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Literature for peptidase C14.009: caspase-8

Summary Gene structure Alignment Tree Sequences Sequence features Distribution Structure Literature Substrates Pharma

(Topics flags: S Structure, A Assay, T Target, K Knockout, P Specificity, E Expression, V Review, M Mutation, R Splicing, I Inhibitor, L Localization, U Therapeutic. To select only the references relevant to a single topic, click the link above. See explanation.)

    2025
  1. Androulidaki,A., Liu,F., Bebber,C.M., Kisis,I., Sakthivelu,V., Hunold,P., Koerner,L., Dahlhaus,A., Yapici,F.I., Grimm,C., Pacholewska,A., Tishina,S., Doskotz,F., Torres Fernandez,L.A., Stroh,J., Abdallah,A.T., Beck,J., Mulalic,L., Schmitt,A., Grull,H., Persigehl,T., Quaas,A., Peifer,M., Bragelmann,J., Reinhardt,H.C., Nieper,P., Hansel-Hertsch,R., Thomas,R.K., George,J., Schweiger,M.R., Pasparakis,M., Beleggia,F. and von Karstedt,S.<br>Lack of caspase 8 directs neuronal progenitor-like reprogramming and small cell lung cancer progression<br>Nat Commun (2025) 16, 11280-11280. PubMed  Europe PubMed DOI  PMC  EPMC
  2. Bader,M., Scherer,L., Bhandari,R., Motyer,A.J., Cooney,J.P., Mackiewicz,L., Dayton,M., Sheerin,D., Romero,V.L., Schaefer,J., Pang,J., Chen,S., Schoffer,K., Wang,L., Jin,X., Batey,D., Yip,R.K.H., Zaman,I., Rajasekhar,P., Gartner,M.J., Wilcox,S., Whitehead,L., Georgy,S.R., Maluenda,A., Davidson,K.C., Allison,C.C., Bowden,R., Brinkmann,K., Asselin-Labat,M.L., Phipson,B., Tanzer,M.C., Herold,M.J., Samson,A.L., Vince,J.E., Strasser,A., Pellegrini,M. and Doerflinger,M.<br>Non-apoptotic caspase-8 is critical for orchestrating exaggerated inflammation during severe SARS-CoV-2 infection<br>Nat Commun (2025) 16, 9822-9822. PubMed  Europe PubMed DOI  PMC  EPMC
  3. Chen,Y., Huynh,V.T., Lai,L., Liu,P., Li,T., Tan,Y.B., Chew,C.S., Velazquez,A.M.V., Samsudin,F., Marzinek,J.K., Bond,P.J., Wu,B., Luo,D. and Tergaonkar,V.<br>(FADD)DED filaments coordinate complex IIa assembly during TNF-induced apoptosis<br>Proc Natl Acad Sci U S A (2025) 122, e2425802122-e2425802122. PubMed  Europe PubMed DOI  PMC  EPMC
  4. Fosuah,E., Shen,Z., Xie,J., Wang,C., Lin,Q. and Fu,T.M.<br>Assembly and activation of the death-inducing signaling complex<br>Proc Natl Acad Sci U S A (2025) 122, e2504819122-e2504819122. PubMed  Europe PubMed DOI
  5. Huang,X., Li,F., Liu,L., Li,Y., Zhang,M., Ma,G., Gao,Y., Shan,B., Liang,X., Yuan,J. and Pan,H.<br>PARP12-mediated mono-ADP-ribosylation as a checkpoint for necroptosis and apoptosis<br>Proc Natl Acad Sci U S A (2025) 122, e2426660122-e2426660122. PubMed  Europe PubMed DOI  PMC  EPMC
  6. Konig,C. and Lavrik,I.N.<br>Protocol for measuring the caspase-8 activity at the DED filaments in adherent cells<br>STAR Protoc (2025) 6, 104131-104131. PubMed  Europe PubMed DOI  PMC  EPMC
  7. Ma,M., Wang,F., Cui,P., Zhang,Y., Ma,H., He,Y., Cheng,Y., Huang,J., Wang,J., Wu,X., Yang,H., Zheng,R., Ma,H., Cai,Q., Wang,L. and Ge,B.<br>RIOK2 kinase regulates the translocation of the FADD-RIPK1-Caspase-8 complex to the ER and the cleavage of Gasdermin D to drive pyroptosis<br>Nat Commun (2025) 16, 10060-10060. PubMed  Europe PubMed DOI  PMC  EPMC
