Searches of the MEROPS database
Display Known Cleavages for a Protein
Please enter a UniProt accession (eg P05067):
Sequence P43243
,
Click here to display alignment and conservation of cleavage sites of this sequence with close homologues. This will take a few moments.
Peptide and protein substrates that are thought to be physiologically relevant are indicated by P.
Peptide and protein substrates that are not physiologically relevant are indicated by N.
How cleavage sites have been identified are indicated by the following evidence codes:
NT = N-terminal sequencing,
MS = mass spectroscopy,
MU = mutation,
CS = consensus sequence,
LC = liquid chromatography.
To see all annotated cleavages for a peptidase, click on the peptidase name.
| Cleavage Site |
Peptidase |
Residue range |
Cleavage type |
Description |
Evidence |
Reference |
|---|
| 1 |
unknown peptidase |
1-847 |
P |
|
NT |
<%Agarwal et al., 2012[]%> |
| 3 |
granzyme A |
1-847 |
N |
|
|
Van Damme et al., 2010 |
| 74 |
cathepsin S |
52-84 |
N |
|
MS |
Biniossek et al., 2011 |
| 136 |
glutamyl endopeptidase I |
132-146 |
N |
|
MS |
Schilling & Overall, 2008 |
| 146 |
trypsin 1 |
1-847 |
N |
|
MS |
Schilling & Overall, 2008 |
| 147 |
trypsin 1 |
1-847 |
N |
|
|
Van Damme et al., 2009 |
| 149 |
trypsin 1 |
1-847 |
N |
|
MS |
Schilling & Overall, 2008 |
| 160 |
trypsin 1 |
1-847 |
N |
|
MS |
Schilling & Overall, 2008 |
| 187 |
caspase-1 |
2-847 |
N |
|
MS |
Agard et al., 2010 |
| 275 |
astacin |
272-287 |
N |
|
MS |
Becker-Pauly et al., 2011 |
| 275 |
LAST_MAM peptidase (Limulus-type) |
272-287 |
N |
|
MS |
Becker-Pauly et al., 2011 |
| 277 |
matrix metallopeptidase-2 |
270-287 |
N |
|
MS |
Schilling & Overall, 2008 |
| 279 |
cathepsin K |
270-287 |
N |
|
MS |
Schilling & Overall, 2008 |
| 287 |
trypsin 1 |
1-847 |
N |
|
MS |
Schilling & Overall, 2008 |
| 293 |
cathepsin L |
288-304 |
N |
|
MS |
Biniossek et al., 2011 |
| 293 |
cathepsin S |
288-304 |
N |
|
MS |
Biniossek et al., 2011 |
| 356 |
cathepsin L |
319-366 |
N |
|
MS |
Biniossek et al., 2011 |
| 363 |
cathepsin B |
319-373 |
N |
|
MS |
Biniossek et al., 2011 |
| 363 |
matrix metallopeptidase-2 |
318-373 |
N |
|
MS |
Schilling & Overall, 2008 |
| 364 |
cathepsin B |
319-373 |
N |
|
MS |
Biniossek et al., 2011 |
| 373 |
granzyme A |
1-847 |
N |
|
|
Van Damme et al., 2010 |
| 373 |
trypsin 1 |
1-847 |
N |
|
MS |
Schilling & Overall, 2008 |
| 460 |
cathepsin B |
434-467 |
N |
|
MS |
Biniossek et al., 2011 |
| 501 |
elastase-2 |
496-515 |
N |
|
MS |
Schilling & Overall, 2008 |
| 515 |
trypsin 1 |
1-847 |
N |
|
MS |
Schilling & Overall, 2008 |
| 547 |
cathepsin S |
543-554 |
N |
|
MS |
Biniossek et al., 2011 |
| 680 |
caspase-3 |
636-739 |
N |
|
CS |
Valencia et al., 2007 |
| 680 |
caspase-7 |
640-693 |
N |
|
MS |
Schilling & Overall, 2008 |
| 680 |
caspase-8 |
633-704 |
N |
|
CS |
Valencia et al., 2007 |
| 693 |
trypsin 1 |
1-847 |
N |
|
MS |
Schilling & Overall, 2008 |
| 711 |
lysyl endopeptidase (bacteria) |
1-847 |
N |
|
MS |
|
| 763 |
unknown peptidase |
|
P |
|
MS |
Mahrus et al., 2008 |
| 787 |
meprin beta subunit |
784-798 |
N |
|
MS |
Becker-Pauly et al., 2011 |
