europe PubMed DOI
  57. Zhao,F., Li,J., Lu,Q., Chen,E. and Yuan,L.
    [Danggui Niantong decoction induces apoptosis by activating Fas/caspase-8 pathway in rheumatoid arthritis fibroblast-like synoviocytes]
    Nan Fang Yi Ke Da Xue Xue Bao40, 1119-1126. PubMed  Europe PubMed DOI
  58. Zheng,M., Williams,E.P., Malireddi,R.K.S., Karki,R., Banoth,B., Burton,A., Webby,R., Channappanavar,R., Jonsson,C.B. and Kanneganti,T.D.
    Impaired NLRP3 inflammasome activation/pyroptosis leads to robust inflammatory cell death via caspase-8/RIPK3 during coronavirus infection
    J Biol Chem295, 14040-14052. PubMed  Europe PubMed DOI
  59. Zuo,H., Chen,C., Ma,L., Min,Q.X. and Shen,Y.H.
    Caspase-8 knockdown suppresses apoptosis, while induces autophagy and chemo-sensitivity in non-small cell lung cancer cells
    Am J Transl Res12, 6478-6489. PubMed  Europe PubMed
    60. 2019
  60. Du,H., Song,G.X., Fang,M.Z., Shu,Y.Q., Zhao,X. and Zhu,L.J.
    A meta-analysis of caspase-8 -652 6N del polymorphism and digestive tract cancer risk
    J Biomed Res33, 173-180. PubMed  Europe PubMed DOI  M
  61. Fritsch,M., Gunther,S.D., Schwarzer,R., Albert,M.C., Schorn,F., Werthenbach,J.P., Schiffmann,L.M., Stair,N., Stocks,H., Seeger,J.M., Lamkanfi,M., Kronke,M., Pasparakis,M. and Kashkar,H.
    Caspase-8 is the molecular switch for apoptosis, necroptosis and pyroptosis
    Nature575, 683-687. PubMed  Europe PubMed DOI
  62. Gram,A.M., Booty,L.M. and Bryant,C.E.
    Chopping GSDMD: caspase-8 has joined the team of pyroptosis-mediating caspases
    EMBO J38, e102065-e102065. PubMed  Europe PubMed DOI
  63. Kuhlmann,J.D., Bachmann,H.S., Link,T., Wimberger,P., Krober,E., Thomssen,C., Malle,B., Bethmann,D., Vetter,M. and Kantelhardt,E.J.
    Association of caspase 8 polymorphisms -652 6N InsDel and Asp302His with progression-free survival and tumor infiltrating lymphocytes in early breast cancer
    Sci Rep9, 12594-12594. PubMed  Europe PubMed DOI  M
  64. Li,M., Le Wei, Zhang,X.M., Zhang,Y.J., Jiang,J. and Liu,P.Y.
    The M476W/Q482H mutation of procaspase-8 restored caspase-8-mediated apoptosis
    Biochem Biophys Res Commun514, 653-658. PubMed  Europe PubMed DOI  M
  65. Lin,H., Yang,W.Q., Ye,Z. and Zhang,C.J.
    Identification of potent caspase-8 inhibitors from a library of fluorescent natural products screened by an AIEgen-based light-up probe
    Chembiochem20, 1292-1296. PubMed  Europe PubMed DOI  A  I
  66. Nakano,K., Iwanaga,M., Utsunomiya,A., Uchimaru,K. and Watanabe,T.
    Functional analysis of aberrantly spliced caspase 8 variants in adult T-cell leukemia cells
    Mol Cancer Res17, 2522-2536. PubMed  Europe PubMed DOI  M
  67. Newton,K., Wickliffe,K.E., Dugger,D.L., Maltzman,A., Roose-Girma,M., Dohse,M., Komuves,L., Webster,J.D. and Dixit,V.M.
    Cleavage of RIPK1 by caspase-8 is crucial for limiting apoptosis and necroptosis
    Nature574, 428-431. PubMed  Europe PubMed DOI
  68. Park,H.H.
    Molecular basis of dimerization of initiator caspase was revealed by crystal structure of caspase-8 pro-domain
