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Literature for peptidase S08.072: PCSK1 peptidase

Summary Gene structure Alignment Tree Sequences Sequence features Distribution Structure Literature Substrates Pharma

(Topics flags: S Structure, A Assay, M Mutation, P Specificity, K Knockout, I Inhibitor, E Expression, V Review. To select only the references relevant to a single topic, click the link above. See explanation.)

    2024
  1. Moeller,J. and Meier,D.T.
    Ablation of PC1/3 in POMC-Expressing Tissues but Not in Immune Cells Induces Sepsis Hypersensitivity
    J Endocr Soc8, bvae171-bvae171. PubMed  Europe PubMed DOI
    2. 2023
  2. Guijo,B., Argente,J. and Martos-Moreno,G.A.
    The N221D variant in PCSK1 is highly prevalent in childhood obesity and can influence the metabolic profile
    J Pediatr Endocrinol Metab36, 1140-1145. PubMed  Europe PubMed DOI
    3. 2022
  3. Basak,S. and Basak,A.
    Proteins and proteases of Prader-Willi syndrome: a comprehensive review and perspectives
    Biosci Rep42, PubMed  Europe PubMed DOI
  4. Ni,Y., Chen,X., Sun,Y., Pan,J., Tang,C. and Yuan,T.
    Modulation of PC1/3 activity by a rare double-site homozygous mutation
    Front Pediatr10, 1026707-1026707. PubMed  Europe PubMed DOI
  5. Yoon,M.C., Ames,J., Mosier,C., Jiang,Z., Podvin,S., O'Donoghue,A.J. and Hook,V.
    Distinct Dibasic Cleavage Specificities of Neuropeptide-Producing Cathepsin L and Cathepsin V Cysteine Proteases Compared to PC1/3 and PC2 Serine Proteases
    ACS Chem Neurosci13, 245-256. PubMed  Europe PubMed DOI
    6. 2021
  6. de Souza,A.A., de Andrade,D.M., Siqueira,F.D.S., Di Iorio,J.F., Veloso,M.P., Coelho,C.M., Viegas Junior,C., Gontijo,V.S., Dos Santos,M.H., Meneghetti,M.C.Z., Nader,H.B., Tersariol,I.L.D.S., Juliano,L., Juliano,M.A. and Judice,W.A.S.
    Semysinthetic biflavonoid Morelloflavone-7,4',7'',3''',4'''-penta-O-butanoyl is a more potent inhibitor of Proprotein Convertases Subtilisin/Kexin PC1/3 than Kex2 and Furin
    Biochim Biophys Acta Gen Subj1865, 130016-130016. PubMed  Europe PubMed DOI  I
  7. Shakya,M. and Lindberg,I.
    Mouse models of human proprotein convertase insufficiency
    Endocr Rev42, 259-294. PubMed  Europe PubMed DOI  V
    8. 2020
  8. Jaimes,J., Millet,J. and Whittaker,G.
    Proteolytic Cleavage of the SARS-CoV-2 Spike Protein and the Role of the Novel S1/S2 Site
    SSRN3581359-3581359. PubMed  Europe PubMed DOI
  9. Muhsin,N.I.A., Bentley,L., Bai,Y., Goldsworthy,M. and Cox,R.D.
    A novel mutation in the mouse Pcsk1 gene showing obesity and diabetes
    Mamm Genome31, 17-29. PubMed  Europe PubMed DOI  M
  10. Ramzy,A., Asadi,A. and Kieffer,T.J.
    Revisiting proinsulin processing: evidence that human beta-cells process proinsulin with prohormone convertase (PC) 1/3 but not PC2
