Searches of the MEROPS database

Display Known Cleavages for a Protein

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Accession:

Sequence P10451

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Peptide and protein substrates that are thought to be physiologically relevant are indicated by P. Peptide and protein substrates that are not physiologically relevant are indicated by N. How cleavage sites have been identified are indicated by the following evidence codes: NT = N-terminal sequencing, MS = mass spectroscopy, MU = mutation, CS = consensus sequence, LC = liquid chromatography. To see all annotated cleavages for a peptidase, click on the peptidase name.

Cleavage Site	Peptidase	Residue range	Cleavage type	Description	Evidence	Reference
16	unknown peptidase	1-314	P	release of a signal peptide		Agnihotri et al., 2001
42	cathepsin D	17-314	N		NT	Christensen et al., 2010
54	cathepsin D	17-314	P	normal turnover	NT	Christensen et al., 2010
120	PHEX peptidase	115-132	N		MS	Addison et al., 2009
126	PHEX peptidase	115-132	N		MS	Addison et al., 2009
135	caspase-8	17-314	P		MU	Kim et al., 2009
157	caspase-3	17-314	P	normal turnover	MU	Kim et al., 2009
157	caspase-8	17-314	P		MU	Kim et al., 2009
166	matrix metallopeptidase-3	17-314	P	normal turnover		<%Agnihotri et al., 2001[]%>
166	matrix metallopeptidase-7	17-314	P	normal turnover		Agnihotri et al., 2001
167	cathepsin D	17-314	P	normal turnover	NT	Christensen et al., 2010
167	carboxypeptidase N	160-168	N		NT	Myles et al., 2003
167	carboxypeptidase B2	160-168	N		NT	Myles et al., 2003
168	thrombin	17-314	P	normal turnover		Agnihotri et al., 2001
168	plasmin	17-314	P	normal turnover	NT	Christensen et al., 2010
169	unknown peptidase	17-314	P		NT	Christensen et al., 2010
170	plasmin	17-314	P	normal turnover	NT	Christensen et al., 2010
171	unknown peptidase	17-314	P		NT	Christensen et al., 2010
172	unknown peptidase	17-314	P		NT	Christensen et al., 2010
174	unknown peptidase	17-314	P		NT	Christensen et al., 2010
178	plasmin	17-314	P	normal turnover	NT	Christensen et al., 2010
201	matrix metallopeptidase-3	17-314	P	normal turnover		Nagase, 2004
203	plasmin	17-314	P	normal turnover	NT	Christensen et al., 2010
210	matrix metallopeptidase-3	17-314	P	normal turnover		<%Agnihotri et al., 2001[]%>
210	matrix metallopeptidase-7	17-314	P	normal turnover		Agnihotri et al., 2001