Searches of the MEROPS database

Display Known Cleavages for a Protein

Please enter a UniProt accession (eg P05067):

Accession:

Sequence P55957

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Peptide and protein substrates that are thought to be physiologically relevant are indicated by P. Peptide and protein substrates that are not physiologically relevant are indicated by N. How cleavage sites have been identified are indicated by the following evidence codes: NT = N-terminal sequencing, MS = mass spectroscopy, MU = mutation, CS = consensus sequence, LC = liquid chromatography. To see all annotated cleavages for a peptidase, click on the peptidase name.

Cleavage Site	Peptidase	Residue range	Cleavage type	Description	Evidence	Reference
54	calpain-1	1-195	P			Gil-Parrado et al., 2002
60	caspase-3	1-195	P	normal turnover		Deqli Esposti et al., 2003
60	caspase-8	1-195	P			Deqli Esposti et al., 2003
61	unknown peptidase	1-195	P		NT	<%Agarwal et al., 2012[]%>
70	calpain-1	1-195	P			Mandic et al., 2002
71	trypsin 1	1-195	N		MS	Schilling & Overall, 2008
75	caspase-3	1-195	P			Deqli Esposti et al., 2003
75	caspase-8	1-195	P			Deqli Esposti et al., 2003
75	granzyme B (Homo sapiens-type)	1-195	P			Casciola-Rosen et al., 2007
76	unknown peptidase	1-195	P		NT	<%Agarwal et al., 2012[]%>
84	trypsin 1	1-195	N		MS	Schilling & Overall, 2008
99	unknown peptidase	1-195	P		NT	<%Agarwal et al., 2012[]%>
125	trypsin 1	1-195	N		MS	Schilling & Overall, 2008
140	trypsin 1	1-195	N		MS	Schilling & Overall, 2008