  8. Newton,K., Wickliffe,K.E., Dugger,D.L., Maltzman,A., Roose-Girma,M., Dohse,M., Komuves,L., Webster,J.D. and Dixit,V.M.<br>Author Correction: Cleavage of RIPK1 by caspase-8 is crucial for limiting apoptosis and necroptosis<br>Nature (2025) 648, E17-E17. PubMed  Europe PubMed DOI
  9. Newton,K., Wickliffe,K.E., Maltzman,A., Dugger,D.L., Reja,R., Zhang,Y., Roose-Girma,M., Modrusan,Z., Sagolla,M.S., Webster,J.D. and Dixit,V.M.<br>Author Correction: Activity of caspase-8 determines plasticity between cell death pathways<br>Nature (2025) PubMed  Europe PubMed DOI
  10. Nguyen,L., Ajredini,R., Guo,S., Romano,L.E.L., Tomas,R.F., Bell,L.R., Ranum,P.T., Zu,T., Banez Coronel,M., Kelley,C.P., Redding-Ochoa,J., Nizamis,E., Melloni,A., Connors,T.R., Gaona,A., Thangaraju,K., Pletnikova,O., Clark,H.B., Davidson,B.L., Yachnis,A.T., Golde,T.E., Lou,X., Wang,E.T., Renton,A.E., Goate,A., Valdmanis,P.N., Prokop,S., Troncoso,J.C., Hyman,B.T. and Ranum,L.P.W.<br>CASP8 intronic expansion identified by poly-glycine-arginine pathology increases Alzheimer's disease risk<br>Proc Natl Acad Sci U S A (2025) 122, e2416885122-e2416885122. PubMed  Europe PubMed DOI
  11. Shaw,J.J.P., Guy,C., Tummers,B. and Green,D.R.<br>FLIP(L) permits apoptotic and inflammatory signaling and inhibits necroptosis in mice without Caspase-8 oligomerization<br>Proc Natl Acad Sci U S A (2025) 122, e2415992122-e2415992122. PubMed  Europe PubMed DOI
  12. Tweedell,R.E. and Kanneganti,T.D.<br>ExSPECKt the unexpected: NLRP3-caspase-8-dependent cell death in RBCs<br>Cell (2025) 188, 2833-2835. PubMed  Europe PubMed DOI
  13. Wang,X., Chen,L., Qiu,J., Wang,K., Xi,P., Cheng,X., He,Z. and Jiang,H.<br>Dipeptidyl Peptidase 4 Mediated Caspase-8 Affects Cognitive Impairment in Mice With Alzheimer's Disease<br>FASEB J (2025) 39, e71264-e71264. PubMed  Europe PubMed DOI
  14. Yu,H., He,L., Wu,X., Zhang,M., Chen,Z., Sun,J. and Xu,X.<br>Porcine epidemic diarrhea coronavirus infection activates caspase-8 to enhance innate immunity by blocking CYLD-mediated deubiquitination of RIG-I<br>Virology (2025) 604, 110443-110443. PubMed  Europe PubMed DOI
  15. Zhou,T., Solis,N.V., Marshall,M., Yao,Q., Pearlman,E., Filler,S.G. and Liu,H.<br>Fungal Als proteins hijack host death effector domains to promote inflammasome signaling<br>Nat Commun (2025) 16, 1562-1562. PubMed  Europe PubMed DOI  PMC  EPMC
    16. 2024
  16. Ai,Y., Meng,Y., Yan,B., Zhou,Q. and Wang,X.<br>The biochemical pathways of apoptotic, necroptotic, pyroptotic, and ferroptotic cell death<br>Mol Cell (2024) 84, 170-179. PubMed  Europe PubMed DOI  V
  17. Bernabe-Rubio,M. and Watt,F.M.<br>Caspase-8-dependent autophagy regulates neutrophil infiltration in oral squamous cell carcinoma<br>Proc Natl Acad Sci U S A (2024) 121, e2406944121-e2406944121. PubMed  Europe PubMed DOI
