Searches of the MEROPS database

Display Known Cleavages for a Protein

Please enter a UniProt accession (eg P05067):

Accession:

Sequence P55211

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Peptide and protein substrates that are thought to be physiologically relevant are indicated by P. Peptide and protein substrates that are not physiologically relevant are indicated by N. How cleavage sites have been identified are indicated by the following evidence codes: NT = N-terminal sequencing, MS = mass spectroscopy, MU = mutation, CS = consensus sequence, LC = liquid chromatography. To see all annotated cleavages for a peptidase, click on the peptidase name.

Cleavage Site	Peptidase	Residue range	Cleavage type	Description	Evidence	Reference
115	calpain-1	1-416	P			Wolf et al., 1999
115	calpain-2	1-416	P			Chua et al., 2000
120	calpain-1	1-416	P			Wolf et al., 1999
143	calpain-1	1-416	P			Wolf et al., 1999
315	caspase-4	1-416	P		MU	Yamamuro et al., 2011
315	caspase-8	1-416	P		CS	McDonnell et al., 2003
315	caspase-9	1-416	P			Chua et al., 2000
330	calpain-2	1-416	P			Chua et al., 2000
330	caspase-3	1-416	P	conversion to two-chain form		Srinivasula et al., 1996
330	caspase-8	1-416	P		CS	McDonnell et al., 2003