    Diabetes PubMed  Europe PubMed DOI
    11. 2018
  11. Distelmaier,F., Herebian,D., Atasever,C., Beck-Woedl,S., Mayatepek,E., Strom,T.M. and Haack,T.B.
    Blue diaper syndrome and PCSK1 mutations
    Pediatrics141, S501-S501. PubMed  Europe PubMed DOI  M
  12. Kumar,G., Nair,R. and Sohal,A.P.S.
    Proprotein convertase 1/3 deficiency
    Indian J Pediatr85, 320-321. PubMed  Europe PubMed DOI  M
  13. Rodet,F., Capuz,A., Hara,T., van Meel,R., Duhamel,M., Rose,M., Raffo-Romero,A., Fournier,I. and Salzet,M.
    Deciphering molecular consequences of the proprotein convertase 1/3 inhibition in macrophages for application in anti-tumour immunotherapy
    J Biotechnol282, 80-85. PubMed  Europe PubMed DOI  K
    14. 2017
  14. Loffler,D., Behrendt,S., Creemers,J.W., Klammt,J., Aust,G., Stanik,J., Kiess,W., Kovacs,P. and Korner,A.
    Functional and clinical relevance of novel and known PCSK1 variants for childhood obesity and glucose metabolism
    Mol Metab6, 295-305. PubMed  Europe PubMed DOI  M
    15. 2016
  15. Maluch,I., Walewska,A., Sikorska,E. and Prahl,A.
    [Proprotein convertases - family of serine proteases with a broad spectrum of physiological functions]
    Postepy Biochem62, 472-481. PubMed  Europe PubMed  V
  16. Ramos-Molina,B., Martin,M.G. and Lindberg,I.
    PCSK1 variants and human obesity
    Prog Mol Biol Transl Sci140, 47-74. PubMed  Europe PubMed DOI  M
    17. 2015
  17. Elferich,J., Williamson,D.M., David,L.L. and Shinde,U.
    Determination of histidine pKa values in the propeptides of furin and proprotein convertase1/3 using histidine hydrogen-deuterium exchange mass spectrometry
    Anal Chem87, 7909-7917. PubMed  Europe PubMed DOI
  18. Gu,Q., Yazdanpanah,M., van Hoek,M., Hofman,A., Gao,X., de Rooij,F.W. and Sijbrands,E.J.
    Common variants in PCSK1 influence blood pressure and body mass index
    J Hum Hypertens29, 82-86. PubMed  Europe PubMed DOI  M
  19. Williamson,D.M., Elferich,J. and Shinde,U.
    Mechanism of fine-tuning pH sensors in proprotein convertases: identification of a pH-sensing histidine pair in the propeptide of proprotein convertase 1/3
    J Biol Chem290, 23214-23225. PubMed  Europe PubMed DOI
    20. 2014
  20. Blanco,E.H., Peinado,J.R., Martin,M.G. and Lindberg,I.
    Biochemical and cell biological properties of the human prohormone convertase 1/3 Ser357Gly mutation: a PC1/3 hypermorph
    Endocrinology155, 3434-3447. PubMed  Europe PubMed DOI  M
  21. Weiss,N., Stegemann,A., Elsayed,M.A., Schallreuter,K.U., Luger,T.A., Loser,K., Metze,D., Weishaupt,C. and Bohm,M.
    Inhibition of the prohormone convertase subtilisin-kexin isoenzyme-1 induces apoptosis in human melanoma cells
    J Invest Dermatol134, 168-175. PubMed  Europe PubMed DOI  I
  22. Wilschanski,M., Abbasi,M., Blanco,E., Lindberg,I., Yourshaw,M., Zangen,D., Berger,I., Shteyer,E., Pappo,O., Bar-Oz,B., Martin,M.G. and Elpeleg,O.
    A novel familial mutation in the PCSK1 gene that alters the oxyanion hole residue of proprotein convertase 1/3 and impairs its enzymatic activity
    PLoS ONE9, e108878-e108878. PubMed  Europe PubMed DOI  M
    23. 2013
  23. Gagnon,H., Refaie,S., Gagnon,S., Desjardins,R., Salzet,M. and Day,R.
    Proprotein convertase 1/3 (PC1/3) in the rat alveolar macrophage cell line NR8383: localization, trafficking and effects on cytokine secretion
    PLoS ONE8, e61557-e61557. PubMed  Europe PubMed DOI
  24. Martin,M.G., Lindberg,I., Solorzano-Vargas,R.S., Wang,J., Avitzur,Y., Bandsma,R., Sokollik,C., Lawrence,S., Pickett,L.A., Chen,Z., Egritas,O., Dalgic,B., Albornoz,V., De Ridder,L., Hulst,J., Gok,F., Aydogan,A., Al-Hussaini,A., Gok,D.E., Yourshaw,M., Wu,S.V., Cortina,G., Stanford,S. and Georgia,S.