  18. Chen,H., Lin,Y., Chen,J., Luo,X., Kan,Y., He,Y., Zhu,R., Jin,J., Li,D., Wang,Y. and Han,Z.<br>Targeting caspase-8: a new strategy for combating hepatocellular carcinoma<br>Front Immunol (2024) 15, 1501659-1501659. PubMed  Europe PubMed DOI  PMC  EPMC  V
  19. Choudhury,S.M., Sarkar,R., Karki,R. and Kanneganti,T.D.<br>A comparative study of apoptosis, pyroptosis, necroptosis, and PANoptosis components in mouse and human cells<br>PLoS ONE (2024) 19, e0299577-e0299577. PubMed  Europe PubMed DOI  PMC  EPMC
  20. Liu,S., Joshi,K., Zhang,L., Li,W., Mack,R., Runde,A., Hagen,P.A., Barton,K., Breslin,P., Ji,H.L., Kini,A.R., Wang,Z. and Zhang,J.<br>Caspase 8 deletion causes infection/inflammation-induced bone marrow failure and MDS-like disease in mice<br>Cell Death Dis (2024) 15, 278-278. PubMed  Europe PubMed DOI  PMC  EPMC
  21. Osbron,C.A., Lawson,C., Hanna,N., Koehler,H.S. and Goodman,A.G.<br>Caspase-8 activity mediates TNFalpha production and restricts Coxiella burnetii replication during murine macrophage infection<br>Infect Immun (2024) , e0005324-e0005324. PubMed  Europe PubMed DOI
  22. Vesela,B., Sevcikova,A., Holomkova,K., Ramesova,A., Kratochvilova,A., Sharpe,P.T. and Matalova,E.<br>Inhibition of caspase-8 cascade restrains the osteoclastogenic fate of bone marrow cells<br>Pflugers Arch (2024) PubMed  Europe PubMed DOI
    23. 2023
  23. Bazgir,N., Tahvildari,A., Chavoshzade,Z., Jamee,M., Golchehre,Z., Karimi,A., Dara,N., Fallahi,M., Keramatipour,M., Karamzade,A. and Sharafian,S.<br>A rare immunological disease, caspase 8 deficiency: case report and literature review<br>Allergy Asthma Clin Immunol (2023) 19, 29-29. PubMed  Europe PubMed DOI  PMC  EPMC
  24. Bozonet,S.M., Magon,N.J., Schwartfeger,A.J., Konigstorfer,A., Heath,S.G., Vissers,M.C.M., Morris,V.K., Gobl,C., Murphy,J.M., Salvesen,G.S. and Hampton,M.B.<br>Oxidation of caspase-8 by hypothiocyanous acid enables TNF-mediated necroptosis<br>J Biol Chem (2023) 299, 104792-104792. PubMed  Europe PubMed DOI  PMC  EPMC
  25. Bruning,N., Bonnemann,V. and Watzl,C.<br>Analyzing the activity of the proteases granzyme B and caspase-8 inside living cells using fluorescence localization reporters<br>Methods Cell Biol (2023) 178, 13-24. PubMed  Europe PubMed DOI
  26. Contadini,C., Ferri,A., Cirotti,C., Stupack,D. and Barila,D.<br>Caspase-8 and Tyrosine Kinases: A Dangerous Liaison in Cancer<br>Cancers (Basel) (2023) 15 PubMed  Europe PubMed DOI  PMC  EPMC  V
  27. Pang,J. and Vince,J.E.<br>The role of caspase-8 in inflammatory signalling and pyroptotic cell death<br>Semin Immunol (2023) 70, 101832-101832. PubMed  Europe PubMed DOI  V
  28. Peng,F., Zhu,F., Cao,B. and Peng,L.<br>Multidimensional Analysis of PANoptosis-Related Molecule CASP8: Prognostic Significance, Immune Microenvironment Effect, and Therapeutic Implications in Hepatocellular Carcinoma<br>Genet Res (Camb) (2023) 2023, 2406193-2406193. PubMed  Europe PubMed DOI  PMC  EPMC
  29. Sahoo,G., Samal,D., Khandayataray,P. and Murthy,M.K.<br>A Review on Caspases: Key Regulators of Biological Activities and Apoptosis<br>Mol Neurobiol (2023) 60, 5805-5837. PubMed  Europe PubMed DOI  V
    30. 2022
