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Substrates for peptidase S08.072: PCSK1 peptidase

Summary Gene structure Alignment Tree Sequences Sequence features Distribution Structure Literature Substrates Pharma

Peptide and protein substrates that are thought to be physiologically relevant are indicated by P. Peptide and protein substrates that are thought to be pathologically relevant are indicated by D. Peptide and protein substrates that are not physiologically relevant are indicated by N. Synthetic substrates are indicated by S. Click on the symbol to show only physiological, non-physiological or synthetic substrates, or here to display all substrates. How cleavage sites have been identified are indicated by the following evidence codes: NT = N-terminal sequencing, MS = mass spectroscopy, MU = mutation, CS = consensus sequence, LC = liquid chromatography. To see all annotated cleavages for a protein substrate, click on the UniProt Accession.

Substrate Uniprot Residue range Cleavage Site Cleavage type Evidence P4 P3 P2 P1 P1' P2' P3' P4' Reference CutDB MERNUM
Agouti-related protein O00253 21-132 peptide-Arg82+Ser-peptide P Arg Glu Pro Arg Ser Ser Arg Arg Creemers et al., 2006
Agouti-related protein O00253 21-132 peptide-Arg85+Arg-peptide P Arg Ser Ser Arg Arg Cys Val Arg Creemers et al., 2006
Appetite-regulating hormone Q9EQX0 24-75 peptide-Arg51+Ala-peptide P CS Leu Gln Pro Arg Ala Leu Glu Gly Zhu et al., 2006
cholecystokinin P01355 21-115 peptide-Arg45+Ala-peptide P Arg Gln Leu Arg Ala Val Leu Arg Wang et al., 1998 18705
cholecystokinin P01355 21-115 peptide-Arg106+Ser-peptide P Phe Gly Arg Arg Ser Ala Glu Asp Wang et al., 1998
cholecystokinin P01355 21-115 peptide-Arg95+Asp-peptide P Ile Ser Asp Arg Asp Tyr Met Gly Wang et al., 1998
Cholecystokinin precursor P09240 21-115 peptide-Arg70+Lys-peptide P NT Gln Gln Val Arg Lys Ala Pro Ser Rehfeld, 2006
Cholecystokinin precursor P09240 21-115 peptide-Arg64+Tyr-peptide P NT Leu Leu Ala Arg Tyr Ile Gln Gln Rehfeld, 2006
Cocaine- and amphetamine-regulated transcript protein precursor P49192-1 28-129 peptide-Arg81+Ile-peptide P Lys Ser Lys Arg Ile Pro Ile Tyr Stein et al., 2006
Cocaine- and amphetamine-regulated transcript protein precursor P49192-1 28-129 peptide-Arg59+Ala-peptide P Arg Gln Leu Arg Ala Pro Gly Ala Stein et al., 2006
Cocaine- and amphetamine-regulated transcript protein precursor P49192-2 28-129 peptide-Arg36+Ala-peptide P Leu Gln Pro Arg Ala Leu Asp Ile Stein et al., 2006
consensus arginyl bond peptide-Lys-Arg+peptide N - NPe Lys Arg CPe - - - Seidah & Chretien, 2004
consensus arginyl bond peptide-Arg-Arg+peptide N - NPe Arg Arg CPe - - - Seidah & Chretien, 2004
consensus arginyl bond peptide-Arg-Xaa-Xaa-Arg+peptide N Arg Xaa Xaa Arg CPe - - - Seidah & Chretien, 2004
consensus arginyl bond peptide-Lys-Xaa-Xaa-Arg+peptide N Lys Xaa Xaa Arg CPe - - - Seidah & Chretien, 2004
gastrin P48757 22-101 peptide-Arg58+Gln-peptide P His His Arg Arg Gln Leu Gly Pro Rehfeld et al., 2008 21163
gastrin P48757 22-101 peptide-Arg95+Ser-peptide P Phe Gly Arg Arg Ser Ala Glu Glu Rehfeld et al., 2008 21164
