Merops Switch to
Inhibitors

Peptidase

Family Clan SEARCHES BLAST
MEROPS SUBMISSIONS

Other
information

Literature for peptidase S08.072: PCSK1 peptidase

Summary Gene structure Alignment Tree Sequences Sequence features Distribution Structure Literature Substrates Inhibitors Pharma

(Topics flags: S Structure, A Assay, M Mutation, P Specificity, K Knockout, I Inhibitor, E Expression, V Review. To select only the references relevant to a single topic, click the link above. See explanation.)

    2024
  1. Gong,K., Xue,C., Feng,Z., Pan,R., Wang,M., Chen,S., Chen,Y., Guan,Y., Dai,L., Zhang,S., Jiang,L., Li,L., Wang,B., Yin,Z., Ma,L., Iwakiri,Y., Tang,J., Liao,C., Chen,H. and Duan,Y.
    Intestinal Nogo-B reduces GLP1 levels by binding to proglucagon on the endoplasmic reticulum to inhibit PCSK1 cleavage
    Nat Commun (2024) 15, 6845-6845. PubMed  Europe PubMed DOI  PMC  EPMC
  2. Moeller,J. and Meier,D.T.
    Ablation of PC1/3 in POMC-Expressing Tissues but Not in Immune Cells Induces Sepsis Hypersensitivity
    J Endocr Soc (2024) 8, bvae171-bvae171. PubMed  Europe PubMed DOI  PMC  EPMC
    3. 2023
  3. Guijo,B., Argente,J. and Martos-Moreno,G.A.
    The N221D variant in PCSK1 is highly prevalent in childhood obesity and can influence the metabolic profile
    J Pediatr Endocrinol Metab (2023) 36, 1140-1145. PubMed  Europe PubMed DOI
    4. 2022
  4. Basak,S. and Basak,A.
    Proteins and proteases of Prader-Willi syndrome: a comprehensive review and perspectives
    Biosci Rep (2022) 42 PubMed  Europe PubMed DOI  PMC  EPMC
  5. Meier,D.T., Rachid,L., Wiedemann,S.J., Traub,S., Trimigliozzi,K., Stawiski,M., Sauteur,L., Winter,D.V., Le Foll,C., Bregere,C., Guzman,R., Odermatt,A., Boni-Schnetzler,M. and Donath,M.Y.
    Prohormone convertase 1/3 deficiency causes obesity due to impaired proinsulin processing
    Nat Commun (2022) 13, 4761-4761. PubMed  Europe PubMed DOI  PMC  EPMC
  6. Ni,Y., Chen,X., Sun,Y., Pan,J., Tang,C. and Yuan,T.
    Modulation of PC1/3 activity by a rare double-site homozygous mutation
    Front Pediatr (2022) 10, 1026707-1026707. PubMed  Europe PubMed DOI  PMC  EPMC
  7. Yoon,M.C., Ames,J., Mosier,C., Jiang,Z., Podvin,S., O'Donoghue,A.J. and Hook,V.
    Distinct Dibasic Cleavage Specificities of Neuropeptide-Producing Cathepsin L and Cathepsin V Cysteine Proteases Compared to PC1/3 and PC2 Serine Proteases
    ACS Chem Neurosci (2022) 13, 245-256. PubMed  Europe PubMed DOI
    8. 2021
  8. de Souza,A.A., de Andrade,D.M., Siqueira,F.D.S., Di Iorio,J.F., Veloso,M.P., Coelho,C.M., Viegas Junior,C., Gontijo,V.S., Dos Santos,M.H., Meneghetti,M.C.Z., Nader,H.B., Tersariol,I.L.D.S., Juliano,L., Juliano,M.A. and Judice,W.A.S.
    Semysinthetic biflavonoid Morelloflavone-7,4',7'',3''',4'''-penta-O-butanoyl is a more potent inhibitor of Proprotein Convertases Subtilisin/Kexin PC1/3 than Kex2 and Furin
    Biochim Biophys Acta Gen Subj (2021) 1865, 130016-130016. PubMed  Europe PubMed DOI  I
  9. Shakya,M. and Lindberg,I.
    Mouse models of human proprotein convertase insufficiency
    Endocr Rev (2021) 42, 259-294. PubMed  Europe PubMed DOI  V
    10. 2020
  10. Jaimes,J., Millet,J. and Whittaker,G.
    Proteolytic Cleavage of the SARS-CoV-2 Spike Protein and the Role of the Novel S1/S2 Site
    SSRN (2020) , 3581359-3581359. PubMed  Europe PubMed DOI  PMC  EPMC
  11. Muhsin,N.I.A., Bentley,L., Bai,Y., Goldsworthy,M. and Cox,R.D.
    A novel mutation in the mouse Pcsk1 gene showing obesity and diabetes
    Mamm Genome (2020) 31, 17-29. PubMed  Europe PubMed DOI  M
  12. Ramzy,A., Asadi,A. and Kieffer,T.J.
    Revisiting proinsulin processing: evidence that human beta-cells process proinsulin with prohormone convertase (PC) 1/3 but not PC2
