Searches of the MEROPS database

Display Known Cleavages for a Protein

Please enter a UniProt accession (eg P05067):

Accession:

Sequence O60763

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Peptide and protein substrates that are thought to be physiologically relevant are indicated by P. Peptide and protein substrates that are not physiologically relevant are indicated by N. How cleavage sites have been identified are indicated by the following evidence codes: NT = N-terminal sequencing, MS = mass spectroscopy, MU = mutation, CS = consensus sequence, LC = liquid chromatography. To see all annotated cleavages for a peptidase, click on the peptidase name.

Cleavage Site	Peptidase	Residue range	Cleavage type	Description	Evidence	Reference
8	cathepsin L	6-25	N		MS	Biniossek et al., 2011
13	LAST_MAM peptidase (Limulus-type)	10-25	N		MS	Becker-Pauly et al., 2011
29	trypsin 1	1-962	N		MS	Schilling & Overall, 2008
40	trypsin 1	1-962	N		MS	Schilling & Overall, 2008
170	trypsin 1	1-962	N		MS	Schilling & Overall, 2008
179	trypsin 1	1-962	N		MS	Schilling & Overall, 2008
618	trypsin 1	1-962	N		MS	Schilling & Overall, 2008
626	trypsin 1	1-962	N		MS	Schilling & Overall, 2008
643	trypsin 1	1-962	N		MS	Schilling & Overall, 2008
656	trypsin 1	1-962	N		MS	Schilling & Overall, 2008
757	caspase-3	1-962	P	normal turnover		Chiu et al., 2002
757	caspase-8	1-962	P			Chiu et al., 2002
764	trypsin 1	1-962	N		MS	Schilling & Overall, 2008
782	trypsin 1	1-962	N		MS	Schilling & Overall, 2008
791	trypsin 1	1-962	N		MS	Schilling & Overall, 2008
798	trypsin 1	1-962	N		MS	Schilling & Overall, 2008
810	trypsin 1	1-962	N		MS	Schilling & Overall, 2008
849	trypsin 1	1-962	N		MS	Schilling & Overall, 2008
858	trypsin 1	1-962	N		MS	Schilling & Overall, 2008