Searches of the MEROPS database

Display Known Cleavages for a Protein

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Accession:

Sequence P51572

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Peptide and protein substrates that are thought to be physiologically relevant are indicated by P. Peptide and protein substrates that are not physiologically relevant are indicated by N. How cleavage sites have been identified are indicated by the following evidence codes: NT = N-terminal sequencing, MS = mass spectroscopy, MU = mutation, CS = consensus sequence, LC = liquid chromatography. To see all annotated cleavages for a peptidase, click on the peptidase name.

Cleavage Site	Peptidase	Residue range	Cleavage type	Description	Evidence	Reference
1	unknown peptidase	1-246	P		NT	<%Agarwal et al., 2012[]%>
164	caspase-1	2-246	P			<%Granville et al., 1998[]%>
164	caspase-3	159-182	N		MS	Schilling & Overall, 2008
164	caspase-7	159-182	N		MS	Schilling & Overall, 2008
164	caspase-8	2-246	P			Breckenridge et al., 2003
168	meprin alpha subunit	2-246	N		MS	Becker-Pauly et al., 2011
172	meprin alpha subunit	2-246	N		MS	Becker-Pauly et al., 2011
172	meprin beta subunit	2-246	N		MS	Becker-Pauly et al., 2011
182	trypsin 1	2-246	N		MS	Schilling & Overall, 2008
192	meprin alpha subunit	2-246	N		MS	Becker-Pauly et al., 2011
192	meprin beta subunit	2-246	N		MS	Becker-Pauly et al., 2011
232	matrix metallopeptidase-2	229-246	N		MS	Schilling & Overall, 2008
238	caspase-8	2-246	P			Maatta et al., 2000