    Diabetes (2020) PubMed  Europe PubMed DOI
    13. 2018
  13. Distelmaier,F., Herebian,D., Atasever,C., Beck-Woedl,S., Mayatepek,E., Strom,T.M. and Haack,T.B.
    Blue diaper syndrome and PCSK1 mutations
    Pediatrics (2018) 141, S501-S501. PubMed  Europe PubMed DOI  M
  14. Kumar,G., Nair,R. and Sohal,A.P.S.
    Proprotein convertase 1/3 deficiency
    Indian J Pediatr (2018) 85, 320-321. PubMed  Europe PubMed DOI  M
  15. Rodet,F., Capuz,A., Hara,T., van Meel,R., Duhamel,M., Rose,M., Raffo-Romero,A., Fournier,I. and Salzet,M.
    Deciphering molecular consequences of the proprotein convertase 1/3 inhibition in macrophages for application in anti-tumour immunotherapy
    J Biotechnol (2018) 282, 80-85. PubMed  Europe PubMed DOI  K
    16. 2017
  16. Loffler,D., Behrendt,S., Creemers,J.W., Klammt,J., Aust,G., Stanik,J., Kiess,W., Kovacs,P. and Korner,A.
    Functional and clinical relevance of novel and known PCSK1 variants for childhood obesity and glucose metabolism
    Mol Metab (2017) 6, 295-305. PubMed  Europe PubMed DOI  PMC  EPMC  M
    17. 2016
  17. Maluch,I., Walewska,A., Sikorska,E. and Prahl,A.
    [Proprotein convertases - family of serine proteases with a broad spectrum of physiological functions]
    Postepy Biochem (2016) 62, 472-481. PubMed  Europe PubMed  V
  18. Ramos-Molina,B., Martin,M.G. and Lindberg,I.
    PCSK1 variants and human obesity
    Prog Mol Biol Transl Sci (2016) 140, 47-74. PubMed  Europe PubMed DOI  M
    19. 2015
  19. Elferich,J., Williamson,D.M., David,L.L. and Shinde,U.
    Determination of histidine pKa values in the propeptides of furin and proprotein convertase1/3 using histidine hydrogen-deuterium exchange mass spectrometry
    Anal Chem (2015) 87, 7909-7917. PubMed  Europe PubMed DOI
  20. Gu,Q., Yazdanpanah,M., van Hoek,M., Hofman,A., Gao,X., de Rooij,F.W. and Sijbrands,E.J.
    Common variants in PCSK1 influence blood pressure and body mass index
    J Hum Hypertens (2015) 29, 82-86. PubMed  Europe PubMed DOI  M
  21. Williamson,D.M., Elferich,J. and Shinde,U.
    Mechanism of fine-tuning pH sensors in proprotein convertases: identification of a pH-sensing histidine pair in the propeptide of proprotein convertase 1/3
    J Biol Chem (2015) 290, 23214-23225. PubMed  Europe PubMed DOI
    22. 2014
  22. Blanco,E.H., Peinado,J.R., Martin,M.G. and Lindberg,I.
    Biochemical and cell biological properties of the human prohormone convertase 1/3 Ser357Gly mutation: a PC1/3 hypermorph
    Endocrinology (2014) 155, 3434-3447. PubMed  Europe PubMed DOI  M
  23. Weiss,N., Stegemann,A., Elsayed,M.A., Schallreuter,K.U., Luger,T.A., Loser,K., Metze,D., Weishaupt,C. and Bohm,M.
    Inhibition of the prohormone convertase subtilisin-kexin isoenzyme-1 induces apoptosis in human melanoma cells
    J Invest Dermatol (2014) 134, 168-175. PubMed  Europe PubMed DOI  I
  24. Wilschanski,M., Abbasi,M., Blanco,E., Lindberg,I., Yourshaw,M., Zangen,D., Berger,I., Shteyer,E., Pappo,O., Bar-Oz,B., Martin,M.G. and Elpeleg,O.
    A novel familial mutation in the PCSK1 gene that alters the oxyanion hole residue of proprotein convertase 1/3 and impairs its enzymatic activity
    PLoS ONE (2014) 9, e108878-e108878. PubMed  Europe PubMed DOI  PMC  EPMC  M
    25. 2013
  25. Gagnon,H., Refaie,S., Gagnon,S., Desjardins,R., Salzet,M. and Day,R.
    Proprotein convertase 1/3 (PC1/3) in the rat alveolar macrophage cell line NR8383: localization, trafficking and effects on cytokine secretion
    PLoS ONE (2013) 8, e61557-e61557. PubMed  Europe PubMed DOI  PMC  EPMC
  26. Martin,M.G., Lindberg,I., Solorzano-Vargas,R.S., Wang,J., Avitzur,Y., Bandsma,R., Sokollik,C., Lawrence,S., Pickett,L.A., Chen,Z., Egritas,O., Dalgic,B., Albornoz,V., De Ridder,L., Hulst,J., Gok,F., Aydogan,A., Al-Hussaini,A., Gok,D.E., Yourshaw,M., Wu,S.V., Cortina,G., Stanford,S. and Georgia,S.
    Congenital proprotein convertase 1/3 deficiency causes malabsorptive diarrhea and other endocrinopathies in a pediatric cohort
    Gastroenterology (2013) 145, 138-148. PubMed  Europe PubMed DOI  M
  27. Pickett,L.A., Yourshaw,M., Albornoz,V., Chen,Z., Solorzano-Vargas,R.S., Nelson,S.F., Martin,M.G. and Lindberg,I.
    Functional consequences of a novel variant of PCSK1
    PLoS ONE (2013) 8, e55065-e55065. PubMed  Europe PubMed DOI  PMC  EPMC  M
  28. Seidah,N.G., Sadr,M.S., Chretien,M. and Mbikay,M.
    The multifaceted proprotein convertases: their unique, redundant, complementary, and opposite functions
    J Biol Chem (2013) 288, 21473-21481. PubMed  Europe PubMed DOI  V
  29. Turpeinen,H., Ortutay,Z. and Pesu,M.
    Genetics of the first seven proprotein convertase enzymes in health and disease
    Curr Genomics (2013) 14, 453-467. PubMed  Europe PubMed DOI  PMC  EPMC  V
  30. Vivoli,M. and Lindberg,I.
    Prohormone convertase 1/3
     (2013) 2, 1789-1796. DOI  V
    31. 2012
  31. Creemers,J.W., Choquet,H., Stijnen,P., Vatin,V., Pigeyre,M., Beckers,S., Meulemans,S., Than,M.E., Yengo,L., Tauber,M., Balkau,B., Elliott,P., Jarvelin,M.R., Van Hul,W., Van Gaal,L., Horber,F., Pattou,F., Froguel,P. and Meyre,D.