    Congenital proprotein convertase 1/3 deficiency causes malabsorptive diarrhea and other endocrinopathies in a pediatric cohort
    Gastroenterology145, 138-148. PubMed  Europe PubMed DOI  M
  25. Pickett,L.A., Yourshaw,M., Albornoz,V., Chen,Z., Solorzano-Vargas,R.S., Nelson,S.F., Martin,M.G. and Lindberg,I.
    Functional consequences of a novel variant of PCSK1
    PLoS ONE8, e55065-e55065. PubMed  Europe PubMed DOI  M
  26. Seidah,N.G., Sadr,M.S., Chretien,M. and Mbikay,M.
    The multifaceted proprotein convertases: their unique, redundant, complementary, and opposite functions
    J Biol Chem288, 21473-21481. PubMed  Europe PubMed DOI  V
  27. Turpeinen,H., Ortutay,Z. and Pesu,M.
    Genetics of the first seven proprotein convertase enzymes in health and disease
    Curr Genomics14, 453-467. PubMed  Europe PubMed DOI  V
  28. Vivoli,M. and Lindberg,I.
    Prohormone convertase 1/3
    2, 1789-1796. DOI  V
    29. 2012
  29. Creemers,J.W., Choquet,H., Stijnen,P., Vatin,V., Pigeyre,M., Beckers,S., Meulemans,S., Than,M.E., Yengo,L., Tauber,M., Balkau,B., Elliott,P., Jarvelin,M.R., Van Hul,W., Van Gaal,L., Horber,F., Pattou,F., Froguel,P. and Meyre,D.
    Heterozygous mutations causing partial prohormone convertase 1 deficiency contribute to human obesity
    Diabetes61, 383-390. PubMed  Europe PubMed DOI  M
  30. Cyr,N.E., Stuart,R.C., Zhu,X., Steiner,D.F. and Nillni,E.A.
    Biosynthesis of proTRH-derived peptides in prohormone convertase 1 and 2 knockout mice
    Peptides35, 42-48. PubMed  Europe PubMed DOI  K
  31. Dillon,S.L., Williamson,D.M., Elferich,J., Radler,D., Joshi,R., Thomas,G. and Shinde,U.
    Propeptides are sufficient to regulate organelle-specific pH-dependent activation of furin and proprotein convertase 1/3
    J Mol Biol423, 47-62. PubMed  Europe PubMed DOI
  32. Fontanesi,L., Bertolini,F., Scotti,E., Trevisi,P., Buttazzoni,L., Dall'Olio,S., Davoli,R., Bosi,P. and Russo,V.
    Polymorphisms in an obesity-related gene (PCSK1) are associated with fat deposition and production traits in Italian heavy pigs
    Animal6, 1913-1924. PubMed  Europe PubMed DOI  M
  33. Refaie,S., Gagnon,S., Gagnon,H., Desjardins,R., D'Anjou,F., D'Orleans-Juste,P., Zhu,X., Steiner,D.F., Seidah,N.G., Lazure,C., Salzet,M. and Day,R.
    Disruption of proprotein convertase 1/3 (PC1/3) expression in mice causes innate immune defects and uncontrolled cytokine secretion