gastrin precursor P01350 59-101 peptide-Lys75+Gln-peptide P NT Pro Ser Lys Lys Gln Gly Pro Trp Sawada et al., 2000
gastrin precursor P01350 22-101 peptide-Arg95+Ser-peptide P NT Phe Gly Arg Arg Ser Ala Glu Asp Sawada et al., 2000
gastrin precursor P01350 22-101 peptide-Arg58+Gln-peptide P NT His His Arg Arg Gln Leu Gly Pro Sawada et al., 2000
Glp-Arg-Thr-Lys-Arg-NHMec Glp-Arg-Thr-Lys-Arg+NHMec S Arg Thr Lys Arg AMC - - - Seidah & Chretien, 2004
glucagon P29794 21-180 peptide-Arg83+Asn-peptide N Asn Thr Lys Arg Asn Lys Asn Asn 17580
glucagon P01275 21-180 peptide-Arg83+Asn-peptide P NT Asn Thr Lys Arg Asn Arg Asn Asn Bonic & Mackin, 2003
glucagon P01275 21-180 peptide-Arg91+His-peptide P NT Ile Ala Lys Arg His Asp Glu Phe Bonic & Mackin, 2003
glucagon P01275 21-180 peptide-Arg97+His-peptide P NT Glu Phe Glu Arg His Ala Glu Gly Bonic & Mackin, 2003
glucagon P01275 21-180 peptide-Arg130+Asp-peptide P NT Arg Gly Arg Arg Asp Phe Pro Glu Bonic & Mackin, 2003
glucagon P01275 21-180 peptide-Arg145+His-peptide P NT Leu Gly Arg Arg His Ala Asp Gly Bonic & Mackin, 2003
glucagon precursor P29794 21-180 peptide-Arg91+His-peptide N Ile Ala Lys Arg His Asp Glu Phe
glucagon precursor P29794 21-180 peptide-Arg97+His-peptide N Glu Phe Glu Arg His Ala Glu Gly
glucagon precursor P29794 21-180 peptide-Arg130+Asp-peptide N Arg Gly Arg Arg Asp Phe Pro Glu
glucagon precursor P29794 21-180 peptide-Arg145+His-peptide N Phe Arg Arg Arg His Ala Asp Gly 17577
glucagon precursor P01275 21-178 peptide-Arg91+His-peptide N Ile Ala Lys Arg His Asp Glu Phe
glucagon precursor P01275 21-178 peptide-Arg97+His-peptide N Glu Phe Glu Arg His Ala Glu Gly
glucagon precursor P01275 21-178 peptide-Arg130+Asp-peptide N Arg Gly Arg Arg Asp Phe Pro Glu
glucagon precursor P01275 21-178 peptide-Arg145+His-peptide N Leu Gly Arg Arg His Ala Asp Gly
glucagon precursor P55095 21-180 peptide-Arg91+His-peptide P Ile Ala Lys Arg His Asp Glu Phe Rouillé et al., 1995 18643
glucagon precursor P55095 21-180 peptide-Arg97+His-peptide P Glu Phe Glu Arg His Ala Glu Gly Rouillé et al., 1995 18644
glucagon precursor P55095 21-180 peptide-Arg130+Asp-peptide P Arg Gly Arg Arg Asp Phe Pro Glu Rouillé et al., 1995 18645
glucagon precursor P55095 21-180 peptide-Arg145+His-peptide P Leu Gly Arg Arg His Ala Asp Gly Rouillé et al., 1995 18646
glucagon precursor P55095 21-180 peptide-Arg83+Asn-peptide P Asn Thr Lys Arg Asn Arg Asn Asn
glucagon precursor P01275 21-178 peptide-Arg83+Asn-peptide N Asn Thr Lys Arg Asn Arg Asn Asn 17581
IAPP Q0ZD87 23-89 peptide-Arg73+Asn-peptide P Tyr Gly Lys Arg Asn Ala Val Glu Wang et al., 2001 3398
insulin I P01325 25-108 peptide-Arg56+Glu-peptide P Lys Ser Arg Arg Glu Val Glu Asp Furuta et al., 1998 18649
insulin II P01326 25-110 peptide-Arg56+Glu-peptide P Met Ser Arg Arg Glu Val Glu Asp Furuta et al., 1998 18652
insulin precursor P01308 25-110 peptide-Arg89+Gly-peptide P Leu Gln Lys Arg Gly Ile Val Glu Seidah & Chretien, 1994 17599
insulin precursor P01308 25-110 peptide-Arg56+Glu-peptide P Lys Thr Arg Arg Glu Ala Glu Asp Seidah & Chretien, 1994 18655