    Cell Death Differ26, 1213-1220. PubMed  Europe PubMed DOI  S
  69. Poreba,M., Groborz,K., Navarro,M., Snipas,S.J., Drag,M. and Salvesen,G.S.
    Caspase selective reagents for diagnosing apoptotic mechanisms
    Cell Death Differ26, 229-244. PubMed  Europe PubMed DOI  P
    70. 2018
  70. Keller,N., Ozmadenci,D., Ichim,G. and Stupack,D.
    Caspase-8 function, and phosphorylation, in cell migration
    Semin Cell Dev Biol82, 105-117. PubMed  Europe PubMed DOI
  71. Legarda,D. and Ting,A.T.
    Analysis of CYLD proteolysis by caspase 8 in bone marrow-derived macrophages
    Methods Mol Biol1857, 181-188. PubMed  Europe PubMed DOI
  72. Li,M., Yao,J., Zhang,X., Chen,X., Chen,J., Guan,Y. and Yang,X.
    Q482H mutation of procaspase-8 in acute myeloid leukemia abolishes caspase-8-mediated apoptosis by impairing procaspase-8 dimerization
    Biochem Biophys Res Commun495, 1376-1382. PubMed  Europe PubMed DOI  M
  73. Shen,C., Pei,J., Guo,X., Zhou,L., Li,Q. and Quan,J.
    Structural basis for dimerization of the death effector domain of the F122A mutant of caspase-8
    Sci Rep8, 16723-16723. PubMed  Europe PubMed DOI  M  S
  74. Su,W., Han,L., Chen,X., Yu,J., Cheng,X., Huang,J., Xiao,Y., Tian,Y., Olsen,N., Zheng,S.G. and Liang,D.
    Pharmacological inhibition of caspase-8 suppresses inflammation-induced lymphangiogenesis and allograft rejection in the cornea
    J Allergy Clin Immunol142, 290-294. PubMed  Europe PubMed DOI  I
    75. 2017
  75. Yan,A., Ren,C., Chen,T., Jiang,X., Sun,H., Huo,D., Hu,C. and Wen,J.
    The first tropical sea cucumber caspase-8 from Holothuria leucospilota: molecular characterization, involvement of apoptosis and inducible expression by immune challenge
    Fish Shellfish Immunol72, 124-131. PubMed  Europe PubMed DOI
    76. 2016
  76. Fu,T.M., Li,Y., Lu,A., Li,Z., Vajjhala,P.R., Cruz,A.C., Srivastava,D.B., Dimaio,F., Penczek,P.A., Siegel,R.M., Stacey,K.J., Egelman,E.H. and Wu,H.
    Cryo-EM structure of caspase-8 tandem DED filament reveals assembly and regulation mechanisms of the death-inducing signaling complex
    Mol Cell64, 236-250. PubMed  Europe PubMed DOI  S
  77. Huang,K., Zhang,J., O'Neill,K.L., Gurumurthy,C.B., Quadros,R.M., Tu,Y. and Luo,X.
    Cleavage by caspase 8 and mitochondrial membrane association activate the BH3-only protein Bid during TRAIL-induced apoptosis
    J Biol Chem291, 11843-11851. PubMed  Europe PubMed DOI
  78. Julien,O., Zhuang,M., Wiita,A.P., O'Donoghue,A.J., Knudsen,G.M., Craik,C.S. and Wells,J.A.
    Quantitative MS-based enzymology of caspases reveals distinct protein substrate specificities, hierarchies, and cellular roles
    Proc Natl Acad Sci U S A113, E2001-E2010. PubMed  Europe PubMed DOI  P
  79. Liu,W., Liu,S.J., Kuang,Y.Q., Luo,F.Y. and Jiang,J.H.
    Developing activity localization fluorescence peptide probe using thiol-ene click reaction for spatially resolved imaging of caspase-8 in live cells
    Anal Chem88, 7867-7872. PubMed  Europe PubMed DOI  L
  80. Oliva-Martin,M.J., Sanchez-Abarca,L.I., Rodhe,J., Carrillo-Jimenez,A., Vlachos,P., Herrera,A.J., Garcia-Quintanilla,A., Caballero-Velazquez,T., Perez-Simon,J.A., Joseph,B. and Venero,J.L.
    Caspase-8 inhibition represses initial human monocyte activation in septic shock model
    Oncotarget7, 37456-37470. PubMed  Europe PubMed DOI  T  I
  81. Sagulenko,V., Lawlor,K.E. and Vince,J.E.
    New insights into the regulation of innate immunity by caspase-8
    Arthritis Res Ther18, 4-4. PubMed  Europe PubMed DOI
  82. Schleich,K., Buchbinder,J.H., Pietkiewicz,S., Kahne,T., Warnken,U., Ozturk,S., Schnolzer,M., Naumann,M., Krammer,P.H. and Lavrik,I.N.
    Molecular architecture of the DED chains at the DISC: regulation of procaspase-8 activation by short DED proteins c-FLIP and procaspase-8 prodomain
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