Searches of the MEROPS database

Display Known Cleavages for a Protein

Please enter a UniProt accession (eg P05067):

Accession:

Sequence Q99L47

,

Click here to display alignment and conservation of cleavage sites of this sequence with close homologues. This will take a few moments.

Peptide and protein substrates that are thought to be physiologically relevant are indicated by P. Peptide and protein substrates that are not physiologically relevant are indicated by N. How cleavage sites have been identified are indicated by the following evidence codes: NT = N-terminal sequencing, MS = mass spectroscopy, MU = mutation, CS = consensus sequence, LC = liquid chromatography. To see all annotated cleavages for a peptidase, click on the peptidase name.

Cleavage Site	Peptidase	Residue range	Cleavage type	Description	Evidence	Reference
83	caspase-8	1-371	P			Caruso & Reiners, 2006
91	granzyme B, rodent-type	1-371	P			Caruso & Reiners, 2006
157	cathepsin D	1-371	P		MS	Impens et al., 2010
157	cathepsin E	1-371	P		MS	Impens et al., 2010
204	cathepsin E	1-371	P		MS	Impens et al., 2010
206	cathepsin E	1-371	P		MS	Impens et al., 2010
210	cathepsin E	1-371	P		MS	Impens et al., 2010
211	cathepsin D	1-371	P		MS	Impens et al., 2010