    Heterozygous mutations causing partial prohormone convertase 1 deficiency contribute to human obesity
    Diabetes (2012) 61, 383-390. PubMed  Europe PubMed DOI  M
  32. Cyr,N.E., Stuart,R.C., Zhu,X., Steiner,D.F. and Nillni,E.A.
    Biosynthesis of proTRH-derived peptides in prohormone convertase 1 and 2 knockout mice
    Peptides (2012) 35, 42-48. PubMed  Europe PubMed DOI  K
  33. Dillon,S.L., Williamson,D.M., Elferich,J., Radler,D., Joshi,R., Thomas,G. and Shinde,U.
    Propeptides are sufficient to regulate organelle-specific pH-dependent activation of furin and proprotein convertase 1/3
    J Mol Biol (2012) 423, 47-62. PubMed  Europe PubMed DOI
  34. Fontanesi,L., Bertolini,F., Scotti,E., Trevisi,P., Buttazzoni,L., Dall'Olio,S., Davoli,R., Bosi,P. and Russo,V.
    Polymorphisms in an obesity-related gene (PCSK1) are associated with fat deposition and production traits in Italian heavy pigs
    Animal (2012) 6, 1913-1924. PubMed  Europe PubMed DOI  M
  35. Refaie,S., Gagnon,S., Gagnon,H., Desjardins,R., D'Anjou,F., D'Orleans-Juste,P., Zhu,X., Steiner,D.F., Seidah,N.G., Lazure,C., Salzet,M. and Day,R.
    Disruption of proprotein convertase 1/3 (PC1/3) expression in mice causes innate immune defects and uncontrolled cytokine secretion
    J Biol Chem (2012) 287, 14703-14717. PubMed  Europe PubMed DOI  K
  36. Seidah,N.G. and Prat,A.
    The biology and therapeutic targeting of the proprotein convertases
    Nat Rev Drug Discov (2012) 11, 367-383. PubMed  Europe PubMed DOI  V
  37. Seidah,N.G.
    Proprotein convertase 1/3
    [ISSN:978-0-12-407742-3] (2012) 3, 3286-3290. DOI
    38. 2011
  38. Basak,A., Chen,A., Majumdar,S. and Smith,H.P.
    In vitro assay for protease activity of proprotein convertase subtilisin kexins (PCSKs): an overall review of existing and new methodologies
    Methods Mol Biol (2011) 768, 127-153. PubMed  Europe PubMed DOI  A
  39. Bramante,G., Patel,O., Shulkes,A. and Baldwin,G.S.
    Ferric ions inhibit proteolytic processing of progastrin
    Biochem Biophys Res Commun (2011) 404, 1083-1087. PubMed  Europe PubMed DOI
  40. Choquet,H., Stijnen,P. and Creemers,J.W.
    Genetic and functional characterization of PCSK1
    Methods Mol Biol (2011) 768, 247-253. PubMed  Europe PubMed DOI
  41. Icimoto,M.Y., Barros,N.M., Ferreira,J.C., Marcondes,M.F., Andrade,D., Machado,M.F., Juliano,M.A., Judice,W.A., Juliano,L. and Oliveira,V.
    Hysteretic behavior of proprotein convertase 1/3 (PC1/3)
    PLoS ONE (2011) 6, e24545-e24545. PubMed  Europe PubMed DOI  PMC  EPMC
  42. Mbikay,M., Sirois,F., Nkongolo,K.K., Basak,A. and Chretien,M.
    Effects of rs6234/rs6235 and rs6232/rs6234/rs6235 PCSK1 single-nucleotide polymorphism clusters on proprotein convertase 1/3 biosynthesis and activity
    Mol Genet Metab (2011) 104, 682-687. PubMed  Europe PubMed DOI  M
  43. Seidah,N.G.
    What lies ahead for the proprotein convertases?
    Ann N Y Acad Sci (2011) 1220, 149-161. PubMed  Europe PubMed DOI  V
  44. Seidah,N.G.
    The proprotein convertases, 20 years later
    Methods Mol Biol (2011) 768, 23-57. PubMed  Europe PubMed DOI  V
    45. 2010
  45. Chang,Y.C., Chiu,Y.F., Shih,K.C., Lin,M.W., Sheu,W.H., Donlon,T., Curb,J.D., Jou,Y.S., Chang,T.J., Li,H.Y. and Chuang,L.M.