  30. Bai,Z.Q., Ma,X., Liu,B., Huang,T. and Hu,K.<br>Solution structure of c-FLIP death effector domains<br>Biochem Biophys Res Commun (2022) 617, 1-6. PubMed  Europe PubMed DOI
  31. Geng,S., Gu,L., Zhong,L., Xu,T. and Sun,Y.<br>Genomic organization, evolution and functional characterization of caspase-2 and caspase-8 in miiuy croaker (Miichthys miiuy)<br>Dev Comp Immunol (2022) 127, 104308-104308. PubMed  Europe PubMed DOI
  32. Jantaree,P., Chaithongyot,S., Sokolova,O. and Naumann,M.<br>USP48 and A20 synergistically promote cell survival in Helicobacter pylori infection<br>Cell Mol Life Sci (2022) 79, 461-461. PubMed  Europe PubMed DOI  PMC  EPMC
  33. Kim,S., Lu,H.C., Steelman,A.J. and Li,J.<br>Myeloid caspase-8 restricts RIPK3-dependent proinflammatory IL-1beta production and CD4 T cell activation in autoimmune demyelination<br>Proc Natl Acad Sci U S A (2022) 119, e2117636119-e2117636119. PubMed  Europe PubMed DOI  PMC  EPMC
  34. Mollinedo,F. and Gajate,C.<br>Clusters of apoptotic signaling molecule-enriched rafts, CASMERs: membrane platforms for protein assembly in Fas/CD95 signaling and targets in cancer therapy<br>Biochem Soc Trans (2022) 50, 1105-1118. PubMed  Europe PubMed DOI  PMC  EPMC
  35. Rodriguez,D.A., Quarato,G., Liedmann,S., Tummers,B., Zhang,T., Guy,C., Crawford,J.C., Palacios,G., Pelletier,S., Kalkavan,H., Shaw,J.J.P., Fitzgerald,P., Chen,M.J., Balachandran,S. and Green,D.R.<br>Caspase-8 and FADD prevent spontaneous ZBP1 expression and necroptosis<br>Proc Natl Acad Sci U S A (2022) 119, e2207240119-e2207240119. PubMed  Europe PubMed DOI  PMC  EPMC
  36. Satoh,K.<br>Caspase-8 Promotes the Development of Pulmonary Hypertension<br>Arterioscler Thromb Vasc Biol (2022) 42, 689-690. PubMed  Europe PubMed DOI
  37. Vesela,B., Killinger,M., Rihova,K., Benes,P., Svandova,E., Kratochvilova,A., Trcka,F., Kleparnik,K. and Matalova,E.<br>Caspase-8 Deficient Osteoblastic Cells Display Alterations in Non-Apoptotic Pathways<br>Front Cell Dev Biol (2022) 10, 794407-794407. PubMed  Europe PubMed DOI  PMC  EPMC
  38. Weir,A. and Vince,J.E.<br>No longer married to inflammasome signaling: the diverse interacting pathways leading to pyroptotic cell death<br>Biochem J (2022) 479, 1083-1102. PubMed  Europe PubMed DOI  PMC  EPMC  V
    39. 2021
  39. Du,Y., Taylor,C.G., Aukema,H.M. and Zahradka,P.<br>Regulation of docosahexaenoic acid-induced apoptosis of confluent endothelial cells: Contributions of MAPKs and caspases<br>Biochim Biophys Acta Mol Cell Biol Lipids (2021) 1866, 158902-158902. PubMed  Europe PubMed DOI
  40. Fox,J.L., Hughes,M.A., Meng,X., Sarnowska,N.A., Powley,I.R., Jukes-Jones,R., Dinsdale,D., Ragan,T.J., Fairall,L., Schwabe,J.W.R., Morone,N., Cain,K. and MacFarlane,M.<br>Cryo-EM structural analysis of FADD:Caspase-8 complexes defines the catalytic dimer architecture for co-ordinated control of cell fate<br>Nat Commun (2021) 12, 819-819. PubMed  Europe PubMed DOI  PMC  EPMC
  41. Jiang,M., Qi,L., Li,L., Wu,Y., Song,D. and Li,Y.<br>Caspase-8: A key protein of cross-talk signal way in "PANoptosis" in cancer<br>Int J Cancer (2021) PubMed  Europe PubMed DOI
