Searches of the MEROPS database

Display Known Cleavages for a Protein

Please enter a UniProt accession (eg P05067):

Accession:

Sequence P70444

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Peptide and protein substrates that are thought to be physiologically relevant are indicated by P. Peptide and protein substrates that are not physiologically relevant are indicated by N. How cleavage sites have been identified are indicated by the following evidence codes: NT = N-terminal sequencing, MS = mass spectroscopy, MU = mutation, CS = consensus sequence, LC = liquid chromatography. To see all annotated cleavages for a peptidase, click on the peptidase name.

Cleavage Site	Peptidase	Residue range	Cleavage type	Description	Evidence	Reference
6	cathepsin H	1-195	P	normal turnover		Cirman et al., 2004
12	cathepsin S	1-195	P	normal turnover		Cirman et al., 2004
12	cathepsin K	1-195	P	normal turnover		Cirman et al., 2004
12	cathepsin H	1-195	P	normal turnover		Cirman et al., 2004
47	cathepsin S	1-195	P	normal turnover		Cirman et al., 2004
47	cathepsin H	1-195	P	normal turnover		Cirman et al., 2004
57	cathepsin S	1-195	P	normal turnover		Cirman et al., 2004
59	caspase-8	1-195	P			Stoka et al., 2001
59	caspase-14	1-75	N			Mikolajczyk et al., 2004
60	unknown peptidase	1-195	P		NT	<%Agarwal et al., 2012[]%>
65	cathepsin L	1-195	P	normal turnover		Cirman et al., 2004
65	cathepsin S	1-195	P	normal turnover		Cirman et al., 2004
65	cathepsin K	1-195	P	normal turnover		Cirman et al., 2004
65	cathepsin B	1-195	P	normal turnover		Cirman et al., 2004
66	cathepsin B	1-195	P	normal turnover		Cirman et al., 2004
67	cathepsin B	1-195	P	normal turnover		Cirman et al., 2004
71	cathepsin H	1-195	P	normal turnover		Cirman et al., 2004
75	granzyme B (Homo sapiens-type)	1-195	N			Casciola-Rosen et al., 2007
98	unknown peptidase	1-195	P		NT	<%Agarwal et al., 2012[]%>