    Common PCSK1 haplotypes are associated with obesity in the Chinese population
    Obesity (Silver Spring) (2010) 18, 1404-1409. PubMed  Europe PubMed DOI  M
  46. Ozawa,A., Peinado,J.R. and Lindberg,I.
    Modulation of prohormone convertase 1/3 properties using site-directed mutagenesis
    Endocrinology (2010) 151, 4437-4445. PubMed  Europe PubMed DOI
  47. Tian,S. and Jianhua,W.
    Comparative study of the binding pockets of mammalian proprotein convertases and its implications for the design of specific small molecule inhibitors
    Int J Biol Sci (2010) 6, 89-95. PubMed  Europe PubMed  PMC  EPMC  P  I
  48. Wardman,J.H., Zhang,X., Gagnon,S., Castro,L.M., Zhu,X., Steiner,D.F., Day,R. and Fricker,L.D.
    Analysis of peptides in prohormone convertase 1/3 null mouse brain using quantitative peptidomics
    J Neurochem (2010) 114, 215-225. PubMed  Europe PubMed DOI  K
  49. Zhou,J. and Cai,Z.H.
    Molecular cloning and characterization of prohormone convertase 1 gene in abalone (Haliotis diversicolor supertexta)
    Comp Biochem Physiol B Biochem Mol Biol (2010) 155, 331-339. PubMed  Europe PubMed DOI
    50. 2009
  50. Blanchard,A., Iwasiow,B., Yarmill,A., Fresnosa,A., Silha,J., Myal,Y., Murphy,L.C., Chretien,M., Seidah,N. and Shiu,R.P.
    Targeted production of proprotein convertase PC1 enhances mammary development and tumorigenesis in transgenic mice
    Can J Physiol Pharmacol (2009) 87, 831-838. PubMed  Europe PubMed DOI
  51. Dikeakos,J.D., Di Lello,P., Lacombe,M.J., Ghirlando,R., Legault,P., Reudelhuber,T.L. and Omichinski,J.G.
    Functional and structural characterization of a dense core secretory granule sorting domain from the PC1/3 protease
    Proc Natl Acad Sci U S A (2009) 106, 7408-7413. PubMed  Europe PubMed DOI  PMC  EPMC  S
  52. Morash,M.G., MacDonald,A.B., Croll,R.P. and Anini,Y.
    Molecular cloning, ontogeny and tissue distribution of zebrafish (Danio rerio) prohormone convertases: pcsk1 and pcsk2
    Gen Comp Endocrinol (2009) 162, 179-187. PubMed  Europe PubMed DOI
  53. Rholam,M. and Fahy,C.
    Processing of peptide and hormone precursors at the dibasic cleavage sites
    Cell Mol Life Sci (2009) 66, 2075-2091. PubMed  Europe PubMed DOI
    54. 2008
  54. Benzinou,M., Creemers,J.W., Choquet,H., Lobbens,S., Dina,C., Durand,E., Guerardel,A., Boutin,P., Jouret,B., Heude,B., Balkau,B., Tichet,J., Marre,M., Potoczna,N., Horber,F., Le Stunff,C., Czernichow,S., Sandbaek,A., Lauritzen,T., Borch-Johnsen,K., Andersen,G., Kiess,W., Korner,A., Kovacs,P., Jacobson,P., Carlsson,L.M., Walley,A.J., Jorgensen,T., Hansen,T., Pedersen,O., Meyre,D. and Froguel,P.
    Common nonsynonymous variants in PCSK1 confer risk of obesity
    Nat Genet (2008) 40, 943-945. PubMed  Europe PubMed DOI  M
  55. Creemers,J.W. and Khatib,A.M.
    Knock-out mouse models of proprotein convertases: unique functions or redundancy?
    Front Biosci (2008) 13, 4960-4971. PubMed  Europe PubMed DOI  K
  56. Rehfeld,J.F., Zhu,X., Norrbom,C., Bundgaard,J.R., Johnsen,A.H., Nielsen,J.E., Vikesaa,J., Stein,J., Dey,A., Steiner,D.F. and Friis-Hansen,L.
    Prohormone convertases 1/3 and 2 together orchestrate the site-specific cleavages of progastrin to release gastrin-34 and gastrin-17
    Biochem J (2008) 415, 35-43. PubMed  Europe PubMed DOI
    57. 2007
  57. Dikeakos,J.D., Mercure,C., Lacombe,M.J., Seidah,N.G. and Reudelhuber,T.L.
    PC1/3, PC2 and PC5/6A are targeted to dense core secretory granules by a common mechanism
    FEBS J (2007) 274, 4094-4102. PubMed  Europe PubMed DOI
  58. Farooqi,I.S., Volders,K., Stanhope,R., Heuschkel,R., White,A., Lank,E., Keogh,J., O'Rahilly,S. and Creemers,J.W.
    Hyperphagia and early-onset obesity due to a novel homozygous missense mutation in prohormone convertase 1/3
    J Clin Endocrinol Metab (2007) 92, 3369-3373. PubMed  Europe PubMed DOI  M
  59. Lou,H., Smith,A.M., Coates,L.C., Cawley,N.X., Loh,Y.P. and Birch,N.P.
    The transmembrane domain of the prohormone convertase PC3: a key motif for targeting to the regulated secretory pathway
    Mol Cell Endocrinol (2007) 267, 17-25. PubMed  Europe PubMed DOI  PMC  EPMC
  60. Mbikay,M., Croissandeau,G., Sirois,F., Anini,Y., Mayne,J., Seidah,N.G. and Chretien,M.
    A targeted deletion/insertion in the mouse Pcsk1 locus is associated with homozygous embryo preimplantation lethality, mutant allele preferential transmission and heterozygous female susceptibility to dietary fat
    Dev Biol (2007) 306, 584-598. PubMed  Europe PubMed DOI  K
  61. Rabah,N., Gauthier,D., Dikeakos,J.D., Reudelhuber,T.L. and Lazure,C.
    The C-terminal region of the proprotein convertase 1/3 (PC1/3) exerts a bimodal regulation of the enzyme activity in vitro
    FEBS J (2007) 274, 3482-3491. PubMed  Europe PubMed DOI
    62. 2006
  62. Lloyd,D.J., Bohan,S. and Gekakis,N.
    Obesity, hyperphagia and increased metabolic efficiency in Pc1 mutant mice
    Hum Mol Genet (2006) 15, 1884-1893. PubMed  Europe PubMed DOI  M
  63. [YEAR:11-1-2006]Rabah,N., Gauthier,D., Wilkes,B.C., Gauthier,D.J. and Lazure,C.