    J Biol Chem287, 14703-14717. PubMed  Europe PubMed DOI  K
  34. Seidah,N.G. and Prat,A.
    The biology and therapeutic targeting of the proprotein convertases
    Nat Rev Drug Discov11, 367-383. PubMed  Europe PubMed DOI  V
  35. Seidah,N.G.
    Proprotein convertase 1/3
    [ISSN:978-0-12-407742-3]3, 3286-3290. DOI
    36. 2011
  36. Basak,A., Chen,A., Majumdar,S. and Smith,H.P.
    In vitro assay for protease activity of proprotein convertase subtilisin kexins (PCSKs): an overall review of existing and new methodologies
    Methods Mol Biol768, 127-153. PubMed  Europe PubMed DOI  A
  37. Bramante,G., Patel,O., Shulkes,A. and Baldwin,G.S.
    Ferric ions inhibit proteolytic processing of progastrin
    Biochem Biophys Res Commun404, 1083-1087. PubMed  Europe PubMed DOI
  38. Choquet,H., Stijnen,P. and Creemers,J.W.
    Genetic and functional characterization of PCSK1
    Methods Mol Biol768, 247-253. PubMed  Europe PubMed DOI
  39. Icimoto,M.Y., Barros,N.M., Ferreira,J.C., Marcondes,M.F., Andrade,D., Machado,M.F., Juliano,M.A., Judice,W.A., Juliano,L. and Oliveira,V.
    Hysteretic behavior of proprotein convertase 1/3 (PC1/3)
    PLoS ONE6, e24545-e24545. PubMed  Europe PubMed DOI
  40. Mbikay,M., Sirois,F., Nkongolo,K.K., Basak,A. and Chretien,M.
    Effects of rs6234/rs6235 and rs6232/rs6234/rs6235 PCSK1 single-nucleotide polymorphism clusters on proprotein convertase 1/3 biosynthesis and activity
    Mol Genet Metab104, 682-687. PubMed  Europe PubMed DOI  M
  41. Seidah,N.G.
    The proprotein convertases, 20 years later
    Methods Mol Biol768, 23-57. PubMed  Europe PubMed DOI  V
  42. Seidah,N.G.
    What lies ahead for the proprotein convertases?
    Ann N Y Acad Sci1220, 149-161. PubMed  Europe PubMed DOI  V
    43. 2010
  43. Chang,Y.C., Chiu,Y.F., Shih,K.C., Lin,M.W., Sheu,W.H., Donlon,T., Curb,J.D., Jou,Y.S., Chang,T.J., Li,H.Y. and Chuang,L.M.
    Common PCSK1 haplotypes are associated with obesity in the Chinese population
    Obesity (Silver Spring)18, 1404-1409. PubMed  Europe PubMed DOI  M
  44. Ozawa,A., Peinado,J.R. and Lindberg,I.
    Modulation of prohormone convertase 1/3 properties using site-directed mutagenesis
    Endocrinology151, 4437-4445. PubMed  Europe PubMed DOI
  45. Tian,S. and Jianhua,W.
    Comparative study of the binding pockets of mammalian proprotein convertases and its implications for the design of specific small molecule inhibitors
    Int J Biol Sci6, 89-95. PubMed  Europe PubMed  P  I
  46. Wardman,J.H., Zhang,X., Gagnon,S., Castro,L.M., Zhu,X., Steiner,D.F., Day,R. and Fricker,L.D.
    Analysis of peptides in prohormone convertase 1/3 null mouse brain using quantitative peptidomics
    J Neurochem114, 215-225. PubMed  Europe PubMed DOI  K
  47. Zhou,J. and Cai,Z.H.
    Molecular cloning and characterization of prohormone convertase 1 gene in abalone (Haliotis diversicolor supertexta)
    Comp Biochem Physiol B Biochem Mol Biol155, 331-339. PubMed  Europe PubMed DOI
    48. 2009
  48. Blanchard,A., Iwasiow,B., Yarmill,A., Fresnosa,A., Silha,J., Myal,Y., Murphy,L.C., Chretien,M., Seidah,N. and Shiu,R.P.
