Searches of the MEROPS database

Display Known Cleavages for a Protein

Please enter a UniProt accession (eg P05067):

Accession:

Sequence P10636

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Peptide and protein substrates that are thought to be physiologically relevant are indicated by P. Peptide and protein substrates that are not physiologically relevant are indicated by N. How cleavage sites have been identified are indicated by the following evidence codes: NT = N-terminal sequencing, MS = mass spectroscopy, MU = mutation, CS = consensus sequence, LC = liquid chromatography. To see all annotated cleavages for a peptidase, click on the peptidase name.

Cleavage Site	Peptidase	Residue range	Cleavage type	Description	Evidence	Reference
1	unknown peptidase	1-758	P		NT	<%Agarwal et al., 2012[]%>
11	calpain-2	2-758	P			Yang et al., 1995
44	calpain-2	2-758	P			Yang et al., 1995
420	caspase-3	2-758	P			Gamblin et al., 2003
420	caspase-7	2-758	P			Gamblin et al., 2003
420	caspase-8	2-758	P			Gamblin et al., 2003
511	granzyme A	1-758	N			Van Damme et al., 2010
511	trypsin 1	2-758	N		MS	Schilling & Overall, 2008
526	trypsin 1	2-758	N		MS	Schilling & Overall, 2008
547	calpain-2	2-758	P			Yang et al., 1995
571	calpain-2	2-758	P	normal turnover		Yang et al., 1995
574	calpain-2	2-758	P	normal turnover		Yang et al., 1995
584	calpain-2	2-758	P	normal turnover		Yang et al., 1995
627	calpain-2	2-758	P	normal turnover		Yang et al., 1995
646	meprin alpha subunit	643-657	N		MS	Becker-Pauly et al., 2011
657	calpain-2	2-758	P	normal turnover		Yang et al., 1995
711	calpain-2	2-758	P	normal turnover		Yang et al., 1995
737	caspase-3	2-758	P			Fasulo et al., 2000
738	caspase-1	2-758	P	normal turnover		Gamblin et al., 2003
738	caspase-7	2-758	P			Gamblin et al., 2003
738	caspase-6	2-758	P			Gamblin et al., 2003
738	caspase-8	2-758	P			Gamblin et al., 2003