    Single amino acid substitution in the PC1/3 propeptide can induce significant modifications of its inhibitory profile toward its cognate enzyme
    J Biol Chem (11-1-2006) 281, 7556-7567. PubMed  Europe PubMed DOI
  64. Scamuffa,N., Calvo,F., Chretien,M., Seidah,N.G. and Khatib,A.M.
    Proprotein convertases: lessons from knockouts
    FASEB J (2006) 20, 1954-1963. PubMed  Europe PubMed DOI  K  V
    65. 2005
  65. [YEAR:14-1-2005]Henrich,S., Lindberg,I., Bode,W. and Than,M.E.
    Proprotein convertase models based on the crystal structures of furin and kexin: explanation of their specificity
    J Mol Biol (14-1-2005) 345, 211-227. PubMed  Europe PubMed DOI  S
  66. [YEAR:29-3-2005]Pan,H., Nanno,D., Che,F.Y., Zhu,X., Salton,S.R., Steiner,D.F., Fricker,L.D. and Devi,L.A.
    Neuropeptide processing profile in mice lacking prohormone convertase-1
    Biochemistry (29-3-2005) 44, 4939-4948. PubMed  Europe PubMed DOI  K
  67. [YEAR:12-4-2005]Stettler,H., Suri,G. and Spiess,M.
    Proprotein convertase PC3 is not a transmembrane protein
    Biochemistry (12-4-2005) 44, 5339-5345. PubMed  Europe PubMed DOI
  68. [YEAR:23-6-2005]Tagen,M.B. and Beinfeld,M.C.
    Recombinant prohormone convertase 1 and 2 cleave purified pro cholecystokinin (CCK) and a synthetic peptide containing CCK 8 Gly Arg Arg and the carboxyl-terminal flanking peptide
    Peptides (23-6-2005) 26, 2530-2535. PubMed  Europe PubMed DOI
    69. 2004
  69. Cain,B.M., Connolly,K., Blum,A.C., Vishnuvardhan,D., Marchand,J.E., Zhu,X., Steiner,D.F. and Beinfeld,M.C.
    Genetic inactivation of prohormone convertase (PC1) causes a reduction in cholecystokinin (CCK) levels in the hippocampus, amygdala, pons and medulla in mouse brain that correlates with the degree of colocalization of PC1 and CCK mRNA in these structures in rat brain
    J Neurochem (2004) 89, 307-313. PubMed  Europe PubMed DOI  K
  70. Dey,A., Norrbom,C., Zhu,X., Stein,J., Zhang,C., Ueda,K. and Steiner,D.F.
    Furin and prohormone convertase 1/3 are major convertases in the processing of mouse pro-growth hormone-releasing hormone
    Endocrinology (2004) 145, 1961-1971. PubMed  Europe PubMed DOI
  71. Lee,S.N., Prodhomme,E. and Lindberg,I.
    Prohormone convertase 1 (PC1) processing and sorting: effect of PC1 propeptide and proSAAS
    J Endocrinol (2004) 182, 353-364. PubMed  Europe PubMed DOI
  72. Posner,S.F., Vaslet,C.A., Jurofcik,M., Lee,A., Seidah,N.G. and Nillni,E.A.
    Stepwise posttranslational processing of progrowth hormone-releasing hormone (proGHRH) polypeptide by furin and PC1
    Endocrine (2004) 23, 199-213. PubMed  Europe PubMed DOI
  73. Rabah,N., Gauthier,D.J., Gauthier,D. and Lazure,C.
    Improved PC1/3 production through recombinant expression in insect cells and larvae
    Protein Expr Purif (2004) 37, 377-384. PubMed  Europe PubMed DOI  E
  74. Seidah,N.G. and Chretien,M.
    Proprotein convertase 1
    [ISSN:0-12-079610-4] (2004) 2, 1861-1864.  V
  75. [YEAR:20-11-2004]Ugleholdt,R., Zhu,X., Deacon,C.F., Orskov,C., Steiner,D.F. and Holst,J.J.
    Impaired intestinal proglucagon processing in mice lacking prohormone convertase 1
    Endocrinology (20-11-2004) 145, 1349-1355. PubMed  Europe PubMed DOI  K
    76. 2003
  76. Jackson,R.S., Creemers,J.W., Farooqi,I.S., Raffin-Sanson,M.L., Varro,A., Dockray,G.J., Holst,J.J., Brubaker,P.L., Corvol,P., Polonsky,K.S., Ostrega,D., Becker,K.L., Bertagna,X., Hutton,J.C., White,A., Dattani,M.T., Hussain,K., Middleton,S.J., Nicole,T.M., Milla,P.J., Lindley,K.J. and O'Rahilly,S.
    Small-intestinal dysfunction accompanies the complex endocrinopathy of human proprotein convertase 1 deficiency
    J Clin Invest (2003) 112, 1550-1560. PubMed  Europe PubMed DOI  PMC  EPMC  K
  77. Peinado,J.R., Li,H., Johanning,K. and Lindberg,I.
    Cleavage of recombinant proenkephalin and blockade mutants by prohormone convertases 1 and 2: an in vitro specificity study
    J Neurochem (2003) 87, 868-878. PubMed  Europe PubMed DOI
  78. Taylor,N.A., Van de Ven,W.J. and Creemers,J.W.
    Curbing activation: proprotein convertases in homeostasis and pathology
    FASEB J (2003) 17, 1215-1227. PubMed  Europe PubMed DOI  K
  79. [YEAR:13-5-2003]Ueda,K., Lipkind,G.M., Zhou,A., Zhu,X., Kuznetsov,A., Philipson,L., Gardner,P., Zhang,C. and Steiner,D.F.