    Targeted production of proprotein convertase PC1 enhances mammary development and tumorigenesis in transgenic mice
    Can J Physiol Pharmacol87, 831-838. PubMed  Europe PubMed DOI
  49. Dikeakos,J.D., Di Lello,P., Lacombe,M.J., Ghirlando,R., Legault,P., Reudelhuber,T.L. and Omichinski,J.G.
    Functional and structural characterization of a dense core secretory granule sorting domain from the PC1/3 protease
    Proc Natl Acad Sci U S A106, 7408-7413. PubMed  Europe PubMed DOI  S
  50. Morash,M.G., MacDonald,A.B., Croll,R.P. and Anini,Y.
    Molecular cloning, ontogeny and tissue distribution of zebrafish (Danio rerio) prohormone convertases: pcsk1 and pcsk2
    Gen Comp Endocrinol162, 179-187. PubMed  Europe PubMed DOI
  51. Rholam,M. and Fahy,C.
    Processing of peptide and hormone precursors at the dibasic cleavage sites
    Cell Mol Life Sci66, 2075-2091. PubMed  Europe PubMed DOI
    52. 2008
  52. Benzinou,M., Creemers,J.W., Choquet,H., Lobbens,S., Dina,C., Durand,E., Guerardel,A., Boutin,P., Jouret,B., Heude,B., Balkau,B., Tichet,J., Marre,M., Potoczna,N., Horber,F., Le Stunff,C., Czernichow,S., Sandbaek,A., Lauritzen,T., Borch-Johnsen,K., Andersen,G., Kiess,W., Korner,A., Kovacs,P., Jacobson,P., Carlsson,L.M., Walley,A.J., Jorgensen,T., Hansen,T., Pedersen,O., Meyre,D. and Froguel,P.
    Common nonsynonymous variants in PCSK1 confer risk of obesity
    Nat Genet40, 943-945. PubMed  Europe PubMed DOI  M
  53. Creemers,J.W. and Khatib,A.M.
    Knock-out mouse models of proprotein convertases: unique functions or redundancy?
    Front Biosci13, 4960-4971. PubMed  Europe PubMed DOI  K
  54. Rehfeld,J.F., Zhu,X., Norrbom,C., Bundgaard,J.R., Johnsen,A.H., Nielsen,J.E., Vikesaa,J., Stein,J., Dey,A., Steiner,D.F. and Friis-Hansen,L.
    Prohormone convertases 1/3 and 2 together orchestrate the site-specific cleavages of progastrin to release gastrin-34 and gastrin-17
    Biochem J415, 35-43. PubMed  Europe PubMed DOI
    55. 2007
  55. Dikeakos,J.D., Mercure,C., Lacombe,M.J., Seidah,N.G. and Reudelhuber,T.L.
    PC1/3, PC2 and PC5/6A are targeted to dense core secretory granules by a common mechanism
    FEBS J274, 4094-4102. PubMed  Europe PubMed DOI
  56. Farooqi,I.S., Volders,K., Stanhope,R., Heuschkel,R., White,A., Lank,E., Keogh,J., O'Rahilly,S. and Creemers,J.W.
    Hyperphagia and early-onset obesity due to a novel homozygous missense mutation in prohormone convertase 1/3
    J Clin Endocrinol Metab92, 3369-3373. PubMed  Europe PubMed DOI  M
  57. Lou,H., Smith,A.M., Coates,L.C., Cawley,N.X., Loh,Y.P. and Birch,N.P.
    The transmembrane domain of the prohormone convertase PC3: a key motif for targeting to the regulated secretory pathway
    Mol Cell Endocrinol267, 17-25. PubMed  Europe PubMed DOI
  58. Mbikay,M., Croissandeau,G., Sirois,F., Anini,Y., Mayne,J., Seidah,N.G. and Chretien,M.
    A targeted deletion/insertion in the mouse Pcsk1 locus is associated with homozygous embryo preimplantation lethality, mutant allele preferential transmission and heterozygous female susceptibility to dietary fat
    Dev Biol306, 584-598. PubMed  Europe PubMed DOI  K
  59. Rabah,N., Gauthier,D., Dikeakos,J.D., Reudelhuber,T.L. and Lazure,C.
    The C-terminal region of the proprotein convertase 1/3 (PC1/3) exerts a bimodal regulation of the enzyme activity in vitro
    FEBS J274, 3482-3491. PubMed  Europe PubMed DOI
    60. 2006
  60. Lloyd,D.J., Bohan,S. and Gekakis,N.
    Obesity, hyperphagia and increased metabolic efficiency in Pc1 mutant mice
    Hum Mol Genet15, 1884-1893. PubMed  Europe PubMed DOI  M
  61. [YEAR:11-1-2006]Rabah,N., Gauthier,D., Wilkes,B.C., Gauthier,D.J. and Lazure,C.
