Searches of the MEROPS database

Display Known Cleavages for a Protein

Please enter a UniProt accession (eg P05067):

Accession:

Sequence P62306

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Peptide and protein substrates that are thought to be physiologically relevant are indicated by P. Peptide and protein substrates that are not physiologically relevant are indicated by N. How cleavage sites have been identified are indicated by the following evidence codes: NT = N-terminal sequencing, MS = mass spectroscopy, MU = mutation, CS = consensus sequence, LC = liquid chromatography. To see all annotated cleavages for a peptidase, click on the peptidase name.

Cleavage Site	Peptidase	Residue range	Cleavage type	Description	Evidence	Reference
1	unknown peptidase	1-86	P		NT	<%Agarwal et al., 2012[]%>
13	matrix metallopeptidase-2	1-22	N		MS	Schilling & Overall, 2008
15	cathepsin L	9-22	N		MS	Biniossek et al., 2011
15	cathepsin S	9-22	N		MS	Biniossek et al., 2011
22	trypsin 1	1-86	N		MS	Schilling & Overall, 2008
52	caspase-3	30-65	N		MS	Schilling & Overall, 2008
52	caspase-7	30-65	N		MS	Schilling & Overall, 2008
65	trypsin 1	1-86	N		MS	Schilling & Overall, 2008
81	caspase-1	2-86	P			Malmegrim de Farias et al., 2003
81	caspase-8	2-86	P			Malmegrim de Farias et al., 2003