    Mutational analysis of predicted interactions between the catalytic and P domains of prohormone convertase 3 (PC3/PC1)
    Proc Natl Acad Sci U S A (13-5-2003) 100, 5622-5627. PubMed  Europe PubMed DOI  PMC  EPMC
    80. 2002
  80. Fugere,M. and Day,R.
    Inhibitors of the subtilase-like pro-protein convertases (SPCs)
    Curr Pharm Des (2002) 8, 549-562. PubMed  Europe PubMed DOI  V  I
  81. Seidah,N.G. and Prat,A.
    Precursor convertases in the secretory pathway, cytosol and extracellular milieu
    Essays Biochem (2002) 38, 79-94. PubMed  Europe PubMed
  82. [YEAR:19-7-2002]Tangrea,M.A., Bryan,P.N., Sari,N. and Orban,J.
    Solution structure of the pro-hormone convertase 1 pro-domain from Mus musculus
    J Mol Biol (19-7-2002) 320, 801-812. PubMed  Europe PubMed DOI
  83. [YEAR:6-8-2002]Zhu,X., Orci,L., Carroll,R., Norrbom,C., Ravazzola,M. and Steiner,D.F.
    Severe block in processing of proinsulin to insulin accompanied by elevation of des-64,65 proinsulin intermediates in islets of mice lacking prohormone convertase 1/3
    Proc Natl Acad Sci U S A (6-8-2002) 99, 10299-10304. PubMed  Europe PubMed DOI  PMC  EPMC  K
    84. 2001
  84. [YEAR:31-8-2001]Basak,A., Koch,P., Dupelle,M., Fricker,L.D., Devi,L.A., Chretien,M. and Seidah,N.G.
    Inhibitory specificity and potency of proSAAS-derived peptides toward proprotein convertase 1
    J Biol Chem (31-8-2001) 276, 32720-32728. PubMed  Europe PubMed DOI  I
  85. [YEAR:8-5-2001]Tangrea,M.A., Alexander,P., Bryan,P.N., Eisenstein,E., Toedt,J. and Orban,J.
    Stability and global fold of the mouse prohormone convertase 1 pro-domain
    Biochemistry (8-5-2001) 40, 5488-5495. PubMed  Europe PubMed DOI
    86. 2000
  86. [YEAR:12-5-2000]Cameron,A., Fortenberry,Y. and Lindberg,I.
    The SAAS granin exhibits structural and functional homology to 7B2 and contains a highly potent hexapeptide inhibitor of PC1
    FEBS Lett (12-5-2000) 473, 135-138. PubMed  Europe PubMed DOI
  87. [YEAR:15-1-2000]Fricker,L.D., McKinzie,A.A., Sun,J., Curran,E., Qian,Y., Yan,L., Patterson,S.D., Courchesne,P.L., Richards,B., Levin,N., Mzhavia,N., Devi,L.A. and Douglass,J.
    Identification and characterization of proSAAS, a granin-like neuroendocrine peptide precursor that inhibits prohormone processing
    J Neurosci (15-1-2000) 20, 639-648. PubMed  Europe PubMed
  88. Hwang,S.R., Ng,S.M., Steineckert,B., Seidah,N.G. and Hook,V.Y.H.
    Molecular cloning demonstrates structural features of homologous bovine prohormone convertases 1 and 2
    DNA Cell Biol (2000) 19, 409-419. PubMed  Europe PubMed DOI
  89. [YEAR:4-8-2000]Qian,Y., Devi,L.A., Mzhavia,N., Munzer,S., Seidah,N.G. and Fricker,L.D.
    The C-terminal region of proSAAS is a potent inhibitor of prohormone convertase 1
    J Biol Chem (4-8-2000) 275, 23596-23601. PubMed  Europe PubMed DOI
  90. Sawada,M., Finniss,S. and Dickinson,C.J.
    Diminished prohormone convertase 3 expression (PC1/PC3) inhibits progastrin post-translational processing
    Regul Pept (2000) 89, 19-28. PubMed  Europe PubMed DOI
  91. [YEAR:28-8-2000]Winsky-Sommerer,R., Benjannet,S., Rovere,C., Barbero,P., Seidah,N.G., Epelbaum,J. and Dournaud,P.
    Regional and cellular localization of the neuroendocrine prohormone convertases PC1 and PC2 in the rat central nervous system
    J Comp Neurol (28-8-2000) 424, 439-460. PubMed  Europe PubMed
    92. 1999
  92. Muller,L. and Lindberg,I.
    The cell biology of the prohormone convertases PC1 and PC2
    Prog Nucleic Acid Res Mol Biol (1999) 63, 69-108. PubMed  Europe PubMed
  93. Rovere,C., Luis,J., Lissitzky,J.C., Basak,A., Marvaldi,J., Chretien,M. and Seidah,N.G.
    The RGD motif and the C-terminal segment of proprotein convertase 1 are critical for its cellular trafficking but not for its intracellular binding to integrin alpha5beta1
    J Biol Chem (1999) 274, 12461-12467. PubMed  Europe PubMed DOI
  94. Seidah,N.G., Benjannet,S., Hamelin,J., Mamarbachi,A.M., Basak,A., Marcinkiewicz,J., Mbikay,M., Chretien,M. and Marcinkiewicz,M.