    Single amino acid substitution in the PC1/3 propeptide can induce significant modifications of its inhibitory profile toward its cognate enzyme
    J Biol Chem281, 7556-7567. PubMed  Europe PubMed DOI
  62. Scamuffa,N., Calvo,F., Chretien,M., Seidah,N.G. and Khatib,A.M.
    Proprotein convertases: lessons from knockouts
    FASEB J20, 1954-1963. PubMed  Europe PubMed DOI  K  V
    63. 2005
  63. [YEAR:14-1-2005]Henrich,S., Lindberg,I., Bode,W. and Than,M.E.
    Proprotein convertase models based on the crystal structures of furin and kexin: explanation of their specificity
    J Mol Biol345, 211-227. PubMed  Europe PubMed DOI  S
  64. [YEAR:29-3-2005]Pan,H., Nanno,D., Che,F.Y., Zhu,X., Salton,S.R., Steiner,D.F., Fricker,L.D. and Devi,L.A.
    Neuropeptide processing profile in mice lacking prohormone convertase-1
    Biochemistry44, 4939-4948. PubMed  Europe PubMed DOI  K
  65. [YEAR:12-4-2005]Stettler,H., Suri,G. and Spiess,M.
    Proprotein convertase PC3 is not a transmembrane protein
    Biochemistry44, 5339-5345. PubMed  Europe PubMed DOI
  66. [YEAR:23-6-2005]Tagen,M.B. and Beinfeld,M.C.
    Recombinant prohormone convertase 1 and 2 cleave purified pro cholecystokinin (CCK) and a synthetic peptide containing CCK 8 Gly Arg Arg and the carboxyl-terminal flanking peptide
    Peptides26, 2530-2535. PubMed  Europe PubMed DOI
    67. 2004
  67. Cain,B.M., Connolly,K., Blum,A.C., Vishnuvardhan,D., Marchand,J.E., Zhu,X., Steiner,D.F. and Beinfeld,M.C.
    Genetic inactivation of prohormone convertase (PC1) causes a reduction in cholecystokinin (CCK) levels in the hippocampus, amygdala, pons and medulla in mouse brain that correlates with the degree of colocalization of PC1 and CCK mRNA in these structures in rat brain
    J Neurochem89, 307-313. PubMed  Europe PubMed DOI  K
  68. Dey,A., Norrbom,C., Zhu,X., Stein,J., Zhang,C., Ueda,K. and Steiner,D.F.
    Furin and prohormone convertase 1/3 are major convertases in the processing of mouse pro-growth hormone-releasing hormone
    Endocrinology145, 1961-1971. PubMed  Europe PubMed DOI
  69. Lee,S.N., Prodhomme,E. and Lindberg,I.
    Prohormone convertase 1 (PC1) processing and sorting: effect of PC1 propeptide and proSAAS
    J Endocrinol182, 353-364. PubMed  Europe PubMed DOI
  70. Posner,S.F., Vaslet,C.A., Jurofcik,M., Lee,A., Seidah,N.G. and Nillni,E.A.
    Stepwise posttranslational processing of progrowth hormone-releasing hormone (proGHRH) polypeptide by furin and PC1
    Endocrine23, 199-213. PubMed  Europe PubMed DOI
  71. Rabah,N., Gauthier,D.J., Gauthier,D. and Lazure,C.
    Improved PC1/3 production through recombinant expression in insect cells and larvae
    Protein Expr Purif37, 377-384. PubMed  Europe PubMed DOI  E
  72. Seidah,N.G. and Chretien,M.
    Proprotein convertase 1
    [ISSN:0-12-079610-4]2, 1861-1864.  V
  73. [YEAR:20-11-2004]Ugleholdt,R., Zhu,X., Deacon,C.F., Orskov,C., Steiner,D.F. and Holst,J.J.