  42. Lee,S.H., Jung,S., Lee,Y.J., Hyun,M. and Chung,K.C.<br>FBXO7 triggers caspase 8-mediated proteolysis of the transcription factor FOXO4 and exacerbates neuronal cytotoxicity<br>J Biol Chem (2021) 297, 101426-101426. PubMed  Europe PubMed DOI  PMC  EPMC
  43. Muendlein,H.I., Connolly,W.M., Magri,Z., Smirnova,I., Ilyukha,V., Gautam,A., Degterev,A. and Poltorak,A.<br>ZBP1 promotes LPS-induced cell death and IL-1beta release via RHIM-mediated interactions with RIPK1<br>Nat Commun (2021) 12, 86-86. PubMed  Europe PubMed DOI  PMC  EPMC
  44. Sun,L., Chen,H., Ming,X., Bo,Z., Shin,H.J., Jung,Y.S. and Qian,Y.<br>Porcine Epidemic Diarrhea Virus Infection Induces Caspase-8 mediated G3BP1 Cleavage and Subverts Stress Granules to Promote Viral Replication<br>J Virol (2021) PubMed  Europe PubMed DOI
  45. Xiang,Y.K., Peng,F.H., Guo,Y.Q., Ge,H., Cai,S.Y., Fan,L.X., Peng,Y.X., Wen,H., Wang,Q. and Tao,L.<br>Connexin32 Activates Necroptosis via Src-Mediated Inhibition of Caspase 8 in Hepatocellular Carcinoma<br>Cancer Sci (2021) 112, 3507-3519. PubMed  Europe PubMed DOI
  46. Zhang,L.S., Xu,H.L., Xia,Y., Bi,J.P., Zhang,C.Z., Xi,Z., Li,L.Y. and Zhang,Z.S.<br>Real-time monitoring of caspase-3/8 activity by self-assembling nanofiber probes in living cells<br>Chem Commun (Camb) (2021) 57, 797-800. PubMed  Europe PubMed DOI
  47. Zhu,Y., Zhou,J., Niu,P., Chen,H. and Shi,D.<br>Cardamonin inhibits cell proliferation by caspase-mediated cleavage of Raptor<br>Naunyn Schmiedebergs Arch Pharmacol (2021) 394, 809-817. PubMed  Europe PubMed DOI  I
  48. Zou,J., Xia,H., Zhang,C., Xu,H., Tang,Q., Zhu,G., Li,J. and Bi,F.<br>Casp8 acts through A20 to inhibit PD-L1 expression: The mechanism and its implication in immunotherapy<br>Cancer Sci (2021) 112, 2664-2678. PubMed  Europe PubMed DOI
    49. 2020
  49. Ashida,H., Sasakawa,C. and Suzuki,T.<br>A unique bacterial tactic to circumvent the cell death crosstalk induced by blockade of caspase-8<br>EMBO J (2020) , e104469-e104469. PubMed  Europe PubMed DOI
  50. Cui,X.Y., Park,S.H. and Park,W.H.<br>Auranofin inhibits the proliferation of lung cancer cells via necrosis and caspasedependent apoptosis<br>Oncol Rep (2020) 44, 2715-2724. PubMed  Europe PubMed DOI  I
  51. de Vasconcelos,N.M., Van Opdenbosch,N., Van Gorp,H., Martin-Perez,R., Zecchin,A., Vandenabeele,P. and Lamkanfi,M.<br>An Apoptotic Caspase Network Safeguards Cell Death Induction in Pyroptotic Macrophages<br>Cell Rep (2020) 32, 107959-107959. PubMed  Europe PubMed DOI
  52. Eslami,F., Mahdavi,M., Babaei,E., Hussen,B.M., Mostafavi,H., Shahbazi,A. and Hidayat,H.J.<br>Down-regulation of Survivin and Bcl-2 concomitant with the activation of caspase-3 as a mechanism of apoptotic death in KG1a and K562 cells upon exposure to a derivative from ciprofloxacin family<br>Toxicol Appl Pharmacol (2020) 409, 115331-115331. PubMed  Europe PubMed DOI
  53. Fathi,E. and Vietor,I.<br>Mesenchymal stem cells promote caspase expression in Molt-4 leukemia cells via GSK-3alpha/beta and ERK1/2 signaling pathways as a therapeutic strategy<br>Curr Gene Ther (2020) PubMed  Europe PubMed DOI