insulin-1 P01322 25-110 peptide-Arg56+Glu-peptide P Lys Ser Arg Arg Glu Val Glu Asp Irminger et al., 1997
insulin-1 P01322 25-110 peptide-Arg89+Gly-peptide P Arg Gln Lys Arg Gly Ile Val Asp Irminger et al., 1997
insulin-2 P01323 25-110 peptide-Arg89+Gly-peptide P Arg Gln Lys Arg Gly Ile Val Asp Irminger et al., 1997 18654
insulin-2 P01323 25-110 peptide-Arg56+Glu-peptide P Met Ser Arg Arg Glu Val Glu Asp Irminger et al., 1997
neuroendocrine protein 7B2 P12961 27-212 peptide-Arg181+Ser-peptide P CS Arg Lys Arg Arg Ser Val Asn Pro De Bie et al., 1995
neuropeptide Y P07808 30-98 peptide-Arg68+Ser-peptide P Tyr Gly Lys Arg Ser Ser Pro Glu Brakch et al., 1998 18709
neurotensin/neuromedin N P20068 23-169 peptide-Arg141+Lys-peptide P Val Ile Lys Arg Lys Ile Pro Tyr Rovère et al., 1996 18673
neurotensin/neuromedin N P20068 23-169 peptide-Arg149+Gln-peptide P Ile Leu Lys Arg Gln Leu Tyr Glu Rovère et al., 1996 18676
neurotensin/neuromedin N P20068 23-169 peptide-Arg164+Ala-peptide P Ile Leu Lys Arg Ala Ser Tyr Tyr Rovère et al., 1996 18678
oxytocin-neurophysin 1 P01179 1-125 peptide-Arg31+Ala-peptide P Gly Gly Lys Arg Ala Ala Leu Asp Coates & Birch, 1998 18712
pro-melanin-concentrating hormone P14200 22-165 peptide-Arg146+Asp-peptide P Ile Gly Arg Arg Asp Phe Asp Met Viale et al., 1999 18661
pro-opiomelanocortin P01190 1-265 peptide-Lys262+Lys-Lys-Gly P NT Asn Ala His Lys Lys Gly Gln - Zhou et al., 1992
prodynorphin P06300 22-248 peptide-Arg201+Tyr-peptide P Leu Tyr Lys Arg Tyr Gly Gly Phe Seidah & Chretien, 1994 17590
prodynorphin P06300 22-248 peptide-Arg234+Ser-peptide P Val Val Thr Arg Ser Gln Glu Asn Seidah & Chretien, 1994 17591
prodynorphin P06300 22-255 peptide-Arg234+Ser-peptide P Val Val Thr Arg Ser Gln Glu Asn Dupuy et al., 1994 18704
prodynorphin P06300 22-248 peptide-Arg165+Tyr-peptide P Gln Ala Lys Arg Tyr Gly Gly Phe Dupuy et al., 1994 17589
prodynorphin P06300 22-248 peptide-Arg176+Ser-peptide P Tyr Pro Lys Arg Ser Ser Glu Met Dupuy et al., 1994
proenkephalin A P04094 25-269 peptide-Lys99+Tyr-peptide P Leu Ala Lys Lys Tyr Gly Gly Phe Johanning et al., 1997 18679
proenkephalin A P04094 25-269 peptide-Arg238+Phe-peptide P Phe Leu Lys Arg Phe Ala Glu Ser Johanning et al., 1997 18693
proenkephalin-A P01210 25-267 peptide-Arg260+Tyr-peptide P Met Glu Lys Arg Tyr Gly Gly Phe Seidah & Chretien, 1994 18695
proenkephalin-A P01210 25-267 peptide-Arg185+Tyr-peptide P Val Ser Lys Arg Tyr Gly Gly Phe Seidah & Chretien, 1994 17592
proenkephalin-A P01210 25-267 peptide-Arg236+Phe-peptide P Phe Leu Lys Arg Phe Ala Glu Ala Seidah & Chretien, 1994 17595
proenkephalin-A P01210 25-267 peptide-Arg229+Tyr-peptide P Tyr Gln Lys Arg Tyr Gly Gly Phe Seidah & Chretien, 1994 18692
proenkephalin-A P01210 25-267 peptide-Arg195+Ser-peptide P Gly Leu Lys Arg Ser Pro Gln Leu Seidah & Chretien, 1994 18688
proenkephalin-A P01210 25-267 peptide-Lys142+Asp-peptide P Phe Met Lys Lys Asp Ala Glu Glu Seidah & Chretien, 1994 17597
proopiomelanocortin P01193 27-235 peptide-Arg123+Ser-peptide P Glu Gly Lys Arg Ser Tyr Ser Met Benjannet et al., 1991 17602