    Impaired intestinal proglucagon processing in mice lacking prohormone convertase 1
    Endocrinology145, 1349-1355. PubMed  Europe PubMed DOI  K
    74. 2003
  74. Jackson,R.S., Creemers,J.W., Farooqi,I.S., Raffin-Sanson,M.L., Varro,A., Dockray,G.J., Holst,J.J., Brubaker,P.L., Corvol,P., Polonsky,K.S., Ostrega,D., Becker,K.L., Bertagna,X., Hutton,J.C., White,A., Dattani,M.T., Hussain,K., Middleton,S.J., Nicole,T.M., Milla,P.J., Lindley,K.J. and O'Rahilly,S.
    Small-intestinal dysfunction accompanies the complex endocrinopathy of human proprotein convertase 1 deficiency
    J Clin Invest112, 1550-1560. PubMed  Europe PubMed DOI  K
  75. Peinado,J.R., Li,H., Johanning,K. and Lindberg,I.
    Cleavage of recombinant proenkephalin and blockade mutants by prohormone convertases 1 and 2: an in vitro specificity study
    J Neurochem87, 868-878. PubMed  Europe PubMed DOI
  76. Taylor,N.A., Van de Ven,W.J. and Creemers,J.W.
    Curbing activation: proprotein convertases in homeostasis and pathology
    FASEB J17, 1215-1227. PubMed  Europe PubMed DOI  K
  77. [YEAR:13-5-2003]Ueda,K., Lipkind,G.M., Zhou,A., Zhu,X., Kuznetsov,A., Philipson,L., Gardner,P., Zhang,C. and Steiner,D.F.
    Mutational analysis of predicted interactions between the catalytic and P domains of prohormone convertase 3 (PC3/PC1)
    Proc Natl Acad Sci U S A100, 5622-5627. PubMed  Europe PubMed DOI
    78. 2002
  78. Fugere,M. and Day,R.
    Inhibitors of the subtilase-like pro-protein convertases (SPCs)
    Curr Pharm Des8, 549-562. PubMed  Europe PubMed DOI  V  I
  79. Seidah,N.G. and Prat,A.
    Precursor convertases in the secretory pathway, cytosol and extracellular milieu
    Essays Biochem38, 79-94. PubMed  Europe PubMed
  80. [YEAR:19-7-2002]Tangrea,M.A., Bryan,P.N., Sari,N. and Orban,J.
    Solution structure of the pro-hormone convertase 1 pro-domain from Mus musculus
    J Mol Biol320, 801-812. PubMed  Europe PubMed DOI
  81. [YEAR:6-8-2002]Zhu,X., Orci,L., Carroll,R., Norrbom,C., Ravazzola,M. and Steiner,D.F.
    Severe block in processing of proinsulin to insulin accompanied by elevation of des-64,65 proinsulin intermediates in islets of mice lacking prohormone convertase 1/3
    Proc Natl Acad Sci U S A99, 10299-10304. PubMed  Europe PubMed DOI  K
    82. 2001
  82. [YEAR:31-8-2001]Basak,A., Koch,P., Dupelle,M., Fricker,L.D., Devi,L.A., Chretien,M. and Seidah,N.G.
    Inhibitory specificity and potency of proSAAS-derived peptides toward proprotein convertase 1
    J Biol Chem276, 32720-32728. PubMed  Europe PubMed DOI  I
  83. [YEAR:8-5-2001]Tangrea,M.A., Alexander,P., Bryan,P.N., Eisenstein,E., Toedt,J. and Orban,J.
    Stability and global fold of the mouse prohormone convertase 1 pro-domain
    Biochemistry40, 5488-5495. PubMed  Europe PubMed DOI
    84. 2000
  84. [YEAR:12-5-2000]Cameron,A., Fortenberry,Y. and Lindberg,I.
    The SAAS granin exhibits structural and functional homology to 7B2 and contains a highly potent hexapeptide inhibitor of PC1
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