    The subtilisin/kexin family of precursor convertases. Emphasis on PC1, PC2/7B2, POMC and the novel enzyme SKI-1
    Ann N Y Acad Sci (1999) 885, 57-74. PubMed  Europe PubMed
  95. [YEAR:15-9-1999]Udupi,V., Lee,H.M., Kurosky,A. and Greeley,G.H., Jr.
    Prohormone convertase-1 is essential for conversion of chromogranin A to pancreastatin
    Regul Pept (15-9-1999) 83, 123-127. PubMed  Europe PubMed DOI
    96. 1998
  96. Boudreault,A., Gauthier,D., Rondeau,N., Savaria,D., Seidah,N.G., Chretien,M. and Lazure,C.
    Molecular characterization, enzymatic analysis, and purification of murine proprotein convertase-1/3 (PC1/PC3) secreted from recombinant baculovirus-infected insect cells
    Protein Expr Purif (1998) 14, 353-366. PubMed  Europe PubMed DOI  E
  97. [YEAR:15-9-1998]Scougall,K., Taylor,N.A., Jermany,J.L., Docherty,K. and Shennan,K.I.
    Differences in the autocatalytic cleavage of pro-PC2 and pro-PC3 can be attributed to sequences within the propeptide and Asp310 of pro-PC2
    Biochem J (15-9-1998) 334, 531-537. PubMed  Europe PubMed  PMC  EPMC
    98. 1997
  98. Jackson,R.S., Creemers,J.W., Ohagi,S., Raffin-Sanson,M.L., Sanders,L., Montague,C.T., Hutton,J.C. and O'Rahilly,S.
    Obesity and impaired prohormone processing associated with mutations in the human prohormone convertase 1 gene
    Nat Genet (1997) 16, 303-306. PubMed  Europe PubMed DOI  K
  99. [YEAR:15-9-1997]Lusson,J., Benjannet,S., Hamelin,J., Savaria,D., Chretien,M. and Seidah,N.G.
    The integrity of the RRGDL sequence of the proprotein convertase PC1 is critical for its zymogen and C-terminal processing and for its cellular trafficking
    Biochem J (15-9-1997) 326, 737-744. PubMed  Europe PubMed  PMC  EPMC
    100. 1996
  100. Paquet,L., Zhou,A., Chang,E.Y. and Mains,R.E.
    Peptide biosynthetic processing: Distinguishing prohormone convertases PC1 and PC2
    Mol Cell Endocrinol (1996) 120, 161-168. PubMed  Europe PubMed DOI
  101. Rovere,C., Barbero,P. and Kitabgi,P.
    Evidence that PC2 is the endogenous pro-neurotensin convertase in rMTC 6-23 cells and that PC1- and PC2-transfected PC12 cells differentially process pro-neurotensin
    J Biol Chem (1996) 271, 11368-11375. PubMed  Europe PubMed
    102. 1995
  102. Brakch,N., Galanopoulou,A.S., Patel,Y.C., Boileau,G. and Seidah,N.G.
    Comparative proteolytic processing of rat prosomatostatin by the convertases PC1, PC2, furin, PACE4 and PC5 in constitutive and regulated secretory pathways
    FEBS Lett (1995) 362, 143-146. PubMed  Europe PubMed DOI
  103. Jean,F., Basak,A., DiMaio,J., Seidah,N.G. and Lazure,C.
    An internally quenched fluorogenic substrate of prohormone convertase 1 and furin leads to a potent prohormone convertase inhibitor
    Biochem J (1995) 307, 689-695. PubMed  Europe PubMed  PMC  EPMC  A  I
  104. Nillni,E.A., Friedman,T.C., Todd,R.B., Birch,N.P., Loh,Y.P. and Jackson,I.M.
    Pro-thyrotropin-releasing hormone processing by recombinant PC1
    J Neurochem (1995) 65, 2462-2472. PubMed  Europe PubMed
  105. Rouille,Y., Martin,S. and Steiner,D.F.
    Differential processing of proglucagon by the subtilisin-like prohormone convertases PC2 and PC3 to generate either glucagon or glucagon-like peptide
    J Biol Chem (1995) 270, 26488-26496. PubMed  Europe PubMed DOI
  106. Yoon,J.Y. and Beinfeld,M.C.
    Expression of antisense PC1 in stably transfected RIN5F cells significantly reduces CCK 8 biosynthesis
    Regul Pept (1995) 59, 221-227. PubMed  Europe PubMed DOI
  107. [YEAR:15-9-1995]Zhou,A., Paquet,L. and Mains,R.E.
    Structural elements that direct specific processing of different mammalian subtilisin-like prohormone convertases
    J Biol Chem (15-9-1995) 270, 21509-21516. PubMed  Europe PubMed DOI
    108. 1994
  108. Dupuy,A., Lindberg,I., Zhou,Y., Akil,H., Lazure,C., Chretien,M., Seidah,N.G. and Day,R.
    Processing of prodynorphin by the prohormone convertase PC1 results in high molecular weight intermediate forms. Cleavage at a single arginine residue