proopiomelanocortin P01193 27-235 peptide-Arg204+Tyr-peptide P Lys Asp Lys Arg Tyr Gly Gly Phe Benjannet et al., 1991 17601
proopiomelanocortin P01193 27-235 peptide-Arg164+Glu-peptide P Glu Phe Lys Arg Glu Leu Glu Gly Benjannet et al., 1991 17600
proopiomelanocortin P01193 27-235 peptide-Lys233+Gly-peptide P Ala His Lys Lys Gly Gln - - Benjannet et al., 1991 18671
proprotein convertase 1 P63239 28-753 peptide-Arg110+Ser-peptide P NT Arg Ser Lys Arg Ser Val Gln Lys Boudreault et al., 1999 18722
prosomatostatin P60042 25-116 peptide-Lys102+Ala-peptide P Arg Glu Arg Lys Ala Gly Cys Lys Seidah & Chretien, 1994 18713
prothyroliberin P20396 25-242 peptide-Arg83+Gln-peptide P Leu Ser Lys Arg Gln His Pro Gly Seidah & Chretien, 2004 17609
prothyroliberin P20396 25-242 peptide-Arg89+Gln-peptide P Pro His Lys Arg Gln His Pro Gly Seidah & Chretien, 2004 17604
prothyroliberin P20396 25-242 peptide-Arg134+Gln-peptide P Gln His Lys Arg Gln His Pro Gly Seidah & Chretien, 2004 17605
prothyroliberin P20396 25-242 peptide-Arg151+Gln-peptide P Val Pro Lys Arg Gln His Pro Gly Seidah & Chretien, 2004 17606
prothyroliberin P20396 25-242 peptide-Arg185+Gln-peptide P Pro Glu Lys Arg Gln His Pro Gly Seidah & Chretien, 2004 17607
prothyroliberin P20396 25-242 peptide-Arg226+Gln-peptide P Glu Glu Lys Arg Gln His Pro Gly Seidah & Chretien, 2004 17608
prothyroliberin P01150 25-255 peptide-Arg52+Phe-peptide P Pro Glu Arg Arg Phe Leu Trp Lys Friedman et al., 1995 18657
prothyroliberin P01150 25-255 peptide-Arg153+Gln-peptide P Gln Val Lys Arg Gln His Pro Gly Nillni et al., 1995
prothyroliberin P01150 25-255 peptide-Arg159+Ser-peptide P Pro Gly Arg Arg Ser Phe Pro Trp Nillni et al., 1995
prothyroliberin P01150 25-255 peptide-Arg114+Ala-peptide P Pro Gly Arg Arg Ala Asn Gln Asp Nillni et al., 1995
prothyroliberin P01150 25-255 peptide-Arg207+Ala-peptide P Pro Gly Lys Arg Ala Leu Gly His Nillni et al., 1995
prothyroliberin P01150 25-255 peptide-Arg82+Glu-peptide P Pro Gly Lys Arg Glu Glu Glu Glu Nillni et al., 1995
prothyroliberin P01150 25-255 peptide-Arg76+Gln-peptide P Ile Thr Lys Arg Gln His Pro Gly Nillni et al., 1995
renin precursor P00797 24-406 peptide-Arg66+Leu-peptide P Pro Met Lys Arg Leu Thr Leu Gly Seidah & Chretien, 1994 18715
renin-2 precursor P00796 26-401 peptide-Arg63+Leu-peptide P Phe Thr Lys Arg Ser Ser Leu Thr Seidah & Chretien, 1994 17611
secretogranin-1 P16014 21-677 peptide-Arg574+Pro-peptide P Trp Glu Arg Arg Pro Phe Ser Glu Laslop et al., 1998 18716
secretogranin-1 P16014 21-677 peptide-Arg587+Ser-peptide P Tyr Glu Lys Arg Ser Phe Ala Arg Laslop et al., 1998 18719
serum albumin precursor P02768 19-609 peptide-Arg24+Asp-peptide P Val Phe Arg Arg Asp Ala His Lys Rufaut et al., 1993 18720
serum albumin precursor P19121 24-615 peptide-Arg26+Asp-peptide P Arg Phe Ala Arg Asp Ala Glu His Rufaut et al., 1993 18721
vasopressin-neurophysin 2-copeptin P01186 24-168 peptide-Arg125+Ala-peptide P Arg Leu Thr Arg Ala Arg Glu Gln Coates et al., 1998 18711

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