Searches of the MEROPS database

Display Known Cleavages for a Protein

Please enter a UniProt accession (eg P05067):

Accession:

Sequence P05198

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Peptide and protein substrates that are thought to be physiologically relevant are indicated by P. Peptide and protein substrates that are not physiologically relevant are indicated by N. How cleavage sites have been identified are indicated by the following evidence codes: NT = N-terminal sequencing, MS = mass spectroscopy, MU = mutation, CS = consensus sequence, LC = liquid chromatography. To see all annotated cleavages for a peptidase, click on the peptidase name.

Cleavage Site	Peptidase	Residue range	Cleavage type	Description	Evidence	Reference
1	unknown peptidase	1-315	P		NT	<%Agarwal et al., 2012[]%>
133	trypsin 1	2-315	N		MS	Schilling & Overall, 2008
141	trypsin 1	2-315	N		MS	Schilling & Overall, 2008
244	trypsin 1	2-315	N		MS	Schilling & Overall, 2008
255	meprin alpha subunit	2-315	N		MS	Becker-Pauly et al., 2011
255	meprin beta subunit	2-315	N		MS	Becker-Pauly et al., 2011
259	trypsin 1	2-315	N		MS	Schilling & Overall, 2008
273	meprin alpha subunit	2-315	N		MS	Becker-Pauly et al., 2011
276	trypsin 1	2-315	N		MS	Schilling & Overall, 2008
288	trypsin 1	2-315	N		MS	Schilling & Overall, 2008
301	caspase-3	2-315	P			Satoh et al., 1999
301	caspase-6	2-315	P			<%Marissen et al., 2000[]%>
301	caspase-8	2-315	P			<%Marissen et al., 2000[]%>
301	caspase-10	2-315	P			Satoh et al., 1999
304	caspase-3	2-315	P			Satoh et al., 1999