    FEBS Lett (1994) 337, 60-65. PubMed  Europe PubMed DOI
  109. Ftouhi,N., Day,R., Mbikay,M., Chretien,M. and Seidah,N.G.
    Gene organization of the mouse pro-hormone and pro-protein convertase PC1
    DNA Cell Biol (1994) 13, 395-407. PubMed  Europe PubMed
  110. Lindberg,I., Ahn,S.C. and Breslin,M.B.
    Cellular distributions of the prohormone processing enzymes PC1 and PC2
    Mol Cell Neurosci (1994) 5, 614-622. PubMed  Europe PubMed DOI
  111. Seidah,N.G. and Chretien,M.
    Pro-protein convertases of subtilisin/kexin family
    Methods Enzymol (1994) 244, 175-188. PubMed  Europe PubMed DOI  V
    112. 1993
  112. Jean,F., Basak,A., Rondeau,N., Benjannet,S., Hendy,G.N., Seidah,N.G., Chretien,M. and Lazure,C.
    Enzymic characterization of murine and human prohormone convertase-1 (mPC1 and hPC1) expressed in mammalian GH4C1 cells
    Biochem J (1993) 292, 891-900. PubMed  Europe PubMed  PMC  EPMC  I
  113. Rufaut,N.W., Brennan,S.O., Hakes,D.J., Dixon,J.E. and Birch,N.P.
    Purification and characterization of the candidate prohormone-processing enzyme SPC3 produced in a mouse L cell line
    J Biol Chem (1993) 268, 20291-20298. PubMed  Europe PubMed  P
  114. Zhou,A., Bloomquist,B.T. and Mains,R.E.
    The prohormone convertases PC1 and PC2 mediate distinct endoproteolytic cleavages in a strict temporal order during proopiomelanocortin biosynthetic processing
    J Biol Chem (1993) 268, 1763-1769. PubMed  Europe PubMed
  115. [YEAR:15-3-1993]Zhou,Y. and Lindberg,I.
    Purification and characterization of the prohormone convertase PC1(PC3)
    J Biol Chem (15-3-1993) 268, 5615-5623. PubMed  Europe PubMed
    116. 1992
  116. Chan,S.J., Oliva,A.A., Jr., LaMendola,J., Grens,A., Bode,H. and Steiner,D.F.
    Conservation of the prohormone convertase gene family in metazoa: Analysis of cDNAs encoding a PC3-like protein from Hydra
    Proc Natl Acad Sci U S A (1992) 89, 6678-6682. PubMed  Europe PubMed DOI  PMC  EPMC
  117. Seidah,N.G., Hamelin,J., Gaspar,A.M., Day,R. and Chretien,M.
    The cDNA sequence of the human pro-hormone and pro-protein convertase PC1
    DNA Cell Biol (1992) 11, 283-289. PubMed  Europe PubMed
  118. Seidah,N.G. and Chretien,M.
    Proprotein and prohormone convertases of the subtilisin family. Recent developments and future perspectives
    Trends Endocrinol Metab (1992) 3, 133-140. PubMed  Europe PubMed
  119. Seidah,N.G., Fournier,H., Boileau,G., Benjannet,S., Rondeau,N. and Chretien,M.
    The cDNA structure of the porcine pro-hormone convertase PC2 and the comparative processing by PC1 and PC2 of the N-terminal glycopeptide segment of porcine POMC
    FEBS Lett (1992) 310, 235-239. PubMed  Europe PubMed DOI
  120. Smeekens,S.P., Montag,A.G., Thomas,G., Albiges-Rizo,C., Carroll,R., Benig,M., Phillips,L.A., Martin,S., Ohagi,S., Gardner,P., Swift,H.H. and Steiner,D.F.
    Proinsulin processing by the subtilisin-related proprotein convertases furin, PC2, and PC3
    Proc Natl Acad Sci U S A (1992) 89, 8822-8826. PubMed  Europe PubMed  PMC  EPMC
  121. Steiner,D.F., Smeekens,S.P., Ohagi,S. and Chan,S.J.
    The new enzymology of precursor processing endoproteases
    J Biol Chem (1992) 267, 23435-23438. PubMed  Europe PubMed
    122. 1991
  122. Nakayama,K., Hosaka,M., Hatsuzawa,K. and Murakami,K.
    Cloning and functional expression of a novel endoprotease involved in prohormone processing at dibasic sites
    J Biochem (1991) 109, 803-806. PubMed  Europe PubMed
  123. Seidah,N.G., Day,R., Marcinkiewicz,M., Benjannet,S. and Chretien,M.
    Mammalian neural and endocrine pro-protein and pro-hormone convertases belonging to the subtilisin family of serine proteinases
    Enzyme (1991) 45, 271-284. PubMed  Europe PubMed
  124. Seidah,N.G., Mattei,M.G., Gaspar,L., Benjannet,S., Mbikay,M. and Chretien,M.
    Chromosomal assignments of the genes for neuroendocrine convertase PC1 (NEC1) to human 5q15-21, neuroendocrine convertase PC2 (NEC2) to human 20p11.1-11.2, and Furin (mouse 7[D1- E2] region)
    Genomics (1991) 11, 103-107. PubMed  Europe PubMed
  125. Smeekens,S.P., Avruch,A.S., LaMendola,J., Chan,S.J. and Steiner,D.F.
    Identification of a cDNA encoding a second putative prohormone convertase related to PC2 in AtT20 cells and islets of Langerhans
    Proc Natl Acad Sci U S A (1991) 88, 340-344. PubMed  Europe PubMed DOI  PMC  EPMC
    126. 1990
  126. Seidah,N.G., Gaspar,L., Mion,P., Marcinkiewicz,M., Mbikay,M. and Chretien,M.
    cDNA sequence of two distinct pituitary proteins homologous to Kex2 and furin gene products: tissue-specific mRNAs encoding candidates for pro-hormone processing proteinases
    DNA Cell Biol (1990) 9, 415-424. PubMed  Europe PubMed

feedback
Page created 8-September-2023

EMBL-EBI logo

© 2026 EBI
Terms of use