  54. Fu,S., Ding,M., Wang,J., Yin,X., Zhou,E., Kong,L., Tu,X., Guo,Z., Wang,A., Huang,Y. and Ye,J.<br>Identification and functional characterization of three caspases in Takifugu obscurus in response to bacterial infection<br>Fish Shellfish Immunol (2020) PubMed  Europe PubMed DOI  I
  55. Gao,H., Wen,N., Xu,X., Hong,G. and Lai,X.<br>[Endoplasmic reticulum stress enhances tumor necrosis factor-alpha expression in rat Kupffer cells to trigger hepatic stellate apoptosis cell through TNFR/caspase-8 pathway]<br>Nan Fang Yi Ke Da Xue Xue Bao (2020) 40, 632-639. PubMed  Europe PubMed DOI  PMC  EPMC
  56. Hong,W., Gu,Y., Guan,R., Xie,D., Zhou,H. and Yu,M.<br>Pan-cancer analysis of the CASP gene family in relation to survival, tumor-infiltrating immune cells and therapeutic targets<br>Genomics (2020) PubMed  Europe PubMed DOI
  57. Israelov,H., Ravid,O., Atrakchi,D., Rand,D., Elhaik,S., Bresler,Y., Twitto-Greenberg,R., Omesi,L., Liraz-Zaltsman,S., Gosselet,F., Schnaider Beeri,M. and Cooper,I.<br>Caspase-1 has a critical role in blood-brain barrier injury and its inhibition contributes to multifaceted repair<br>J Neuroinflammation (2020) 17, 267-267. PubMed  Europe PubMed DOI  PMC  EPMC  I
  58. Ivanisenko,N.V. and Lavrik,I.N.<br>Mathematical Modeling Reveals the Importance of the DED Filament Composition in the Effects of Small Molecules Targeting Caspase-8/c-FLIPL Heterodimer<br>Biochemistry (Mosc) (2020) 85, 1134-1144. PubMed  Europe PubMed DOI
  59. Jin,Q., Lin,C., Zhu,X., Cao,Y., Guo,C. and Wang,L.<br>(125)I seeds irradiation inhibits tumor growth and induces apoptosis by Ki-67, P21, survivin, livin and caspase-9 expression in lung carcinoma xenografts<br>Radiat Oncol (2020) 15, 238-238. PubMed  Europe PubMed DOI  PMC  EPMC
  60. Lee,S.E., Okhlopkova,Z., Lim,C. and Cho,S.<br>Dracocephalum palmatum Stephan extract induces apoptosis in human prostate cancer cells via the caspase-8-mediated extrinsic pathway<br>Chin J Nat Med (2020) 18, 793-800. PubMed  Europe PubMed DOI
  61. Lees,A., McIntyre,A.J., Crawford,N.T., Falcone,F., McCann,C., Holohan,C., Quinn,G.P., Roberts,J.Z., Sessler,T., Gallagher,P.F., Gregg,G.M.A., McAllister,K., McLaughlin,K.M., Allen,W.L., Egan,L.J., Ryan,A.E., Labonte-Wilson,M.J., Dunne,P.D., Wappett,M., Coyle,V.M., Johnston,P.G., Kerr,E.M., Longley,D.B. and McDade,S.S.<br>The pseudo-caspase FLIP(L) regulates cell fate following p53 activation<br>Proc Natl Acad Sci U S A (2020) 117, 17808-17819. PubMed  Europe PubMed DOI  PMC  EPMC
  62. Li,S., Zhang,Y., Guan,Z., Li,H., Ye,M., Chen,X., Shen,J., Zhou,Y., Shi,Z.L., Zhou,P. and Peng,K.<br>SARS-CoV-2 triggers inflammatory responses and cell death through caspase-8 activation<br>Signal Transduct Target Ther (2020) 5, 235-235. PubMed  Europe PubMed DOI  PMC  EPMC
  63. Lorente,L., Martin,M.M., Ortiz-Lopez,R., Gonzalez-Rivero,A.F., Perez-Cejas,A., Martin,M., Gonzalez,V., Perez,A., Rodin,M. and Jimenez,A.<br>Blood caspase-8 concentrations and mortality among septic patients<br>Med Intensiva (2020) PubMed  Europe PubMed DOI
  64. Mandal,R., Barron,J.C., Kostova,I., Becker,S. and Strebhardt,K.<br>Caspase-8: the double-edged sword<br>Biochim Biophys Acta Rev Cancer (2020) 1873, 188357-188357. PubMed  Europe PubMed DOI
  65. Pereira,L.M.N., Assis,P.A., de Araujo,N.M., Durso,D.F., Junqueira,C., Ataide,M.A., Pereira,D.B., Lien,E., Fitzgerald,K.A., Zamboni,D.S., Golenbock,D.T. and Gazzinelli,R.T.<br>Author Correction: Caspase-8 mediates inflammation and disease in rodent malaria<br>Nat Commun (2020) 11, 5673-5673. PubMed  Europe PubMed DOI  PMC  EPMC
  66. Rashidbaghan,A., Mostafaie,A., Yazdani,Y. and Mansouri,K.<br>Urtica dioica agglutinin (a plant lectin) has a caspase-dependent apoptosis induction effect on the acute lymphoblastic leukemia cell line<br>Cell Mol Biol (Noisy-le-grand) (2020) 66, 121-126. PubMed  Europe PubMed
  67. Soni,U.K., Chadchan,S.B., Joshi,A., Kumar,V., Maurya,V.K., Verma,R.K. and Jha,R.K.<br>Poly(ADP-ribose) polymerase-2 is essential for endometrial receptivity and blastocyst implantation, and regulated by caspase-8<br>Mol Cell Endocrinol (2020) , 110946-110946. PubMed  Europe PubMed DOI
  68. Sun,H., Zong,H. and Wu,G.<br>2Hydroxypropylbetacyclodextrin blocks autophagy flux and triggers caspase8mediated apoptotic cascades in HepG2 cells<br>Mol Med Rep (2020) 22, 1901-1909. PubMed  Europe PubMed DOI
  69. Willson,J.<br>A matter of life and death for caspase 8<br>Nat Rev Mol Cell Biol (2020) 21, 63-63. PubMed  Europe PubMed DOI
  70. Wolin,I.A.V., Heinrich,I.A., Nascimento,A.P.M., Welter,P.G., Sosa,L.D.V., De Paul,A.L., Zanotto-Filho,A., Nedel,C.B., Lima,L.D., Osterne,V.J.S., Pinto-Junior,V.R., Nascimento,K.S., Cavada,B.S. and Leal,R.B.<br>ConBr lectin modulates MAPKs and Akt pathways and triggers autophagic glioma cell death by a mechanism dependent upon caspase-8 activation<br>Biochimie (2020) 180, 186-204. PubMed  Europe PubMed DOI
  71. Xie,B., Yao,Q., Xiang,J. and Minh,D.D.L.<br>A Structural Model for Bax2-Mediated Activation of Caspase 8-Dependent Apoptosis<br>Int J Mol Sci (2020) 21 PubMed  Europe PubMed DOI
  72. Yu,H., Sun,Q., Yun,F., Xu,X., Ding,F., Li,S. and Zhao,P.<br>XCHD Inhibits C6 Cell Growth Primarily via the p53/Caspase Pathway<br>Evid Based Complement Alternat Med (2020) 2020, 7973639-7973639. PubMed  Europe PubMed DOI  PMC  EPMC
  73. Zhang,Y., Zhou,G., Chen,Z., Guan,W., Zhang,J., Bi,M., Wang,F., You,X., Liao,Y., Zheng,S., Xu,K. and Yang,H.<br>Si-Wu-Tang Alleviates Nonalcoholic Fatty Liver Disease via Blocking TLR4-JNK and Caspase-8-GSDMD Signaling Pathways<br>Evid Based Complement Alternat Med (2020) 2020, 8786424-8786424. PubMed  Europe PubMed DOI  PMC  EPMC
  74. Zhang,Y., Zhou,G., Chen,Z., Guan,W., Zhang,J., Bi,M., Wang,F., You,X., Liao,Y., Zheng,S., Xu,K. and Yang,H.<br>Si-Wu-Tang Alleviates Nonalcoholic Fatty Liver Disease via Blocking TLR4-JNK and Caspase-8-GSDMD Signaling Pathways<br>Evid Based Complement Alternat Med (2020) 2020, 8786424-8786424. PubMed  Europe PubMed DOI  PMC  EPMC
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